• Title/Summary/Keyword: initial damage level

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Analysis of Specificity for Tumor Marker CYFRA 21-1 in Patients with Pulmonary Tuberculosis (폐결핵 환자에서 종양표지자 CYFRA 21-1의 특이도 분석)

  • Ha, Hyun-Cheol;Lee, Jae-Sung;Song, Sun-Dae;Kim, Cheol-Min;Lee, Min-Gi;Kim, In-Joo
    • Tuberculosis and Respiratory Diseases
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    • v.45 no.2
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    • pp.290-300
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    • 1998
  • Background: CYFRA 21-1 is a tumor marker which measures a fragment of cytokeratin 19 expressed by epithelial cells in bronchus. It is known that cytokeratin 19 is abundant in squamous epithelial cell cancer of the lung. However, if the incidence of elevated serum CYFRA 21-1 level in patients with benign lung diseases or pulmonary tuberculosis with severe parenchymal damage is high the specificity of CYFRA 21-1 could be decreased. The purpose of this study is to investigate the changes of serum CYFRA 21-1 according to the degree of parenchymal damage and the usefulness of CYFRA 21-1 for diagnosing possibly combined lung cancer in patients with pulmonary tuberculosis. Method: We studied the changes of serum CYFRA 21-1 according to the sputum AFB stain, radiologic manifestation and history of treatment in 81 patients with pulmonary tuberculosis, and 20 healthy persons, 25 patients with lung cancer, as a control group. CYFRA 21-1 concentration in serum was quantified by the immunoradiometry assay(Centocor$^{(R)}$). Result: The results were as follow; Serum CYFRA 21-1 level was significantly lower in patients with pulmonary tuberculosis($1.54{\pm}1.19ng/mL$, p<0.01) as compared to patients with lung cancer($12.25{\pm}15.97ng/mL$), and was slightly higher than the level in heathy persons($0.90{\pm}0.49ng/mL$) but there was no significant difference. Serum CYFRA 21-1 level was below the cut-off value of 3.3ng/mL in 95 percent of patients with pulmonary tuberculosis but it was above the cut-off value in 64 percent of patients with lung cancer. Serum CYFRA 21-1 level was significantly higher in the initial treatment group($1.91{\pm}1.55ng/mL$, p<0.05) as compared to the treatment. failure group ($0.92{\pm}0.30ng/mL$). According to the sputum AFB smear, serum CYFRA 21-1 level in patients with negative result was slightly higher than the level in patients with positive result but there was no significant difference. According to the radiologic manifestation, serum CYFRA 21-1 level was significantly higher in patients with infiltrative lesion ($2.15{\pm}1.63ng/mL$, p<0.01) as compared to patients with destructive lesion ($l.04{\pm}0.54ng/mL$). As the size of cavity or destructive lesion was larger, the level was significantly lower(p<0.05). Conclusion: As serum CYFRA 21-1 level was significantly higher in the initial treatment group and patients with infiltrative lesion, it suppose to be closely related with the degree of parenchymal damage of the lung of the pulmonary tuberculosis. However CYFRA 21-1 could be useful method for diagnosing lung cancer even in patients with pulmonary tuberculosis combined with lung cancer because of the fact that it was below the cutoff value of 3.3ng/mL in 95 percent of patients with pulmonary tuberculosis.

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Economic Threshold for the Diamondback Moth (Plutella xylostella L., Lepidoptera: Plutellidae) on Leaf Broccoli (Brassica oleracea var. botrytis italiana) (잎브로콜리에서 배추좀나방 요방제 수준 설정)

  • Choi, Seon Wu;Lim, Ju Rak;Kim, Ju-Hee;Lee, Gong-Jun;Moon, Young-Hun;Cheong, Seong-Soo;Lee, Gi-Kwon
    • Korean journal of applied entomology
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    • v.54 no.1
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    • pp.1-6
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    • 2015
  • This study was conducted to estimate the economic injury level (EIL) to leaf broccoli (leaf vegetable) by the diamondback moth (Plutella xylostella L.) in 2007 and obtain basic data for pest management. To investigate the relationship between initial density of diamondback moth larvae and broccoli leaf yield, experimental plots with five treatments (0, 0.5, 1.0, 1.5 and 2.0 larvae per plant) as initial density were established. We inoculated larvae on cheesecloth covering to survey changes in larval density. When grown for consumption, leaves of broccoli are harvested in periods. High levels of larvae were associated with significant reductions in leaf yield. There were 0%, 15%, 35%, 42%, 44% yield reductions due to a density of 0, 0.5, 1.0, 1.5, 2.0 diamond back moth larvae per plant, respectively, 25 days after larva inoculation. The regression equation used to predict leaf yield based on the number of initial larvae per plant was y = 1636-394x($R^2=0.79^{***}$>). EIL of the diamondback moth on leaf broccoli was 2~3 larvae per 10 plants for a damage level of 5%. The economic threshold was 1~2 larvae per 10 plants. Thus, diamondback moth management should be initiated when 1~2 larvae appear on 10 plants.

A study on the estimation of hydrologic function for ecological restoration at forested wetland (산지습지의 생태적 복원을 위한 수문학적 기능 평가에 관한 연구)

  • Jung, Yu-Gyeong;Kang, Won-Seok;Lee, Heon-Ho
    • Journal of the Korean Society of Environmental Restoration Technology
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    • v.25 no.3
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    • pp.97-111
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    • 2022
  • This study was conducted as restoration work to improve the discharge in forested wetlands where there is a concern of damage and observed changes in the discharge and groundwater level. The monthly changes showed that during the wet season, the amount of discharge decreased after restoration and GWL increased. It showed that during the dry season, the GWL and discharge increased. The increased discharge after restoration seems to be the difference in the number of days with no rainfall duration. The change in discharge for each unit of rainfall showed a tendency to increase the baseflow and decrease the direct discharge after restoration. The recharge ratio of GWL showed a decreasing tendency as rainfall was higher. After restoration, it showed a higher tendency under rainfall with less than 20mm. It has been confirmed that the restoration implemented by the study caused such an effect as the increased baseflow and increased GWL. It would be an effective restoration method to maintain water resources in forested wetlands. In the initial rainfall, it demonstrated a certain level of effect, but it is necessary to develop a restoration technology that can decrease the amount of water discharged after the end of rainfall or during the period of no rainfall to protect and maintain the forested wetlands. Streamflow should be identified by each type of terrain of wetlands and a proper restoration countermeasure should be devised for the site where the discharge frequently occurs.

Comparative study of meteorological data for river level prediction model (하천 수위 예측 모델을 위한 기상 데이터 비교 연구)

  • Cho, Minwoo;Yoon, Jinwook;Kim, Changsu;Jung, Heokyung
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • 2022.05a
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    • pp.491-493
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    • 2022
  • Flood damage due to torrential rains and typhoons is occurring in many parts of the world. In this paper, we propose a water level prediction model using water level, precipitation, and humidity data, which are key parameters for flood prediction, as input data. Based on the LSTM and GRU models, which have already proven time-series data prediction performance in many research fields, different input datasets were constructed using the ASOS(Automated Synoptic Observing System) data and AWS(Automatic Weather System) data provided by the Korea Meteorological Administration, and performance comparison experiments were conducted. As a result, the best results were obtained when using ASOS data. Through this paper, a performance comparison experiment was conducted according to the input data, and as a future study, it is thought that it can be used as an initial study to develop a system that can make an evacuation decision in advance in connection with the flood risk determination model.

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Control of Both Foam and Dissolved Oxygen in the Presence of a Surfactant for Production of $\beta$-Carotene in Blakeslea trispora

  • Kim, Seon-Won;Lee, In-Young;Jeong, Jae-Cheol;Lee, Jung-Heon;Park, Young-Hoon
    • Journal of Microbiology and Biotechnology
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    • v.9 no.5
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    • pp.548-553
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    • 1999
  • A production of $\beta-Carotene$was attempted in a fed-batch culture of Blakeslea trispora by controlling both foam and dissolved oxygen in the presence of surfactant, Span 20. Results obtained from the shake flask cultures indicated that a high concentration of dissolved oxygen was needed for both cell growth and $\beta-Carotene$ synthesis, and the optimal concentration of glucose was found to be in the range of 50-100 g/l. In order to maintain the dissolved oxygen concentration level at higher than 50% of air saturation, pure oxygen was automatically sparged into the medium with air. Foam was controlled by bypassing air from the submerged aeration to the headspace in response to the foam that was caused by Span 20. High agitation speed was found to be detrimental to the cell growth due to shear damage, even though it provided sufficient dissolved oxygen. On the other hand, a low aeration speed caused stagnant regions in the fermentor because of improper mixing. Thus, for the fed-batch operation, agitation speed was increased gradually from 300 to 700 rpm to prevent cell damage at the initial stage of fermentation and to give efficient mixing for a viscous culture broth as the culture proceeded. By controlling dissolved oxygen and foam, a high concentration of $\beta-Carotene$otene (1,190 mg/l) was obtained in 6 days of the fed-batch culture of B. trispora with 2.5% of the dry cell weight, which was approximately 5 times higher than that of the batch cultures.

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Iatrogenic Ureteral Injury: When and How to Treat? (의인성 요관손상: 언제, 어떻게 치료할 것인가?)

  • Seo, Kang Il;Lee, Jong Bouk
    • Journal of Trauma and Injury
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    • v.21 no.1
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    • pp.8-14
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    • 2008
  • Iatrogenic ureteral injury is a complication that can occur during a variety of pelvic or abdominal surgeries. The most frequent causes are gynecological ones, followed by colon and vascular surgeries. Management of ureteric injury depends on the time of diagnosis and the severity of organ damage. Injuries diagnosed intraoperatively should be treated immediately. Occasionally, intraoperative ureteral injury is overlooked, and symptoms of the late diagnosis of ureteral injury are usually nonspecific; therefore, the diagnosis is delayed for days or weeks postoperatively. Management of injuries diagnosed postoperatively is more complex. There are differing opinions on whether an initial conservative or immediate operative intervention is the best line of action. Delayed repair is suggested on the grounds that it will reduce inflammation and tissue edema. However, many authors are in favor of early repair, perhaps because tissue planes are easier to find before fibrosis becomes too dense. Ureteral injuries occurring at the level of the pelvic brim should be best managed with an end-to-end anastomosis, preferably around a ureteric stent. More distal injuries also should be ideally managed with an end-to-end anastomosis, after excision of the crushed or compromised segments. However, if the remaining distal segment is short, ureteral reimplantation is the procedure of choice. The Boari flap technique for ureteral reimplantation is invaluable in cases with a short proximal segment. Delayed recognition of iatrogenic ureteral injury may be associated with serious complications, so prompt recognition of ureteral injuries is important. Recognition of the injury before closure is the key to easy, successful, and complications-free repair. Increased awareness of the risk for ureteral damage during certain operative maneuvers is vital to prevent injury, and to decrease the incidence of iatrogenic injury. A sound knowledge of abdominal and pelvic anatomy is the best prevention.

Effect of Density of Helicotylenchus dihystera on Growth of Solanum lycopersicum (나선선충 접종 밀도가 토마토 생육에 미치는 영향)

  • Kim, Donggeun;Ryu, Younghyun;Lee, Younsu;Choi, Insoo;Hu, Changsuk
    • Research in Plant Disease
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    • v.20 no.2
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    • pp.107-111
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    • 2014
  • A greenhouse experiment was conducted to examine the effect of initial population density (Pi) of Helicotylenchus dihystera on six commercial tomato cultivars. Two-week-old tomato seedlings of six commercial cultivars were transplanted in d-10-cm clay pot and was inoculated with to give 0, 0.02, 0.2, and 2 nematodes/g soil. Plants were grown in a greenhouse for 60 days. Root and plant weights were unaffected but plant height declined only at inoculum level of 2 nematodes/g soil. At the highest initial population density (2 nematodes/g soil), plant height of tomato cv. Poseidon was reduced by 24%. Tomato cv. Hoyong produced the most nematodes with 7.0 nematodes/g soil and the least was tomato cv. Miniheuksu with 2.2 nematodes/g soil.

Interfacial stresses in damaged RC beams strengthened by externally bonded prestressed GFRP laminate plate: Analytical and numerical study

  • Chergui, Selma;Daouadji, Tahar Hassaine;Hamrat, Mostefa;Boulekbache, Bensaid;Bougara, Abdelkader;Abbes, Boussad;Amziane, Sofiane
    • Advances in materials Research
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    • v.8 no.3
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    • pp.197-217
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    • 2019
  • In this study, the interfacial stresses in RC beams strengthened by externally bonded prestressed GFRP laminate are evaluated using an analytical approach, based on the equilibrium equations and boundary conditions. A comparison of the interfacial stresses obtained from the present analytical model and other existing models is undertaken. Otherwise, a parametric study is conducted to investigate the effects of geometrical and material properties on the variation of interfacial stresses in damaged RC beams strengthened by externally bonded prestressed GFRP laminate. The results obtained indicate that the damage degree has little effect on the maximum shear stress, with a variation less than 5% between the damaged and undamaged RC beams. However, the results also reveal that the prestressing level has a significant effect on the interfacial stresses; hence the damaged RC beam strengthened with an initial prestressing force of 100 kN gives 110% higher maximum shear stress than the damaged RC beam strengthened with an initial prestressing force of 50 kN. The values of shear stress obtained by the analytical approach are approximately equal to 44% of those obtained from the numerical solution, while the interfacial normal stresses predicted by the numerical study are approximately 26% higher than those calculated by the analytical solution.

Dynamic quantitative risk assessment of accidents induced by leakage on offshore platforms using DEMATEL-BN

  • Meng, Xiangkun;Chen, Guoming;Zhu, Gaogeng;Zhu, Yuan
    • International Journal of Naval Architecture and Ocean Engineering
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    • v.11 no.1
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    • pp.22-32
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    • 2019
  • On offshore platforms, oil and gas leaks are apt to be the initial events of major accidents that may result in significant loss of life and property damage. To prevent accidents induced by leakage, it is vital to perform a case-specific and accurate risk assessment. This paper presents an integrated method of Ddynamic Qquantitative Rrisk Aassessment (DQRA)-using the Decision Making Trial and Evaluation Laboratory (DEMATEL)-Bayesian Network (BN)-for evaluation of the system vulnerabilities and prediction of the occurrence probabilities of accidents induced by leakage. In the method, three-level indicators are established to identify factors, events, and subsystems that may lead to leakage, fire, and explosion. The critical indicators that directly influence the evolution of risk are identified using DEMATEL. Then, a sequential model is developed to describe the escalation of initial events using an Event Tree (ET), which is converted into a BN to calculate the posterior probabilities of indicators. Using the newly introduced accident precursor data, the failure probabilities of safety barriers and basic factors, and the occurrence probabilities of different consequences can be updated using the BN. The proposed method overcomes the limitations of traditional methods that cannot effectively utilize the operational data of platforms. This work shows trends of accident risks over time and provides useful information for risk control of floating marine platforms.

Nonlinear spectral design analysis of a structure for hybrid self-centring device enabled structures

  • Golzar, Farzin G.;Rodgers, Geoffrey W.;Chase, J. Geoffrey
    • Structural Engineering and Mechanics
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    • v.61 no.6
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    • pp.701-709
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    • 2017
  • Seismic dissipation devices can play a crucial role in mitigating earthquake damages, loss of life and post-event repair and downtime costs. This research investigates the use of ring springs with high-force-to-volume (HF2V) dissipaters to create damage-free, recentring connections and structures. HF2V devices are passive rate-dependent extrusion-based devices with high energy absorption characteristics. Ring springs are passive energy dissipation devices with high self-centring capability to reduce the residual displacements. Dynamic behaviour of a system with nonlinear structural stiffness and supplemental hybrid damping via HF2V devices and ring spring dampers is used to investigate the design space and potential. HF2V devices are modelled with design forces equal to 5% and 10% of seismic weight and ring springs are modelled with loading stiffness values of 20% and 40% of initial structural stiffness and respective unloading stiffness of 7% and 14% of structural stiffness (equivalent to 35% of their loading stiffness). Using a suite of 20 design level earthquake ground motions, nonlinear response spectra for 8 different configurations are generated. Results show up to 50% reduction in peak displacements and greater than 80% reduction in residual displacements of augmented structure compared to the baseline structure. These gains come at a cost of a significant rise in the base shear values up to 200% mainly as a result of the force contributed by the supplemental devices.