• Journal of Institute of Control, Robotics and Systems
• /
• v.10 no.12
• /
• pp.1172-1180
• /
• 2004

Recently, the gene expression data, product of high-throughput technology, appeared in earnest and the studies related with it (so-called bioinformatics) occupied an important position in the field of biological and medical research. The microarray is a revolutionary technology which enables us to monitor several thousands of genes simultaneously and thus to gain an insight into the phenomena in the human body (e.g. the mechanism of cancer progression) at the molecular level. To obtain useful information from such gene expression measurements, it is essential to analyze the data with appropriate techniques. However the high-dimensionality of the data can bring about some problems such as curse of dimensionality and singularity problem of matrix computation, and hence makes it difficult to apply conventional data analysis methods. Therefore, the development of method which can effectively treat the data becomes a challenging issue in the field of computational biology. This research focuses on the gene selection and classification for cancer subtype discrimination based on gene expression (microarray) data.

• Asian Pacific Journal of Cancer Prevention
• /
• v.17 no.5
• /
• pp.2535-2537
• /
• 2016

Background: Most of the cervical cancer patients, including those with cervical adenocarcinomas, come at advanced stage in the developing world so its mortality is high. Radiotherapy is one of the treatment modality for advanced stage cervical adenocarcinomas, but its efficacy depends on several prognostic factors such as the stage, histopathology, presence of organ dysfunction and expression of cellular biology markers mainly involve in cell proliferation such as the epidermal growth factor receptor (EGFR). Some research indicates that activation of EGFR in malignancy (including cervical cancer) correlates with aggressive behavior, a poor prognosis and decreasing sensitivity of radiotherapy. However, the combination between targeted therapies and radiotherapy are innovative approaches which may provide a good result. This study aimed to assess any correlation between expression of EGFR and response to radiotherapy in cervical adenocarcinoma cases. Materials and Methods: A total of 32 women were registered in a retrospective study period January 2007 and May 2014. Paraffin blocks from these patients were processed by classical histological techniques and for immunohistochemical staining of EGFR, scoring being accomplished according to the immunoreactive scoring (IRS) of Remmele and Stegner. Results: Among the studied molecular factors, there was significant correlation expression of EGFR with poor response to radiotherapy (p=0.0001). Conclusions: The result of this study showed a significant correlation between expression of EGFR and sensitivity of radiation in cervical adenocarcinoma cases. Further research is necessary to obtain information about new therapeutic management.

• Journal of KIISE
• /
• v.42 no.10
• /
• pp.1280-1285
• /
• 2015

Many hardware-based regular expression matching architectures are proposed for high performance matching. In particular, regular expression processors such as ReCPU and SMPU perform pattern matching in a similar approach to that used in general purpose processors, which provide the flexibility when updating patterns. However, these processors are inefficient in performing class matching since they do not provide character class matching capabilities. This paper proposes an instruction set and architecture of a regular expression matching processor, which can support character class matching. The proposed processor can efficiently perform character class matching since it includes character class, character range, and negated character class matching capabilities.

• Korean Journal of Cognitive Science
• /
• v.14 no.4
• /
• pp.33-42
• /
• 2003

This paper presents a new system for facial expression recognition based in dimension model of internal states. The information of facial expression are extracted to the three steps. In the first step, Gabor wavelet representation extracts the edges of face components. In the second step, sparse features of facial expressions are extracted using fuzzy C-means(FCM) clustering algorithm on neutral faces, and in the third step, are extracted using the Dynamic Model(DM) on the expression images. Finally, we show the recognition of facial expression based on the dimension model of internal states using a multi-layer perceptron. The two dimensional structure of emotion shows that it is possible to recognize not only facial expressions related to basic emotions but also expressions of various emotion.

• Environmental Analysis Health and Toxicology
• /
• v.24 no.2
• /
• pp.107-117
• /
• 2009

Metal pollution of aquatic ecosystems is a problem of economic and health importance. Information regarding molecular responses to metal exposure is sorely needed in order to identify potential biomarkers. To determine the effects of heavy metals on chironomids, the full-length cDNA of alcohol dehydrogenase (ADH3) from Chironomus riparius was determined through molecular cloning and rapid amplification of cDNA ends (RACE). The expression of ADH3 was analyzed under various cadmium and copper concentrations. A comparative and phylogenetic study among different orders of insects and vertebrates was carried out through analysis of sequence databases. The complete cDNA sequence of the ADH3 gene was 1134 bp in length. The sequence of C. riparius ADH3 shows a low degree of amino acid identity (around 70%) with homologous sequences in other insects. After exposure of C. riparius to various concentrations of copper, ADH3 gene expression significantly decreased within 1 hour. The ADH3 gene expression was also suppressed in C. riparius after cadmium exposure for 24 hour. However, the effect of cadmium on ADH3 gene expression was transient in C. riparius. The results show that the suppression of ADH3 gene by copper exposure could be used as a possible biomarker in aquatic environmental monitoring and imply differential toxicity to copper and cadmium in C. riparius larvae.

• International Journal of Industrial Entomology and Biomaterials
• /
• v.23 no.1
• /
• pp.137-141
• /
• 2011

A previous data was provided information for tissuespecific expression genes by means of whole-genome oligonucleotide microarray in the silkworm. We analyzed the tissue-specific expression patterns in the hemocyte tissue on 5 days of 5th instar larvae during the development of $B.$ $mori$. Total 5 candidates pick out from the $Bombyx$ $mori$ Microarray Database (BmMDB; http://silkworm.swu.edu.cn/microarray). To verify the hemocyte-specific expression, we analyzed by semi-quantitative and real-time quantitative RT-PCR using the highly expressed endogenous $Actin$ RNA as an intrinsic reference. In this study, we confirmed that one gene-sw17255- out of 5 candidates expressed in the hemocyte tissue, which was consistent with the previous data. Circulating hemocytes in the body fluid of the $B.$ $mori$ are most powerful target organ for producing biomaterials. We need further studies to find hemocyte-specific promoter region from sw17255 gene. Finally, this result can be applied in creating transgenic silkworms as a biomedical insect.

• Journal of the Institute of Electronics Engineers of Korea SP
• /
• v.46 no.4
• /
• pp.157-164
• /
• 2009

An efficient pipeline MDC Radix-4 FFT structure is proposed in this paper. Every stages in pipeline FFT structure consists of delay' commutator and butterfly. Proposed butterflies in front and rear stages utilize CORDIC and Common Sub-expression Sharing(CSS) techniques, respectively. It is shown that proposed butterfly structure can reduce the number of adders through sharing common patterns of CSD type coefficients. The Verilog-HDL modeling and Synopsys logic synthesis results that the proposed structure show 48.2% cell area reduction in the complex multiplication part and 22.1% cell area reduction in overall 256-point FFT structure comparison with those of the conventional structures. Consequently, the proposed FFT structure can be efficiently used in various OFDM systems.

• Journal of the Korean Society of Costume
• /
• v.60 no.10
• /
• pp.47-64
• /
• 2010

This study was to define the factors of inspiration and expression methods of Viktor & Rolf known for distinctive works in order to find the ways of creative fashion designing. For the research method, the literature reviews were done by designer's books, collection reviews, and related articles. To find the ideas of design inspiration, interview data with Viktor & Rolf were used. The results of this study were as follows. Their conceptional attitude and the fashion shows like performance indicated that the designer's introspection became the origin of the concept and the ideas expanded the fields of expression. The expression of surrealistic fantasy was done by free imagination and daydreams, which was appeared as fantastical world beyond the everyday life. The expression of paradox and contrast overcame stereotype views with inversion, paradox, and ironical expression. The distortion of shape and the extreme exaggeration by overlap and repetition had a intention that magnity the miserable self-images on purpose, which had started from the debut and appeared ever after on collections and which sought the practicality, infinity exceeding the standard of ideal beauty. The harmony between classicism and avant-guard originated from the insights of tradition demonstrated the wits of designers showing the unique ideas with the base of classics.

• KNOM Review
• /
• v.24 no.2
• /
• pp.35-47
• /
• 2021

Various stress exists in a modern society, which requires constant competition and improvement. A person under stress often shows his pressure in his facial expression and language. Therefore, it is possible to measure the pressure using facial expression and language analysis. The paper proposes a stress measurement system using facial expression and language sensitivity analysis. The method analyzes the person's facial expression and language sensibility to derive the stress index based on the main emotional value and derives the integrated stress index based on the consistency of facial expression and language. The quantification and generalization of stress measurement enables many researchers to evaluate the stress index objectively in general.

• Journal of the Korea Fashion and Costume Design Association
• /
• v.26 no.3
• /
• pp.113-127
• /
• 2024

The purpose of this study is to analyze expression characteristics and directing effects for the use of technology in stage costumes and to explore future directions by comparing technology fashion. To this end, the study first investigates technology fashion and identifies its expression characteristics through previous research. Second, it examines the use of technology in stage costumes and studies expression characteristics and directing effects through cases. Third, by comparing technology fashion with stage costumes, it explores future directions for integrating technology into stage costume design. Study methods, include a literature review accompanied by a case study. The findings are as follows: First, the expression characteristics of technology fashion is that digital technology is applied to variable molds according to interaction with the wearer to virtually realize the fluid dematerialization of fashion. Second, the expression characteristics of stage costumes using technology mirror those of technology fashion. However, the visual information expressed through the use of technology was maximized by harmonizing with various stage arts the stage space was expanded to a virtual space. Third, as a result of comparing each other, there is a difference in the objects that cause interaction, so efforts of technology development are required so stage costumes can interact with the performers' acting.