• Biomolecules & Therapeutics
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• v.25 no.4
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• pp.441-451
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• 2017

Imperatorin, a major bioactive furanocoumarin with multifunctions, can be used for treating neurodegenerative diseases. In this study, we investigated the characteristics of imperatorin transport in the brain. Experiments of the present study were designed to study imperatorin transport across the blood-brain barrier both in vivo and in vitro. In vivo study was performed in rats using single intravenous injection and in situ carotid artery perfusion technique. Conditionally immortalized rat brain capillary endothelial cells were as an in vitro model of blood-brain barrier to examine the transport mechanism of imperatorin. Brain distribution volume of imperatorin was about 6 fold greater than that of sucrose, suggesting that the transport of imperatorin was through the blood-brain barrier in physiological state. Both in vivo and in vitro imperatorin transport studies demonstrated that imperatorin could be transported in a concentration-dependent manner with high affinity. Imperatorin uptake was dependent on proton gradient in an opposite direction. It was significantly reduced by pretreatment with sodium azide. However, its uptake was not inhibited by replacing extracellular sodium with potassium or N-methylglucamine. The uptake of imperatorin was inhibited by various cationic compounds, but not inhibited by TEA, choline and organic anion substances. Transfection of plasma membrane monoamine transporter, organic cation transporter 2 and organic cation/carnitine transporter 2/1 siRNA failed to alter imperatorin transport in brain capillary endothelial cells. Especially, tramadol, clonidine and pyrilamine inhibited the uptake of [$^3H$]imperatorin competitively. Therefore, imperatorin is actively transported from blood to brain across the blood-brain barrier by passive and carrier-mediated transporter.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.14 no.1
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• pp.157-168
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• 2013

This study is for finding out Career-barrier of the disabled, and for analyzing the effect of Career-barrier on the dysfunctional career-thought. For this study, 180 disabled people were surveyed. The results are as follows; First, the career-barriers that the disabled people perceive are in order; lack of occupational information, lack of social support, low self-concept clarity, low self-efficiency, and conflict with significant-others. Secondly, difference of career-barrier, caused by the traits of the disabled, has influenced the lack of self clarity and occupational information. In addition, among the types of the disabilities, it is proven that the psychological disability highly correlated to the social support, unlikely to gender difference and job experience. Thirdly, the most influential reason on the decision-making confusion for finding job among the sub-variables of dysfunctional career-thought were; low self-concept clarity, conflict with significant-others, and low self-efficiency. While it turned out that the most influential career-barrier on the performance anxiety for disabled people were low self-efficiency and conflict with significant-others.

• Journal of the Society of Disaster Information
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• v.18 no.1
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• pp.1-9
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• 2022

Purpose: In this study, we used hydrophilic waterstop used in geosynthetics vertical barrier system to evaluate the performance of impermeability under sealing conditions. Method: ASTM D5887 and ASTM D6766 were applied to determine the capability of the connection during the geosynthetics vertical barrier system. Hydrophilic waterstop was saturated in each solution and the weight, thickness, and volume changes were analyzed over elapsed time. Hydrophilic waterstop was installed at the geosynthetics vertical barrier system connection to evaluate the permeability characteristics. Results: As the expansion reaction time of hydrophilic waterstop increased relatively under saline conditions, the decrease in permeability also showed a smaller decrease in fresh water. Furthermore, the method of engagement of the geosynthetics vertical barrier system showed somewhat better performance of the impermeability due to the large pressure resistance caused by the roll joint type than interlock type. Conclusion: In urban pollutants, which can estimate the outflow of pollutants such as oil storage facilities and industrial complexes, proactive response technologies that can prevent the contaminant diffusion can significantly reduce the damage.

• Journal of the Korean Data and Information Science Society
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• v.7 no.1
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• pp.69-78
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• 1996

Consider a natural model for stochastic flow systems is Brownian motion, which is Brownian motion on the positive real line with constant drift and constant diffusion coefficient, modified by an impenetrable reflecting barrier at $x_{0}$. In this paper, we investigate the joint distribution functions and study on the distribution of the first-passage time. Also we find out the distribution of ${\mu}-RBMPx_{0}$.

• Journal of Korea Society of Digital Industry and Information Management
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• v.9 no.2
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• pp.151-163
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• 2013

It goes without saying that the technology innovation plays an important role in the sustainable growth of the firm in the global economy. It, however, is not easy to fulfill this simple and obvious fact. Because there are a lot of barriers hindering innovation activities of firms and innovations are interrupted or don't even attempts by this barriers. So in this paper, I study barriers of firms that try to innovation and how much negative impact exist on firm's innovation performance by that. And also I try to find influence on firm's performance because of declined innovation activities. To prove this, KIS(Korean Innovation Survey) 2008, which was surveyed by STEPI(Science and Technology Policy Institute), is used to find relationships among variables; innovation barriers, innovation activities and firm's performance. In the result, I find that financial barrier influence negatively to the process innovation with small business, capable barrier influence negatively to the process innovation with large business and organizational barrier influence negatively to the process innovation with both small and large business. And, it also appear that organizational barrier has not moderating effect but process efficiency has moderating effect significantly with small business that have more positive effect.

• The Journal of Information Systems
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• v.23 no.3
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• pp.25-46
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• 2014

As the use of smartphone has rapidly spread into the current society, the mobile instant messenger applications such as Kakaotalk, Tiktok, and Line have become an indispensable part of our daily lives. While, the mobile instant messenger has brought us many positive changes, social problems stemming from the dependency on the mobile instant messenger has been occurred. The dependency of the mobile instant messenger can negatively affect daily lives and lead to stress or addiction. Therefore, it is very important to examine how we can prevent such dependency and addiction. In this respect, the purpose of this study is to investigate determinants impacting on the mobile instant messenger dependency, barrier of living, and intention to digital break. The statistical analysis of survey results shows that enjoyment, identity, relationship commitment, critical mass and ease of use are significantly related to mobile instant messenger dependency, while media richness is not significantly related. Mobile instant messenger dependency have a positive effect on barrier of living, which then has a positive effect on digital break. Lastly, the moderating effect of perceived risk is significant. This research suggests theoretical and business implications to prevent mobile instant messenger dependency.

• Journal of the Society of Disaster Information
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• v.12 no.3
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• pp.279-285
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• 2016

Road sides safety barrier system is the last safety during traffic accident. The structural performance of a roadside safety barrier should be kept above expectations. It is possible to protect the passenger's life. End treatment part is installed in the end of the barrier it prevents a phenomenon in which for the vehicle for the guardrail during a vehicle collision it is facility of the absorbing of car crashed impact. By repeated analysis through computer simulation for improving the vehicle crash it will be able to develop crash barriers to respond appropriately to various parameters.

• International Commerce and Information Review
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• v.11 no.3
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• pp.311-335
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• 2009

This study investigates the factors barrier the performance of Korean manufacturing firms in China. Also an empirical data use the field survey of Korean manufacturing firms in China. as a result, First, we find that employment-cost factor, that is rising labor costs, a change of occupation is an effect the performance of Korean manufacturing firms in China. Second, business beginning year and by 7 region factor is very significant on the performance of Korean FDI firms in china. And then, Korean corporate investment in China is a desirable form of long-term investment shall be determined. also we know that regions of China, differentiated investment approach is effective. finally, The result shows that FDI to China is need of the long term plan, and In actual use, these FDI should be applied flexibly in china business environment.

• International Journal of Fuzzy Logic and Intelligent Systems
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• v.6 no.3
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• pp.217-222
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• 2006

Recently, LG chemical corporation developed new material called HYPERIER, which has an excellent barrier characteristic. It has many layers which are made of nano-composite within LDPE(Low-Density Poly Ethylene). In order to guarantee the quality of the final product from the production line, a certain test equipment is required to investigate the existence of layers inside the HYPERIER. In this work, ultrasonic sensor based test equipment for investigating the existence of inner layers is proposed. However, it is a tedious job for human operators to check the existence by just looking at the resounding waveform from ultrasonic sensor. Therefore, to enhance the performance of the ultrasonic test equipment, wavelet and PCA(Principle Componet Analysis) schemes are introduced into neural network scheme which is used for classification. To verify the feasibility of the proposed scheme, some experiments are executed.

• Journal of The Korea Institute of Healthcare Architecture
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• v.16 no.4
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• pp.25-32
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• 2010

Despite the growing interest in recreation as one of the ways to maintain physical and mental health in modern society, access to leisure facility is an issue for individuals with disabilities. This paper identifies inaccessible features to propose the ways to promote participation and usage of the leisure facilities for individuals with disabilities. A survey of individuals with disabilities is conducted to determine preferred leisure facilities depending on types of disabilities. The result of this survey is used to evaluate current condition of regulated National leisure facility and forest, which include barrier-free facilities (e.g. interconnecting zones, interior spaces, lavatories and other facilities), signage, approachable information kiosks, emergency egress, and detectable warnings. The common issues (e.g. guiding mechanism, accessible route, safety factors, and barrier-free facilities/services) in various types of recreational facilities (e.g. forest recreational center, spa and hot springs, Amusement Park, ski resort) were identified and analyzed.