• Proceedings of the PSK Conference
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• 2002.10a
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• pp.218-219
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• 2002

In the past, the development of pharmacokinetic/pharmacodynamic (PK/PD) models for quantitating the time course of drug responses was mainly based on two types of models, the empirical effect compartment model that simply accounts for the delay between effect and plasma concentration (hysteresis) and the mechanism-based so-called indirect response model. The first approach traces back to a paper by Segre (1) and its application was popularized by Holford and Sheiner (2); indirect response models were introduced by Jusko's group (3). (omitted)

• Restorative Dentistry and Endodontics
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• v.21 no.1
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• pp.121-135
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• 1996

Actinomyces are Gram-positive, non-acid-fast, anaerobic or microaerophilic filamentous bacteria. These organisms are frequently detected from infected root canals and periapical lesion. The purpose of this study was to use indirect immunofluorescence to determine the prescence of select Actinomyces species in a survey of teeth associated with periapical lesion, to clarify the relationship between clinical symptoms of periapical lesions and the Actinomyces species and to study on the cross reaction among Actinomyces. Actinomyces israelii serotype I (ATCC 12102), Actinomyces israelii serotype II (ATCC 29322), Actinomyces viscosus serotype II (ATCC 19246), Actinomyces naslundii serotype I (ATCC 12104) were cultured in anaerobic condition. Rabbit antisera were prepared by intravenous injection of formalized whole cells. Indirect immunofluorescence method was used to achieve the purpose. The following results were obtained. 1. There was a relationship between Actinomyces and periapical disease. 2. A. israelii serotype I, II were frequently identified with Indirect Immunofluorescence and most often assosiated with periapical disease. In culture finding, there was no significant difference between each group. 3. Indirect Immunofluoresence is both more sensitive and more rapid than culture for identification of Actinomyces species in patients with periapical lesion. 4. A. israelii serotype I, II was highly isolated in infected root canals with local swelling, A. naslundii serotype I was highly isolated in those with foul odor, and A. israelii serotype I was found in higher frequncy in those with exudate than other bacteria. 5. In the Indirect Immunofluorescence (1 : 320), A positive cross reaction was obtained between A. israelii serotype I and A. israelii serotype II, also, A. viscosus serotype II and A. naslundii serotype I. There was no cross reaction between A. israelii serotype I, II and A. viscosus serotype II, A. naslundii serotype I.

• Journal of Korean society of Dental Hygiene
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• v.19 no.5
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• pp.665-676
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• 2019

Objectives: The purpose of the study was to analyze the association between indirect vision skills and neck, shoulder, and back pain in dental hygienists. Methods: This cross-sectional study included 85 dental hygienists working full-time at dental clinics. A survey was performed for musculoskeletal symptoms in the neck, shoulders, and back of the subjects. The O'Connor tweezer dexterity test was performed using a mirror to evaluate their indirect vision skills. For statistical analyses, the t-test and one-way analysis of variance were performed. Results: The neck was the most common region of musculoskeletal pain (89.4%). The most intense pain was experienced in the neck (70.6%) and right shoulder (60.0%). Neck pain (20.0%) caused the most interference with clinical practice. Indirect vision skills were lower in the group with severe pain in the left shoulder or with high interference in work due to the left shoulder pain (p=0.026 and p= 0.017, respectively) or right shoulder pain (p=0.004). Conclusions: In this study, neck pain was a major musculoskeletal symptom among dental hygienists, and poor indirect vision skills were associated with the development of shoulder pain. Therefore, to prevent such musculoskeletal symptoms, dental hygienists should become proficient in indirect visualization, which enables a balanced and neutral posture.

• Journal of Technologic Dentistry
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• v.40 no.2
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• pp.57-62
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• 2018

Purpose: The aim of this study is to evaluate composite resins of indirect restorations for testing of flexural strength according to various polymerization methods. Methods: Specimen was produced a total of 40 to 10 per each group with a length 25 mm, width 2 mm, thickness 2 mm using a Teflon zig. The polymerization groups were classified into four groups. The first group proceeded with light curing only(LC group). The second group proceeded with light and heat curing(LHC group). The third group proceeded with air press and light curing(ALC group). The fourth group proceeded with air press, light and heat curing(ALHC group). Each prepared group was evaluated by flexural strength test. Statistical analysis was performed by one-way ANOVA. Post-test was performed with Tukey test. Results: The lowest in the ALC group was 119.18 MPa and the highest in the ALHC group was 168.15 MPa. There were statistically significant differences. Conclusion : The composite resin of the indirect restoration is recommended to heat curing along with the air press.

• Journal of Preventive Medicine and Public Health
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• v.34 no.3
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• pp.269-276
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• 2001

Objectives : To evaluate the internal burden and hazardous effects associated with smoking in middle and high school students. Methods : We analysed urinary cotinine(U-cotinine) concentrations and the frequency of Sister Chromatid Exchanges (SCE). A comparison was done of U-cotinine concentrations and the frequency of SCE in peripheral lymphocytes across school levels (middle vs. high) and smoking types (direct: daily & occasional smoking, indirect; usual indirect & non-smoking), in 122 males. Results : The middle school student group comprised 6.8% daily smokers, 15.9% occasional smokers, 40.9% daily indirect smokers, and 35.4% nonsmokers, while the high school student group comprised 18.0%, 20.5%, 35.7%, and 21.8%, respectively. The U-cotinine concentration and the frequency of SCE among the middle school students were $79.11{\mu}g/l$ and 2.0 per cell, respectively, which were significantly lower than the $146.85{\mu}g/l$ (p=0.078) and 2.6 per cell (p=0.005) of the high school students. Among the 40 direct smokers, these two biomarkers were $236.66{\mu}g/l$ and 2.59 per cell, significantly higher than the $67.33{\mu}g/l$ (p=0.0001) and 2.1 per cell (p=0.003) among indirect smoking groups. The variation in individual U-cotinine concentration ranged widely in both the indirect and direct smoking groups. Conclusion : Urinary cotinine concentrations and the frequency of Sister Chromatid Exchange seem to objectively and effectively evaluate student exposure whether it was direct or indirect smoking. Consequently, these biomarkers may be useful in monitoring the objective efficacy of anti-smoking programs in adolescent populations.

• The Journal of Korean Academy of Prosthodontics
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• v.45 no.5
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• pp.611-620
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• 2007

Statement of problem: Second-generation indirect composite resins have been improved flexural strength, compressive strength, hydrolytic degradation resistance, wear resistance compared to first-generation indirect composite resins, but there are still some problems as hydrolysis and low wear resistance. Some manufacturers claim that wear resistance of their materials has been improved, but little independent study has been published on wear properties of these materials and the properties specified in the advertising materials are largely derived from in-house or contracted testing. Purpose: This study was to evaluate the wear of indirect composite resins (SR Adore, Sinfony, Tescera ATL) and gold alloy against the human enamel. Material and method: Extracted human incisors and premolars were sectioned to $2{\times}2{\times}2mm$ cube and embedded in the clear resin and formed conical shaped antagonist to fit the jig of pin-on-disk tribometer. Total 20 antagonists were stored in distilled water. Five disk samples, 24mm in diameter and 1.5mm thick, were made for each of three groups of indirect composite resins and gold alloy group, and polished to #2,000 SiC paper on auto-polishing machine. Disk specimens were tested for wear against enamel antagonists. Wear test were conducted in distilled water using a pin-on-disk tribometer under condition (sliding speed 200rpm contact load 24N, sliding distance 160m). The wear of the enamel was determined by weighing the enamel antagonist before and after test, and the weight was converted to volumes by average density. The wear tracks were analyzed by scanning electron microscopy and surface profilometer to elucidate the wear mechanisms. Statistical analysis of the enamel wear volume, wear track depth and wear tract width of disk specimens were accomplished with one-way ANOVA and the means were compared for significant differences with Scheffe's test. Results: 1. The enamel wear was most in gold alloy, but there were no statistically significant differences among all the groups (P>.05). 2. In indirect composite resin groups, the group to make the most shallow depth of wear tract was Sinfony, followed by Tescera ATL, SR Adoro (P<.05). Gold alloy was shallower than Sinfony, but there was no statistically significant difference between Sinfony and gold alloy (P>.05). 3. The width of wear tract of SR Adore was larger than the other groups (P<.05), and there were no statistically significant differences among the other groups (P>.05). 4. SEM analysis revealed that Sinfony and gold alloy showed less wear scars after test, Tescera ATL showed more wear scars and SR Adore showed the most. Conclusion: Within the limits of this study, Sinfony and gold alloy showed the least wear rates and showed similar wear patterns.

• The Korean Journal of Health Service Management
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• v.6 no.1
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• pp.141-151
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• 2012

In this study a survey was conducted of a total of 187 insurance sales workers from 10 branches of S Insurance Company located around Korea to gather information on causes of dental fear. Results revealed that the group who had experienced direct dental pain in the past showed higher fear levels than the group without such experience. With respect to indirect dental pain, the group with such experience showed higher fear levels in 'fear of dental appointments' and 'fear of antiseptic smells than the group without such experience. Concerning gender, higher fear levels were observed among females than among males. It was also found that the majority of the respondents seldom go for a regular dental check-up regardless of whether they had experienced direct or indirect pain during dental treatment. In addition, there was positive correlation among all the items in the Dental Fear Survey Scale at a significance level of 0.1%. Twenty of all the DFS items were found to be related to causes of dental fear, meaning that most of the elements involving the dentistry may contribute to the development of dental fear among dentally fearful people.

• 한국정보통신설비학회:학술대회논문집
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• 2007.08a
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• pp.336-340
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• 2007

This paper proposes a multicast scheme over IEEE 802.16 networks which support multiple upper layer protocols such as ATM, IPv4 packets, IPv6 packets, IEEE 802.3 over IPv4 and so on. The multicast capabilities over IEEE 802.16 are important both control plane and data plane. The proposed multicast scheme can be divided into two types: direct mapping and indirect mapping. The direct mapping scheme is that layer 3 address is directly mapped into CID information which is used for connection identifier at IEEE 802.16 link layer. The indirect mapping scheme has two steps for mapping between layer 3 address and layer 2 CID. Firstly, a layer 3 address translates to Ethernet MAC address with group MAC address. Secondly, a group MAC address is mapped into CID. The mapping scheme depends on the upper layer protocols.

• Journal of the Korean Operations Research and Management Science Society
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• v.16 no.2
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• pp.137-137
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• 1991

This paper compares and evaluates the performances of the two types of mathematical programming models for solving the machine-part cell formation problem in group technology manufacturing : indirect formulation relying on surrogate measure such as similarity coefficient and direct formulation seeking to minimize the number of exceptional elements. New indirect formulation, called the generalized p-median model. is proposed. Unlike existing p-median formulations, proposed formulation includes the classical cell formation problem in which only one process plan exsits for each part as a special case. The proposed new formulation can also deal with the cell formation problem in which alternative process plans exist for a part. The indirect formulation is compared with a new direct formulation which needs much fewer extra variables and constraints than existing direct formulations. Some significant findings from comparative experiment are discussed.

• Korean Management Science Review
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• v.16 no.2
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• pp.137-147
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• 1999

This paper compares and evaluates the performances of the two types of mathematical programming models for solving the machine-part cell formation problem in group technology manufacturing : indirect formulation relying on surrogate measure such as similarity coefficient and direct formulation seeking to minimize the number of exceptional elements. New indirect formulation, called the generalized {{{{ { p}_{ } }}-median model. is proposed. Unlike existing {{{{ { p}_{ } }}-median formulations, proposed formulation includes the classical cell formation problem in which only one process plan exsits for each part as a special case. The proposed new formulation can also deal with the cell formation problem in which alternative process plans exist for a part. The indirect formulation is compared with a new direct formulation which needs much fewer extra variables and constraints than existing direct formulations. Some significant findings from comparative experiment are discussed.