• 한국융합학회논문지
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• 제7권3호
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• pp.99-109
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• 2016

본 연구는 대사증후군의 위험요인과의 관계를 분석함을 통해 대사증후군 및 심혈관 질환의 효과적인 예방 관리 체계 수립을 위한 근거자료를 제시하고, 대사증후군 환자 교육과 직장인의 만성질환에 관한 중요한 기초자료를 제공하고자 우리나라 직장인의 건강검진 결과를 통하여 건강관련 행위, 흡연 음주 등과 운동이 대사증후군에 미치는 영향력을 알아보고자 하였다. 연구의 조사대상은 서울에 기반한 전문 건강검진센터에서 직장의료보험으로 검진을 받은 직장인 291명으로 하였다. 본 연구의 자료는 직장인 건강검진 내용을 바탕으로 하였다.연구방법으로는 SPSS/Win Program ver 20.0을 이용하여 분석하였으며, 독립변수와 종속변수와의 관계를 분석하기 위하여 F-test 검증 및 ANOVA test를 실시하였으며, 연관성의 검증을 위해서는 $x^2$(Chi-square) 검증을 실시하였다. 연구결과는 직장인 291명 중 대사증후군 유병률이 19.2%로 나타났고, 흡연행태로 인한 대사증후군 유병률의 비흡연 그룹은 12.7%, 과거 흡연 그룹 중에서 가볍게 흡연했던 그룹은 25.0% 중흡연 그룹은 25.9%, 현재 흡연 그룹 중에서 경흡연 그룹은 29.7% 중흡연 그룹 26.7%로 분석되었다. 결과적으로, 본 연구는 직장인의 흡연과 음주 생활형태가 직장인의 대사증후군 유병률과 밀접한 융합적 관련성이 있음을 시사하고 있다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권17호
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• pp.7425-7432
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• 2014

Aim: To investigate the expression of protein kinase $CK2{\alpha}$ ($CK2{\alpha}$) in human thyroid disease and its relationship with thyroid cancer metastasis. Materials and Methods: Using immunohistochemistry we measured the expression of $CK2{\alpha}$ in 76 benign and malignant human thyroid cancer tissues, including 10 pairs of papillary carcinoma tissues with or without lymph node cancerous metastasis and similarly 10 pairs of lymph nodes. Results: The expression of $CK2{\alpha}$ was found to be higher in thyroid carcinoma cases (papillary carcinoma, follicular carcinoma, anaplastic carcinoma and medullary carcinoma) than in ones such as chronic lymphocytic thyroiditis, nodular goiter and adenoma. These findings were also confirmed by RT-PCR and Western blotting. More strikingly, elevated expression of $CK2{\alpha}$ in thyroid papillary carcinoma tissues was not only significantly associated with lymph node cancerous metastasis and clinical stage of thyroid cancers; but also correlated with epithelial-mesenchymal transition (EMT) and high tenascin C (TNC) expression. In addition, EMT and high TNC expression in thyroid carcinoma tissues was significantly associated with lymph node cancerous metastasis. Conclusions: Elevated expression of nuclear $CK2{\alpha}$ is a poor prognosis indicator in lymph node cancerous metastasis of human thyroid cancers.

• IMMUNE NETWORK
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• 제1권1호
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• pp.70-76
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• 2001

Background: Rheumatoid arthritis is an autoimmune disease characterized by a chronic inflammatory process, primarily involving the synovial membrane of peripheral j oints, where T cell activation is found. To address the superantigen stimulation in rheumatoid arthritis, T cell clonality and the expression of activation markers were analyzed. Methods: To detect TCRB V usage, inverse PCR and sequencing were done. Monoclonal antibodies were used for flow cytometric analysis of TCRBV8 or TCRBV5. As results, a restricted usage of TCRBV3 gene was detected in synovial lymphocytes from one rheumatoid arthritis patient. However, preferential usage for TCRB V8, which may be one indicator for stimulation by staphylococcal superantigen, was not obvious although general activation of T cells was found as high DR+ percentage in synovial T cells. These data show specific antigen rather than superantigen might involve the pathogenesis of rheumatoid arthritis.

• The Journal of Asian Finance, Economics and Business
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• 제7권2호
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• pp.131-141
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• 2020

This study examines the poverty indicators in Northeast region of Thailand by adopting the global Multidimensional Poverty Index (MPI) methodology and the national survey of Minimum Basic Needs (MBN) of Thailand. Data are collected from three different districts in Khon Kaen province namely: Khok Po Chai, Sam Sung, and Nam Pong. The sample size is 187 households. Data analysis uses Ordinary Least Square (OLS) regression approach and includes 7 dimensions of poverty (health, environment, education, economy, Thai value, asset? empowerment, and digital literacy) with a total of 41 indicators. This study has found that poverty indicators in Khon Kaen province remains centered around the aspects of health and employment dimensions. While a change of family structure in the Thai society since 1960s reduces the family size, household saving substantially increases over the years. The effects of health dimension in poverty, on the other hand, appears on the other poverty dimension of Thai value, which include (1) a bad living habit of head of household (smoke or alcohol consumption) that links with illness and disease, (2) religious practice, and (3) chronic illness. Lastly, there are income gaps of different careers in the area, which suggests the issue of income inequality.

• Tuberculosis and Respiratory Diseases
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• 제80권4호
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• pp.385-391
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• 2017

Background: Men with chronic obstructive pulmonary disease, have reduced endogenous testosterone levels, but the relationship between pulmonary function and endogenous testosterone levels, is inconsistent. Testicular volume is a known indicator of endogenous testosterone levels, male fertility, and male potency. In the present study, the authors investigated the relationship, between testicular volume and lung function. Methods: One hundred and eighty-one South Korean men age 40-70, hospitalized for urological surgery, were retrospectively enrolled, irrespective of the presence of respiratory disease. Study subjects underwent pulmonary function testing, prior to procedures, and testicular volumes were measured by orchidometry. Testosterone levels of patients in blood samples collected between $7{\small{AM}}$ and $11{\small{AM}}$, were measured by a direct chemiluminescent immunoassay. Results: The 181 study subjects were divided into two groups, by testicular volume (${\geq}35mL$ vs. <35 mL), the larger testes group, had better lung functions (forced vital capacity [FVC]: $3.87{\pm}0.65L$ vs. $3.66{\pm}0.65L$, p=0.037; forced expiratory volume in 1 second [$FEV_1$]: $2.92{\pm}0.57L$ vs. $2.65{\pm}0.61L$, p=0.002; FVC % predicted: $98.2{\pm}15.2%$ vs. $93.8{\pm}13.1%$, p=0.040; $FEV_1$ % predicted: $105.4{\pm}19.5%$ vs. $95.9{\pm}21.2%$, p=0.002). In addition, the proportion of patients with a $FEV_1/FVC$ of <70%, was lower in the larger testes group. Univariate analysis conducted using linear regression models, revealed that testicular volume was correlated with FVC (r=0.162, p=0.029), $FEV_1$ (r=0.218, p=0.003), $FEV_1/FVC$ (r=0.149, p=0.046), and $FEV_1$ % predicted (r=0.178, p=0.017), and multivariate analysis using linear regression models, revealed that testicular volume was a significant predictive factor for $FEV_1$ % predicted (${\beta}=0.159$, p=0.041). Conclusion: Larger testicular volume was independently associated, with favorable indices of lung function. These results suggest that androgens, may contribute to better lung function.

• 대한지역사회영양학회지
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• 제28권1호
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• pp.38-47
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• 2023

Objectives: This study examined the association between the experience of disease management education and the use of nutrition labels according to the sociodemographic characteristics and health behaviors of people diagnosed with hypertension and diabetes living in the community. Methods: Among the participants from the Community Health Survey (2018), 74,283 individuals diagnosed with hypertension or diabetes were included in the study population. According to gender, this study evaluated nutrition label use by the experience of disease management education, individual sociodemographic characteristics, and health behavior. Finally, using multiple logistic regression analysis, the association between disease management education and nutrition labels was calculated using the odds ratio (OR) and 95% confidence interval (CI). Results: Males (24.5%) experienced more disease management education than females (22.6%). In addition, younger age, higher education level, and higher equalized personal income experienced more disease management education (P < 0.001). The educational experience rate was higher in the male subjects who did not smoke or were involved in high-risk alcohol consumption (P < 0.001). In addition, the rate of disease management education experience was significantly higher for both men and women who exercised by walking (P < 0.001). The use of nutrition labels was higher in females (9.9%) than males (5.8%), and both males and females were significantly higher in young age, high education, high income, and professional and office positions (P < 0.001). The utilization rate of nutrition labels was high in non-smoking male subjects and high-risk-drinking female subjects. In addition, the utilization rate of nutrition labels was significantly higher in males and females who exercised by walking and those who experienced disease management education (P < 0.001). After adjusting for individual sociodemographic characteristics, health behavior, and disease management education, the use of nutrition labels was high among females (OR 3.19, 95% CI 2.85-3.58), high income (Q4; OR 1.62, 95% CI 1.41-1.87, Q5; OR 1.58, 95% CI 1.37-1.84) and highly educated (high school; OR 2.87, 95% CI 2.62-3.14, above college; OR 5.60, 95% CI 5.02-6.23) while it was low in the elderly (OR 0.43, 95% CI 0.40-0.47), and economically inactive (OR 0.86, 95% CI 0.76-0.96). The use of nutrition labels was high in non-smokers (OR 1.29, 95% CI 1.13-1.48), nonhigh-risk drinkers (OR 1.22, 95% CI 1.08-1.38), and subjects who exercised walking (OR 1.44, 95% CI 1.34-1.54). There was no difference in the utilization rate of nutrition labels according to obesity, and the utilization rate of nutrition labels was significantly higher in subjects who had experienced disease education (OR 1.34, 95% CI 1.24-1.44). Conclusions: Education on the use of nutrition labels, which contributes to food selection for healthy eating, might be a tool for dietary management. Moreover, the utilization rate can be a good indicator for predicting the proportion of the population practicing the guide for disease management. Improving the utilization rate of nutrition labels through disease management education can be a useful intervention for people with chronic diseases who need healthy eating habits for disease management and preventing complications, particularly those diagnosed with hypertension and diabetes.

• 보건교육건강증진학회지
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• 제35권5호
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• pp.17-24
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• 2018

Objectives: After many national physical activity guidelines have established, recent changes are deep and rapid. So the major features and implication to reverse worsening Korean physical activity indicator is desprate but related knowledge and informations are few. So review of recent features and implications of new physical activity guidelines have made. Methods: National physical activity guidelines of advanced countries were searched through snowballing methods. Major features were described according to the nation. Implication were drew through discussion for Korean realitiy. Results: New Australian physical activity and sedentary behaviour guideline explicitly included sedentary behaviour. The age in the guideline expanded to early years. Canada also presented 24-hour movement guidelines to early years. The second generation of the physical activity guidelines reflects the extensive amount of new knowledge. New aspects include discussions of additional health benefits related to brain health, additional cancer sites, and fall-related injuries; immediate and longer term benefits for how people feel, function, and sleep; further benefits among older adults and people with additional chronic conditions; risks of sedentary behavior and their relationship with physical activity; elimination of the requirement for physical activity benefits to occur in bouts of at least 10 minutes; and tested strategies that can be used to get the population more active. Conclusions: The most important message from the new guidelines is that the greatest health benefits accrue by moving from no, to even small amounts of, physical activity. Multiple studies demonstrate that the steepest reduction in disease risk occurs at the lowest levels of physical activity. People need to understand that even small amounts of physical activity are beneficial and that reductions in the risk of disease and disability occur by simply getting moving. So various evidence based proven strstegies are needed in Korea including workforce training.

• 한국인구학
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• 제9권2호
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• pp.79-92
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• 1986

Death is one of the population movement phenomena used as an important health index in most society. Especially it is regarded as group phenomenon in a specific group rather than individual one and considered important in public health field because the level and cause of death is related to health of public. The auther examined the changes of the Korean mortality pattern to evaluate the status of the Korean public health by studying mortality indicator using the population census and other materials from 1930 to 1980. The results are as follows: First, the Korean crude death rate was reduced to one third in 1980 compared to that in 1930, but the crude birth rate was constant from 1930 to 1960 causing the increase of population. So the population pattern is changing from the classic pyramic shape to bell shape and the dependency ratio was reduced from 78 in 1930 to 61 in 1980. Second, the infant mortality rate decrease rapidly. In 1980 it was one seventh of that in 1930 which was proved by the change of the age-specific death rate curve from U to J shape. Third, the male mortality reduction after the age of forty was much less than that of female, which explained the specific death pattern of high mortality in Korean middle and oldaged males. Fourth, the main cause of death was changed from infectious, parasitic, respiratory and digestive system disease to circulatory of tumorous diseases. Considering the above results, Korean health problem is now changing from the infant infection to geriatric chronic regressive disease. That naturally the direction of health service should be turned from the infant stage maternal and child health to the health problems of old people.

• 대한보건연구
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• 제44권4호
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• pp.35-49
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• 2018

연구목적: 본 연구의 목적은 종합건강검진 수검자의 신체측정과 혈액검사를 통해 탈수 위험요인에 대해 조사하는 것이다. 연구방법: 연구 분석을 위해 Sodium ($Na^+$), BUN (Blood Urea Nitrogen) 및 FBS (Fasting Blood Sugar)의 데이터가 유효한 5,391개의 샘플을 선택하여 혈장삼투압 탈수지표를 계산하였다. 조사 데이터는 2014.01.01과 2015.12.31사이에 삼육서울의료원 종합건강검진센터를 방문한 검진 수검자로부터 수집되었다. 탈수와 연령, 체질량지수(BMI), 질병노출(고혈압, 당뇨병, 이상지질혈증, 신장장애)의 관계를 성별로 구분하여 분석하였다. 연구결과: 탈수 교차비는 남성과 여성 모두 50대 이상 연령부터 통계적 유의성이 나타났다. 비만여성은 탈수에 취약했으나 남성은 BMI 차이에 통계적 유의성이 나타나지 않았다. 질병에 노출된 그룹(고혈압, 당뇨병, 이상 지질 혈증, 신장 장애)은 탈수에 취약하였다. 또한 질병노출 수가 많을수록 교차비가 높아 탈수 위험도가 높은 것으로 나타났다. 결론: 노화, BMI증가, 질병노출은 탈수에 취약하게 하는 위험요인으로 나타났다. 50세 이후 연령대는 탈수예방을 위해 BMI와 만성질환 조절에 특별한 주의가 요구된다. 질병발생에 잠재적인 자극 메커니즘으로 혈장 삼투압 증가에 영향을 끼치는 탈수 위험요인에 대한 추가 연구를 제안한다.

• 정보처리학회논문지:소프트웨어 및 데이터공학
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• 제8권11호
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• pp.433-440
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• 2019

최근에 이르러, 기계학습 및 데이터마이닝은 수많은 질병 예측 및 진단에 활용되고 있다. 만성질환은 전체 사망률의 약 80%를 차지하는 질병으로, 점점 증가하는 추세이다. 만성질환 관련 예측 모델을 연구한 기존 연구들은 예측 모델을 구성하는 데이터로 혈당, 혈압, 인슐린 수치 등의 건강검진 수준의 데이터를 이용한다. 본 논문은 만성질환의 위험 요인인 이상지질혈증과 안면 정보의 연관성을 검증하고, 기계학습 기반 안면 정보를 이용한 이상지질혈증 예측 모델을 세계 최초로 개발한다. 본 연구는 5390명의 임상 데이터 중 안면 정보와 중성지방혈증 정보를 바탕으로 수행하였다. 중성지방혈증은 이상지질혈증을 판단하는 척도이다. 연구의 결과로 얼굴의 하악(mandibular) 간의 거리를 나타내는 FD_43_143_aD(p<0.0001, Area Under the receiver operating characteristics Curve(AUC)=0.652) 와 고중성지방혈증이 매우 높은 연관성을 가진 것을 밝혀냈고, 이를 기반으로 구축한 모델은 0.662의 AUC값을 획득하였다. 이러한 연구결과는 향후 질병 역학 및 대중 보건 영역의 스크리닝 단계에서 안면정보만으로 다양할 질병을 예측할 수 있는 기반을 제공할 수 있을 것이다.