• Journal of Biomedical Engineering Research
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• v.43 no.4
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• pp.185-192
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• 2022

Early detection of mild cognitive impairment can help prevent the progression of dementia. The purpose of this study was to design and validate a machine learning model that automatically differential diagnosed patients with mild cognitive impairment and identified cognitive decline characteristics compared to a control group with normal cognition using resting-state quantitative electroencephalogram (qEEG) with eyes closed. In the first step, a rectified signal was obtained through a preprocessing process that receives a quantitative EEG signal as an input and removes noise through a filter and independent component analysis (ICA). Frequency analysis and non-linear features were extracted from the rectified signal, and the 3067 extracted features were used as input of a linear support vector machine (SVM), a representative algorithm among machine learning algorithms, and classified into mild cognitive impairment patients and normal cognitive adults. As a result of classification analysis of 58 normal cognitive group and 80 patients in mild cognitive impairment, the accuracy of SVM was 86.2%. In patients with mild cognitive impairment, alpha band power was decreased in the frontal lobe, and high beta band power was increased in the frontal lobe compared to the normal cognitive group. Also, the gamma band power of the occipital-parietal lobe was decreased in mild cognitive impairment. These results represented that quantitative EEG can be used as a meaningful biomarker to discriminate cognitive decline.

• Journal of agricultural medicine and community health
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• v.48 no.1
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• pp.1-12
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• 2023

Objective: The purpose of this study was to identify factors associated with subjective memory impairment in patients with diabetes mellitus in a metropolitan city. Methods: The subjects of this study were 351 patients with diabetes mellitus aged 50 and over from five districts of Gwangju who participated in the 2018 Community Health Survey. We analyzed general characteristics, health-related behaviors and health related conditions and subjective experience of memory impairment. To find factors associated with subjective memory impairment, the chi-square test and multiple logistic regression analysis were used. Results: Of all subjects, 31.3% was reported subjective experience of memory impairment. The odds ratios (ORs; 95% confidence interval (CI)) for subjective memory impairment according to age were statistically significant at 1.9 (0.9-4.3) in patients in 60s and 2.2 (1.1-4.7) in patients in beyond 70s compared to those in 50s. The OR (95% CI) of ex-smoker compared to the non-smoker was 0.3 (0.8-0.9). The OR (95% CI) of depressive symptom compared to no depressive symptoms was 4.9 (95% CI: 1.8-13.7). Conclusion: In this study, subjective memory impairment in patients with diabets mellitus was associated with age, smoking, and depressive symptoms. Based on the results of this study, subjective memory impairment should be detected early through periodic cognitive function evaluation for elderly patients with diabetes mellitus, and a program for healthy cognitive function should be included in diabetes management program.

• Journal of the Korean Society of Physical Medicine
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• v.3 no.4
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• pp.285-292
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• 2008

Purpose : To estimate the prevalence of and identity the associates of cognitive function and depression among people over 70 years of age, and to examine the relationship between cognitive impairment and depression, Methods : The elderly in Pusan area were studied on the Korea version Mini Mental Scale Examination instrument(MMSE-K), Short form of Geriatic Depression Scale(SGDS). Results : The prevalence of cognitive impairment($MMSE{\leq}24$) was 64.4% and that of depression($GDS{\geq}8$) was 40.7% Lower education, no religion and no work experience were associated with cognitive impairment. Depression in demented group was 68.2%, in suspect dementia group was 43.7% and in non-demented group was 9.5%. Conclusion : The prevalence of cognitive impairment and depression in elderly was high and depression was in association with cognitive impairment.

• Journal of Microbiology and Biotechnology
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• v.28 no.9
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• pp.1443-1446
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• 2018

In the present study, we examined whether Lactobacillus johnsonii CJLJ103 (LJ) could alleviate cholinergic memory impairment in mice. Oral administration of LJ alleviated scopolamine-induced memory impairment in passive avoidance and Y-maze tasks. Furthermore, LJ treatment increased scopolamine-suppressed BDNF expression and CREB phosphorylation in the hippocampi of the brain, as well as suppressed $TNF-{\alpha}$ expression and $NF-{\kappa}B$ activation. LJ also increased BDNF expression in corticosterone-stimulated SH-SY5Y cells and inhibited $NF-{\kappa}B$ activation in LPS-stimulated microglial BV2 cells. However, LJ did not inhibit acetylcholinesterase activity. These findings suggest that LJ, a member of human gut microbiota, may mitigate cholinergic memory impairment by increasing BDNF expression and inhibiting $NF-{\kappa}B$ activation.

• The Journal of the Korean dental association
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• v.56 no.4
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• pp.218-230
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• 2018

According to the burst of aged people, researchers have focused on aging-related diseases. Cognitive impairment including Alzheimer's disease (AD), one of the representative diseases related to aging, has no treatment option until now. Recently, it has been revealed that systemic inflammation plays a fundamental role in the pathogenesis of AD. Previous studies have suggested the association between poor oral health and cognitive impairment. Poor oral health can cause dental caries, chronic periodontitis, multiple tooth loss, and poor chewing ability, etc. Especially, periodontitis is a well-known chronic inflammatory disease and affects cognitive impairment directly and indirectly by inflammatory products mediators. Therefore, reduction of pathogenic microbial burden and inflammatory products by treating periodontitis can be a therapeutic modality to prevent cognitive impairment or to slow down the progression of it. Future studies are necessary to elucidate the causal relations and plausible mechanisms between poor oral health and cognitive impairment.

• Journal of Acupuncture Research
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• v.25 no.5
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• pp.191-195
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• 2008

Objectives : To estimate clinical effect of acupuncture treatment for astigmatism and visual impairment. Methods : Acupuncture treatment was performed on a young child, diagnosed as astigmatism and visual impairment from 23th May 2008 through 23th July 2008. Visual acuity and astigmatism were measured before and after treatment. Results : Visual acuity and astigmatism were improved after acupuncture treatment. Conclusions : This case demonstrates that acupuncture treatment has clinical possibilities for improving astigmatism and visual impairment and future studies will be required.

• Journal of Korean Academy of Nursing
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• v.33 no.4
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• pp.503-509
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• 2003

Purpose. The purpose of this study was to survey the prevalence rate of cognitive impairments and to identify the factors influencing cognitive impairment in the elderly in rural communities of Jeju Province. Methods. 590 elderly in 6 rural communities of Jeju Province were interviewed, using a questionnaire consisting of sociodemographic characteristics, health behavior, quality of life, and MMSE-K Results. Prevalence of cognitive impairment was 33.1 % (39.1 % of females, 16.76% of males). Prevalence of dementia was 12.4% (16.3% of females, 2.87% of males). Factors related to cognitive impairment were age, sex, education, standard of living, employment status, and subjective health state. Conclusions. In community health care for the elderly, factors relating to cognitive impairment have to be considered. When planning community health care, priority should be given to the elderly; who need care but live alone; who lack social support; who have a low standard of living; who experience discomfort in the activities of daily living; who believe they are not in a good state of health; or whose life satisfaction is low.

• Journal of Preventive Medicine and Public Health
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• v.19 no.2 s.20
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• pp.263-272
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• 1986

During the 8 months from October 1985 to May 1986, the survey was performed on 211 leprosy patients over fifty years old, settled in the four villages of Iksan county, North of Chulla province. In that obserbation, we investigated the frequency and the degree of impairments according to sex, age, and anatomical location by the 'guides to the evaluation of permanent impairment'. The noticeable findings were made as follows: 1) Frequency of impairment by anatomical location was significantly higher in hand than eye and foot (p<0.01). 2) Frequency of impairment was significantly increased in eye according as age increase (p<0.01). 3) The degree of impairments of all patients was the highest in hand as 28.7%. 4) By the kinds of impairment, the flextion and the amputation were most common in hand and foot, and loss of central vision was common symptom in eye. 5) The degree of impairments of 211 leprosy patients was shown as 44.1% and increased according as age increase.

• International Journal of Computer Science & Network Security
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• v.22 no.8
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• pp.55-60
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• 2022

Specific Language Impairment is one of the serious disorders that interferes with spontaneous communication skills in children. Children suffering from this disorder may have reading, speaking, or listening impairments, and such type of disorders are also termed Autism Speech Disorder (ASD) in medical terminology. The aim of the article is to define specific language impairment in children and the problems it can cause. The different methods adopted by speech pathologists to diagnose language impairment. Finally implementing machine learning models to automate the process and help speech pathologists and pediatricians/ in diagnosing the specific language impairment.

• Journal of People, Plants, and Environment
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• v.22 no.4
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• pp.365-373
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• 2019

This study was conducted to determine the effects of horticultural therapy on self-esteem of women with hearing impairment. Ten women with hearing impairment registered in the Mokpo Branch of the Korean Association of the Deaf participated in the horticultural therapy programs (HTP) for self-esteem. The self-esteem scale was used to evaluate the effects of the programs and scores were compared to determine the difference before and after the programs. Self-esteem was improved in all 10 subjects, and its mean value increased with statistical significance from 22.5 points before the programs to 29.8 points after the programs. The programs preferred by women with hearing impairment included 'making a centerpiece using scented candles and flowers', 'packing and planting pot spray chrysanthemum', 'making a topiary', 'planting Hedera helix', and 'planting cyclamen'. Therefore, it was suggested that self-esteem of women with hearing impairment were improved by increasing social and family support, emotional stability, positive feedback, and self-expression through horticultural therapy programs.