• IMMUNE NETWORK
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• v.23 no.1
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• pp.7.1-7.27
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• 2023

The mammalian intestines harbor trillions of commensal microorganisms composed of thousands of species that are collectively called gut microbiota. Among the microbiota, bacteria are the predominant microorganism, with viruses, protozoa, and fungi (mycobiota) making up a relatively smaller population. The microbial communities play fundamental roles in the maturation and orchestration of the immune landscape in health and disease. Primarily, the gut microbiota modulates the immune system to maintain homeostasis and plays a crucial role in regulating the pathogenesis and pathophysiology of inflammatory, neuronal, and metabolic disorders. The microbiota modulates the host immune system through direct interactions with immune cells or indirect mechanisms such as producing short-chain acids and diverse metabolites. Numerous researchers have put extensive efforts into investigating the role of microbes in immune regulation, discovering novel immunomodulatory microbial species, identifying key effector molecules, and demonstrating how microbes and their key effector molecules mechanistically impact the host immune system. Consequently, recent studies suggest that several microbial species and their immunomodulatory molecules have therapeutic applicability in preclinical settings of multiple disorders. Nonetheless, it is still unclear why and how a handful of microorganisms and their key molecules affect the host immunity in diverse diseases. This review mainly discusses the role of microbes and their metabolites in T helper cell differentiation, immunomodulatory function, and their modes of action.

• Asia pacific journal of information systems
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• v.30 no.3
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• pp.513-531
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• 2020

Online Word-of-Mouth communication, or eWOM, has dramatically changed the way people network, interact, and share knowledge. Studies have examined why consumers choose to share knowledge online, especially online product reviews, as well as the motivations of individuals to share product ideas online. However, the role of gender in shaping the motivation and types of knowledge shared online has been given little consideration. Using concepts from Social Exchange Theory and the Theory of Reasoned Action, we address this research gap by developing and testing a model of gender's influence on knowledge sharing in a social media context. A PLS analysis of survey data from 257 students indicates that reputation, altruism, and subjective norms are key motivators for knowledge sharing intention in social media. More importantly, that gender plays a moderating role within the motivation-knowledge sharing relationship. We also find that subjective norms have a greater impact on knowledge sharing with women than with men. Collectively, our research results highlight individualized factors for improving customer participation in external facing social media for marketing and product innovation.

• Journal of East Asia Management
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• v.5 no.1
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• pp.1-31
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• 2024

Based on the perspective of consumers and the method of value engineering, this paper uses "CSR expectation deviate level" to measure corporate social responsibility, and discusses the influence of corporate social responsibility on financial performance and its action path. This paper collected the questionnaire survey data of 878 consumers and the panel data of 98 listed companies from 2009 to 2012. The empirical results show that: (1) Consumers pay more attention to products and services, charity, environmental protection and their responsibilities to employees, and less attention to their responsibilities to shareholders or creditors and partners; (2) Corporate social responsibility is negatively correlated with financial performance, and corporate marketing ability plays a moderating role in it. That is, the smaller the gap between the level of corporate social responsibility fulfilled by enterprises and consumers' expectations, the better the financial performance of enterprises, which also reminds enterprises that they need to rationally allocate corporate social responsibility resources and constantly cultivate their own marketing capabilities, so as to better meet the level of corporate social responsibility expected by consumers. The value engineering method quantifies consumers' value perception of corporate social responsibility, which has a certain practical guiding role. Of course, there are some limitations in this paper, and future research can further explore the potential impact mechanism.

• Animal Bioscience
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• v.37 no.1
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• pp.1-15
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• 2024

Poultry coccidiosis is an intestinal infection caused by an intracellular parasitic protozoan of the genus Eimeria. Coccidia-induced gastrointestinal inflammation results in large economic losses, hence finding methods to decrease its prevalence is critical for industry participants and academic researchers. It has been demonstrated that coccidiosis can be effectively controlled and managed by employing anticoccidial chemical compounds. However, as a result of their extensive use, anticoccidial drug resistance in Eimeria species has raised concerns. Phytochemical/herbal medicines (Artemisia annua, Bidens pilosa, and garlic) seem to be a promising strategy for preventing coccidiosis, in accordance with the "anticoccidial chemical-free" standards. The impact of herbal supplements on poultry coccidiosis is based on the reduction of oocyst output by preventing the proliferation and growth of Eimeria species in chicken gastrointestinal tissues and lowering intestinal permeability via increased epithelial turnover. This review provides a thorough up-to-date assessment of the state of the art and technologies in the prevention and treatment of coccidiosis in chickens, including the most used phytochemical medications, their mode of action, and the applicable legal framework in the European Union.

• Biomedical Science Letters
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• v.30 no.3
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• pp.137-142
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• 2024

The aim of this study was to investigate the inhibitory effects of Alismatis rhizoma extract on breast cancer cell growth and elucidate the underlying mechanisms. The growth inhibitory effects of Alismatis rhizoma extract on breast cancer cells were measured using the WST-1 assay, while its impact on relevant proteins and genes was analyzed using real-time polymerase chain reaction. The results demonstrated significant inhibition of breast cancer cell growth by Alismatis rhizoma, with the inhibitory effect showing a positive correlation with the dosage, treatment duration, and quantity. Furthermore, Alismatis rhizoma extract markedly decreased the expression levels of cell cycle protein D1 and suppressed cell migration and invasion. In conclusion, Alismatis rhizoma exhibits the potential to inhibit breast cancer cell growth, possibly by regulating cell cycle progression and inhibiting cell migration and invasion. These findings suggest that Alismatis rhizoma extract possesses anticancer properties against human breast cancer cells. Further investigation of its reuglation of action will provide foundational data, potentially paving the way for its development as an anticancer therapeutic agent.

• Journal of Venture Innovation
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• v.2 no.2
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• pp.65-78
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• 2019

Companies with ethical management can be said to influence the performance of an organization based on the ethical judgment of its members. In this study, ethical judgment was set up as the subject of the ethical judgment, and the ethical judgment was set up by bosses and colleagues who are members of the business and organization as the factors of ethical judgment. The research was designed to examine the impact of ethical judgment on job satisfaction and organizational civic behavior, the impact of ethical judgment on organizational trust, and analyzed the medium effect of organizational trust in the relationship between ethical judgment and job satisfaction and organized civic action. The target of this study was to survey 450 workers in Seoul, Gyeonggi Province and South Chungnam Province from October 7, 2019 to November 2, using them as empirical data. The SPS 24.0 Statistical Analysis Program was used for the analysis of data. The study confirmed that ethical judgment was affecting task satisfaction, organizational civic behavior, and organizational trust, and that parameters such as organizational trust affected task satisfaction and organizational civic behavior depending on how individuals perceive the organization. Ethical judgment has a high impact on organized citizen behavior and job satisfaction, and ethical management of how to improve ethical judgment is absolutely necessary to enhance organizational citizen behavior and job satisfaction, and it is necessary to develop and implement various programs that enable a sense of unity with the organization.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.3
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• pp.488-496
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• 2020

This study was based on nitrate chemical accidents at home and abroad. Toxic gases due to adverse reactions are generated in the workplace, laboratory, hospital, container damage, and chemical misinjection. Through a case review of possible situations and safety, this study analyzed various cases of accidents, accident status, accident type, cause of the accident, location of the accidents, etc. from 2014 to 2018. The plans for improvement in education and nitrate accidents were reviewed. As a result, 36 nitrate chemical accidents were investigated, including 16 careless worker accidents, eight transportation accidents, and 12 facilities shortages. Nitrate chemical accidents are occurring continuously. Based on this, the range of toxic effects using CARIS was calculated at the worst-case scenario, and the effective response range was measured through the damage impact range. For this purpose, the impact range was predicted based on the strengthening of safety education, emergency action plan and correlation, and the quantified data was identified. In addition, the reliability of the scope of impact was reviewed based on the correlation formula that could facilitate the evacuation of residents, and it was applied to actual accident scenarios of the workplace to present the effects of the accident response and preventive measures.

• 대한공업교육학회지
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• v.41 no.2
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• pp.1-23
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• 2016

This study was conducted to analyze the effect Meister high school students' career maturity with respect to the impact on school maladjustment. Also, this study clarify the relationship. This study purpose is to permanently provide Meister as the basis for the vocational education sector career education needed to faithfully serve as a special purpose high schools. Tools used for the survey is maladaptive measurement tools developed by Leegyumi (2004) and Career maturity measurement tools developed at Korea Research Institute for Vocational Education and Training (2012). Using these tools, a reliability test was conducted. Meister students' career maturity was conducted correlation analysis and multiple regression analysis to analyze the impact of school maladjustment. Independent variables are consisted of career maturity and independence, attitude toward the job, planning, self-understanding, rational decision-making, information retrieval, knowledge of the desired job, career exploration and ready for action. Meister high school student's career maturity according to the students' background variables are little girls was higher than boys, but it was not statistically significant. T-test was conducted to ascertain the career maturity and school maladjustment differences of adaptation groups and maladaptive group in meister school students in background variables. A career maturity and school maladjustment between adaptive and maladaptive population groups showed a statistically significant difference in background variables.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.14 no.1
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• pp.47-58
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• 2019

This paper is brought to analyze an impact of coaching activities over entrepreneur with respect to entrepreneurs' personal characteristics on the performance of Startups focusing on entrepreneur's awareness conversion effect. In particular, the situation of falling focus of serious startup failure on uncoachable obstinate entrepreneur among the several causes of startup failures, this paper define the research mission of reducing this risk by inducing coaching types of cooperations between senior entrepreneur having serial successful startup experiences and beginning entrepreneur. This paper carry out literature reviews chiefly on startup coaching researches rather than mentoring studies because coaching stressing on self-oriented problem defining and solving by entrepreneur actively tend to be more effective than mentoring relying on mentor's guideline passively as solving startup's main upcoming problems. This paper implement four related researches. First, the impact analysis of entrepreneur's personal characteristics on coaching activities, second, influences of entrepreneurs environmental factors on them, Third, impact of coaching activities on entrepreneur's awareness conversion effect, Fourth, how strongly this conversion effect contributing on the performance of startup. As results of empirical research, first, this paper prove that entrepreneur's environmental factors impact positively on coaching activities over entrepreneur although failing on validating on significant impact of entrepreneur's personal characteristics on coaching activities. Second, this paper prove that coaching activities positively influence on entrepreneur's awareness conversion, hence ultimately positively on the performance of startups. As conclusion, this paper validate that coaching activities over entrepreneur through inducing on the conversion of entrepreneur's awareness lead entrepreneur to setting the bar high and accountable planning of business milestone. This paper contribute on delivering policy implication that government initiatin action-oriented training program for entrepreneurs should accept the module of coaching session to produce more effective results.

• Journal of Nutrition and Health
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• v.55 no.1
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• pp.174-187
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• 2022

Purpose: This study was performed to evaluate an education program for housewives to reduce sodium intake based on the social cognitive theory. Methods: Housewives (n = 387) received 2 education sessions focused on food purchase and cooking, and completed a questionnaire on their perceptions of environmental, cognitive, and behavioral factors and the stages of behavioral change to reducing sodium intake both before and after the education program. Results: After the education program, the recognition of social efforts for sodium reduction and sodium labeling and experience with low-sodium products increased. Positive expectancies for the prevention of osteoporosis by the reduction of sodium were enhanced while the main barriers in practicing sodium reduction decreased, especially 'interrupting social relationships when dining with others', 'bad taste', 'preference for soup or stew', and 'limited knowledge and skills to practice'. In addition, cognition and nutrition knowledge related to reducing sodium intake were improved on all scores, but the effect on self-efficacy and dietary behavior was limited to only a few items. The percentage of participants in the pre-action stage (including pre-contemplation, contemplation, and preparation stages) for reducing sodium intake decreased from 43.2% before education to 21.5% after education, while that in the action stage increased from 19.6% before education to 43.5% after education (p < 0.001). The education program had the most significant impact on participants who were in the pre-action stage and showed improved scores in all sections. Conclusion: These results suggest that a customized education program for housewives could be an effective tool to reduce sodium intake by improving personal expectancies, cognition, and nutrition knowledge regarding sodium reduction and enabling a greater section of the population to move to the action stage of reducing sodium intake.