Biomedical Science Letters (대한의생명과학회지)

The Korean Society for Biomedical Laboratory Sciences (대한의생명과학회)
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Suppression of MCF-7 Breast Cancer Cell Multiplication by Alismatis rhizoma Extract

  • Da Hyun Kim (Department of Biomedical Laboratory Science, Kyungbok University) ;
  • Eun Ju Yang (Department of Biomedical Laboratory Science, Daegu Haany University) ;
  • Jeong Hyun Chang (Department of Biomedical Laboratory Science, Daegu Haany University)
  • Received : 2024.05.31
  • Accepted : 2024.09.09
  • Published : 2024.09.30
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Abstract

The aim of this study was to investigate the inhibitory effects of Alismatis rhizoma extract on breast cancer cell growth and elucidate the underlying mechanisms. The growth inhibitory effects of Alismatis rhizoma extract on breast cancer cells were measured using the WST-1 assay, while its impact on relevant proteins and genes was analyzed using real-time polymerase chain reaction. The results demonstrated significant inhibition of breast cancer cell growth by Alismatis rhizoma, with the inhibitory effect showing a positive correlation with the dosage, treatment duration, and quantity. Furthermore, Alismatis rhizoma extract markedly decreased the expression levels of cell cycle protein D1 and suppressed cell migration and invasion. In conclusion, Alismatis rhizoma exhibits the potential to inhibit breast cancer cell growth, possibly by regulating cell cycle progression and inhibiting cell migration and invasion. These findings suggest that Alismatis rhizoma extract possesses anticancer properties against human breast cancer cells. Further investigation of its reuglation of action will provide foundational data, potentially paving the way for its development as an anticancer therapeutic agent.

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