• Parasites, Hosts and Diseases
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• v.43 no.3 s.135
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• pp.75-92
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• 2005

Extensive previous studies on taxonomy, behavior/bionomics and control of Anopheles sinensis are reviewed and summarized. Recent molecular identification revealed that the population of An. sinensis complex includes An. sinensis, An. pullus, An. lesteri and at least two new species, and An. yatsushiroensis is synonmy of An. pullus. An. sinensis is the main vector specie of vivax malaria in Korea. Larvae of An. sinensis breed in wide range of habitats which are naturally-made clean water, stagnant or flowing; main habitats include rice fields, ditches, streams, irrigation cannals, marshes, ponds, ground pools, etc. Their host preferences are highly zoophilic. Human blood rate is very low ($0.7-1.7\%$); nevertheless An. sinensis readily feeds on man when domestic animals are not found near by. They feed on hosts throughout the night from dusk to dawn with a peak period of 02:00-04:00 hours; they are slightly more exophagic (biting outdoors); much larger numbers come into the room when light is on. Main resting places are outdoors such as grasses, vegetable fields and rice fields. A mark-release-recapture study resulted that $37.1\%$ was recaptured within 1 km, $29.4\%$ at 1-3 km, $21.1\%$ at 3-6 km, $10.3\%$ at 6-9 km and $2.1\%$ at 9-12 km distance. An. sinensis hibernate outdoors (mostly under part of dense grasses) during October-March. At the end of the hibernation period (March-April) they feed on cows at daytime. Until today any single measure to effectively control An. sinensis population has not been found. Indoor residual spray with a long-lasting insecticide can not reduce vector population densities, but shorten their life spans in some degree, so contributes to malaria control.

• Parasites, Hosts and Diseases
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• v.51 no.2
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• pp.259-263
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• 2013

Human taeniasis was investigated in Lao People's Democratic Republic (Lao PDR) between 2000 and 2011 as part of the nation's helminthiasis survey. A total of 55,038 inhabitants, including 29,846 school children, were examined using the Kato-Katz and scotch-tape anal swab method, and morphological observation of adult worms. Molecular identification of Taenia tapeworms was performed by multiplex PCR or DNA sequence analysis of the mitochondrial cox1 gene. Taenia eggs were present at a rate of 1.5% (845/55,038) in the subject population. Adult tapeworms were identified as T. solium or T. saginata by analyzing the collectable stool specimens (n=126). Three specimens identified as T. solium were found in Luang Prabang, while the remaining 123 specimens, which were T. saginata, were found in Bokeo, Bolikhamxay, Champasak, Houaphan, Khammouane, Luang Namta, Luang Prabang, Oudomxay, Phongsaly, Saysomboune, Saravane, Savannakhet, Xayaboury, Xekong, Xieng Khouang Province, and Vientiane Municipality.

• Journal of Preventive Medicine and Public Health
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• v.23 no.2 s.30
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• pp.207-215
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• 1990

In order to investigate the occurrence characteristics of cancer in terms of industry in Kwangju-Chonnam area, medical utilization records of industrial medical insurance corporations during the period of 1987 to 1988 were reviewed for the identification of neoplastic disease. The cases obtained from the medical records were followed up for the verification and to get additional information. Standardized incidence data were compared by occupational characteristics. Multiple logistic regression analysis was applied to analyze the difference of incidence or distribution of cancer as a whole or of some selected cancer. Total cases of cancer identified were 242 during the study period. Annual incidence rate was calculated as 123.1 per 100,000 person. The frequent types of cancer were cancers of stomach, liver, lung, colon and rectum, bladder and lymphoma in descending order. Employees of mine and other sand handling industries showed significantly higher risks for cancer of stomach and cancer as a whole. Employees of the transportation industry showed the higher risk for cancer of liver, Workers in small-sized industry (${\leqq}100$) had a higher risk for cancer than who in large-sized industry (<100). These findings suggested the effect of occupational environmental exposure to cancer development.

• Korean Journal of Food Science and Technology
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• v.38 no.5
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• pp.621-627
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• 2006

To characterize aroma properties of burnt beef reaction flavor manufactured by extrusion, volatile flavor compounds and aroma-active compounds were analyzed by simultaneous steam distillation and solvent extraction (SDE)-gas chromatography-mass spectrometry-olfactometry (GC-MS-O). Hydrolyzed vegetable protein (HVP) was successfully extruded with precursors (glucose, cystine, furaneol, thiamin, methionine, garlic powder, and lecithin) at $160^{\circ}C$, screw speed of 45 rpm, and feed rate of 38 kg/hr. Sixty eight volatile flavor compounds were found in burnt beef reaction flavor. The number of volatile flavor compounds decreased significantly when HVP was extruded either with furaneol-free precursors or without precursors. Twenty seven aroma-active compounds were detected in burnt beef reaction flavor. Of these, methional and 2-methyl-3-furanthiol were the most intense aroma-active compounds. It was suggested that furaneol played an important role in the formation of burnt beef reaction flavor.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.3
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• pp.1149-1155
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• 2016

Background: Examination of sentinel lymph node (SLN) biopsies provides accurate nodal staging for breast cancer and plays a key role in patient management. Procurement of SLNs and the methods used to process specimens are equally important. Increasing the level of detail in histopathological examination of SLNs increases detection of metastatic tumours but will also increase the burden of busy laboratories and thus may not be carried out routinely. Recommendation of a reasonable standard in SLN examination is required to ensure high sensitivity of results while maintaining a manageable practice workload. Materials and Methods: Twenty-four patients with clinically node-negative breast cancer were recruited. Combined radiotracer and blue dye methods were used for identification of SLNs. The nodes were thinly sliced and embedded. Serial sectioning and immunohistochemical (IHC) staining against AE1/AE3 were performed if initial H&E sections of the blocks were negative. Results: SLNs were successfully identified in all patients. Ten cases had nodal metastases with 7 detected in SLNs and 3 detected only in axillary nodes (false negative rate, FNR=30%). Some 5 out of 7 metastatic lesions in the SLNs (71.4%) were detected in initial sections of the thinly sliced tissue. Serial sectioning detected the remaining two cases with either micrometastases or isolated tumour cells (ITC). Conclusions: Thin slicing of tissue to 3-5mm thickness and serial sectioning improved the detection of micro and macro-metastases but the additional burden of serial sectioning gave low yield of micrometastases or ITC and may not be cost effective. IHC validation did not further increase sensitivity of detection. Therefore its use should only be limited to confirmation of suspicious lesions. False negative cases where SLNs were not involved could be due to skipped metastases to non-sentinel nodes or poor technique during procurement, resulting in missed detection of actual SLNs.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.9
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• pp.4487-4490
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• 2016

Background: Methylation at cg 16941656 of FRY is exclusively found in normal pancreatic tissue and has been proven to be specific for pancreatic-in-origin among several adenocarcinomas. Here, we investigated methylated DNA in the bile as a biomarker to differentiate the cause of obstruction between pancreatic cancer and benign causes. Materials and Methods: Bile samples of 45 patients with obstructive jaundice who underwent ERCP were collected and classified into pancreatic cancer (group 1) and benign causes (group 2) in 24 and 21 patients, respectively. DNA was extracted from bile and bisulfite modification was performed. After, methylation in cg 16941656 of FRY was identified by real-time PCR, with beta-actin used as a positive control. Results: Methylated DNA was identified in 10/24 (41.67%) and 1/21 (4.8%) of cases in groups 1 and 2, respectively (P= 0.012). The sensitivity, specificity, positive predictive value and negative predictive value to differentiate pancreatic cancer from benign causes were 42%, 95%, 91%, and 59%, respectively. Conclusions: Detecting a methylation at cg 16941656 of FRY in bile has high specificity, with an acceptable positive likelihood rate, and may therefore be helpful in distinguish pancreatic cancer from benign strictures.

• Journal of the Korea Society of Computer and Information
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• v.16 no.4
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• pp.93-99
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• 2011

Recently, the development of internet technology makes user's personal data used by being saved in USB. But there is a critical issue that personal data can be exposed with malicious purpose because that personal data doesn't need to be certificate to use. This paper proposes USB security framework to prevent a duplicate use of personal data for protecting the data which in USB. The proposed USB security framework performs certification process of user with additional 4bite of user's identification data and usage choice of USB security token before certification data when the framework uses USB security product in different network. It makes communication overhead and service delay increased. As a result of the experiment, packet certification delay time is more increased by average 7.6% in the proposed USB security framework than simple USB driver and USB Token, and procedure rate of certification server on the number of USB is also increased by average 9.8%.

• Nuclear Engineering and Technology
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• v.44 no.7
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• pp.735-744
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• 2012

In order to quantify the flow distribution characteristics of APR+ reactor, a test was performed on a test facility, ACOP ($\underline{A}$PR+ $\underline{C}$ore Flow & $\underline{P}$ressure Test Facility), having a length scale of 1/5 referring to the prototype plant. The major parameters are core inlet flow and outlet pressure distribution and sectional pressure drops along the major flow path inside reactor vessel. To preserve the flow characteristics of prototype plant, the test facility was designed based on a preservation of major flow path geometry. An Euler number is considered as primary dimensionless parameter, which is conserved with a 1/40.9 of Reynolds number scaling ratio. ACOP simplifies each fuel assembly into a hydraulic simulator having the same axial flow resistance and lateral cross flow characteristics. In order to supply boundary condition to estimate thermal margins of the reactor, the distribution of inlet core flow and core exit pressure were measured in each of 257 fuel assembly simulators. In total, 584 points of static pressure and differential pressures were measured with a limited number of differential pressure transmitters by developing a sequential operation system of valves. In the current study, reactor flow characteristics under the balanced four-cold leg flow conditions at each of the cold legs were quantified, which is a part of the test matrix composing the APR+ flow distribution test program. The final identification of the reactor flow distribution was obtained by ensemble averaging 15 independent test data. The details of the design of the test facility, experiment, and data analysis are included in the current paper.

• Proceedings of the Korean Society of Crop Science Conference
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• 2017.06a
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• pp.116-116
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• 2017

Low-temperature is one of the environmental stress factors that affect plant growth and development and consequently limit crop productivity. The control of seed germination under low-temperature is organized by many genes which are called quantitative trait loci (QTLs). High germination rate for low-temperature is an important factor of growing rice. Previously, we identified a major QTL controlling low-temperature germinability in rice using 96 introgression lines (ILs) derived from a cross between Oryza rufipogon (Rufi) and the Korean japonica cultivar, 'Hwaseongbyeo (HS)'. A $BC_3F_7$ line (TR5) showed better low-temperature germinability than its recurrent parent. TR5 was crossed with HS to develop a segregating F2:3 populations for the target QTL. Six SSR markers polymorphic between HS and Rufi were used to screen and fine map the qLTG1. The qLTG1 on chromosome 1, which accounted for 55.5% of the total phenotypic variation, confirmed that Rufi allele enhanced the low-temperature germinability. Intervals between markers CRM16 and CRM15, four candidate genes were identified. The identified candidate genes, which are encoded by a protein of unknown function, showed their direct involvement on seed germination at low-temperature. To identify genes targeted by qLTG1, we investigated the expression profiles of these candidate genes and germination behavior of qLTG1 under different stress conditions and compared to HS, Rufi, and TR5 at $13{\pm}2^{\circ}C$ for 3 days after incubation. Furthermore, transgenic rice plants will also be developed to conduct a detailed investigation on low-temperature germinability. Hence, the QTL for low-temperature germinability would be useful in rice breeding programs especially in the development of lines possessing low-temperature germinability.

• Journal of Korean society of Dental Hygiene
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• v.13 no.6
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• pp.977-985
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• 2013

Objectives : The purpose of the study is to investigate Korean scaling fear (KSF)-1.1 and related factors in scaling patients. Methods : The subjects were 314 scaling patients in 7 dental clinics in Daegu from April to June, 2013. Data were analyzed for simple frequency rate, t-test and ANOVA(Sheffes's post hoc) for the identification of the differences between KSF-1.1 and variables. Multiple regression was analyzed for the impact of independent variable on the score of KSF-1.1. Results : Mean score of KSF-1.1 in 314 scaling patients was 2.60. Female patients (2.71) had a higher score than male (2.47) (p<0.01). Those who didn't get a regular dental check up(2.87) tended to have higher fear level than those who had regular checkup (2.46) (p<0.001). Those who experienced dental pain (2.90) had significantly higher score than those who had not (2.46) (p<0.001). There was a significant difference between three groups (yes 3.03, ordinary 2.79, and no 2.42) in scaling (p<0.001) and financial burden (p<0.001). Variables associated with score of KSF-1.1 were gender(${\beta}$=0.21, p<0.05), waiting time for scaling(${\beta}$=0.24, p<0.01) and financial burden (${\beta}$=0.22, p<0.02) by multiple regression analysis. Conclusions : The influencing factors of scaling were gender, financial burden, waiting time for scaling that may effect on a score of KSF-1.1.