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A Subband Structured Digital Hearing Aid Design for Compensating Sensorineural Hearing Loss (감음성 난청 보상을 위한 부밴드 구조 디지털 보청기 설계)

  • Park Jo-Dong;Choi Hun;Bae Hveon-Deok
    • The Journal of the Acoustical Society of Korea
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    • v.24 no.5
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    • pp.238-247
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    • 2005
  • In this Paper. we Presents subband design techniques of a compensating filter and adaptive feedback canceller for the digital hearing aid. The sensorineural hearing loss has a hearing threshold that shows a nonlinear characteristic in frequency domain. and its compensation suffers from an echo that produced by an undesired time varying feedback path. Therefore. the digital hearing aid requires the compensator that can adjust gains nonlinearly in frequency bands and eliminate the echo rapidly In the Proposed digital hearing aid. the compensating filter is designed by the adaptive system identification method in subband structure, and the adaptive feedback canceller is designed by the subband affine projection algorithm. The designed compensation filter can control the nonlinear gain in each subband respectively, therefore precise compensation is possible. And the feedback canceller using the subband adaptive filter achieves fast convergence rate. The Performances of the Proposed method are verified by computer simulations as comparing with the behaviors of the previous trials.

Biotransformation of major ginsenosides in ginsenoside model culture by lactic acid bacteria

  • Park, Seong-Eun;Na, Chang-Su;Yoo, Seon-A;Seo, Seung-Ho;Son, Hong-Seok
    • Journal of Ginseng Research
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    • v.41 no.1
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    • pp.36-42
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    • 2017
  • Background: Some differences have been reported in the biotransformation of ginsenosides, probably due to the types of materials used such as ginseng, enzymes, and microorganisms. Moreover, most microorganisms used for transforming ginsenosides do not meet food-grade standards. We investigated the statistical conversion rate of major ginsenosides in ginsenosides model culture during fermentation by lactic acid bacteria (LAB) to estimate possible pathways. Methods: Ginsenosides standard mix was used as a model culture to facilitate clear identification of the metabolic changes. Changes in eight ginsenosides (Rb1, Rb2, Rc, Rd, Re, Rf, Rg1, and Rg2) during fermentation with six strains of LAB were investigated. Results: In most cases, the residual ginsenoside level decreased by 5.9-36.8% compared with the initial ginsenoside level. Ginsenosides Rb1, Rb2, Rc, and Re continuously decreased during fermentation. By contrast, Rd was maintained or slightly increased after 1 d of fermentation. Rg1 and Rg2 reached their lowest values after 1-2 d of fermentation, and then began to increase gradually. The conversion of Rd, Rg1, and Rg2 into smaller deglycosylated forms was more rapid than that of Rd from Rb1, Rb2, and Rc, as well as that of Rg1 and Rg2 from Re during the first 2 d of fermentation with LAB. Conclusion: Ginsenosides Rb1, Rb2, Rc, and Re continuously decreased, whereas ginsenosides Rd, Rg1, and Rg2 increased after 1-2 d of fermentation. This study may provide new insights into the metabolism of ginsenosides and can clarify the metabolic changes in ginsenosides biotransformed by LAB.

Characterization of biopolymer produced by Bacillus coagulans DL-1 and optimization of its production (Bacillus coagulans DL-1이 생산하는 고분자 중합체의 특성과 생산조건의 최적화)

  • 김지모;손창우;서형필;문병주;도성국;이진우
    • Journal of Life Science
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    • v.13 no.2
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    • pp.214-222
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    • 2003
  • The microorganism isolated from soil was identified as Bacillus coagulans by morphological and biochemical analyses and API-50CH/B kit, which was an identification kit for Bacillus species, and named as B. coagulans DL-1. It produced an extracellular biopolymer. Maximum production of biopolymer was 5.00 $\pm$0.15 g/$\ell$ in a $7\ell$bioreactor with an aeration rate of 1.0 vvm and an agitation speed of 500 rpm when concentrations of glucose and yeast as the optimal carbon and nitrogen sources were 2.0% (w/v) and 0.25% (w/v), which were optimized with a flask scale. Gas chromatographic analysis showed that the biopolymer producded by B. coagulans DL-1 consisted of glucose and rhanmose and their molar ratios was about 9 : 1. Its average molecular weight was 2.80$\times$$10^5$ with gel permeation chromatographic (GPC) analysis.

Compression Strength Size Effect on Carbon-PEEK Fiber Composite Failing by Kink Band Propagation

  • Kim, Jang-Ho
    • KCI Concrete Journal
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    • v.12 no.1
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    • pp.57-68
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    • 2000
  • The effect of structure size on the nominal strength of unidirectional fiber-polymer composites, failing by propagation of a kink band with fiber microbuckling, is analyzed experimentally and theoretically. Tests of novel geometrically similar carbon-PEEK specimens, with notches slanted so as to lead to a pure kink band (without shear or splitting cracks), are conducted. The specimens are rectangular strips of widths 15.875, 31.75. and 63.5 mm (0.625, 1.25 and 2.5 in and gage lengths 39.7, 79.375 and 158.75 mm (1.563, 3.125 and 6.25 in.). They reveal the existence of a strong (deterministic. non-statistical) size effect. The doubly logarithmic plot of the nominal strength (load divided by size and thickness) versus the characteristic size agrees with the approximate size effect law proposed for quasibrittle failures in 1983 by Bazant This law represents a gradual transition from a horizontal asymptote, representing the case of no size effect (characteristic of plasticity or strength criteria), to an asymptote of slope -1/2 (characteristic of linear elastic fracture mechanics. LEFM) . The size effect law for notched specimens permits easy identification of the fracture energy of the kink bandand the length of the fracture process zone at the front of the band solely from the measurements of maximum loads. Optimum fits of the test results by the size effect law are obtained, and the size effect law parameters are then used to identify the material fracture characteristics, Particularly the fracture energy and the effective length of the fracture process zone. The results suggest that composite size effect must be considered in strengthening existing concrete structural members such as bridge columns and beams using a composite retrofitting technique.

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Distribution and Properties of Microorganisms in Soil of Representative Vegetation of Mt. Nam (남산 주요 식생의 토양 미생물의 분포 및 생리적 특성)

  • 성치남;백근식;김종홍;전영문;김정근
    • The Korean Journal of Ecology
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    • v.21 no.5_3
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    • pp.703-712
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    • 1998
  • Physicochemical factors, microbial population size and the properties of the bacterial isolates were estimated to find out the nature of soil ecosystem of Mt. Nam. Samples were obtained from the surface layer of soils on which specific plant community is developed. Average content of moisture and organic matter of the soils were 21.6% and 17.3%, respectively. These values were similar to those of developing forest soils, but were slightly lower than those of climax ecosystem such as Piagol in Mt. Chiri. Chiri. Content of phosphate was higher than those of other forest soils. The population size of soil bacteria ranged from 27.4 to 195.8 ${\times}\;10^5$ CFU/g. duy soil, and the size is somewhat dependent on the moisture and oranic matter content of soils. A large number of bacteria were able to decompose macromolecules such as starch, elastin and gelatin. Bacterial species composition of each soil was comparatively simple. Pseudomonas, Agrobacterium, Flavobacterium and Xanthomonas which are Gram-negative short rods were widely distributed in the forest soils. The endospore forming Bacillus species were also the main constituents of the soil microflroa. Actinomycetes were widely distributed in the forest soils, but the distribution pattern varied in each site. Most of the actinomycetes were also able to decompose organic macromolecules. The rate of resistant actinomycete strains to antibiotics and heavy metals were lower than those from cultivated soils, but higher than those from well-preserved forest soils. Antibiosis pattern of the actinomycete isolates was similiar to the resistance pattern. This means the forest soils of Mt. nam was somewhat interferred by artificial behabiour.

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DL Radio Transmission Technologies for WRAN Applications : Adaptive Sub-channel Allocation and Stationary Beamforming Algorithms for OFDMA CR System (WRAN 응용을 위한 하향링크 무선전송 방식 : OFDMA 상황인식 시스템에서의 적응 부채널 할당 및 고정 빔 형성 기법)

  • Kim Jung-Ju;Ko Sang-Jun;Chang Kyung-Hi
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.31 no.3A
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    • pp.291-303
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    • 2006
  • In this paper, we analyze functional requirements of the IEEE 802.22 WRAN, and propose a downlink 프레임 structure satisfying the requirements. The proposed downlink 프레임 structure maximizes e transmission efficiency by adopting the cognative radio to assign the sub-channel by reflecting the channel environment of WRAN. We also calculate the signalling overhead for both downlink and uplink, and analyze the performances of time synchronization, frequency synchronization and cell identification based on the 프리앰블 in downlink and suggest the channel estimation method tough 프리앰블 or pilot. As a final result, e stationary beamforming (SBF) algorithm with dynamic channel allocation(DCA) is proposed. The proposed OFDMA downlink 프레임 structure with channel adaptive sub-channel allocation for cognitive radio applications is verified to meet the requirements of IEEE 802.22 WRAN, by computer simulations.

Investigation of an Apartment Fire - Site Surveys and Burn Tests for Estimation of the Progress on Initial Fire Spread - (공동주택의 화재조사 - 현장조사 및 연소실험에 의한 초기 화재확대과정 추정 -)

  • Nam, Dong-Gun;Hasemi, Yuji
    • Fire Science and Engineering
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    • v.23 no.4
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    • pp.120-129
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    • 2009
  • Identification of the exact cause of a building fire is generally difficult, because the source and initially ignited objects are often severely damaged or even lost during the early stages of the fire. We made an experimental attempt to reasonably estimate the burning during the very early stages of a fire, and identify its source and causes. The case we studied was an apartment fire, which occurred in Tokyo, in July 2002. The fire was extinguished just after flashover, and the on-site investigations suggested the fire started from the TV and TV stand, which had been damaged so severely that it was difficult to conclude that the TV was the ultimate cause of the fire, simply from the on-site investigation. We conducted a series of burn tests using a TV and other products identical to those actually used in the apartment. Tests were set-up and procedures were carefully studied to recreate the conditions of the articles that remained, and of the room itself. The tests demonstrated that the conditions in the apartment could be recreated only when the fire started inside the TV and came into close contact with dresser.

Recognition of Unconstrained Handwritten Numerals using Modified Chaotic Neural Networks (수정된 카오스 신경망을 이용한 무제약 서체 숫자 인식)

  • 최한고;김상희;이상재
    • Journal of the Institute of Convergence Signal Processing
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    • v.2 no.1
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    • pp.44-52
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    • 2001
  • This paper describes an off-line method for recognizing totally unconstrained handwritten digits using modified chaotic neural networks(MCNN). The chaotic neural networks(CNN) is modified to be a useful network for solving complex pattern problems by enforcing dynamic characteristics and learning process. Since the MCNN has the characteristics of highly nonlinear dynamics in structure and neuron itself, it can be an appropriate network for the robust classification of complex handwritten digits. Digit identification starts with extraction of features from the raw digit images and then recognizes digits using the MCNN based classifier. The performance of the MCNN classifier is evaluated on the numeral database of Concordia University, Montreal, Canada. For the relative comparison of recognition performance, the MCNN classifier is compared with the recurrent neural networks(RNN) classifier. Experimental results show that the classification rate is 98.0%. It indicates that the MCNN classifier outperforms the RNN classifier as well as other classifiers that have been reported on the same database.

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Effect of Crystal Form on Bioavailability (결정형이 생체이용률에 미치는 영향)

  • Sohn, Young-Taek
    • Journal of Pharmaceutical Investigation
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    • v.34 no.6
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    • pp.443-452
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    • 2004
  • Habit is the description of the outer appearance of a crystal. If the environment of a growing crystal affects its external shape without changing its internal structure, a different habit results. Crystal habit and the internal structure of a drug can affect bulk and physicochemical properties, which range from flowability to chemical stability. A polymorph is a solid crystalline phase of a given compound resulting from the possibility of at least two different arrangements of the molecules of that compound in the solid state. Chemical stability and solubility changes due to polymorphism can have an impact on a drug's bioavailability and its development program. During crystallization from a solution, crystals separating may consist of a pure component or be a molecular compound. Solvates are molecular complexes that have incorporated the crystallizing solvent molecule in their lattice. When the solvent incorporated in the solvate is water, it is called a hydrate. To distinguish solvates from polymorphs, which are not molecular compounds, the term pseudopolymorph is used. Identification of possible hydrate compounds is important since their aqueous solubilities can be significantly less than their anhydrous forms. Conversion of an anhydrous compound to a hydrate within the dosage form may reduce the dissolution rate and extent of drug absorption. An amorphous solid may be treated as a supercooled liquid in which the arrangement of molecules is random. Amorphous solids lack the three-dimensional long-range order found in crystalline solids. Since amorphous forms are usually of higher thermodynamic energy than corresponding crystalline forms, solubilities as well as dissolution rates are generally greater. A study on crystal form includes characterization of (l)crystal habit, (2)polymorphism, (3)pseudopolymorphism, (4)amorphous solid.

Identification of Ligand for Salivary Lipocalin Secreted from the Uterine Endometrium during Early Pregnancy in Pigs

  • Seo, Hee-Won;Kim, Min-Goo;Ka, Hak-Hyun
    • Journal of Embryo Transfer
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    • v.24 no.4
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    • pp.259-263
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    • 2009
  • Salivary lipocalin (SAL1) is a member of the lipocalin protein family that has a property to associate with many lipophilic molecules and was identified as pheromone-binding protein in pigs. Our previous study has shown that SAL1 is expressed in the uterine endometrium in a cell type- and implantation stage-specific manner and secreted into the uterine lumen in pigs. However, function of SAL1 in the uterus during pregnancy in pigs is still not known. To understand physiological function of SAL1 in the uterine endometrium during pregnancy in pigs, it needs to elucidate the ligand(s) for SAL1. Thus, to identify the ligand for SAL1 in the porcine uterus, we collected uterine luminal fluid from pigs on day 12 of pregnancy by flushing with PBS. Proteins from the uterine luminal fluid were separated by ion exchange chromatography and gel filtration. Fractions containing SAL1 protein were pooled and concentrated. Immunoblot analysis confirmed successful purification of SAL1. Then, we extracted lipids from the purified SAL1 protein and analyzed the lipids by liquid chromatography-mass spectrometry, and predicted to be steroid hormones and prostaglandins as SAL1 ligands. Results in this study showed that SAL1 protein in the uterine secretions has a small lipophilic molecule as a natural ligand. Further characterization of ligand extracted from purified SAL1 will be useful for understanding physiological function of SAL1 during pregnancy and its application to increase the pregnancy rate in pigs.