• Journal of the Korea institute for structural maintenance and inspection
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• v.12 no.6
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• pp.81-88
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• 2008

The purpose of this study is to improve and modify the evaluation method of load carrying capacity for simply supported PSC I Typed girder bridge. To do this, conventional ASD(Allowable Stress Design) and USD(Ultimate Strength Design) evaluation method were initially investigated and it was evaluated that the conventional USD evaluation method may perform the load carrying capacity as conservative because it do not consider the prestressing upper-force effect of simply supported PSC I Typed girder bridge. To reasonably evaluate the load carrying capacity, the upper-force effect should be considered to the PSC I Typed girder bridge. Thus, in this study, the MUSD method was Suggested and compared to the nonlinear FEM based-load carrying capacity using the live load factor and the efficiency of the evaluation method of load carrying capacity was investigated by experimental and analytical result. In the result of this study, the suggested MUSD evaluation method showed a reasonable evaluating result for the simply supported PSC bridge. For the new technique of load carrying capacity based on the nonlinear FEM analysis, it could effectively simulate the load-deflection relationship and the load carrying capacity of the PSC I Typed girder bridge.

• Journal of the Korea institute for structural maintenance and inspection
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• v.20 no.3
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• pp.49-57
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• 2016

This study intended to analyze reinforcement effects of PSC I girder bridges to which prestresses are introduced using V type of external strands. So that series of bridge loading tests are carried out on existing PSC I girder bridge for the cases of before-reinforcement and reinforcement. The measured results from tests being analyzed and compared with the ones from MIDAS structural analyzing program, the reinforcing effects of the reinforcement system adopted in this study were investigated. It is found out that when the V type systems are applied to the bridge girders, the slope of load distribution factor curves become lower improving soundness of bridge upper structure. And also it is confirmed that the reinforcement system in this study can be taken as helpful for improvement of both flexural and shear ability of PSC I girder bridges, as well as dynamic behavior. Furthermore it is found when the elastic pads are applied to the system, dynamic reinforcing effects are maximized.

• Journal of the Korea Concrete Institute
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• v.12 no.5
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• pp.13-23
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• 2000

In this study, an flexural test on half-scale spliced PSC-I girder was conducted to verify the efficiency of the long span spliced girder as suggested by the Korean Highway Design Specification. The experimental results showed that the specimens developed a complex failure mode due to flexural-compression and torsional stress. The cracking moment of each girder was higher the experiment than was calulated by the ACI and the ultimate strength were the almost same. To estimate the safety and the structural efficiency of the spliced girder, the proposed Yielding Resistance Index(YRI) and ductility index by American Concrete Institutes were used based on the energy concept. The proposed YRI defined the ratio of crack resisting energy and the total energy calculated from load-displacement relationship. Based on the analysis of YRI and ductility index, the flexural behavior of the spliced girder was found to be efficient. Through the experimental results, the structural behavior of proposed spliced PSC I-type girder for long span bridge was found to be more efficient than the exsisting PSC I-type girders.

• The Korean Journal of Pesticide Science
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• v.2 no.2
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• pp.10-15
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• 1998

The bimolecular inhibition rate constants of carbofuran and N-dimethylphosphinothioyl carbofuran(PSC) to acetylcholinesterase(AChE) were $7.7{\times}10^{5}\;M^{-1}{\cdot}min^{-1}$ and $1.2{\times}10^{3}\;M^{-1}{\cdot}min^{-1}$, respectively. These results showed that PSC required a bioactivation process for its toxic action because it didn't inhibit the target enzyme effectively. The potency of PSC as an inhibitor of AChE increased when PSC and AChE were incubated with microsomes fortified with NADPH compared with microsome alone. Piperonyl butoxide(PBO) addition to these coupled systems greatly reduced the inhibition of the target enzyme by blocking the bioactivation process. In vivo inhibition study of mouse brain AChE, $I_{50}$ value for AChE was 28 mg/kg for PSC and the value increased to 57 mg/kg when PBO was pretreated. This result showed that cytochrome $P_{450}$ would also play a role in the bioactivation process of PSC in vivo. And conversioin of carbofuran from PSC was 55 % in a chemical oxidation system using meta-chloroperoxybenzoic acid. The oxidative activation of PSC to carbofuran was shown to be essential for showing its toxicological action and cytochrome $P_{450}$ was identified as an important enzyme which participated in this process.

• Journal of the Korea Concrete Institute
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• v.12 no.6
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• pp.13-22
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• 2000

In order to resolve the problem of increasing traffic entailed by the economic development, road system is reorganization and new highways are built, and long span bridges over 40m are being constructed in environmental and aesthetic considerations. Most long span bridges that are currently being constructed are in general steel box girder and preflex girder bridges; however these types of breiges are less efficiency than PSC I-type girder bridges in terms of construction cost and maintenance. Therefore, in these study, structural efficiency of PSC I-type girders based on section parameters, concrete compressive strength and other design parameter is observed to develope new PSC I-type girder for long span bridges. As a results of analysis, most important design parameters that control the stress of the girder are found to be the top flange width and the height of girder. In this light, the relationship between the two variables is determined and cross-section details of the girder that most appropriates for the long span bridges are proposed. The use of high strength concrete appears to increase the general design span however the increase rate of the span from increasing concrete ultimate strength appears to be reduced depending on the span. Also, the optimal girder spacing is determined through the parameter studies of design span using the proposed girder.

• BMB Reports
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• v.48 no.5
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• pp.256-265
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• 2015

Cardiovascular and neurodegenerative diseases are major health threats in many developed countries. Recently, target tissues derived from human embryonic stem (hES) cells and induced pluripotent stem cells (iPSCs), such as cardiomyocytes (CMs) or neurons, have been actively mobilized for drug screening. Knowledge of drug toxicity and efficacy obtained using stem cell-derived tissues could parallel that obtained from human trials. Furthermore, iPSC disease models could be advantageous in the development of personalized medicine in various parts of disease sectors. To obtain the maximum benefit from iPSCs in disease modeling, researchers are now focusing on aging, maturation, and metabolism to recapitulate the pathological features seen in patients. Compared to pediatric disease modeling, adult-onset disease modeling with iPSCs requires proper maturation for full manifestation of pathological features. Herein, the success of iPSC technology, focusing on patient-specific drug treatment, maturation-based disease modeling, and alternative approaches to compensate for the current limitations of patient iPSC modeling, will be further discussed. [BMB Reports 2015; 48(5): 256-265]

• KSCE Journal of Civil and Environmental Engineering Research
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• v.29 no.3A
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• pp.235-241
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• 2009

PSC girder bridge is known to be more economical than other types of bridges and has been usually applied to a span range of 25 m to 35 m according to the standard shapes for highway bridges in Korea. The spans of the recently developed new types of PSC girders are also limited to 50 m at most. In this study, therefore, feasibility of the long-span PSC girder that reaches more than 50 m is investigated by applying several strategies from the perspectives of materials, design and construction. A systematic procedure is proposed that can be used to assess the effect of each strategy on the span. The proposed scheme adopts a graphical approach that represents a relationship between the number of prestressing tendons and the span, and is derived on a basis of safety assessment equations of the girder in each stage of fabrication and in service. In the companion paper, the amount of span extension is quantitatively evaluated by applying the proposed scheme into a sample PSC girder bridge.

• Journal of Animal Reproduction and Biotechnology
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• v.34 no.3
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• pp.232-239
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• 2019

In general, cloned pigs have been produced using the somatic cell nuclear transfer (SCNT) technique with various types of somatic cells; however, the SCNT technique has disadvantages not only in its low efficiency but also in the development of abnormal clones. This study aimed to compare early embryonic development and quality of SCNT embryos with those of induced pluripotent stem cells (iPSCs) NT embryos (iPSC-NTs). Ear fibroblast cells were used as donor cells and iPSCs were generated from these cells by lentiviral transduction with human six factors (Oct4, Sox2, c-Myc, Nanog, Klf4 and Lin28). Blastocyst formation rate in iPSC-NT (23/258, 8.9%) was significantly lower than that in SCNT (46/175, 26.3%; p < 0.05). Total cell number in blastocysts was similar between two groups, but blastocysts in iPSC-NT had a lower number of apoptotic cells than in SCNT (2.0 ± 0.6 vs. 9.8 ± 2.9, p < 0.05). Quantitative PCR data showed that apoptosis-related genes (bax, caspase-3, and caspase-9) were highly expressed in SCNT than iPSC-NT (p < 0.05). Although an early development rate was low in iPSC-NT, the quality of cloned embryos from porcine iPSC was higher than that of embryos from somatic cells. Therefore, porcine iPSCs could be used as a preferable cell source to create a clone or transgenic animals by using the NT technique.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.30 no.5A
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• pp.463-473
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• 2010

The purpose of this study was to investigate the performance of precast concrete copings for precast segmental PSC bridge columns. The proposed system can reduce work at a construction site and makes construction periods shorter. The precast concrete copings provides an alternative to current cast-in-place systems, particularly for areas where reduced construction time is desired. A model of precast concrete copings was tested under quasistatic monotonic loading. As a result, proposed precast coping system was equal to existing cast-in-place system in terms of required performance. In the companion paper, the experimental and analytical study for the performance assessment of precast concrete copings for precast segmental PSC bridge columns is performed.

• Journal of the Korea Concrete Institute
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• v.19 no.6
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• pp.755-762
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• 2007

For the evaluation of the load carrying capacity of the deteriorated PSC I girder bridge in service load state and the verification of the grade to the reinforcement effect of actual bridge strengthened by external prestressing tendons, the field test using vehicles is applied widely. Because this teat was executed in elastic range, the investigation of the characteristics of behavior caused by live load is only available. And it is impossible to estimate load carrying capacity in limit state and nonlinear behavior after that a crack is appeared. In this study, the 27-year-old prestressed concrete girder bridge is used and various load tests are performed, so we evaluate the behavior characteristics of the bridge in service load state and ultimate load state, and estimate the load carrying capacity of bridge. In addition, the artificial damages are induced from cutting internal tendons, and external tendons is added to strengthen it as much as vanished internal tendons. Next we compare the damage state with the strengthening state. In case of the application of external prestressing method to PSC I girder bridge, the present experiment result may decide more exactly the load carrying capacity of actual bridge, the amount for reinforcement, and the standard of quality control etc. at reinforcement work.