• Title/Summary/Keyword: iPSC

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Analysis of Lateral Behavior of PSC Bridge Girders under Wind Load During Construction (시공 중 풍하중에 의한 PSC 교량 거더의 횡방향 거동 해석)

  • Lee, Jong-Han;Kim, Kyung Hwan;Cho, Baiksoon
    • Journal of the Korea Concrete Institute
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    • v.27 no.4
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    • pp.377-385
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    • 2015
  • The span-lengthening of PSC I girder has increased the risk of lateral instability of the girder with the increases in the aspect ratio and self-weight of the girder. Recently, collapses of PSC I girder during construction raise the necessity of evaluating the lateral instability of the girder. Thus, the present study evaluated the lateral behavior and instability of PSC I girders under wind load, regarded as one of the main causes of the roll-over collapse during construction. Lateral instability of the girder is mainly dependent on the length of the girder and the stiffness of the support. The analysis results of this study showed the decrease in the critical wind load and the increase in the critical deformation and angle of the girder, leading to the lateral instability of the girder. Finally, this study proposed analytical equations that can predict the critical amount of wind load and lateral deformation of the girder, which would provide quantitative management values to maintain lateral stability of PSC I girder during construction.

Experimental Performance Estimate of a 40m PSC I Girder for Railway Bridges (40m PSC I형 철도교의 동적 성능 평가)

  • Yeo, Inho
    • Journal of the Korean Society for Railway
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    • v.16 no.5
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    • pp.394-401
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    • 2013
  • Here we report the results of an experimental laboratory test to verify the applicability to railway bridges of a PSC I girder of which the upper flange thickness was increased to improve sectional performance. The thicker this flange is, the further upward the neutral axis is moved. If in this way the span length can be increased to 40m long, the bridge may be constructed with four girders instead of five. Therefore, construction cost could be lowered by reducing the weight of the long span structure due to increased sectional efficiency. It was also necessary to be certain that the dynamic performance of this relatively flexible structure would be applicable to railway bridges. Therefore numerical analysis, as well as static and dynamic tests, was carried out for a full-size PSC I girder. Based on these results, it was verified that the performance of the PSC I railway bridge satisfied the performance criteria of the design code.

Evaluation of Bursting Behavior in Anchorage Zone of PSC I Girders (PSC I 거더의 정착부 파열거동 평가)

  • Choi, Kyu Chon;Park, Young Ha;Paik, In Yeol
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.30 no.3A
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    • pp.329-336
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    • 2010
  • An experimental study to evaluate bursting behavior in anchorage zone of the standard PSC I girders (span length : 30 m) has been carried out. The arrangement of bursting reinforcement in anchorage zone of the standard PSC I girders is considered to be designed without accurately reflecting the stress flows in the end zone of the PSC I girders caused by presstressing forces of the tendons. Also, due to excessive arrangement of the bursting bars, the workability of the girder is decreased greatly. In this study, three specimens with the same dimensions as the end zone of the standard PSC I girder are prepared and the experiment is carried out by applying PS forces. The bursting reinforcement of each specimen consists of 100 mm, 200 mm, and 300mm spacings, respectively. The experimental results show that the range of the PS forces to cause crack in the anchorage zone of the specimen are more than 1.6 times of the design PS forces. The bursting cracks occur in the vertical direction on the inside of all specimens. After applying 2.7 times of the design PS force, some of the transverse bursting reinforcements only in the specimen reinforced by 300 mm spacing yielded. The experimental results show that the anchorage zone of the standard PSC I girders arranged by 300 mm spacing of the bursting reinforcements which is the maximum spacing allowed in the road bridge design specifications, can be considered safe enough.

Evaluation of the Load Carrying Capacity of Existing Bridges with Long Span Hollow Web Prestressed Concrete Girder by Static Load Test (정적재하시험을 통한 장경간 중공 웨브 PSC 거더교의 내하력 평가)

  • Kim, Seong-Kyum;Jang, Pan-Ki;Jang, Il-Young
    • Journal of the Korea institute for structural maintenance and inspection
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    • v.22 no.3
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    • pp.97-102
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    • 2018
  • Conventional PSC I type girders were adversely affected by the self - weight of concrete, anchorage, prestressing. In order to overcome this problem, PSC girder was constructed with a hollow in the web and developed a hollow web PSC type I girder which is applicable to 50 - 70m span by multistage stressing and then actually long span hollow web PSC girder bridge was constructed. In this study, the results of Static Load Test and the Finite Element Analysis of the hollow web PSC I girder bridges were compared and analyzed, and the Load Carrying Capacity and safety of PSC girder bridges were evaluated. The Static Load Test and the numerical analysis results of this bridge showed similar tendency and the behavior of the hollow web PSC I girder was well simulated. The entire girders of the bridges had sufficient Load Carrying Capacity under the live load design condition and the bridges satisfied the safety and confirmed the appropriateness of the construction.

Optimal Design of PSC-I Girder Bridge Considering Life Cycle Cost (생애주기비용을 고려한 PSC-I형 교량의 최적설계)

  • Park, Jang-Ho;Shin, Yung-Seok
    • Journal of the Korean Society of Safety
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    • v.24 no.5
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    • pp.48-56
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    • 2009
  • This paper presents the procedure for the optimal design of a PSC-I girder bridge considering life cycle cost (LCC). The load carrying capacity curves for the concrete deck, PSC-I girder and $\pi$-type pier were derived and used for the estimate of service lives. Total life cycle cost for the service life was calculated as sum of initial cost, damage cost, maintenance cost, repair and rehabilitation cost, user cost, and disposal cost. The advanced First Order Second Moment method was used to estimate the damage cost. The optimization method was applied to the design of PSC-I girder bridge. The objective function was set to the annual cost, which is defined by dividing the total life cycle cost by the service life, and constraints were formulated on the basis of Korean Standards. The optimal design was performed for various service lives and the effects of design factors were investigated.

Am Experimental Study on the Flexural Behavior after Crack Initiation of PSC I-Girder (PSC-I 거더의 균열 발생 이후의 휨거동에 관한 실험적 연구)

  • 심종성;오홍섭;김민수
    • Proceedings of the Korea Concrete Institute Conference
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    • 1999.10a
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    • pp.541-544
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    • 1999
  • The main objective of this study is to develope the PSC-I girder for long span bridge. This study investigates the structural behavior of Postcracking stage and efficiency of proposed PSC-I girder using 1/2 scaled prototype beam specimen. Three specimens are tested under three point static loading system. Ideally, the Load-displacement relationship is trilinear. The crack patterns and failure mode of each specimen are reported in this paper and they are compared to each other with ductility and strength.

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Analysis of Behavior due to Tendon Damage for Maintenance of PSC I Girder Bridge (PSC I 거더교 유지관리를 위한 긴장재 손상에 따른 거동 분석)

  • Jongho Park;Jinwoong Choi
    • Journal of the Korea institute for structural maintenance and inspection
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    • v.28 no.2
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    • pp.53-60
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    • 2024
  • Prestressed concrete (PSC) bridges are vulnerable to corrosion and fracture of tendons, and in particular, structures using the internal post-tensioned with grouted system have difficulties in maintenance due to limitations of inspection. In this study, the actual behavior of PSC I girder bridge was analyzed according to tendon damage. The target PSC I girder bridge, an decommissioned highway bridge of upper and lower bridges, had the service period of 33 years and 20 years, respectively. Deflection and concrete strain were measured according to the location of damaged tendon and loading method. Regardless of the age of the bridge, its structural performance decreased when the damaged tendon was closer to the center of the girder. The change in behavior increased as the truck load approached to the girder where the tendon cut. If the load was applied to the adjacent girder where the tendon was cut, the structural performance was likely to be maintained due to the influence of the entire structural system. The change in deflection was difficult to observe visually, while the concrete strain exceeded the cracking strain. Therefore, it is recommended that future monitoring and inspection of PSC I girder bridges should focus on concrete strain or cracking.

Modified HAZUS Method for Seismic Fragility Assessment of Domestic PSC-I Girder Bridges (PSC-I 거더교의 지진취약도 평가를 위한 HAZUS 방법의 국내 적용성 연구)

  • Seo, Hyeong-Yeol;Yi, Jin-Hak;Kim, Doo-Kie;Song, Jong-Keol
    • Journal of the Korea institute for structural maintenance and inspection
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    • v.14 no.2
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    • pp.161-170
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    • 2010
  • To reduce the amount of seismic damage, several design codes are being improved considering the earthquake resistant systems, and many researches are being conducted to develop the earthquake damage evaluation techniques. This study develops the Korean seismic fragility function using the modified HAZUS method applicable to PSC-I girder bridges in Korea. The major coefficients are modified considering the difference between the seismic design levels of America and Korea. Seismic fragility function of the PSC-I girder bridge (one of the standard bridge types in Korea) is evaluated using two methods: numerical analysis and modified HAZUS method. The main coefficients are obtained about 70% of the proposed values in HAZUS. It is found that the seismic fragility function obtained using the modified HAZUS method closes to the fragility function obtained by conventional numerical analysis method.

Selection of iPSCs without mtDNA deletion for autologous cell therapy in a patient with Pearson syndrome

  • Yeonmi Lee;Jongsuk Han;Sae-Byeok Hwang;Soon-Suk Kang;Hyeoung-Bin Son;Chaeyeon Jin;Jae Eun Kim;Beom Hee Lee;Eunju Kang
    • BMB Reports
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    • v.56 no.8
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    • pp.463-468
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    • 2023
  • Screening for genetic defects in the cells should be examined for clinical application. The Pearson syndrome (PS) patient harbored nuclear mutations in the POLG and SSBP1 genes, which could induce systemic large-scale mitochondrial genome (mtDNA) deletion. We investigated iPSCs with mtDNA deletions in PS patient and whether deletion levels could be maintained during differentiation. The iPSC clones derived from skin fibroblasts (9% deletion) and blood mononuclear cells (24% deletion) were measured for mtDNA deletion levels. Of the 13 skin-derived iPSC clones, only 3 were found to be free of mtDNA deletions, whereas all blood-derived iPSC clones were found to be free of deletions. The iPSC clones with (27%) and without mtDNA deletion (0%) were selected and performed in vitro and in vivo differentiation, such as embryonic body (EB) and teratoma formation. After differentiation, the level of deletion was retained or increased in EBs (24%) or teratoma (45%) from deletion iPSC clone, while, the absence of deletions showed in all EBs and teratomas from deletion-free iPSC clones. These results demonstrated that non-deletion in iPSCs was maintained during in vitro and in vivo differentiation, even in the presence of nuclear mutations, suggesting that deletion-free iPSC clones could be candidates for autologous cell therapy in patients.

A Study on the Evaluation Methods of the Load-Carrying Capacity of PSC I Type Girder Considering Material Nonlinear (재료 비선형을 고려한 PSC I형 거더교의 내하력평가 기법에 관한 고찰)

  • 심종성;김규선;문도영;주민관
    • Proceedings of the Korea Concrete Institute Conference
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    • 2003.05a
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    • pp.187-192
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    • 2003
  • Nowadays, It has adapted both Ultimate Strength Design(USD) and Allowable Stress Design(ASD) Method evaluating load-carrying capacity of PSC I Type Girder Bridge. But it has confused because the each method has brought some different results. This study shows some results of loading test of the PSC I type Girder Bridge and analyzed the structural behavior by FEM analysis considering material nonlinear. Parametric study of effective prestress of post tendon is performed and compared to results of loading test.

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