• Environmental Analysis Health and Toxicology
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• 제18권2호
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• pp.145-153
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• 2003

The goal of this study is to develop a biomarker used in monitoring abnormal behaviors of Japanese medaka (Oryzias latipes) as a model organism caused by hazardous chemicals. Japanese medaka was treated by copper of appropriate sublethal concentrations after starvation for 48 hr. The untreated individuals showed common behavioral characteristics (i.e. , smooth and linear movements). Locomotive activity of the fish was monitored using an image processing and automatic data acquisition system. When treated with copper (100 ppb), the fish showed shaking patterns more frequently. As the concentration of copper increased to 1,000 ppb, activity decreated, and the fish showed an erratic movement. Fish were exposed to copper at various concentrations (0,100 and 1,000 ppb) for 24 hrs, and acetylcholine esterase (AChE) activity was observed. When fish were exposed to 1,000 ppb of copper, the body AChE activities appeared to decrease but the head AChE activities showed little change. Expressions of tyrosine hydroxylase (TH) protein in the different organs from both head (brain) and body (kidney) portions affected by the copper treatment were analyzed using immunohistochemical technique compared with control. Five organs of the fish (olfactory bulb, hyothalamus, optic lobe, pons and myelencephalon regions) showed a relatively strong TH protein expression in the control experiment. A differential expression of TH, however, was observed in the treatment (100 ppb and 1,000 ppb). The treatment (1,000 ppb) significantly suppressed TH protein production in the brain regions. In kidney, however, the same treatment caused little suppression compared with the control. Copper appeared to be less effective in suppression of TH than diazinon, a known TH suppressor. It was concluded that TH could be used at a potential biomarker to monitor the acute copper toxicity in Japanese medaka.

• Journal of Biosystems Engineering
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• 제15권3호
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• pp.244-256
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• 1990

본 연구는 기계화(機械化) 영농단(營農團)의 조직, 농기계(農機械) 보유(保有) 및 이용(利用), 경지규모 등을 조사분석하고, 농기계(農機械) 이용비용(利用費用), 작업시간, 소요 노동력 등을 산출할 수 있는 수학적(數學的) 모델을 개발한 후, NGP를 이용하여 기계화 영농단의 규모별 적정(適正) 농기계(農機械)의 기종(機種) 및 태수(台數)를 결정하고자 수행되었다. 이를 위하여 충남지방의 50개의 기계화 영농단에 대하여 조사표에 의한 조사분석을 실시하고, 시스템분석을 통하여 수학적(數學的) 모델과 컴퓨터 프로그램의 개발에 필요한 각종 자료를 준비한 후, 컴퓨터 프로그램 MFSDlNGP를 개발한 후, 이것을 이용하여 기계화(機械化) 영농단(營農團)의 5ha규모에서부터 40ha까지 9개 수준의 규모에 대하여 적정(適正) 농기계(農機械)를 선정하였으며 그 결과는 표(表)8과 같다. 적정기종(適正機種) 선정결과(選定結果) 다음과 같은 결론을 얻을 수 있었다. (1) 기계화영농단의 규모 5~40ha 범위에서 적정농기계(適正農機械) 선정에 따른 年間利用費用(연간이용비용)은 1,444~37,663천원/yr와 289~942천원/ha-yr로 분석되었다. (2) 기계화영농단의 규모 20ha에서 부터는 농기계(農機械) 이용비용(利用費用)이 급격히 증가하는 것으로 분석되어 대규모(大規模) 기계화(機械化) 영농단(營農團)을 위한 적합기종(適合機種)의 개발이 필요한 것으로 나타났다.

• 융합정보논문지
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• 제11권2호
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• pp.163-172
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• 2021

이 연구의 목적은 노인의료복지시설 종사자들의 근무환경과 관리자 신뢰, 그리고 서비스 질과의 구조적 관계를 분석하기 위하여 연구 모델을 설정하고 이를 규명하는데 있다. 그 결과 첫째, 노인의료복지시설 종사자들의 근무환경과 서비스 질 간에 유의한 인과관계가 있는 것으로 나타났다. 둘째, 노인의료복지시설 종사자들의 근무환경과 관리자 신뢰는 유의한 인과관계가 있는 것으로 나타났다. 따라서 노인의료복지시설의 목표 달성과 서비스 질 향상을 위해서는 구성원들의 근무환경 조성과 신뢰관계 형성이 선행적으로 이루어져야 할 것이다. 아울러 노인의료복지시설 종사자들의 역량 함양과 질 높은 서비스를 제공하기 위해서 관리자들은 구성원들의 개인 특성을 이해하고, 역할에 따른 임무를 부여하기 위하여 정확한 업무 분장과 인사관리가 필요 할 것이다.

• Smart Structures and Systems
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• 제29권1호
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• pp.181-193
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• 2022

Data-driven structural health monitoring (SHM) of civil infrastructure can be used to continuously assess the state of a structure, allowing preemptive safety measures to be carried out. Long-term monitoring of large-scale civil infrastructure often involves data-collection using a network of numerous sensors of various types. Malfunctioning sensors in the network are common, which can disrupt the condition assessment and even lead to false-negative indications of damage. The overwhelming size of the data collected renders manual approaches to ensure data quality intractable. The task of detecting and classifying an anomaly in the raw data is non-trivial. We propose an approach to automate this task, improving upon the previously developed technique of image-based pre-processing on one-dimensional (1D) data by enriching the features of the neural network input data with multiple channels. In particular, feature engineering is employed to convert the measured time histories into a 3-channel image comprised of (i) the time history, (ii) the spectrogram, and (iii) the probability density function representation of the signal. To demonstrate this approach, a CNN model is designed and trained on a dataset consisting of acceleration records of sensors installed on a long-span bridge, with the goal of fault detection and classification. The effect of imbalance in anomaly patterns observed is studied to better account for unseen test cases. The proposed framework achieves high overall accuracy and recall even when tested on an unseen dataset that is much larger than the samples used for training, offering a viable solution for implementation on full-scale structures where limited labeled-training data is available.

• 대한약침학회지
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• 제26권4호
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• pp.319-326
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• 2023

Objectives: The study's goal was to find out whether Chrysanthemum rubellum extract has anti-diabetic properties by concentrating on α-glucosidase and the PTP-1B signaling pathway. C. rubellum flowers were used for extraction using Methanol/water (80/20) as solvent. Methods: LC-MS techniques was used to check the presence of phytoconstituents present in C. rubellum extract. In vitro antidiabetic activity was evaluated using α-glucosidase inhibitory activity and PTP-1B signaling pathway. On Streptozotocin (STZ)-induced rats with diabetes, the in vivo antidiabetic efficacy was assessed using a test for oral glucose tolerance. Results: The phytoconstituents identified in the extract of C. rubellum were apigenin, diosmin, myricetin, luteolin, luteolin-7-glucoside, and Quercitrin as compound 1-6, respectively. Results showed that diosmin exhibited highest α-glucosidase inhibitory activity i.e. 90.39%. The protein level of PTP-1B was lowered and the insulin signalling activity was directly increased by compounds 1-6. The maximum blood glucose levels were seen in all groups' OGTT findings at 30 minutes following glucose delivery, followed by gradual drops. In comparison to the control group, the extract's glucose levels were 141 mg/dL at 30 minutes before falling to 104 mg/dL after 120 minutes. The current study has demonstrated, in summary, that extract with phytoconstituents reduce blood sugar levels in rats. Conclusion: This finding suggests that extract may reduce the chance of insulin resistance and shield against disorders like hyperglycemia.

• 대한원격탐사학회지
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• 제39권5_3호
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• pp.891-907
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• 2023

Compact Advanced Satellite 500-4 (CAS500-4) is scheduled to be launched to collect high spatial resolution data focusing on vegetation applications. To achieve this goal, accurate surface reflectance retrieval through atmospheric correction is crucial. Therefore, a machine learning-based atmospheric correction algorithm was developed to simulate atmospheric correction from a radiative transfer model using Sentinel-2 data that have similarspectral characteristics as CAS500-4. The algorithm was then evaluated mainly for forest areas. Utilizing the atmospheric correction parameters extracted from Sentinel-2 and GEOKOMPSAT-2A (GK-2A), the atmospheric correction algorithm was developed based on Random Forest and Light Gradient Boosting Machine (LGBM). Between the two machine learning techniques, LGBM performed better when considering both accuracy and efficiency. Except for one station, the results had a correlation coefficient of more than 0.91 and well-reflected temporal variations of the Normalized Difference Vegetation Index (i.e., vegetation phenology). GK-2A provides Aerosol Optical Depth (AOD) and water vapor, which are essential parameters for atmospheric correction, but additional processing should be required in the future to mitigate the problem caused by their many missing values. This study provided the basis for the atmospheric correction of CAS500-4 by developing a machine learning-based atmospheric correction simulation algorithm.

• 한국조경학회지
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• 제18권3호통권39호
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• pp.99-113
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• 1990

The purpose of this study was to prepare some more up-dated and advanced curriculum in Landscape Architecture in Junior College education to bring up a leading professional who can meet the changing social needs. To achieve this goal, the data about the actual employment status of graduates, current relevant systems and legistations, the questionnaires of Landscape companies, graduates and undergraduates, and the current relevant curriculum of domain 6 junior colleges and Japanese relevant curriculum was gathered and analyzed The results are as follows ; 1. Currently the majority of the graduates are employed in Construction field, but the employment trend of graduates shows diversification and subdividing as following 5 fields, that is Construction, Design, Maintenance, Administration and Indoor Landscaping. 2. It is essential to bring up a Landscape Technician who has a Landscape Certificate of qualifications(esp. 2nd class). 3. Lately, the actual Practice came to be one item of the qualifying examination, so the subjects of Landscape Design, Landscape Construction and Landscape Estimation Should be emphasized, Accordingly, current curriculum should be revised. 4. Currant curriculum model(1979) made by the Ministry of Education doesn't play a real and adequate role and should be up-dated in view of the current curriculum of domain 6 junior colleges has no regular standards. In preparation for new standardized curriculum model, following criterior could be suggested, that is, ratio of the Major Required Subjects vs. The Major Optional Subjects would be 50 : 50, and the Major Optional Subject would be 48 credits which is 150% of the Required Credits(32 credits) 5. The subjects such as Basic Agriculture, Afforestation, Nature Conservation, Sketch, Civil Engineering, Landscape Seminar and Modelling Practice would be deleted in the curriculum model established in 1983. 6. The subjects such as Perspective Practice, Indoor Landscaping, Landscape Legislation and Landscape Design( III ) could be newly opened to meet the social needs, to prepare for the qualifying examination and to serve well in the employment fields. 7. The subjects of Surveying ( I ) & ( II ) would be unified into one Subject as Surveying, and some in view of the average situation of 6 junior colleges. 8. It is urgent to open some subject related to computer. At first, An Introduction to Computer could be recommended in the cultural studies course and Landscape Computer Technique as the Major Optional Subjects.

• 문화기술의 융합
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• 제8권5호
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• pp.279-284
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• 2022

블렌디드 러닝방식을 통해 디자인 교육에 대한 블렌디드 러닝 방식의 연구로서, 더 발전된 학습자 주도의 맞춤형 디자인 교육이 가능한 것을 제안하고자 한다. 대면 수업에서의 이해와 비대면에서의 장점을, 원격 수업에서 적절한 방식으로 보충할 수 있다. 발전한 인공지능과 빅데이터 기술은 디자인 분야 수업에서의 정량화된 데이터를 토대로 학습자의 수준과 관심에 맞는 개별화되고 세분화 된 맞춤형 학습 자료와 효과적인 학습 방법을 제공할 수 있다. 본론에서는 알 라 카르테 모델 (A La Carte) 제안을 통한 시·공간의 제약을 넘는 방식의 적용으로 수업의 효율을 극대화를 제안하였다. 언제 어디서나 들을 수 있는 원격 수업으로 소외 지역에 사는 학생들에게 제공되는 교육의 질과 교육 격차 해소에도 가능하다. 창의융합형 미래 인재를 양성하는 목표로서, 빠른 기술 발전 속도를 가지고 달라지고 있기에. 이에 발맞춘 학습 방법의 변화에 적응력을 지닐 필요가 있다. 알 라 카르테 모델 (A La Carte) 제안을 통한 인포그래픽 가상공간 디자인과 구축과정에 대한 분석을 제시하였다. 단순히 지식을 습득하는 것이 아니라, 지식을 선별하고, 구분하고, 학습하고, 자신만의 지식으로 손쉽게 재탄생시킬 수 있을 것으로 기대한다.

• Korean Journal of Radiology
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• 제24권7호
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• pp.647-659
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• 2023

Objective: The study was conducted to investigate the effect of correct occlusion of the left atrial appendage (LAA) on intracardiac blood flow and thrombus formation in patients with atrial fibrillation (AF) using four-dimensional (4D) flow magnetic resonance imaging (MRI) and three-dimensional (3D)-printed phantoms. Materials and Methods: Three life-sized 3D-printed left atrium (LA) phantoms, including a pre-occlusion (i.e., before the occlusion procedure) model and correctly and incorrectly occluded post-procedural models, were constructed based on cardiac computed tomography images from an 86-year-old male with long-standing persistent AF. A custom-made closed-loop flow circuit was set up, and pulsatile simulated pulmonary venous flow was delivered by a pump. 4D flow MRI was performed using a 3T scanner, and the images were analyzed using MATLAB-based software (R2020b; Mathworks). Flow metrics associated with blood stasis and thrombogenicity, such as the volume of stasis defined by the velocity threshold ($\left|\vec{V}\right|$ < 3 cm/s), surface-and-time-averaged wall shear stress (WSS), and endothelial cell activation potential (ECAP), were analyzed and compared among the three LA phantom models. Results: Different spatial distributions, orientations, and magnitudes of LA flow were directly visualized within the three LA phantoms using 4D flow MRI. The time-averaged volume and its ratio to the corresponding entire volume of LA flow stasis were consistently reduced in the correctly occluded model (70.82 mL and 39.0%, respectively), followed by the incorrectly occluded (73.17 mL and 39.0%, respectively) and pre-occlusion (79.11 mL and 39.7%, respectively) models. The surfaceand-time-averaged WSS and ECAP were also lowest in the correctly occluded model (0.048 Pa and 4.004 Pa^-1, respectively), followed by the incorrectly occluded (0.059 Pa and 4.792 Pa^-1, respectively) and pre-occlusion (0.072 Pa and 5.861 Pa^-1, respectively) models. Conclusion: These findings suggest that a correctly occluded LAA leads to the greatest reduction in LA flow stasis and thrombogenicity, presenting a tentative procedural goal to maximize clinical benefits in patients with AF.

• Asia Marketing Journal
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• 제13권3호
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• pp.25-53
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• 2011

이번 연구는 실제 기업 자료를 기반으로 고객보상 프로그램이 고객 유지(retention)에 미치는 영향을 살펴보았다. 특히 고객보상 프로그램의 효과를 보다 명확히 확인하기 위해 유사실험설계(quasi-experimental design)를 사용하였다. 그리고 1년이 넘는 장기적인 시간 프레임 속에서 고객보상 프로그램의 도입 시점을 전후로 소비자 집단을 구분하고 이들 집단의 비교를 통해 고객보상 프로그램의 효과를 파악하였다. 이러한 연구 설계를 고려한 이유는 종적 자료를 사용한 선행 연구들이 고객보상 프로그램의 도입 시점 이후부터 가입 고객과 비가입 고객을 대상으로 프로그램의 효과를 측정하였기 때문에 자기선택오류(self-selection bias)의 가능성이 존재하였기 때문이다. 이번 연구는 고객보상 프로그램의 도입 시점을 전후로 두 집단을 비교하기 위해 자료를 특정 시점을 기준으로 절단(censoring)하였다. 생존분석(survival analysis)은 다른 분석기법에 비해 불완전한 자료가 포함되더라도 분석이 상대적으로 용이하므로 이번 연구의 분석방법으로 선택하였다. 분석 결과 고객보상 프로그램을 실시하기 전에는 소비자들의 거래기간이 평균 179일이었으나 고객보상 프로그램을 도입한 이후에는 227일로 약 50일 정도 더 늘어났다. 이러한 차이는 통계적으로 유의한 것으로 나타나 연구 가설을 지지하였다. 또한 콕스 비례위험모형을 사용하여 고객보상 프로그램과 영향 변수들의 상호작용효과를 확인한 결과 기존고객들은 고객보상 프로그램이 도입된 후 신규고객들에 비해 회사와의 거래기간이 유의하게 증가한 것으로 나타났으며 긍정적인 서비스(예: 30일 이내 입회)를 경험한 고객들도 회사와의 거래기간이 유의하게 증가하는 것으로 나타났다. 한편 부정적인 서비스(예: 30일 이후 입회)를 경험한 고객이라 하더라도 고객보상 프로그램을 도입한 이후에는 회사와의 거래기간이 증가하였다. 이번 연구에서 나타난 결과들을 정리하면 고객보상 프로그램은 고객과 긍정적인 관계를 형성하는 데 기여할 뿐만 아니라 이탈 장벽까지 구축해 줌으로써 기업의 경쟁력을 강화시키는 수단으로서의 가치가 있다고 생각할 수 있다.