• 농촌의학ㆍ지역보건
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• 제16권2호
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• pp.120-124
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• 1991

From the medical examination held on 1988, an interested fact was observed that the cardiovascular disease related examination results of the Ulleung-Gun inhabitants were more marked than those of other areas. An intended search for hypertension with related tests was executed from September $3^{th}$, 1989 to September $7^{th}$, 1989 on 344 Ulleung-Gun inhabitant and the results were as follows. 1) Among the 344 subjects, males were 94 and female, 250. The reason of showing lower number of males than the number of females was due to the fishing work season of showing lower medical examination period was overlapped. 2) 58% of the subjects are the age of over 50 years old. 3) The suspected cases were 68 among 344, and the suspected rate was 19.7%. 4) Abnormality rates of related tests were as follows : suspected ECG 10.1%, hypertension 9.0%. high triglyceride value 5.8%, and high total cholesterol value 4.6%. 5) Table 5 shows that the higher of ages, the higher of ages, the higher of the suspected rates of all 4 related and results. especially the abnormality of hypertension and EOG was marked. 6) Table 6 shows that the incidence of hypertension was higher from the subjects having family history than those who had no family history, from those taking foods salty than those taking foods unsalty, from those taking diet of meat than those taking vegetable diets. 22 cases among 31 had abnormal ECG results and/or high triglyceride values. But there were 5 subjects who had no hypertension related factor.

• 한국융합학회논문지
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• 제9권9호
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• pp.363-369
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• 2018

본 연구는 경계성 고혈압 및 고혈압 환자를 대상으로 근육신전운동프로그램을 통해 측정변인의 상관관계 및 대사증후군 지표의 변화를 살펴보고자 하였다. 이를 위해 경계성 고혈압 및 고혈압 환자를 대상으로 15주간 근육 신전운동프로그램을 실시하였다. 연구대상은 28명으로 15주간 주 3회, 40분간의 근육 신전운동프로그램에 참여하였다. 이와 같은 과정을 통해 다음과 같은 결론을 얻었다. 첫째, 근육 신전운동프로그램에 참여 전 대사증후군 지표의 상관관계에서 지표 간 유의한 상관관계를 나타냈으며, 참여 후 대사증후군 지표 간에 참여 전과 차이는 있었지만 전반적으로 유의한 상관관계를 나타냈다. 둘째, 15주간의 근육 신전운동프로그램 전과 후의 비교에서 체중, 근육량, 체지방량, BMI, 허리둘레, 이완기 혈압, 혈당 등에서 유의한 차이를 나타냈다. 이는 근육의 신전운동만으로도 고혈압 환자의 대사증후군 지표의 개선을 가져올 수 있다고 판단되며, 이에 관련된 연구가 필요하다고 사료된다.

• Nutrition Research and Practice
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• 제9권3호
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• pp.313-318
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• 2015

BACKGROUND/OBJECTIVES: Dietary pattern and its association with cardio-cerebrovascular disease have not been studied in Baoji city by now. This study was aimed to identify the dietary patterns among Chinese adults in Baoji, and explore the association between these dietary patterns and cardio-cerebrovascular disease. SUBJECTS/METHODS: A total of 4,968 participants were included in this study at 12 counties. With multistage stratified random sampling and semi quantitative food frequency questionnaire, the prevalence of cardio-cerebrovascular disease and dietary intake were investigated in 2013. We used factor analysis to establish dietary patterns. RESULTS: A total of 4,968 participants over 15 years old were included in this study. Five dietary patterns were identified in Baoji: protein, balanced, beans, prudent, and traditional patterns. The protein dietary pattern mainly included animal and plant proteins and was negatively associated with hypertension as well as stroke. The balanced pattern included carbohydrates, protein, and fat and was negatively associated with hypertension as well as stroke. The beans pattern was mainly beans and beans products and was negatively associated with hypertension. The prudent pattern only included staple foods and pickled vegetables and was positively associated with hypertension as well as coronary heart disease. The traditional pattern was representative of local Baoji traditional recipes and was positively associated with hypertension. CONCLUSIONS: The protein, balanced, and beans dietary patterns showed many protective effects on cardio-cerebrovascular disease. Based on these results, Baoji city residents should be encouraged to choose protein, balanced, and beans dietary patterns and abandon prudent and traditional patterns to prevent incidence of hypertension, coronary heart disease, and stroke.

• Clinical and Experimental Pediatrics
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• 제57권9호
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• pp.403-409
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• 2014

Purpose: Although high morning blood pressure (BP) is known to be associated with the onset of cardiovascular events in adults, data on its effects in children with hypertension are limited. Our retrospective study aimed to define the clinical characteristics of children with morning hypertension (MH) and to determine its associated factors. Methods: We reviewed 31 consecutive patients with hypertension, confirmed by the ambulatory blood pressure monitoring (ABPM). We divided these patients into 2 groups: the MH group (n=21, 67.7%), morning BP above the 95th percentile for age and height (2 hours on average after waking up) and the normal morning BP group (n=10, 32.3%). We compared the clinical manifestations, laboratory results, and echocardiographic findings including left ventricular hypertrophy (LVH) between the groups. Results: The early/atrial (E/A) mitral flow velocity ratio in the MH group was significantly lower than that in the normal morning BP group. In addition, LV mass was higher in the MH group than in the normal morning BP group, although the difference was not statistically significant. The age at the time of hypertension diagnosis was significantly higher in the MH group than in the normal morning BP group (P =0.003). The incidence of hyperuricemia was significantly higher in the MH group than in the normal morning BP group. Conclusion: Older patients and those with hyperuricemia are at higher risk for MH. The rise in BP in the morning is an important factor influencing the development of abnormal relaxation, as assessed by echocardiography. Clinical trials with longer follow-up periods and larger sample sizes are needed to clarify the clinical significance of MH.

• 동의생리병리학회지
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• 제22권5호
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• pp.1240-1249
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• 2008

Kamigingansikpung-tang(KGST) has been used for many years as a therapeutic agent for acute stage of cerebrovascular disease and hypertension in oriental medicine. But the effect of KGST on hypertension and vascular system is not well-known. This study was done to investigate the effects of KGST on hypertension. The results were obtained as follow: KGST showed scavenging activity on DPPH free radical. KGST showed the inhibitory effect on ROS and ACE, and the accelerated SOD activity. KGST significantly decreased the blood pressure and pulse in DOCA-salt induced hypertensive rat. KGST significantly decreased the levels of aldosterone in DOCA-salt induced hypertensive rat. KGST significantly decreased the levels of dopamine, epinephrine in DOCA-salt induced hypertensive rat. KGST significantly decreased the levels of potassium(K+) and chloride(Cl-) in DOCA-salt induced hypertensive rat. KGST significantly decreased the levels of uric acid and creatine in DOCA-salt induced hypertensive rat. KGST has an effect on inhibiting cell damage of the heart, liver, kidney, and adrenal gland. results suggest that KGST might be effective in treatment and prevention of hypertension.

• 생약학회지
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• 제31권3호
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• pp.310-319
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• 2000

WooHwangChungSimWon is a traditional prescription formula for treating with hypertension, arteriosclerosis, coma, and stroke in China, Korea, and Japan. In the new prescription of WooHwangChungSimWon, the civet is substituted for the musk, the major component of WooHwangChungSimwon, because of the prohibition law (CITES) on the commercial use of musk. We have made a comparative study of the effects on the hypertension and contractile force of heart between the musk-containing and civet-containing WooHwangChungSimWon. The SHR rats were used for investigating the effects on the hypertension and the rabbits were used for investigating effects on the contractile force of isolated heart. The blood pressure which was recorded during the adminstration period showed that all the samples except the low dose of musk-containing WooHwangChungSimWon decreased the blood pressure, and the effects on the heart works of all the samples were higher than control group, which resulted from the examination of isolated heart. These results suggest that all the musk-containing and civet-containing WooHwangChungSimWon formula have similar protective effects on hypertension and palpitation.

• 응용통계연구
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• 제33권5호
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• pp.555-567
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• 2020

고혈압은 발병률이 꾸준히 증가하고 있을 뿐 아니라, 심혈관 질환과 같은 2차 질병의 주된 위험 요인이 되었다. 게다가 고혈압은 뇌졸중, 혈관성 치매와 같은 다른 합병증을 유발하는 질병이다. 따라서 고혈압 발병률을 예측하는 것은 중요한 일이다. 본 연구에서, 고혈압 발병률을 예측할 수 있는 노모그램을 구축하였다. 데이터는 2013년부터 2016년까지의 국민건강영양조사로부터 얻어졌다. 복합 표본의 특성을 고려하여 Rao-Scott chi-squared test를 통해 고혈압에 영향을 미치는 10가지 요인을 규명하였다. 하지만 로지스틱 회귀분석 시, 흡연 상태와, 운동 유무는 유의하지 않았다. 따라서 8개의 주 효과를 고혈압의 위험요인으로 최종 선별하였다. 그리고 최종 선별된 위험 요인들로 로지스틱 노모그램과 베이지안 노모그램을 제시 및 비교하였다. 마지막으로 ROC curve 그래프와 calibration plot을 통해 노모그램을 검증하였다.

• 가정간호학회지
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• 제19권1호
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• pp.74-82
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• 2012

Purpose: The aim of this study is to evaluate the effects of community based chronic disease management program for managing hypertension and diabetes mellitus. Method: The subjects of this study were 1,000 clients, who participated in a city community based chronic disease management program. The data were collected by a phone survey directly, and selected from DB of community based chronic disease management program, indirectly. The data were analyzed by the STATA program, using descriptive statistics, t-test, and Multiple regression analysis. Results: The mean score of knowledge of hypertension was 4.33 and diabetes mellitus was 2.52. The affecting factors of knowledge of hypertension were the clinic visiting point and blood sugar. However, the affecting factors of knowledge of diabetes mellitus was core lab point, diastolic blood pressure, and blood sugar. Conclusion: the results of this study showed that knowledge of hypertension increased with higher level of education, and younger ages, while knowledge of diabetes mellitus increased with higher level education, more core lab point, younger ages, and in males. Therefore, to control the chronic diseases more effectively in a community, it is important to develop a more systematic education and self- managing programs, using collaboration of health centers and local clinics.

• 보건교육건강증진학회지
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• 제30권5호
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• pp.79-90
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• 2013

Objectives: This study is based on Public Care Service for Chronic Diseases in Incheon Metropolitan City featuring Health-Point Service. It is objective to evaluate whether the service could improve self-management ability of hypertension and diabetes patients. Methods: The knowledge about diabetes and hypertension, which can be improved by educational intervention, is considered as one of the most important factor for self-management ability. While the education service have been conducted, 194 patients who have been diagnosed as hypertension and diabetes within 3 months were included. They completed questionnaires two times within 4 months period, which give information about the knowledge, service registration and education experiences. For further inspection, 396 patients who had been diagnosed formerly were studied by cross-sectional analysis. Results: Regardless of service registration or educational intervention, there wasn't statistically meaningful difference between the initial and the follow-up assessments on the knowledge. However, when investigating formerly diagnosed patients, educated patients had better knowledge on hypertension compared with non-educated patients and registered patients, educated patients had the better knowledge on diabetes compared with non-registered patients, non-educated patients. Additionally, analyzing each questions, educated patients got higher grades in questions about definition of hypertension, diabetes managements which they can practice in daily lives. Conclusions: It is probable that long-term service registration and education experiences could improve the knowledge and self-management ability.

• Genomics & Informatics
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• 제6권3호
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• pp.110-116
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• 2008

Blood pressure refers to the force exerted by circulating blood on the walls of blood vessels, and chronical elevation of blood pressure is known as hypertension. Although hypertension is affected by genetic and environmental factors, the genetic background of hypertension is not fully understood. One of the candidate genetic factors, Prostaglandin-endoperoxide synthase 2 (PTGS2), is a membrane-bound enzyme, catalyzing the conversion of arachidonic acid to prostaglandin, and recently SNPs of PTGS2 gene was associated with hypertension in Japanese population. Therefore the association of PTGS2 polymorphisms was investigated with blood pressure in healthy Korean subjects, 470 unrelated individuals randomly selected from Ansung and Ansan cohorts. The 25 SNPs of PTGS2 gene were identified by the sequencing analysis of 24 Korean samples. Among identified polymorphisms, three SNPs (rs689466, -1329A>G; rs5275, +6365T>C; rs4648308, +8806G> A) were selected for further association analysis, and rs689466 located in promoter region was associated with blood pressure as well as triglyceride level in the blood. By in silico analysis, rs689466 locates in v-Myb transcription factor binding site, and the v-Myb site disappears when the SNP is changed from A to G nucleotide. Individuals with A/G and G/G genotype in rs689466 have higher blood pressure than those with A/A genotype, and the regression p-value is 0.008 for systolic and 0.004 for diastolic blood pressure. In summary, the PTGS2 polymorphism (rs689466) is associated with blood pressure in Asian populations based on this and Japanese studies, shedding light on it as a genetic risk marker of hypertension.