• Journal of Veterinary Clinics
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• v.18 no.4
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• pp.448-451
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• 2001

Alopecia was the main complaint in a 4 year old female Cocker spaniel dog. bilateral alopecia has been presented on skin lesion for 10 months after ovariohysterectomy about one year ago. Hyperestrogenism was diagnosed by the blood estradiol level test. Left ovarian cyst was resected in the intact ovarian position by laparotomy. Total size of the cyst was about 3 cm and it was the shape of follicular cyst. Blood estradiol level is usually higher than normal in ovarian cyst. But even though estradiol level is in normal range, dermatitis could be induced because the number of estrogen receptor of the skin would be increased or the duration of estrogen secretion would be prolonged. Because the hyperestrogenism in this case is iatrogenic, exact and proper ovariohysterectomy should be made not to induce the complications.

• Journal of Veterinary Clinics
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• v.22 no.4
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• pp.428-430
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• 2005

A female French Bulldog was referred to Veterinary Medical Teaching Hospital, Chungbuk National University. In case, alopecia and erythema nodosum were the main complaints in a 16 months old female dog. Ventral alopecia and dorsal erythema nodosum have been presented on skin lesions for 8 months. There were no specific change with CBC and blood chemistry but plasma estrogen concentration was 68 pg/ml and cornified superficial epithelial cells were detected above $90\%$ by cytology examination of vaginal smear preparation. Ovarian cyst was detected by ultrasonography in the left ovary. Cystic diameter was $14.2\times12.0mm$. Therefore, we diagnosed as unilateral multiple follicular cysts. The dog was treated with GnRH $50{\mu}g$ injection by intramuscularly Cyst size was decreased $7.3\times7.2mm$ after 7 days GnRH treatment and disappeared after 14 days GnRH treatment. Also dermatitis by unilateral multiple follicular cysts were recovered after 21 days GnRH treatment.

• Journal of Veterinary Clinics
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• v.18 no.4
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• pp.474-478
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• 2001

A female mixed miniature pinscher dog, about 5 years old, 4 kg, was referred to veterinary teaching hospital of Chungnam National University with chief complaint of excessive hemorrhagic vaginal discharge for a month, partial alopecia and hyperpigmentation. There are no specific change with CBC, blood chemistry and X-ray findings but we figured out high estrogen concentration with hormone analysis and detected a majority of the superficial epithelial cells with pyknotic nuclei by cytologic examination of vaginal smear preparation and multiple ovarian cysts on both ovaries by ultrasonography. Based on the clinical signs, hormone analysis, vaginal smear preparation and ultrasonography, the authors diagnosed this case as hyperestrogenism with ovarian cysts.