• 한국컴퓨터정보학회논문지
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• 제25권9호
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• pp.143-150
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• 2020

본 연구는 다중위해사례를 중심으로 경호임무수행 간 출입통제 활동을 실시하는 과정에서 유발되는 경호원의 휴먼에러가 무엇인지 규명하고 그에 따른 대책을 제시하는데 목적이 있다. 이를 검증하고자 사건의 순서를 시계열로 배열한 뒤 변동노드를 중심으로 문제점을 파악할 수 있는 'VTA 기법'과 'Why-Why 분석 기법'을 활용하였으며, 추가적으로 'M-SHEL Matrix'를 통하여 휴먼에러를 유발하는 환경요인과 개인요인을 추출하였다. 분석결과, 출입통제 사고를 유발하는 경호환경요인으로는 시간부족(조급함), 방문자에 대한 편견, 편중된 근무방법, 보안 관리미흡, 무사안일주의, 익숙한 분위기(긴장이완), 형식적인 근무활동, 편의제공, 과소평가 등으로 조사되었다. 그리고 경호원 개인적 측면에서 유발되는 휴먼에러는 낮은 경계의식, 형식적인 근무, 검측소홀, 안일한 대처 등으로 조사되었다.

• Asian Pacific Journal of Cancer Prevention
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• 제17권2호
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• pp.677-684
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• 2016

Background: Acute lymphoblastic leukemia (ALL) is a heterogeneous disease which requires a risk-stratified approach for appropriate treatment. Specific chromosomal translocations within leukemic blasts are important prognostic factors that allow identification of relevant subgroups. In this study, we developed a multiplex RT-PCR assay for detection of the 4 most frequent translocations in ALL (BCR-ABL, TEL-AML1, MLL-AF4, and E2A-PBX1). Materials and Methods: A total of 214 diagnosed ALL samples from both adult and pediatric ALL and 14 cases of CML patients (154 bone marrow and 74 peripheral blood samples) were assessed for specific chromosomal translocations by cytogenetic and multiplex RT-PCR assays. Results: The results showed that 46 cases of ALL and CML (20.2%) contained the fusion transcripts. Within the positive ALL patients, the most prevalent cryptic translocation observed was mBCR-ABL (p190) at 8.41%. In addition, other genetic rearrangements detected by the multiplex PCR were 4.21% TEL-AML1 and 2.34% E2A-PBX1, whereas MLL-AF4 exhibited negative results in all tested samples. Moreover, MBCR-ABL was detected in all 14 CML samples. In 16 samples of normal karyotype ALL (n=9), ALL with no cytogentic result (n=4) and CML with no Philadelphia chromosome (n=3), fusion transcripts were detected. Conclusions: Multiplex RT-PCR provides a rapid, simple and highly sensitive method to detect fusion transcripts for prognostic and risk stratification of ALL and CML patients.

• Asian Pacific Journal of Cancer Prevention
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• 제16권2호
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• pp.693-697
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• 2015

Our aims were to evaluate the clinical performance of human telomerase RNA gene component (hTERC gene) amplification assay with high-risk human papillomavirus (HR-HPV) DNA test of Hybrid Capture 2 DNA test (HC2), for the detection of high grade cervical precancerous lesions and cancer (CIN 2+). In addition, the association shown between hTERC gene amplification and HPV DNA test positive in women with and without cervical neoplasia was assessed. There were 92 women who underwent cytology, HR-HPV DNA test, hTERC gene amplification test, colposcopy and biopsy. We compared the clinical performance of hTERC gene test along with HR-HPV DNA test of women with colposcopy and routine screening. The samples were histology-confirmed high-grade cervical intraepithelial neoplasia (CIN 2) or worse (CIN2+) as the positive criterion. The test of hTERC gene showed the hTERC gene amplification positivity increased with the severity of histological abnormality and cytological abnormality. The test of hTERC gene showed higher specificity than HR-HPV DNA test for high-grade lesions (84.4% versus 50%) and also higher positive predictive value (90.4% versus 76.5%). Our results predicted that hTERC gene amplification demonstrated more specific performance for predicting the risk of progression and offer a strong potential as a tool for triage in cervical cancer screening, with the limited sensitive as HR-HPV DNA test.

• Asian Pacific Journal of Cancer Prevention
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• 제15권8호
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• pp.3635-3640
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• 2014

Aim: To determine whether induced abortion (IA) increases breast cancer (BC) risk. Materials and Methods: A population-based case-control study was performed from Dec, 2000 to November, 2004 in Shanghai, China, where IA could be verified through the family planning network and client medical records. Structured questionnaires were completed by 1,517 cases with primary invasive epithelial breast cancer and 1,573 controls frequency-matched to cases for age group. The information was supplemented and verified by the family planning records. Statistical analysis was conducted with SAS 9.0. Results: After adjusting for potential confounders, induced abortions were not found to be associated with breast cancer with OR=0.94 (95%CI= 0.79-1.11). Compared to parous women without induced abortion, parous women with 3 or more times induced abortion (OR=0.66, 95%CI=0.46 to 0.95) and women with 3 or more times induced abortion after the first live birth (OR=0.66, 95%CI =0.45 to 0.97) showed a lower risk of breast cancer, after adjustment for age, level of education, annual income per capita, age at menarche, menopause, parity times, spontaneous abortion, age at first live birth, breast-feeding, oral contraceptives, hormones drug, breast disease, BMI, drinking alcohol, drinking tea, taking vitamin/calcium tablet, physical activity, vocation, history of breast cancer, eating the bean. Conclusions: The results suggest that a history of induced abortions may not increase the risk of breast cancer.

• Nuclear Engineering and Technology
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• 제37권3호
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• pp.207-220
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• 2005

Nuclear power plants (NPP) are complex socio-technological systems that rely on the success of both hardware and human components. Empirical studies of plant operating experience show that human errors are important contributors to accidents and incidents, and that organizational factors play an important role in creating contexts for human errors. Current probabilistic safety assessments (PSA) do not explicitly model the systematic contribution of organizational factors to safety. As some countries, like the United States, are moving towards increased use of risk information in the regulation and operation of nuclear facilities, PSA quality has been identified as an area for improvement. The modeling of human errors, and underlying organizational weaknesses at the root of these errors, are important sources of uncertainty in existing PSAs and areas of on-going research. This paper presents a review of research into the following questions: Is there evidence that organizational factors are important to NPP safety? How do organizations contribute to safety in NPP operations? And how can these organizational contributions be captured more explicitly in PSA? We present a few past incidents that illustrate the potential safety implications of organizational deficiencies, some mechanisms by which organizational factors contribute to NPP risk, and some of the methods proposed in the literature for performing root-cause analyses and including organizational factors in PSA.

• Journal of Korean Society for Atmospheric Environment
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• 제17권E2호
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• pp.43-51
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• 2001

A report by the national research council in the United States suggested that many lung cancer deaths each year be associated with breathing radon in indoor air. Most of the indoor radon comes directly from soil beneath the basement of foundations. Recently, radon released from groundwater is found to contribute to the total inhalation risk from indoor air. This study presents the quantitative assessment of human exposures to radon released from the groundwater into indoor air. At first, a three-compartment model is developed to describe the transfer and distribution of radon released from groundwater in a house through showering, washing clothes, and flushing toilets. Then, to estimate a daily human exposure through inhalation of such radon for an adult. a physiologically-based pharmacokinetic(PBPK) model is developed. The use of a PBPK model for the inhaled radon could provide useful information regarding the distribution of radon among the organs of the human body. Indoor exposure patterns as input to the PBPK model are a more realistic situation associated with indoor radon pollution generated from a three-compartment model describing volatilization of radon from domestic water into household air. Combining the two models for inhaled radon in indoor air can be used to estimate a quantitative human exposure through the inhalation of indoor radon for adults based on two sets of exposure scenarios. The results obtained from the present study would help increase the quantitative understanding of risk assessment issues associated with the indoor radon released from groundwater.

• 한국도시철도학회논문집
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• 제6권4호
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• pp.259-268
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• 2018

본 논문은 서울교통공사 및 한국철도공사의 기관사를 대상으로 인적오류 위험요인과 관련 경험빈도에 대한 설문을 수행하여 기관별 운행시스템과 호선별 운행시스템 관점에서 오류유발 요인을 분석하였다. 도시철도 사고유발의 근본적인 원인 제거와 감소를 목적으로 하며 도시철도를 운영하는 시스템에서 발생하는 인적오류는 사고발생의 종류와 상황에 따라 대처하는 문제와 인지적 문제를 포함하고 있기 때문에 요인별 관점에서의 연구를 기반으로 접근하고자 한다. 인적오류를 감소시키는데 기여하여 도시철도 사고를 저감 하고 지속적으로 안전한 철도 운행이 될 수 있도록 하고자 한다.

• Asian Pacific Journal of Cancer Prevention
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• 제13권11호
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• pp.5363-5369
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• 2012

High-risk human papillomavirus (HPV) especially HPV-16 and HPV-18 types are speculated to be important risk factors in non-smoking associated lung cancer in Asia. Increasing evidence has demonstrated that HPV oncoproteins may contribute to lung tumorigenesis and cell transformation. Importantly, HPV 16/18 E6 and E7 oncoproteins can mediate expression of multiple target genes and proteins, such as p53/pRb, VEGF, HIF-$1{\alpha}$, cIAP-2, and hTERT, and contribute to cell proliferation, angiogenesis and cell immortalization through different signaling pathways in lung cancer. This article provides an overview of experiment data on HPV-associated lung cancer, describes the main targets on which HPV E6/E7 oncoproteins act, and further discusses the potential signaling pathways in which HPV E6/E7 oncoproteins are involved. In addition, we also raise questions regarding existing problems with the study of HPV-associated lung cancer.

• 한국안전학회지
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• 제16권3호
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• pp.125-134
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• 2001

The Advanced Pressurized rater Reactor 1400(APR1400) system is advanced of the successful Korean Nuclear Power Plants(KSNP) design which meets functional needs for safety enhancement reliability improvement, and control in the human-computer monitoring system. Therefore this paper describes the scoring model in order to justify the reliability and safety in APR 1400 under uncertainty. The structure of this paper consists of the human engineering, risk safety, quality function, safety organization management factors of the qualitative factors in chapter 2, and the expectation results of the normalized scoring model in chapter 3. Finally, the proposed reliability model have provided the technical flexibility not only for functional control fields but also for accidents protection systems in APR 1400 under uncertainty.

• 한국안전학회지
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• 제13권3호
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• pp.80-87
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• 1998

This paper presents a study on the development of discharge model and computer program for assessing the risk of electrostatic discharge(ESD) of charged human body This ESD event is modelled as a two-body problem using spherical conductors, simulating the approach of a charged conductor (human body) to a second conductor (electronic equipment). The charge/discharge process for the model is formulated as a matrix of equations by Maxwell's method. Body potentials, energies and the charge transfer during a discharge are calculated. The developed program, based on the suggested scheme in this paper, is applied to a sample system. The results provide a better understanding of ESD event and demonstrate the usefulness of two-body model in practical applications.