• Journal of the Korean Society of Food Science and Nutrition
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• v.41 no.12
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• pp.1753-1757
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• 2012

A new liquid chromatographic tandem mass spectrometric (LC-MS/MS) assay for the quantification of ginsenoside Rb1 in human plasma was developed and validated. The separation was performed on a Agilent C18 column ($4.6mm{\times}150mm$, particle size 5 ${\mu}m$) with a gradient elution of 0.1% formic acid in water and 0.1% formic acid in methanol and a flow rate of 0.9 mL/min. The analyte was determined using electrospray positive ionization mass spectrometry in the multiple reaction monitoring (MRM) mode (m/z 1131.714${\rightarrow}$365.303). Human plasma samples were extracted with acetone : water (50:50) by the liquid-liquid extraction method. The method was linear over the dynamic range of 10~500 ng/mL with a correlation coefficient of r=0.9995. The intra-and inter-day precision over the concentration range of ginsenoside Rb1 was lower than 5.8% (correlation of variance, CV), and the accuracy was between 96.0~104.6%. This LC-MS/MS assay of ginsenoside Rb1 in human plasma is applicable for quantification in a pharmacokinetic study.

• Analytical Science and Technology
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• v.21 no.1
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• pp.34-40
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• 2008

Liquid chromatography-tandem mass spectrometry (LC-MS/MS) method has been developed and validated for the quantitative determination of lercanidipine in human plasma. After addition of internal standard (amlodipine), plasma was precipitated with acetonitrile and the supernatant was evaporated. The residues were dissolved in 50 % acetonitrile and analyzed by LC-MS/MS. Using MS/MS with multiple reaction monitoring(MRM) mode, lercanindipine were selectively detected without severe interference from human plasma. The standard calibration curve for lercanidipine was linear (r = 0.9994) over the concentration range 0.05-20.0 ng/mL in human plasma. The intra- and inter-day precision over the concentration range of lercanidipine was lower than 11.7 % (correlation of variance, CV), and accuracy was between 94.4-114.8 %. This method has been successfully applied to the pharmacokinetic study of lercanidipine in human plasma.

• The Magazine of the IEIE
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• v.31 no.1
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• pp.58-72
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• 2004

Smart sensors and biochip technologies have received a great deal of attention in recent years not only because of the enormous potential markets in the healthcare expenditures but more importantly because of its great impact on the quality of human life in the future. Collaborative research among BT (Bio Technologies), IT (Information Technologies) and NT (Nano Technologies) will bring us a new paradigm of the healthcare services. Examples include disease prediction based on the genetic tests, personal medicines, point-of-care analysis, rapid and sensitive infectious disease diagnostics, environmental monitoring for chemical or biological warfares, intelligent drug delivery systems etc. In this report, recent accomplishment in the research area on biosensors, DNA chips, Protein Chips and Lab-on-a-chips are reviewed.

• Proceedings of the Korea Water Resources Association Conference
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• 2009.05a
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• pp.2200-2204
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• 2009

In this paper the analysis of natural cause of Beijing Storm inundation and the effect of the human activities has been taken. Flood risk can hardly be eliminated solely by projects. Pre-warning system established is an efficient measure to minimize the influence of flood. Several main functions of this system and their examples are described in the paper, such as: monitoring, forecast, scheme, warning, dynamic decision-making and information publication.

• 제어로봇시스템학회:학술대회논문집
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• 2001.10a
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• pp.100.1-100
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• 2001

With the prolific growth of cable, satellite digital broadcasting and internet related industry, new digital contents are being demanded. Today, more end-users seek participations in the media through interactivity. Visual tracking technology, based on image processing, is mainly used in fields of human face tracking, security inspection, and traffic monitoring applications. In this research, we describe the interactive modules such as information display, e1-commerce and other services along with on-screen visuals on the streaming media using object visual tracking technology. The ...

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2000.11a
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• pp.721-724
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• 2000

This paper has been demonstrated to be essential to successful telemanipulator control when the communication delay between master arms in the operator control station and telemanipulators in the remote site. This paper includes the human dynamics to generate a control command, the monitoring force feedback in order to robust under short time delays and the controller not to requre the derivative of interaction forces. Simulation results suggest that, the proposed control system should be superior to conventional systems in terms of performance and robustness under short time delays.

• Journal of Multimedia Information System
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• v.3 no.2
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• pp.9-12
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• 2016

This paper is concerned with the effective and efficient identification of the gender and motion of humans. Tracking this nonverbal behavior is useful for providing clues about the interaction of different types of people and their exact motion. This system can also be useful for security in different places or for monitoring patients in hospital and many more applications. Here we describe a novel method of determining identity using machine learning with Microsoft Kinect. This method minimizes the fitting or overlapping error between an ellipsoid based skeleton.

• 한국기계연구소 소보
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• s.19
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• pp.69-79
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• 1989

Cutting tool life monitoring is a critical element needed for designing unmanned machining systems. This paper describes a tool wear measurement system using computer vision which repeatedly measures flank and crater wear of a single point cutting tool. This direct tool wear measurement method is based on an interactive procedure utilizing a image processor and multi-vision sensors. A measurement software calcultes 7 parameters to characterize flank and crater wear. Performance test revealed that the computer vision technique provides precise, absolute tool-wear quantification and reduces human maesurement errors.

• Proceedings of the Korean Nuclear Society Conference
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• 1996.05d
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• pp.17-22
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• 1996

Individual internal monitoring program by in-vivo measurement technique at the Korea Atomic Energy Research Institute includes the capability for the assessment of uranium and americium lung burdens. This capability is an important part of the health and safety program. This article addresses the lung burden assessment portion of our in vivo measurement capabilities.

• Proceedings of the PSK Conference
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• 2003.10b
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• pp.167.2-168
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• 2003

Anticancer drug resistance occasionally occurs in malignant hematologic diseases such as acute myelocytic leukemia (AML) treated with chemotherapy and is a major problem to complete remission. Malignant cells primarily induce intrinsic resistance to treatment of anticancer drug, but gradually obtain acquired resistance to cytotoxic activities of chemotherapy. In this study, we monitored the expression profiles of doxorubicin resistance-related genes in AML-2/DX100, a doxorubicin-resistant human acute myelocytic leukemia cell line. (omitted)