• 한국게임학회 논문지
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• 제11권1호
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• pp.121-129
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• 2011

온라인 게임에서 오토 프로그램 또는 봇 프로그램으로 인하여 다양한 게임 서비스 피해사례가 발생하고 있다. 특히, 게임 머니 및 아이템의 비정상적인 수집은 게임이 가지는 본연의 재미를 잃어버리게 되고, 궁극적으로 게임 생명주기에 결정적 악영향을 미치게 된다. 본 논문은 게임 봇 감지를 위해 게임 행위 변화 패턴을 수집하고 분석하여 봇 탐지 방법에 적용한다. 인간의 게임 행위 변화 정보와 봇의 게임 행위 변화 정보를 이용하여 유사정도를 측정하고, 봇 탐지 기법에 활용하는 것이다. 실험에서는 서비스 중인 온라인 게임을 이용하여 사용자와 봇의 모델을 생성하고 유사성을 판별하였으며 적절한 결과를 확인하였다.

• Journal of Microbiology and Biotechnology
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• 제14권1호
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• pp.121-127
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• 2004

Amphotericin B (AmB), an amphipathic polyene macrolide, is an antifungal drug produced by Streptomyces nodosus. Recently, AmB has been shown to exert antiviral activity against rubella virus and human immunodeficiency virus by different mechanisms. In this study, we evaluated the antiviral effect of AmB against Japanese encephalitis virus (JEV) and investigated which step of the viral life cycle was inhibited by AmB to understand the mechanism of antiviral action of AmB. AmB reduced both plaque size and number in the infected cells in a dose-dependent manner. In addition, a 200-fold reduction of infectious virus titer was observed by treatment of infected cells with $5\mug/ml$ of AmB. AmB acted at the post virus-infection step, but not during adsorption of virus to host cells. Western blot analysis revealed that the accumulated level of JEV envelope protein dramatically decreased in the infected cells by treatment with $5-10\mug/ml$ of AmB. Our results indicate that AmB inhibits the replication of JEV at the postinfection step by interfering with viral replication and/or by inhibiting the synthesis of viral proteins.

• International Journal of Aeronautical and Space Sciences
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• 제16권3호
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• pp.451-462
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• 2015

Safety is the first priority in civil aviation, and so the International Civil Aviation Organization (ICAO) has introduced and mandated the use of Safety Management Systems (SMS) by airlines, airports, air traffic services, aircraft maintenance organizations, and training organizations. The aircraft manufacturing industry is the last for which ICAO has mandated the implementation of SMS. Since SMS is a somewhat newer approach for most manufacturers in the aviation industry, they hardly believe in the value of implementing SMS. The management of safety risk characteristics that occur during early aircraft development stages and the systematic linkage that the safety risk has to do with an aircraft in service could have a significant influence on the safe operation and life cycle of the aircraft. This paper conducts a case analysis of the McDonnell Douglas MD-11 accident/incident to identify the root causes and safety risk levels, and also verified why aircraft manufacturing industry should begin to adopt SMS in order to prevent aircraft accident.

• 공학교육연구
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• 제18권1호
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• pp.11-19
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• 2015

본 논문은 전 생애주기에 걸쳐 나타나는 우리나라 과학기술인력의 경력이탈 규모와 현황을 추정하는 데 일차적인 목적이 있다. 이를 위해 먼저 과학기술인력의 경력이탈에 대한 조작적 정의를 내리고 이를 분석할 수 있는 기본틀을 크게 인재확보 단계와 활용단계로 구분하여 구축하였다. 이 틀에 입각하여 경력이탈 현황을 진단해 본 결과, 우리나라 과학기술인력의 경력이탈은 주로 활용단계에서 나타나고 양적 이탈보다는 창조경제시대를 이끌어갈 우수 인재의 이탈이라는 질적 이탈 문제가 심각한 것으로 나타났다. 마지막으로 생산가능인구 감소시대를 맞이할 경우 이러한 질적 이탈 문제는 더욱 심각해질 수 있으므로, 좋은 일자리 확보와 경력개발 경로 구축 등의 정책을 우선적으로 추진할 필요가 있다는 대안을 제시하고 있다.

• 한국식생활문화학회지
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• 제26권3호
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• pp.211-219
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• 2011

To examine the key success factors for long-lasting restaurants, we visited 10 restaurants with 30 or more than 30 years of tradition, located in Seoul and Gyeonggi-do districts, to research these restaurant menus and customer characteristics by observation and interview. The results were analyzed using descriptive statistics. The outstanding feature noted was that each and every restaurant had its own simple and specialized menu. We found that this feature created a virtuous circle that reinforced itself through a positive feedback loop. The simple and specialized menu increased both the cooking efficiency and food quality while it reduced both food and labor costs, this enabled the customers to eat at an affordable price and have generous servings. This lead to customer satisfaction and revisits to the restaurant, which triggered word-of-mouth referral and expansion of their customer base. This in turn created higher operating profit margins that could be reinvested in the business. The secret recipes for cooking, invented by their founders, were passed on from generation to generation. Their customer base included customers of all ages from children to senior people. And their regular customers consisted of neighboring office workers and families traveling from a long distance. We hope that our findings on long-lasting restaurants, especially of the virtuous cycle created due to the simple and specialized menus with secret recipes, will contribute to the development of Korean style long-lasting restaurant model.

• 한국CDE학회논문집
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• 제19권3호
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• pp.203-213
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• 2014

The O&M (Operation and Maintenance) phase of offshore plants with a long life cycle requires heavy charges and more efforts than the construction phase, and the occurrence of an accident of an offshore plant causes catastrophic damage. So previous studies have focused on design for reliability, and recently many studies have dealt with a maintenance system to prevent unexpected failures. Nowadays due to the emerging ICTs (Information Communication Technologies) and sensor technologies, it is possible to send health monitoring information of important equipment to administrator of an offshore plant in real time, which leads to having much concern on condition based maintenance policy or predictive maintenance. In this study, we have reviewed previous studies associated with condition-based maintenance of offshore plants, and introduced the approaches predicting failures of the compressor which is one of essential mechanical devices in LNG FPSO.

• 산업경영시스템학회지
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• 제37권4호
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• pp.12-23
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• 2014

The O&M (Operation and Maintenance) phase of offshore plants with a long life cycle requires heavy charges and more efforts than the construction phase, and the occurrence of an accident of an offshore plant causes catastrophic damage. So previous studies have focused on the development of advanced maintenance system to avoid unexpected failures. Nowadays due to the emerging ICTs (Information Communication Technologies) and sensor technologies, it is possible to gather the status data of equipment and send health monitoring data to administrator of an offshore plant in a real time way, which leads to having much concern on the condition based maintenance policy. In this study, we have reviewed previous studies associated with CBM (Condition-Based Maintenance) of offshore plants, and introduced an algorithm predicting the next failure time of the compressor which is one of essential mechanical devices in LNG FPSO (Liquefied Natural Gas Floating Production Storage and Offloading vessel). To develop the algorithm, continuous time Markov model is applied based on gathered vibration data.

• 수면정신생리
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• 제15권1호
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• pp.5-11
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• 2008

Sleep is an essential process maintaining the life cycle of the human. In parallel with physiological, cognitive, subjective, and behavioral changes that take place during the sleep, there are remarkable changes in the electroencephalogram (EEG) that reflect the underlying electro-physiological activity of the brain. However, analyzing EEG and relating the results to clinical observations is often very hard due to the complexity and a huge data amount. In this article, I introduce several linear and non-linear tools, developed to analyze a huge time series data in many scientific researches, and apply them to EEG to characterize various sleep states. In particular, the spectral analysis, detrended fluctuation analysis (DFA), and synchrony analysis are administered to EEG recorded during nocturnal polysomnography (NPSG) processes and daytime multiple sleep latency tests (MSLT). I report that 1) sleep stages could be differentiated by the spectral analysis and the DFA ; 2) the gradual transition from Wake to Sleep during the sleep onset could be illustrated by the spectral analysis and the DFA ; 3) electrophysiological properties of narcolepsy could be characterized by the DFA ; 4) hypnic jerks (sleep starts) could be quantified by the synchrony analysis.

• Safety and Health at Work
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• 제1권2호
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• pp.112-123
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• 2010

The paper gives an overview of the problems to be tackled nowadays by occupational health with regards to shift work as well as the main guidelines at organizational and medical levels on how to protect workers' health and well-being. Working time organization is becoming a key factor on account of new technologies, market globalization, economic competition, and extension of social services to general populations, all of which involve more and more people in continuous assistance and control of work processes over the 24 hours in a day. The large increase of epidemiological and clinical studies on this issue document the severity of this risk factor on human health and well being, at both social and psychophysical levels, starting from a disruption of biological circadian rhythms and sleep/wake cycle and ending in several psychosomatic troubles and disorders, likely also including cancer, and extending to impairment of performance efficiency as well as family and social life. Appropriate interventions on the organization of shift schedules according to ergonomic criteria and careful health surveillance and social support for shift workers are important preventive and corrective measures that allow people to keep working without significant health impairment.

• Biomolecules & Therapeutics
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• 제30권1호
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• pp.64-71
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• 2022

Norovirus (NV) is the most common cause of viral gastroenteritis, with the potential to develop into a fatal disease in those who are immuno-compromised, and effective vaccines and treatments are still non-existent. In this study, we aimed to elucidate the molecular mechanism of the previously identified NV replication inhibitor utilizing a vinyl-stilbene backbone, AC-1858. First, we confirmed the inhibition of the NV RNA replication by a structural analog of AC-1858, AC-2288 with its exclusive cytoplasmic sub-cellular localization. We further validated the induction of one specific host factor, the phosphorylated form of heat shock factor (HSF)-1, and its increased nuclear localization by AC-1858 treatment. Finally, we verified the positive and negative impact of the siRNA-mediated downregulation and lentivirus-mediated overexpression of HSF-1 on NV RNA replication. In conclusion, these data suggest the restrictive role of the host factor HSF-1 in overall viral RNA genome replication during the NV life cycle.