• Journal of the Korean Home Economics Association
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• v.44 no.5 s.219
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• pp.89-98
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• 2006

The purpose of this study is to seek for a direction of child-care development through the basic concepts of home economics which have taken charge of much parts of the studies in child-care in the early years. When the problem of child-care is studied in view of the developmental process or the basic concepts of home economics, it is summed up as follows; First, on the basis of human ecological approach, when we study child-care, it needs to emphasize the mutual relationship between the macro-environment in connection with home and child-care. The study of child-care have to find out the relationship between the micro-environment in connection with children and the macro-environment in connection with home. And on the basis of this study, we must endeavor to build up the desirable environment of child-care. Second, on the basis of the concept of Institutional household, we mud be concerned about the developmental stages of young children, and emphasize 'the principle of love and care'. This means that the institution of child-care must be considered as a place which enlarges the merits of home and complements the defects of home through the strengthener of the function of home. Third, on the basis of healthy family, child-care service must support and complement the function of bringing of home in view of 'total healthiness of home'. Child-care service must be offered to be able to be chosen according to the total conditions of family such as the employment of mother, the family life cycle, the life style, the socioeconomic status of family.

• Proceedings of the KSME Conference
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• 2008.11a
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• pp.1709-1712
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• 2008

The trunk is inclined to the loaded side when carrying an object as one of activities of daily living. As the reaction to this behavior the human body may be inclined to his/her trunk to unloaded side. The present study investigated the biomechanical effects of weight variation for sided load carriage during walking upon joint moments and muscle torques, through the tracker agent and joint driving dynamic analysis. To perform the experiment one male was selected as subject for the study. Gait analysis was performed by using a 3D motion analysis system. Thirty nine 14mm reflective markers, according to the plug-in marker set, were attached to the subject. We used BRG.LifeMOD(Biomechanics Research Group, Inc., USA), for skeletal modeling and inverse and joint driving dynamic simulation during one gait cycle. In walking with a sided load carriage, the subject modeled held the carriage with the right hand, which weighed 0, 5, 10, 15kg, 20kg respectively. The result of this simulation showed that knee and hip in the coronal plane were inclined to the loaded side and loaded side had larger moments as the sided load carriage was increased. On the other hand thoracic and lumbar in the coronal plane had larger negative values as the sided loaded carriage was increased. The thoracic and lumbar in the transverse plane also had larger values as the sided load was increased. And the several muscles of loaded side were increased as increasing sided load. It could be concluded that human body is adopted to side loaded circumstances by showing more biologic force. These results could be very useful in analysis for delivery motion of daily life.

• Korean Journal of Human Ecology
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• v.24 no.2
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• pp.297-325
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• 2015

The purpose of this research is to analyze content elements of Housing area in 2013 middle school Technology Home Economics textbooks 1 and 2, total of 22 according to 2009 revised curriculum. The analysis method was content analysis, focusing on contents of main text, tables & figures, reading material, and activity materials by their content elements. This research will contribute in obtaining suggestion for the post curriculum/textbook development and helping teachers to perform a lesson. The results are as follows. First, Housing area included 1 to 4 content elements per each units, from 2 chapters and 6 units. The content elements stated in Home economics curriculum were total of 16 which consists of 'the meaning of housing,' 'housing types,' 'family forms,' 'family life style cycle,' 'life style,' 'neighboring environment,' 'co-living values,' 'air environment,' 'heat environment,' 'light environment,' 'acoustic environment,' 'space division,' 'circulation', 'effective use of space,' and 'sustainable dwelling practice.' All of these components are dealt with in every textbooks. Second, the numbers of content elements provided in each textbooks were the same, however they showed difference in their contextual aspect. Some contents need supplemental material for their lacking content element. Others need proper understanding of the concept because some showed different contents from the appropriate content elements. Third, repetitions in content elements were observed, the contents of 'co-living values' in textbook 1 and 'sustainable dwelling practice' in textbook 2 were similar in terms of eco-friendly housing, co-housing and universal housing. These two content elements should be merged as one next curriculum, or should be stated together in one subunit.

• Journal of Life Science
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• v.17 no.3 s.83
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• pp.381-385
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• 2007

Facilitates chromatin transcription (FACT) is a chromatin-specific elongation factor required for transcription of chromatin templates in vivo and in vitro. FACT consists of human homologue of the Saccharomyces cerevisiae Spt16/Cdc68 protein (hSpt16) and the high mobility group-1-like protein structure-specific recognition protein-1 (SSRP-1). Here we show that the protein level of hSpt16 is massively down-regulated in quiescent T98C cells using both immunofluorescence and western blot analysis. In contrast, we observe high level of the hspt16 expression in the proliferative T98G cells. Interestingly, the expression of SSRP-1 is not altered in both quiescent and proliferative states. Taken together, our findings implicate that the expression of hSpt16 is associated with the proliferative state and can be used as a proliferation marker.

• Journal of Labour Economics
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• v.24 no.2
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• pp.63-94
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• 2001

Based on the human capital theory, the wage differentials among laborers are generated from the discrepancy of human capital stock which depends on individual laborer's decision. Hence, the wage differentials among laborers or between male and female are not the results of discrimination, but the results of individual choice. But, if the individual choice for human capital stock would be affected by the male-female discrimination, the explanation for male-female wage differentials base on the human capital stock has a bias. Actually, women have experienced in the discrimination on labor market participation due to gravity, parturition, infant rearing. Also, it is a fact that women have been discriminated against men in labor market owing to social, traditional, and cultural discriminations. If woman or her parent will less invest on human capital than man owing to the existence of discrimination in labor market, the 'expected human capital stock' instead of human capital stock will explain male-female wage differentials better. Therefore, in this study, we set up three models; first model includes working hours, industry, occupation, etc which are in general used as explanatory variables for wage decision, second model includes the variables which reflect the traditional human capital stock together with the first model's explanatory variables, third model employes the 'expected human capital stock' instead of traditional human capital stock. From the empirical test, the estimates of discrimination in three models are .93, .60, and, .48 respectively. This result implies that the male-female wage differentials in Korea can be explained by the discrepancy of 'expected human capital stock'. Since the discrepancy in expected human capital stock depend on the disparity in life-cycle labor force participation, male-female wage differentials can largely be attributed to male-female disparity in expected lifetime labor force participation.

• The Journal of Korean Society for School & Community Health Education
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• v.15 no.1
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• pp.105-119
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• 2014

Objectives: This study investigates the factors influencing values on life-respect among middle school students. Methods: The participants in this study were 126 students from S middle school and Y middle school, both located in Gyeongnam province. The experimental group consisted of 40 students from S middle school, Control group-Iconsisted of 39 students from S middle school, and Control group-II consisted of 47 students from Y middle school. The experimental group was provided with 12 incidences of the life-respect education program from April 1st to June 29th. One period took 45 minutes and proceeded according to a structure of introduction, development, and consolidation. The experimental group received a life-respect education program, Control group-I received health teaching, but Control group-II didn't receive any special education except what was regularly part of their curriculum. The content of the life-respect education program included the following topics: value of life-respect, respect for human life and ethics, life-respect campaign, having a healthy mind, suicide prevention, dealing with crisis, prevention of school violence, abortion and life-respect, social weak minority consideration, death, brain death, euthanasia, life cycle and task, and forest activities. Questionnaires were administered as pre and post-tests which consisted of questions regarding death anxiety, suicide risk, and values on life-respect. The pre and post-tests were analyzed with t-tests, paired t-tests, ANOVAs, and factor analyses using SPSS 18.0. Results: 1. There was a statistically significant increase in the experimental group(p<.0001) and control group-I(p<0.05) in value and attitude about life-respect. On the other hand, it was shown that there was no difference between pre and post-test in control group-II. 2. The result of examining the differences between pre and post-tests after education on values and attitudes toward life-respect using ANCOVA showed, there was a statistically significant difference (p<0.001) among the three groups. Conclusion: the life-respect education program which was conducted over 12 meeting with middle school students had an positive effect, which can be used as basic data for fostering values on life-respect. These findings indicate that the life-respect education program this study used is effective for fostering value of life-respect and decreasing suicide risk.

• Journal of Life Science
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• v.17 no.4 s.84
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• pp.552-560
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• 2007

Histone deacetylase (HDAC) is overexpressed in a variety of cancers and is closely correlated with oncogenic factors. HDAC inhibitors such as trichostatin A(TSA) and sodium butyrate (Na-B) have been shown to induce apoptosis in vitro and in vivo in many cancer cells. The anti-apoptotic Bcl-2 protein has the remarkable ability to prevent cell death and Bcl-2 overexpression has been reported to protect against cell death. We previously reported that the apoptotic cell death of human leukemic U937 cells by TSA and Na-B treatment was associated with the down-regulation of Bcl-2 expression and activation of caspases. In the present study, we investigated the effects of Bcl-2 overexpression on the growth inhibition, cell cycle arrest and apoptosis induced by TSA and Na-B in U937 cells. TSA-induced growth inhibition, cell cycle arrest and apoptosis were significantly attenuated in Bcl-2 overexpressing U937/Bcl-2 cells however Na-B did not affected. Induction of apoptosis by TSA was accompanied by down-regulation of Bcl-2 expression, activation of caspase-3, -8 and -9, and degradation of DNA fragmentation factor/inhibitor of caspase-activated DNase, which was blocked by the overexpression of Bcl-2. Collectively, these findings suggest that ectopic expression of Bcl-2 appeared to inhibit TSA-induced apoptosis by interfering with inhibition of Bcl-2 and caspase activation.

• Journal of Life Science
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• v.19 no.1
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• pp.1-8
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• 2009

In this paper, to elucidate the further mechanisms of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced growth arrest, we investigated the effect of MNNG on cell cycle and proliferation in U937 cells, a p53-null human myeloid leukemia cell line. It was found that MNNG causes an arrest at the G2/M phase of the cell cycle and induces apoptosis, which is closely correlated to inhibition of cyclin B1 and cyelin-dependent kinase (Cdk) 2-associated kinase activities. MNNG treatment in. creased protein and mRNA levels of the Cdk inhibitor p21(WAF1/CIP1), and activated the reporter construct of a p21 promoter. By using p21 promoter deletion constructs, the MNNG-responsive element was mapped to a region between 113 and 61 relative to the transcription start site. These data indicate that in U937 cells MNNG can circumvent the loss of wild-type p53 function and induce critical downstream regulatory events leading to transcriptional activation of p21. Present results indicate that the p53-independent up-regulation of p21 by MNNG is likely responsible for the inhibition of cyclin/Cdk complex kinase activity rather than the down-regulation of cyclins and Cdks expression. These novel phenomena have not been previously described and provide important new insights into the possible biological effects of MNNG.

• Journal of Life Science
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• v.22 no.11
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• pp.1552-1557
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• 2012

It has been reported that pipernonaline isolated from Piper longum Linn. has a wide biochemical and pharmacological effect, including antitumor activity in prostate cancer PC-3 cells. However, its mechanism and expression pattern of many genes involved in biological functions are not clearly understood. To perform the gene expression study in PC-3 cells treated with pipernonaline, a cDNA microarray chip composed of 44,000 human cDNA probes was used. As a result, cell cycle-related genes, apoptosis-related genes, and cell proliferation/growth-related genes have been identified in gene ontology of the DAVID database. These results suggest that pipernonaline has antitumor activity by regulating the expression pattern of genes involved in biological signaling pathway in prostate cancer PC-3 cells. Further, additional analysis of these microarray data can be a useful tool to identify the mechanism and discovery of novel genes in cancer therapy.

• Journal of Life Science
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• v.19 no.7
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• pp.871-877
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• 2009

We investigated the effects of sodium butyrate, a histone deacetylase inhibitor, on the cell cycle progression in human monocytic leukemia U937 cells. Exposure of U937 cells to sodium butyrate resulted in growth inhibition, G1 arrest of the cell cycle and induction of apoptosis in a dose-dependent manner as measured by MTT assay and flow cytometry analysis. The increase in G1 arrest was associated with the down-regulation in cyclin D1, E, A, cyclin-dependent kinase (Cdk) 4 and 6 expression, and up-regulation of Cdk inhibitors such as p21 and p27. Sodium butyrate treatment also inhibited the phosphorylation of retinoblastoma protein (pRB) and p130, however, the levels of transcription factors E2F-1 and E2F-4 were not markedly modulated. Furthermore, the down-regulation of phosphorylation of pRB and p130 by this compound was associated with enhanced binding of pRB and E2F-1, as well as p130 and E2F-4, respectively. Overall, the present results demonstrate a combined mechanism involving the inhibition of pRBjp130 phosphorylation and induction of Cdk inhibitors as targets for sodium butyrate that may explain some of its anti-cancer effects in U937 cells.