• The Journal of Asian Finance, Economics and Business
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• 제8권5호
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• pp.667-678
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• 2021

The industrial life cycle theory was extended to the product life cycle theory and the corporate life cycle theory, but a conceptual life cycle was presented, and quantitative empirical evidence for this was insufficient. It is intended to improve appropriate resource planning and resource allocation by quantitatively predicting the industrial cycle and its position (age) in the cycle. Human resources, tangible assets, and industrial output analysis were conducted based on 28 years of actual data of 39 industries in Korea by applying the Gompertz model, which is a population ecology prediction model. By predicting with the Gompertz model, the coefficient of determination R2 value was 97% or more, confirming the high suitability with the actual cumulative sales value of the industry. A numerical model for calculating the life cycle of each industry, calculating the saturation of input resources for each industry, and diagnosing the financial stability of the industry was presented. These results will contribute to the decision-making of industrial policy officers for budget planning appropriately for each stage of industry development. Future research will apply the numerical model of this study to foreign national industries, complete an inter-industry convergence diagnostic model (e.g. ease of convergence, suitability of convergence, etc.) for renewal of fading industries.

• 대한한의학원전학회지
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• 제27권2호
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• pp.49-67
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• 2014

Subject : The Association between Extraordinary Organs(奇恒之腑) and Eight Extra Meridians(奇經 八脈). Objectives : This study research some special aspects of Extraordinary Organs and Eight Extra Meridians which differentiated from ordinary Organs and Meridians, and the association between Extraordinary Organs and Eight Extra Meridians. Methods : First, researched classification standard and physiological characteristics of Extraordinary Organs through studying various chapters of HuangdiNeijing. Second, researched The Association between Extraordinary Organs and Eight Extra Meridians through studying on the origin of Eight Extra Meridians in HuangdiNeijing. Third, from accompanying researching the subject of Cheon-gye(天癸) and human body shape, draw synthetic hypothesis on the relationship among ordinary Meridians and Organs, muscles and skins of body shape, Extraordinary Organs and Eight Extra Meridians. Results & Conclusions : The following conclusions could be drawn. 1. Extraordinary Organs afford background for shaping human body. This is same as the properties of the earth which afford background for shaping all creations. The physiological characteristics of Extraordinary Organs is intermediation and regulation between Ki(氣) of Five Viscera & six Bowels and shape of muscles & skins in human body. 2. The origin of Eight Extra Meridians could be found in HuangdiNeijing. The collateral Meridians of the Uterus and Epiglottis Meridian are specifically formulated to supplying for the Uterus or Epiglottis. From this we can draw The Association between Extraordinary Organs and Eight Extra Meridians, that is Eight Extra Meridians are specifically formulated to supplying for Extraordinary Organs. 3. The Cheon-gye(天癸) is doing significant function in Eight Extra Meridians supplying for Extraordinary Organs. Cheon-gye concerned to growth, secondary sexual characters, generative function, aging process. Theses are all concerned with the changing of human body shape. Cheon-gye urge to change the body shape with following the human life cycle. 4. Human body has vertical symmetry because preserve its shape from the gravitational force. Eight Extra Meridians place at the middle or flank axis of human body, thus do physiological function that assistant human body have vertical symmetry shape. The purpose of shaping vertical symmetry is securing space what the inner Twelve Regular Meridians and Five Viscera & six Bowels create there own physical changes. On the other hand the inner changes need deviation between left and right because of mobility and circulation of force. But human body change the shape in the process of growth, reproduction, aging. Eight Extra Meridians play role at time of these processing, thus they deeply concerned to human's life cycle and reproduction. 5. Eight Extra Meridians and Extraordinary Organs were named 'Extra' because of some special aspects which differentiated from ordinary Meridians and Organs. All they play role to have vertical symmetry shape of human body and maintain the shape, thus they deeply concerned to the change of human life cycle. These shaping maintaining and the change of human life cycle are very special aspects of human body. So they needed to differently cognize separate to the ordinary changes of Five Viscera & six Bowels and Twelve Meridians at inner space.

• BMB Reports
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• 제42권11호
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• pp.725-730
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• 2009

Cyclin E1 (CCNE1), a positive regulator of the cell cycle, controls the transition of cells from G1 to S phase. In numerous human tumors, however, CCNE1 expression is frequently dysregulated, while the mechanism leading to its dysregulation remains incompletely defined. Herein, we showed that CCNE1 expression was subject to post-transcriptional regulation by a microRNA miR-16-1. This was evident at protein level of CCNE1 as well as its mRNA level. Further evident by dual luciferase reporter assay revealed that two evolutionary conserved binding sites on 3' UTR of CCNE1 were the direct functional target sites. Moreover, we showed that miR-16-1 induced G0/G1 cell cycle arrest by targeting CCNE1 and siRNA against CCNE1 partially phenocopied miR-16-1-induced cell cycle phenotype whereas substantially rescued anti-miR-16-1- induced phenotype. Together, all these results demonstrate that miR-16-1 plays a vital role in modulating cellular process in human cancers and indicate the therapeutic potential of miR-16-1 in cancer therapy.

• 미생물학회지
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• 제44권4호
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• pp.299-304
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• 2008

마이엘로이드 계열의 단핵세포는 인체세포거대바이러스(human cytomegalovirus, HCMV)의 잠복 부위로 알려져 있다. 다양한 세포에서 HCMV에 의한 세포주기의 촉진 또는 억제에 관한 연구는 많이 있었지만, 단핵세포에서의 연구는 거의 없는 상태이다. 이에 본 연구에서는 단핵세포에 HCMV가 감염되면 세포주기에 어떤 변화가 나타나는지 알아보고자 하였다. Propidium iodide를 이용한 유세포 분석을 통한 세포주기 분석에서 HCMV에 감염된 THP-1 세포에서는 G0-G1기가 증가하고, 그만큼 S가 감소함을 보았다. 반면 HL-60 세포에서는G0-G1기와 S기의 상대적인 비율에 큰 변화가 없었다. BrdU 유입 실험에서 THP-1세포의 DNA 합성이 HCMV 감염에 의해 억제됨을 알 수 있었다. 세포주기의 G1기에서 S기로의 전환을 억제하는 p21 단백질은HCMV에 감염된 THP-1 세포에서는 발현이 유도되었지만 HL-60 세포에서는 거의 발현이 되지 않았다. 따라서 HCMV는 promocyte THP-1 세포에서 p21 단백질의 유도에 의해 세포주기를 G0-G1기에서 억류함에 따라 세포중식을 억제하는 것으로 생각된다.

• International Journal of Human Ecology
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• 제1권1호
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• pp.79-93
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• 2000

Using the 1995 Survey of Consumer Finances, this study investigates how family life-cycle stages and financial management practices affect household saving. First findings are that household income and householders education, race and ethnicity have significant effects on saving. Second, regarding the effect of the family life-cycle stages, younger married couples without children, middle pre-retired households without dependent children, and older households without dependent children are more likely to save than other similar households in the life-cycle stage of younger single households. Third, households with longer financial planning horizons, saving goals for retirement, purchase of durable goods and emergency goods, and low credit card debt are more likely to save. Based on the results, implications for financial management education and public policy are suggested.

• Asian Pacific Journal of Cancer Prevention
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• 제16권15호
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• pp.6417-6421
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• 2015

Viscum album var (VAV) also known as mistletoe, has long been categorized as a traditional herbal medicine in Asia. In addition to its immunomodulating activities, mistletoe has also been used in the treatment of chronic hepatic disorders in China and Korea. There are numerous reports showing that VAV possesses anti-cancer effects, however influence on human hepatocarcinoma has never been elucidated. In the present study, hot water extracts of VAV was evaluated for its potential anti-cancer effect in vitro. SK-Hep1 cells were treated with VAV (50-400ug/ml) for both 24 and 48 hours then cell viability was measured by cell counting kit-8 (CCK-8). Flow cytometry analysis was used to measure the proportion of SK-Hep1 in the different stages of cell cycle. RT-PCR and Western blot analysis were conducted to measure expression of cell cycle arrest related genes and proteins respectively. VAV dose dependently inhibited the proliferation of SK-Hep1 cells without any cytotoxicity with normal Chang liver cell (CCL-13). Flow cytometry analysis showed that VAV extract inhibited the cell cycle of SK-Hep1 cells via G1 phase arrest. RT-PCR and Western blot analysis both revealed that cyclin dependent kinase 2 (Cdk2) and cyclin D1 gene expression were significantly down regulated while p21 was upregulated dose dependently by VAV treatment. Combined down regulation of Cdk2, Cyclin D1 and up regulation of p21 can result in cell death. These results indicate that VAV showed evidence of anti-cancer activity through G1 phase cell cycle arrest in SK-Hep1 cells.

• Molecules and Cells
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• 제20권3호
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• pp.331-338
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• 2005

Ionizing radiation and doxorubicin both produce oxidative damage and double-strand breaks in DNA. Double-strand breaks and oxidative damage are highly toxic and cause cell cycle arrest, provoking DNA repair and apoptosis in cancer cell lines. To investigate the response of normal human cells to agents causing oxidative damage, we monitored alterations in gene expression in F65 normal human fibroblasts. Treatment with ${\gamma}$-irradiation and doxorubicin altered the expression of 23 and 68 known genes, respectively, with no genes in common. Both agents altered the expression of genes involved in cell cycle arrest, and arrested the treated cells in $G_2M$ phase 12 h after treatment. 24 h after ${\gamma}$-irradiation, the percentage of $G_1$ cells increased, whereas after doxorubicin treatment the percentage of $G_2M$ cells remained constant for 24 h. Our results suggest that F65 cells respond differently to ${\gamma}$-irradiation- and doxorubicin-induced DNA damage, probably using entirely different biochemical pathways.

• 청정기술
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• 제1권1호
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• pp.34-46
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• 1995

Clean Technology goes beyond Clean-UP (or "End of PiPe) Technologies to include Pollution prevention, waste minimisation, and cleaner production. However, the concept of Clean Technology goes deeper than changes in technology, to ways in which human needs can be satisfied sustainably. In other words, Clean Technology, concentrates on delivering a human benefit rather than making a product. Introducing cleaner technology may therefore involve new commercial relationships as well as new technological practices. In some economic sectors, this involves leasing or providing a service rather than selling a product. Life Cycle Assessment (LCA) is an important tool in Clean Technology. LCA involves determining all the resources used and all the wastes and emissions produced in providing the human benefit. Use of LCA ensures that improved environmental performance in one part of the Life Cycle is not achieved merely at the expense of more environmental damage elsewhere. Going beyond LCA, the concepts of Life Cycle Design and "metabolised" use of materials are approaches to obtain maximum benefit from materials as they pass through the human economy. "Closed-loop" use can be a component of clean technology. Looking beyond simple re-use and recycling, a material may pass through a "cascade of uses". typically a series of applications with progressively lower performance specifications. Closed-loop use necessarily involves a change in commercial practice, because the material or product must be recovered after use.

• 기술혁신연구
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• 제17권2호
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• pp.187-206
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• 2009

우리나리는 기존의 모방형 혁신체제에서 창조형 혁신체제로의 전환을 통하여 과학기술적 지식의 효율적 창출 확산 활용이 필요하다. 이를 위해서는 과학기술혁신의 주체인 연구인력의 육성이 핵심적인 필수조건으로 대두되고 있다. 본 논문은 우리나라 국가혁신체제의 핵심 구성요소인 출연연구기관의 창의적 인적자원 양성전략에 관해 논의한다. 본 논문에서는 출연(연)이 과학기술혁신활동을 직접 다루기 때문에 창의적 인적자원의 효율적 관리가 매우 중요성을 강조하고, 이를 위해 '전주기적 인적자원관리 모델'을 제시하고 있다. 이 모델은 우수 연구인의 유치, 연구원의 유동성 강화, 우수연구원의 특정자격 부여, 퇴직연구원의 효율적 활용의 네 단계로 구성되어 있으며 각 단계별 여러 정책과세를 제시하고 있다. 아울러 본 논문은 본 모델의 각 단계가 서로 선순환 구조를 가져야 할 것을 강조한다. 본 논문에서는 출연(연)은 전주기적 인력관리 모델의 추진을 바탕으로 연구인력을 전공분야의 심층적 지식과 관련 분야의 폭넓은 시식을 가지는 '역T자형 인력'으로 육성하여야 함을 강조하고 있다.

• 한국생명과학회:학술대회논문집
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• 한국생명과학회 2001년도 제31회 학술심포지움 및 춘계학술대회
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• pp.15-15
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• 2001