• The Korean Society of Law and Medicine
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• v.11 no.1
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• pp.297-329
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• 2010

The bioethics as a comprehensive and normative control method of life sciences including the technology of advanced medical care, on the one hand, it has modified the conditions for allowing the progress of life sciences. On the other hand, it has put the brakes on attempts of life sciences violating the dignity and value of human beings, natural order. Positively, bioethics presents ethical bases, suggests organization of the legal and institutional conditions, and enables elimination of the legal and institutional obstacles, for the progress of life sciences. Negatively, it has presented justifiable prospects and road maps of life sciences, not to take indiscreet and intemperate turn of violating the dignity and value of human beings, natural order, and its such roles must be carried on.

• BMB Reports
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• v.37 no.4
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• pp.402-407
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• 2004

A human gene T-complex protein 10 like (TCP10L) was cloned in our lab. A previous study showed that it expressed specifically in the liver and testis. A transcription experiment revealed that TCP10L was a transcription factor with transcription inhibition activity. In this study, the human MAD4 was identified to interact with TCP10L by a yeast two-hybrid screen. This finding was confirmed by immunoprecipitation and subcellular localization experiments. As MAD4 is a member of the MAD family, which antagonizes the functions of MYC and promotes cell differentiation, the biological function of the interaction between TCP10L and MAD4 may be to maintain the differentiation state in liver cells. Also, we propose that the up-regulation of Myc is caused by the down-regulation of TCP10L in human hepatocarcinomas.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.25 no.4
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• pp.442-450
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• 2014

This paper is a study of the propagation characteristic of matching liquids in the skin-covered breast model. In order to evaluate the matching liquids, we investigated six kinds of matching liquids applied to proposed 1-D breast model from frequency range of 3~6 GHz. A uniform plane wave is projected / transmitted inside the multi-layered breast model. Then the propagation characteristics inside the model and the transmission loss of each matching liquids were analyzed. The studying method presented in the paper can be used in the breast cancer detection system, the field of cancer detection using human tissue and the field of other medical devices. This paper was applied to the breast cancer detection system. Consequently, these studies could be used to determine the suitable type of matching liquids for breast cancer detection system and to apply useful for performance analysis.

• Food Science and Biotechnology
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• v.16 no.1
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• pp.163-166
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• 2007

The cytotoxic effects of partially purified substances from Bacillus polylfermenticus SCD toward a variety tumor cell lines were studied. Cytotoxic activity was determined with regard to the A549 (human lung carcinoma), AGS (human stomach adenocarcinoma), DLD-1 (human colon adenocarcinoma), HEC-1-B (human uterus adenocarcinoma), SW-156 (human kidney carcinoma), and NIH/3T3 (murine normal fibroblast) cell lines using the MTT assay. Cytotoxic substances were partially purified through Diaion HP-20 columns and extracted with methanol or other organic solvents (n-hexane, chloroform, ethylacetate, and butanol). B. polyfermenticus SCD supernatant showed up to 60% inhibition of cell viability fer all five human cancer cell lines tested. When treated with 10 mg/mL of n-hexane, chloroform, ethylacetate, and butanol extract, HEC-1-B cells showed a 25,62,35, and 63% rate of inhibition respectively, and AGS cells showed a 72, 61, 44, and 67% rate of inhibition, respectively. At a concentration of 10 mg/mL, 100% methanol Diaion HP-20 extracts showed inhibition rates of 97.0% toward A-549 cells, 98.1% toward AGS cells, 81.6% toward DLD-1 cells, 83.5% toward HEC-1-B cells, and 92.7% toward SW-156 cells. These results indicate that partially purified fractions from B. polyfermenticus SCD have the potential to inhibit not only colon cancer cells, but also lung, stomach uterus, and kidney cancer cells. Further studies are needed to characterize the cytotoxic substances released in B. polyfermenticus SCD cultures.

• Human Ecology Research
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• v.62 no.2
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• pp.369-383
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• 2024

The aim of this study was to develop and implement a program based on Cognitive Behavior Therapy (CBT) for female college students experiencing body dissatisfaction. To systematize the program development process, we adopted the service design method. First, we conducted In-Depth Interviews (IDIs) to identify the difficulties faced by six female college students who experience body dissatisfaction, and to determine what kind of help they needed. Second, content analysis of the findings revealed that female college students were experiencing emotional-behavior problems which derived from the discrepancy between their ideal body image and the reality. Third, a prototype of a cognitive reconstruction program was developed to help transform their perceived 'body distortion' to a rational cognitive concept and thus reduce maladaptive consequences of 'body dissatisfaction'. The overall program consisted of three therapeutic components and seven steps. Fourth, to assess the effectiveness of the program, survey and IDIs were conducted. The results revealed that it is appropriate to use a cognitive model to solve problems caused by body dissatisfaction, and that understanding and reconstructing one's own cognitive processes can be effective in reducing body dissatisfaction. However, based on feedback from participants, a number of revisions were proposed, such as including sufficient induction regarding the behavioral change.

• Korean Educational Research Journal
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• v.40 no.2
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• pp.1-16
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• 2019

The society of intelligence-information complex is a fresh world that connects things, knowledge and calculation with human. What is the condition of educational reform in this world? Robinson and Aronica(2015) suggest educational reform at the center of organic agriculture, in which they focus on the dignity of human as an organic being. Human consists in an intelligence and a life. We have to ask to ourselves what is the human in this Age. The development of AI represented by deep-learning will be an actual condition in the educational reform. In the other hand, the combination with an information technology and art rises a question about a life itself. So, we have to ask the question seriously that overlap what is the human and what is a life. Two questions about human and a life cast a philosophical paradox in the age of AI.

• Journal of Engineering Education Research
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• v.17 no.4
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• pp.38-42
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• 2014

The principle of materialized world is the same as of human life. The human life is governed by the human mind composed of the copies of the materialized world. The stress is due to the human mind inside. The creativity is prevented by the copies in the human mind. The convergence is not easy due to the individual copy world which is different from each other. By subtraction of the copies inside the human, the creativity and convergence can be fulfilled. Syllabus of the lecture at KAIST is introduced. Students taking the lecture express the non-materialized world of human mind clearly after the subtraction the copies inside. The students who recognize the stress inside specifically can be free from the stress by discarding the copies inside.

• Genomics & Informatics
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• v.8 no.2
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• pp.86-89
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• 2010

Closely related species share large genomic segments called syntenic regions, where the genomic elements such as genes are arranged co-linearly among the species. While synteny is an important criteria in establishing orthologous regions between species, non-syntenic regions may display species-specific features. As the first step in cataloging human- or primate- specific genomic elements, we surveyed human genomic regions that are not syntenic with any other non-primate mammalian genomes sequenced so far. Based on the data compiled in Ensembl databases, we were able to identify 10 such regions located in eight different human chromosomes. Interestingly, most of these highly human- or primate- specific loci are concentrated in subtelomeric or pericentromeric regions. It has been reported that subtelomeric regions in human chromosomes are highly plastic and filled with recently shuffled genomic elements. Pericentromeric regions also show a great deal of segmental duplications. Such genomic rearrangements may have caused these large human- or primate- specific genome segments.

• Journal of Life Science
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• v.10 no.2
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• pp.12-13
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• 2000

A human-specific retroposon SINE-R.C2 has been derived from a human endogenous retrovirus HER V-K 10. It is absent in the genome of nonhuman primates and present within the third intron of the human C2 gene that is located in the class III region of the major histocompatibility complex. In the present study, we determined the regional location of the human C2 gene. The analysis of the Genebridge 4 radiation hybrid mapping panel using PCR amplification located the C2 gene between D6S1422 (10.1 cR) and CHLC.GATA4A03 (21.3) with a lod score of>3.0. This allowed us to localize C2 gene on the human chromosome 6 band p21.31.

• Journal of the Korea Furniture Society
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• v.23 no.4
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• pp.364-371
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• 2012

I designed a dietary life kitchen utensils which is focused by the shape of split bamboo that has meaning of health and safety and the shaman who is the religion and incantation performer, and who solve problems, which are impossible to solve in common methods, by borrowing the power and granting the meaning which is connected with transcendent existence and principal. Having closest relation with human being's diet culture is being changed with adding beauty instead of the part of simple practical aspect in our normal life. I tried to show incantation effect with keeping the characteristic of kitchen utensils by granting the symbolic meaning of shamanism which is the shelter that is projected the desire of human beings. the materials were produced of an ebony and steel and varnished with lacquer for coloring. For hand shape, which is hard to treat in irregular forms, the religious image of shamanism was formed by casting which expresses the touch of an ebony and the cold characteristic of metal. an overall design doesn't detail excessively distort or largely transform the form of dietary utensils, keeps its individuality, and emphasizes the image by figuring a grip part which a human can see and a body can approach. in addition, I try to show a point that shamanism has affected human life for long time and symbolic meaning of bamboo-shape shows health and safety. And these things vest with each dietary life tools and should be the role of enzyme about the effect of human life.