• Clinical and Experimental Reproductive Medicine
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• 제47권2호
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• pp.122-129
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• 2020

Objective: The survival of a semi-allogeneic fetus depends on several immunological mechanisms, and it has been suggested that recurrent pregnancy loss (RPL) could develop as a result of one or more immunological abnormalities. Methods: Compatibility between partners for human leukocyte antigen (HLA) genotypes and the relationships between maternal killer-cell immunoglobulin-like receptor (KIR) and paternal HLA-Bw4/Bw6 and HLA-C1/C2 supra-groups were investigated in 25 couples with RPL in comparison to healthy couples with children. HLA and KIR genotyping was performed using polymerase chain reaction with sequence-specific primers and/or sequence-specific oligonucleotides. Results: HLA class I incompatibility between partners, especially in HLA-B alleles, was more common in the RPL group (p= 0.01). HLA-C2 homozygosity was more frequent in the male partners of RPL couples than in other groups (p= 0.03). The KIR2DL5 gene frequency was significantly higher in both the female and male partners of RPL couples, whereas the KIR2DS3 gene frequency in male partners of RPL couples was significantly reduced (p= 0.03). The presence of KIR2DL3 in women with RPL was correlated with the presence of HLA-C2 alleles in their spouses (p= 0.03). Conclusion: Our data from a Turkish population suggest that male HLA-C2 homozygosity may play an important role in RPL. Additionally, an incidental match between male HLA-C2 and female HLA-C1 ligand KIR receptors might perturb the balance between activatory and inhibitory KIR-ligand interactions during pregnancy in couples affected by RPL. The roles of orphan KIR2DL5 and orphan KIR2DS3 in RPL remain obscure.

• 디자인학연구
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• 제12권2호
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• pp.97-106
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• 1999

환경오염이라는 인류의 총체적 위기는 인간 중심적 패러다임을 인간과 자연의 공존을 목표로 하는 생태학적 패러다임으로 변화시켰고, 이에 따라 디자이너 역시 인류의 과제인 환경문제 해결에 동참하지 않을 수 없게 되었다. 이러한 사회적 책임과 디자이너 자신의 윤리적 책임은 디자인 방향을 환경을 위한 디자인(Design For Environment)으로 전환하게 하였다. 본 연구는 디자인을 통한 환경 문제 해결이라는 측면에서 그 하나의 실마리를 제공하는 것에 그 목적이 있다. 즉, 제품의 조형에서 내구적 속성을 파악하여 이를 제품에 부가함으로써, 경제적 손실과 환경오염을 줄이는데 기여할 수 있을 것이라는 것이다. 제품의 형태를 결정짓는 디자이너의 입장에서 제품 조형의 내구적 속성을 파악하여 이를 제품에 부여한다는 것은 제품의 수명(Product Life Cycle)을 연장시키는 데 도움을 줌으로써, 제품의 폐기를 유보시킬 수 있을 뿐 아니라 제품이 제 수명을 다하기도 전에 새로운 형태의 제품에 밀려 폐기되는 일을 감소시켜 과잉 생산에서 오는 에너지 낭비와 자원의 소모를 막고, 오염물질의 방출과 쓰레기를 줄여 환경오염을 최소화시킬 수 있는 것이다. 이것은 기본적으로 기업의 과도한 경쟁 의식에 의한 무분별한 제품개발과 소비자의 소비 지향적인 태도에 반발하는 것이다. 이 가정 위에서 제품 조형의 내구적 속성을 밝히는 것이 이 논문의 궁극적 목표라 하겠다.

• 한국정보과학회논문지:컴퓨팅의 실제 및 레터
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• 제8권5호
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• pp.574-582
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• 2002

W3C에 의해 주도되고 있는 차세대 웹 기술은 HTML을 이용한 인간 중심의 웹 한계를 극복하는데 중점을 두고있다. 즉, 기존 웹상의 자료가 급격히 증가하고 있는 상황에서, 사람의 눈으로 내용을 확인해야 하는 HTML기반 기술은, 의미를 잃어가고 있으며, 이를 위한 새로운 대안이 필요하게 된 것이다. 이러한 이유로 사람의 눈 대신에, 기계가 정보를 찾아 주는, 기계 중심의 웹 분야가 새로운 대안으로 연구되고 있다. 본 논문에서는 기계 중심의 웹 환경 구현을 위하여 개발된 많은 방법 중에서 현재 가장 일반적으로 사용되고 있는 의미 서술 언어인 MDL을 소개하고, MDL 모델링 개념과 상세한 방법을 제시한다. 그리고 제안된 모델링 기법의 유용성을 검증하기 위하여 실무 사례를 기반으로 모델링 기법을 적용하였다. 마지막으로, 본 논문은 제안된 모델링 방법에 기반 한 MDL 에디터의 구현 화면을 제시함으로써, MDL 에디터 개발자에게 기술적 도움이 되고자 하였다.

• 한국실내디자인학회논문집
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• 제21권5호
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• pp.145-152
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• 2012

Since 1966 when James Turrell completed his studies on Art, he has been working on the consistent theme of Art. For the 46 years of time, site contexts, scales, methods of light have been changed and they made Turrell's unique 'project series'. Each series has different spatial, visual-perceptual forms and characteristics from other series. The differences were caused by the given situations, but also Turrell intentionally pursued it. However, there are essential theme of art that has not changed in most of Turrell's projects. Target of this paper is to study the unchanged theme as well as the differences. The study starts with three questions: first, what is the geometrical space composition?, second, what is the visual-perceptual phenomenon?, third, what is the hidden consistent theme? This research focuses on three case projects: Wedgework, Space Division Constructions, Skyspaces. These project series are in between the early small object-like installations and the late mega-scale outdoor projects. The study found that geometrical space composition has important role to give visual-perceptual dynamism to the viewer. The phenomenological perception is connected to the questions of relationship between human and space, ultimately human and the world. Although the Merleau-Ponty's philosophy has been related to the work of Turrell in various previous studies, Cartesian 3-dimensional geometry has also crucial role to experiment a viewer's perceptual boundaries. Image of infinity is another aspect of three cases, especially Space Division Constructions and Skyspaces. Through these structure, Turrell's work lead to an ultimate question of meaning for human existence in infinite space. It is hoped that this paper is helpful for Architecture and Interior design field in which light and space are essential.

• 대한금속재료학회지
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• 제50권5호
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• pp.401-406
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• 2012

When viewed using a magnetic resonance imaging (MRI) system, invasive materials inside the human body, in many cases, severely distort the MR image of human tissues. The degree of the MR image distortion increases in proportion not only to the difference in the susceptibility between the invasive material and the human tissue, but also to the intensity of the magnetic field induced by the MRI system. In this study, by blending paramagnetic Ti particles with diamagnetic graphite, we synthesized $Ti_{100-x}C_x$ composites that can reduce the artifact in the MR image under the high-strength magnetic field. Of the developed composites, $Ti_{70}C_{30}$ showed the magnetic susceptibility of ${\chi}=67.6{\times}10^{-6}$, which corresponds to 30% of those of commercially available Ti alloys, the lowest reported in the literature. The level of the MR image distortion in the vicinity of the $Ti_{70}C_{30}$ composite insert was nearly negligible even under the high magnetic field of 4.7 T. In this paper, we reported on a methodology of designing new structural materials for bio-applications, their synthesis, experimental confirmation and measurement of MR images.

• 대한통합의학회지
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• 제9권1호
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• pp.141-150
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• 2021

Purpose : The purpose of this study was to investigate the effect of case-based learning application in human growth development classes on nursing students' problem-solving ability, self-directed learning ability, and academic self-efficacy. Methods : The research method was a self-report questionnaire before and after case-based learning for second-year nursing students who took the human growth development course at U University in K city. The collected data were statistically processed using SPSS WIN 21.0. Results : The results of the study showed that after case-based learning, problem-solving ability, self-directed learning ability, and academic self-efficacy were all significantly improved. In addition, as a result of examining the correlation between each variable after case-based learning, problem solving ability score and self-directed learning ability score (r=.54, ｐ<.01), and problem solving ability scores and academic self-efficacy scores (r=.44, ｐ<.01), were significantly correlated with self-directed learning ability scores and the academic self-efficacy reduction scores (r=.76, ｐ<.01). Conclusion : The results of this study suggested the need for various learning programs such as case-based learning to improve nursing students' problem-solving abilities and self-directed learning abilities and their application. In addition, to improve the learning self-efficacy of nursing students, a continuous and systematic study is suggested to develop and apply customized educational programs according to the learners' preferences. Since the sample group in this study was limited to one university, there were few cases and no control group, so there are limitations in generalizing the test effect, However, significant differences a were verified in the case-based learning pre-tests and post-tests.

• Genomics & Informatics
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• 제20권1호
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• pp.4.1-4.8
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• 2022

Loss of heterozygosity (LOH) is a genomic aberration. In some cases, LOH can be generated without changing the copy number, which is called copy-neutral LOH (CN-LOH). CN-LOH frequently occurs in various human diseases, including cancer. However, the biological and clinical implications of CN-LOH for human diseases have not been well studied. In this study, we compared the performance of CN-LOH determination using three commonly used tools. For an objective comparison, we analyzed CN-LOH profiles from single-nucleotide polymorphism array data from 10 colon adenocarcinoma patients, which were used as the reference for comparison with the CN-LOHs obtained through whole-exome sequencing (WES) data of the same patients using three different analysis tools (FACETS, Nexus, and Sequenza). The majority of the CN-LOHs identified from the WES data were consistent with the reference data. However, some of the CN-LOHs identified from the WES data were not consistent between the three tools, and the consistency with the reference CN-LOH profile was also different. The Jaccard index of the CN-LOHs using FACETS (0.84 ± 0.29; mean value, 0.73) was significantly higher than that of Nexus (0.55 ± 0.29; mean value, 0.50; p = 0.02) or Sequenza (0 ± 0.41; mean value, 0.34; p = 0.04). FACETS showed the highest area under the curve value. Taken together, of the three CN-LOH analysis tools, FACETS showed the best performance in identifying CN-LOHs from The Cancer Genome Atlas colon adenocarcinoma WES data. Our results will be helpful in exploring the biological or clinical implications of CN-LOH for human diseases.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제26권1호
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• pp.50-57
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• 2023

Purpose: The purpose of this study was to determine the pattern of human leukocyte antigen (HLA)-DQ genotype in children diagnosed with celiac disease (CD) (biopsy proven), and to compare this with a control group; and secondarily, to correlate HLA genotypes with clinical profiles of CD. Methods: This cross-sectional comparative observational study included 26 controls and 52 patients diagnosed with CD who presented at Sir Padampat Mother and Child Health Institute, Jaipur, from May, 2017 to October, 2018. HLA DQ genotype was assessed for each patients and correlated with clinical profiles. Results: HLA DQ2/DQ8 genotypes were significantly more common in CD (present in 100.0% cases) than in controls (23.1%) in Northern India (Rajasthan). When HLA DQ2.5 and DQ8 were present together, individuals had significantly more atypical presentations and severe findings on duodenal biopsy. Similarly, patients with the HLA DQ 2.5 genotype were also predisposed to more severe endoscopic findings, while HLA DQ2.2 predisposed them to less severe biopsy findings. HLA DQ8 was significantly associated with later age at diagnosis (>5 years) and shorter stature. The highest HLA DQ relative risk (RR) for CD development was associated with HLA DQ2.5 and DQ2.2 in combination, followed by HLA DQ2.5 and DQ8 in combination, while HLA DQx.5 and HLA DQ2.2 together had the lowest risk. Conclusion: HLA DQ2/DQ8 genotypes are strongly associated with pediatric CD patients in northern India. These genotypes and their combinations may be associated with different clinical presentations of CD, and may help predict severity of CD.

• 융합보안논문지
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• 제22권1호
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• pp.141-148
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• 2022

한국의 ROTC 제도는 유능한 초급장교 충원과 평시부터 예비전력 확보를 위해 1961년에 미국으로부터 도입되었다. 하지만 2000년대 접어들어 저출산에 따른 학령인구 및 병역자원의 감소, 병 복무기간까지 단축되는 획득환경의 변화로 지원율이 점점 하락하는 심각한 위기에 직면하게 되었다. 따라서 본 연구는 이러한 획득환경의 변화와 그에 따른 지원율 감소의 원인을 분석하여 조직편성 및 운영체계를 중심으로 ROTC 제도 개선방안을 제시하고자 하였다. 연구방법은 국내‧외 문헌연구를 통해 미국과 한국의 ROTC 제도에 관한 사례 간 비교기법을 적용하였다. 이론적 측면에서는 지식기반사회에서 조직의 성과달성과 비교경쟁우위 확보를 위해 기업경영에 적용하고 있는 전략적 인적자원관리를 이론적 준거로 삼았다.

• 한국식생활문화학회지
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• 제23권5호
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• pp.616-620
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• 2008

The principal objective of this study was to evaluate the quality characteristics of Bokbunja pudding, using various levels of Bokbunja fruit juice (140, 150, and 130 g), Bokbunja Wine (10, 20, and 20 g), gelatin (18, 17, and 16 g) and sugar (250, 200, and 150 g). In order to establish the optimal added amounts, chemical composition, saccharinity, color, texture, and sensory evaluations were conducted, and the results of various cases were analyzed and assessed. The statistical data analyses were conducted using the SPSS program. The saccharinity of the Bokbunja pudding increased with increasing amountsof added sugar. Additionally, as the amount of added Gelatin was increased, the L values (lightness) of the Bokbunja pudding decreased. Conversely, the hardness, gumminess, and chewiness values all decreased with decreasing levels of added gelatin and sugar. The optimal mixing condition for the Bokbunja pudding was determined via sensory evaluation. Sensory characteristics, including flavor, sweetness, texture, and overall acceptability, were highest in the type C product. The chemical composition of the type C product was as follows: moisture 71.47%, carbohydrate 24.70%, crude protein 3.83%, crude fat 0.001%, and crude ash 0.001%. According to our results, the optimum mixing ratio for the most satisfactory sensory characteristics of Bokbunja was as follows: Bokbunja fruit juice 130 g, Bokbunja Wine 20 g, Gelatin 16 g, Sugar 150 g, Bokbunja Flavor 0.3 g, and Water 400 g.