• Genomics & Informatics
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• v.10 no.2
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• pp.117-122
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• 2012

A sample size with sufficient statistical power is critical to the success of genetic association studies to detect causal genes of human complex diseases. Genome-wide association studies require much larger sample sizes to achieve an adequate statistical power. We estimated the statistical power with increasing numbers of markers analyzed and compared the sample sizes that were required in case-control studies and case-parent studies. We computed the effective sample size and statistical power using Genetic Power Calculator. An analysis using a larger number of markers requires a larger sample size. Testing a single-nucleotide polymorphism (SNP) marker requires 248 cases, while testing 500,000 SNPs and 1 million markers requires 1,206 cases and 1,255 cases, respectively, under the assumption of an odds ratio of 2, 5% disease prevalence, 5% minor allele frequency, complete linkage disequilibrium (LD), 1:1 case/control ratio, and a 5% error rate in an allelic test. Under a dominant model, a smaller sample size is required to achieve 80% power than other genetic models. We found that a much lower sample size was required with a strong effect size, common SNP, and increased LD. In addition, studying a common disease in a case-control study of a 1:4 case-control ratio is one way to achieve higher statistical power. We also found that case-parent studies require more samples than case-control studies. Although we have not covered all plausible cases in study design, the estimates of sample size and statistical power computed under various assumptions in this study may be useful to determine the sample size in designing a population-based genetic association study.

• The Korean Journal of Nuclear Medicine
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• v.4 no.1
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• pp.43-49
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• 1970

In recent years with development of immuno-electrophoresis, more acurate analysis of the serum protein became possible. However, there is few reports in the literature which investigated the changes of the immunoglobulin compared with electrophoretically fractioned serum thyroglobulin in the patients with various thyroid diseases. The purpose of this report is to investigate the changes of thyroglobulin in various thyroid diseases by the method of immuno-electrophoresis and to compare the results with.serum protein fractionated by the method of agar-gel micro-electrophoresis. Materials and Methods: Sera from 9 patients with diffuse toxic goiter, 2 nodular nontoxic goiter, 2 thyroiditis, 3 hypothy, roidism, 1 thyroid cancer, 7 cystic degeneration of the thyroid gland, and 10 normal subject were taken. All cases were confirmed by various laboratory thyroid function tests and thyroid needle biopsy. Immuno-electrophoretic analysis of the serum were performed by Scheidegger's modified micro-immuno-electrophoretic method. The antiserum was obtained from the Travenol Laboratories International, Hyland Products Division and was rabbit anti-human thyroglobulin. Microscope slide agar-gel electrophoresis for serum protein fractionation was performed at $4^{\circ}C$ using veronal buffer, pH 8.6 and ionic strength 0.05, with 54 volts and 2.8 mA for 60 minutes. The fractionated slide was stained with 0.1% thiazine red. The results were as follows: 1) Increase of immune-globulin macroglobulin (IgM), alphaglobulin, and immune-globulin A (IgA) by 95.8%, 100%, 29.2% respectively was found in the serum from various thyroid diseases. 2) Thyroglobulin fraction was found to be increased in 50%, no change in 41.7%, and no line in 8.3% with all of the various goiter patients. On the other hand, 10 normal control group showed only 2 cases of increase, 5 cases of no change and 3 cases of no line.

• Parasites, Hosts and Diseases
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• v.22 no.1
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• pp.61-65
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• 1984

A mass fecal examination was performed in Seoul, Korea from December 1983 to March 1984 and 15 egg positive cases of Fibricola seoulensis were discovered. They were treated with praziquantel($Distocide{\circledR}$) 20mg/kg single dose and magnesium salt for purgation. The adult worms of F. seoulensis were collected from 6 of them. The number of the flukes ranged 1-78 by the case. The cases had no clinical manifestation at all. They were all Korean males in twenties, and had the histories of eating the roast or raw snakes or frogs. Fibricoliasis is expected to be prevalent among the snake-eaters in Korea. Further cases will be detected by sedulous differentiation of thinshelled immature operculated eggs of 0.08~0.102mmn length. Praziquantel seems to be an excellent chemotherapeutic for fibricoliasis.

• The Journal of the Korean life insurance medical association
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• v.1 no.1
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• pp.123-132
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• 1984

Among the person who want to insure, there are not only fair persons who want to become the insurance with not realizing that one was not infected with certain disease but also someones on purpose to overcome the disease through the insurance company with be recognized by oneselves. However, it was found that the ultrasonography and exact effects of medical examination with the existing medical equipments of the insurance company could not be expected. We present some several proven examples for the purpose of getting the advanced effects in medical examination by utilizing the ultrasonic device which is not harmful to human body presently as far as known. We could find affirmation through the check of ultrasonography from 907 cases, in our Department of Medical selection that many portion of the cases checked the medical examination have the present condition of illness even though they enjoy social life with good health and finally the conclusions we have learned are as follows; The aged cases show the increase of rate of possessing disease and man shows 2.2 times of possessing disease than woman. Fatty infiltration of liver take portion of 74.7% from the case checked. 12 cases of cholelithiasis are not conscious of symptom at all. Through the check of ultrasonography in obstetrics and gynecology, myoma uteri be showed high rate of 72.2% from the case of possessing disease. In Case of the potential pregnancing woman it made clear to find pregnancy which was undistincted still more also know the existence and nonexistence of fetal death when pregnancy expected.

• The Journal of the Korean Society for Microbiology
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• v.12 no.1
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• pp.51-56
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• 1977

1. The total 1,204 of human sera from January to December, 1976 of the out-patients in St. Mary's Hospital were tested one by one. The total 57.6% of the 1,204 cases were confirmed as a hemagglutination inhibition antibodies, and 58.18% out of 574 male cases and 57.14% of 630 female cases were confirmed to have antibodies, respectively. 2. The monthly distribution of hemagglutination inhibition antibody was shown to be 91.2% out of 34 cases in October, 1976 but other months it was low. 3. In the group whose age was from 51 to 60, it was 64.6% and this shows that the group was markedly higher than others.

• Journal of Families and Better Life
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• v.28 no.1
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• pp.51-67
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• 2010

This study looked into the current conditions in Korean and Japanese care management for the elderly, cases of consumer counseling in these countries, and the supporting institutions for Japanese users regarding the use of care management for the elderly. The number of recipients of care management for the elderly in both Korea and Japan is growing every year, and more Japanese users receive various services compared to Korean users. The results of an analysis on consumer counseling regarding the use of Korean and Japanese care management revealed, two types of complaints: counseling for the improvement of the institution and complaints related to the procurement of service. Regarding the insurance system, the complaints were mostly related to affirmation of a rating and the burden incurred by cost-sharing. Regarding the use of service, such key impairment cases were related to in-service medical accidents, illegal acts including caregiver contract violations and forced retirement, careless service by workers, and human rights violations of the elderly. Japan has developed governmental and, related-administrative and business services as well as a local governmental system to redress customer impairment issues as this pertains to service for better quality care management. In addition, they have enlarged the locally closed service, provided exact information about the services offered, and improved service appraisal techniques. The Japanese cases will serve as a good reference to improve the Korean system. In particular, the construction of a system that reduces customer losses and the availability of more counseling information are urgently required to improve the system in terms of customer experiences when they seek care management.

• Parasites, Hosts and Diseases
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• v.52 no.1
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• pp.79-83
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• 2014

Human taeniases had been not uncommon in the Republic of Korea (=Korea) until the 1980s. The prevalence decreased and a national survey in 2004 revealed no Taenia egg positive cases. However, a subsequent national survey in 2012 showed 0.04% (10 cases) prevalence of Taenia spp. eggs suggesting its resurgence in Korea. We recently encountered 4 cases of Taenia saginata infection who had symptoms of taeniasis that included discharge of proglottids. We obtained several proglottids from each case. Because the morphological features of T. saginata are almost indistinguishable from those of Taenia asiatica, molecular analyses using the PCR-RFLP and DNA sequencing of the cytochrome c oxidase subunit 1 (cox1) were performed to identify the species. The PCR-RFLP patterns of all of the 4 specimens were consistent with T. saginata, and the cox1 gene sequence showed 99.8-100% identity with that of T. saginata reported previously from Korea, Japan, China, and Cambodia. All of the 4 patients had the history of travel abroad but its relation with contracting taeniasis was unclear. Our findings may suggest resurgence of T. saginata infection among people in Korea.

• Parasites, Hosts and Diseases
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• v.47 no.2
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• pp.153-157
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• 2009

Diagnosis of hydatidosis is based on immunodiagnostic methods along with radiological and ultrasound examinations. The objectives of the present study were to develop a specific and simple antigen-based ELISA method for diagnosis of hydatidosis and compare it with antibody detection method. The subjects in this study included 89 patients in the following groups: surgically confirmed hydatidosis patients (35 cases), control with other parasitic diseases (29 cases), and healthy controls (25 cases). Hyperimmune serum was raised against hydatid cyst fluid in rabbits. Anti-hydatid cyst IgG was purified by affinity chromatography using protein A column and labeled with horseradish peroxidase. Collected sera were assessed for hydatid cyst antigens and antibody by ELISA. Circulating hydatid antigen was found in 9 out of 35 patients with surgically confirmed hydatidosis. A sensitivity of 25.7% and a specificity of 98.0% were calculated for the antigen detection assay. Antibody detection by indirect ELISA, using antigen B, showed that 94.2% of patients (33 cases) have anti-hydatid cyst antibodies in their serum while cross reaction was noted in a few of non-hydatidosis patients. A sensitivity of 94.2% and specificity of 81.6% were found for the antibody detection assay. Findings of this study indicated that antibody detection assay is a sensitive approach for diagnosis of hydatid cyst while antigen detection assay might be a useful approach for assessment of the efficacy of treatment especially after removal of the cyst.

• Journal of Korean Academy of Oral and Maxillofacial Radiology
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• v.28 no.1
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• pp.215-224
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• 1998

The following conclusions were obtained from the non-reconstructed and reconstructed subtraction images of the standard intraoral radiographs which were taken with paralleling technique with Rinn XCP only and with occlusal bite registration for geometric standardization using bilateral mandibular premolar and molar regions of two dry human skulls. 1. The SD of the overall subtraction images of the premolars and molars of the non-reconstructed, that is, the manual superimposition showed statistically significant difference between the non-registered and registered groups. 2. In non-reconstructed and non-registered cases, the quality of the subtraction images were improved when superimposition was focally done and this was more evident in areas where the radiographic images tend to be distorted due to anatomic reasons. 3. In non-reconstructed and registered cases, the subtraction images were consistent regardless of the anatomic site or the focus of superimposition. This means that the geometric standardization with only occlusal bite registration could produce serial radiographs which is suitable for subtraction. 4. The SD of the overall subtraction images of the premolars and molars of the reconstructed, that is, the automatic superimposition showed statistically insignificant difference between the non-registered and registered groups. This means that using reconstruction, subtraction radiography is possible without occlusal bite registration. 5. In reconstructed and non-registered cases, compatible quality of the subtraction images were obtained regardless of the anatomic site or area of the corresponding points. 6. In reconstructed and registered cases, best subtraction images whose quality showed sensitivity to the areas of corresponding points were obtained.

• Journal of Digital Convergence
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• v.16 no.7
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• pp.27-34
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• 2018

This study was conducted to identify the contents of major consulting needs of SMEs using Big Data and to suggest the efficiency of operation. The subjects of the study were counseling cases posted on the website of the Business Support Center of the Ministry of SMEs and Startups. To do this, from 2009 to March 2018, we crawled about 7,000 cases of counseling cases, followed by word cloud analysis centering on effective keyword. The main results were as follows: First, the frequency of counseling cases in each field was found in the order of establishment, management strategy, human resources, financial order. Second, in word cloud analysis, the most frequent keyword related to counseling demand were small businesses, exports, methods, procedures, registration and authentication. In this study, we obtained research results that we can improve the efficiency of the policy in real time from a new point of view by conducting big data analysis on public policy.