• Asian Pacific Journal of Cancer Prevention
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• 제14권12호
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• pp.7261-7264
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• 2013

Recent genome wide sequencing has identified mutations in IDH1/IDH2 predominantly in grade II-III gliomas and secondary glioblastomas which are associated with favorable clinical outcome. These mutations have become molecular markers of significant diagnostic and prognostic relevance in the assessment of human gliomas. In the current study we evaluated IDH1 (R132) and IDH2 (R172) in 32 gliomas of various grades and tumor subtypes. Sequencing analysis revealed R132H mutations in 18.7% tumors, while none of the cases showed IDH2 (R172) mutations. The frequency of IDH1 mutations was higher in females (21.4%) than males (11.1%), and it was significantly higher in younger patients. Histological analyses demonstrated presence of necrosis and micro vascular proliferation in 69% and 75% respectively. Interestingly, IDH1 mutations were predominantly present in non-necrotic tumors as well as in cases showing microvascular proliferation. Of the six IDH1 positive cases, three were glioblastomas (IV), and one each were anaplastic oligoastrocytoma (III), anaplastic oligodendroglioma III (n=1) and diffuse astrocytoma. In conclusion, IDH1 mutations are quite frequent in Indian glioma patients while IDH2 mutations are not observed. Since IDH mutations are associated with good prognosis, their use in routine clinical practice will enable better risk stratification and management of glioma patients.

• 대한상한금궤의학회지
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• 제7권1호
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• pp.87-106
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• 2015

Objective : We analyzed 3 clinical cases to estimate the possibility of shanghanlun as a completed clinical text which has its own diagnostic system. Methods : We collected 3 cases treated by huang lian e jiao tang conducted by a practiced shanghanlun doctor and defined the conceptional meaning of each provisions by analyzing the application of them in each case. Results : Shanghanlun provisions dualized with Je Gang(提綱) and Jo Mun(條文) is the record of preceding factors which describe the phenomenon initiating the diseases. Conclusions : Rudimentarily a factor can bring about many outcomes, so if shanghanlun is structured record of the factors which can make a human sick from many diseases, it can be used as the completed clinical text only with those 113 prescriptions. Factors that shanghanlun recorded seem somewhat different from western conventional medicine because the field of each factors are very varied from biological phenomenon to psychological phenomenon. However it is not that weird because psychosomatic medicine in western conventional medicine also point out the factors come from mental, society and behavior.

• Asian Pacific Journal of Cancer Prevention
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• 제14권1호
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• pp.27-30
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• 2013

Background: Salivary gland tumors (SGT) are one of the most complex human neoplasms, demonstrating variations in their clinicopathological profile related to racial and geographic differences. Few studies with large samples have been reported in Iran. We here investigated a large group of patients in southern Iran. Materials and Methods: In this retrospective study, all cases of primary epithelial salivary gland tumors, which had been recorded in a 5 years period from 2005-2009, were enrolled. Clinical data such as histopathologic type and site of the lesion as well as patients' age and gender were analyzed. Results: Data of 366 cases of SGTs were recorded. Pleomorphic adenoma (80.2%) and adenoid cystic carcinoma (46.6%) were the most common benign and malignant neoplasms. Male to female ratio (M/F) and the mean age of patients were 1:1.05 and 37.7 for benign tumors while they were 1.2:1 and 50.6 for malignant tumors, respectively. Parotid and minor salivary glands were involved more frequently. Conclusions: Although the salivary gland tumours encountered were similar in most of their characteristics to those reported in other countries, some differences such as relative frequency and age and gender prevalence were discovered. These findings should help surgeons and pathologists for more accurate diagnosis, management and treatment.

• 가정과삶의질연구
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• 제30권4호
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• pp.133-146
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• 2012

Community building in Japan, called Machizukuri, has been in existence since the 1960s, and many successful cases are referred to by researchers and public service officials as benchmarks for creating livable cities and towns in Korea. The purpose of this study is to identify the building factors for a sustainable community and to suggest implications through the cases of machizukuri in Japan. Based on the literature review related to the research topic, on-site visit case study was used as the major research methodology. Four cases -Setagaya, Kawagoe, Motomachi, and Manazuru- were selected as the research subjects and interviews with the representatives of the community(resident) council and public officials were conducted during October 19-22, 2011. The project overview, purpose, and planning characteristics of each case were described for data analysis. The major findings are as follows. Although most of the machizukuri in Japan were administration-dependent at the beginning stage, the case projects in this study showed resident-independence (self-support) from the perspective of sustainability. The results showed that successful community building is an everlasting project that requires cooperation among personnels including residents, civic officials, and related council members.

• 복식
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• 제63권1호
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• pp.64-80
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• 2013

The purpose of this study is to examine the cases of Korean requesting fashion designers for uniform design, that were created from the combination of designer's ideas with company identity, and analyze its design characteristics. For research methods, the uniform design cases were investigated and analyzed from 2000 to 2012. Uniform design cases were classified by job categories( airlines, banks, distributions, constructions, communications and restaurants). The most frequently applied trait on the part of uniform design proved to be for the fashion trend, followed by emblematic and functional factor and lastly, by korean tradition. This might be ascribed to the occupational characteristics of the fashion designers, which is the most emphasis on the fashion trend. The uniform of the construction and the distribution companies showed very fashionable designs that would be regarded to be associated with the trendy life styles in these companies' consumers. To the contrary, the uniform of the financial and communication companies showed the functional and emblematic trend that might be due to work conditions with long hours of sitting, coming from the occupational characteristics of these companies.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제38권3호
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• pp.177-183
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• 2012

Herpes zoster is a viral infection caused by the reactivation of the varicella zoster virus, an infection most commonly affecting the thoracolumbar trunk. Herpes Zoster Infection (HZI) may affect the cranial nerves, most frequently the trigeminal. HZI of the trigeminal nerve distribution network manifests as multiple, painful vesicular eruptions of the skin and mucosa which are innervated by the infected nerves. Oral vesicles usually appear after the skin manifestations. The vesicles rupture and coalesce, leaving mucosal erosions without subsequent scarring in most cases. The worst complication of HZI is post-herpetic neuralgia; other complications include facial scarring, motor nerve palsy and optic neuropathy. Osteonecrosis with spontaneous exfoliation of the teeth is an uncommon complication associated with HZI of the trigeminal nerve. We report several cases of osteomyelitis appearing on the mandible, caused by HZI, and triggering osteonecrosis or spontaneous tooth exfoliation.

• Restorative Dentistry and Endodontics
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• 제14권1호
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• pp.25-40
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• 1989

This study was conducted to evaluate the influence of 5 microfilled composite resin to fibroblast cultivated from human pulp (age 13). Each composite resin was manually mixed and filled in cylinder. Resin filled cylinders were placed in dishes (35mm in diameter) containing 3 ml of ${\alpha}$-MEM. Filters (pore size 0.22 ${\mu}m$) to simulate dentin were also placed between the bottom of cylinder and the dish floor. Then stored in 5% $CO_2$ containing incubator for 1 and 2 weeks at the temperature 36.6 C. The results analysed after 1 and 2 weeks were as follows: 1. Experimental group except group 2, 2 weeks incubation cases showed the cytotoxicity compared to the control group in cell count. 2. After 2 week-incubation of group 1 and group 4, cell count was more decreased than 1 week cases and cytotoxicity seemed to be constantly influenced to the cell multiplication. 3. The cell growth rate of 1 week incubation in group 3 and group 5 was similar to the control group and recognized the cytotoxicities of these groups were mild. 4. The cell multiplication rate of 2 week incubation cases in group 2 was greater than control group.

• 천문학회지
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• 제37권2호
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• pp.79-85
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• 2004

We developed an algorithm to identify and determine periods of variable sources. With its robustness and high speed, it is expected to become an useful tool for surveys with large volume of data. This new scheme consists of an initial coarse. process of finding several candidate periods followed by a secondary process of much finer period search. With this multi-step approach, best candidates among statistically possible periods are produced without human supervision and also without any prior assumption on the nature of the variable star in question. We tested our algorithm with 381 stars taken from the ASAS survey and the result is encouraging. In about $76\%$ cases, our results are nearly identical as their published periods. Our algorithm failed to provide convincing periods for only about $10\%$ cases. For the remaining $14\%$, our results significantly differ from their periods. We show that, in many of these cases, our periods are superior and much closer to the true periods. However, the existence of failures, and also periods sometimes worse than manually controlled results, indicates that this algorithm needs further improvement. Nevertheless, the present experiment shows that this is a positive step toward a fully automated period analysis for future variability surveys.

• Safety and Health at Work
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• 제2권2호
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• pp.97-104
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• 2011

N,N-Dimethylformamide (DMF) is globally used as an organic solvent in the production of synthetic leather and resins because of its low volatility, making it an attractive industrial material. Despite its excellent property as a chemical solvent, utilization of DMF is somewhat controversial nowadays due to its hazardous effects on exposed workers in work places. Many toxification cases are being reported globally and the number of cases of liver damage is still increasing in developing countries. On account of this, a series of epidemiologic surveys are being conducted to understand the degrees of liver damage caused by DMF exposure. Furthermore, many investigations have been performed to clarify the mechanism of DMF-induced liver toxicity using both human and experimental animal models. This review summarizes the current occupational cases reported on liver damage from workers exposed to DMF in industrial work places and the research results that account for DMF-induced liver failure and possible carcinogenesis. The findings reviewed here show the synergistic toxicity of DMF exposure with other toxicants, which might occur through complicated but distinct mechanisms, which may extend our knowledge for establishing risk assessments of DMF exposure in industrial work places.

• Parasites, Hosts and Diseases
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• 제40권4호
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• pp.177-180
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• 2002

Gangweon-do is known to be highly endemic area of sparganosis more than other provinces in Korea. A seroepidmiologic examination for the detection of anti-Spirometra erinacei plerocercoid IgG in serum was carried out in normal inhabitants in Hongcheon-gun, Gangweon-do. Sere were tested by enzyme-linked immunosrobent assay (ELISA) for the anti-sparganum antibodies. Positive rate for anti-sparganum antibody in 719 adults was 3.3%. Data of the questionnaire for 24 ELISA positive inhabitants revealed that 20 had a history of eating raw meat of snakes, 24 had a history of eating frogs, and 24 had a history of drinking stream water. Two positive cases had a past history of sparganosis. Two positive cases showed current symptoms of sparganosis. The data revealed that ELISA would be useful to find infected cases among normal inhabitants at sparganosis-endemic areas.