• Genomics & Informatics
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• 제17권3호
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• pp.29.1-29.8
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• 2019

The Wellcome Trust Case Control Consortium (WTCCC) study was a large genome-wide association study that aimed to identify common variants associated with seven diseases. That study combined two control datasets (58C and UK Blood Services) as shared controls. Prior to using the combined controls, the WTCCC performed analyses to show that the genomic content of the control datasets was not significantly different. Recently, the analysis of human leukocyte antigen (HLA) genes has become prevalent due to the development of HLA imputation technology. In this project, we extended the between-control homogeneity analysis of the WTCCC to HLA. We imputed HLA information in the WTCCC control dataset and showed that the HLA content was not significantly different between the two control datasets, suggesting that the combined controls can be used as controls for HLA fine-mapping analysis based on HLA imputation.

• Nuclear Engineering and Technology
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• 제40권5호
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• pp.349-364
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• 2008

Over the years, probabilistic risk assessment (PRA) research activities conducted at the U.S. Nuclear Regulatory Commission (NRC) have played an essential role in support of the agency's move towards risk-informed regulation. These research activities have provided the technical basis for NRC's regulatory activities in key areas; provided PRA methods, tools, and data enabling the agency to meet future challenges; supported the implementation of NRC's 1995 PRA Policy Statement by assessing key sources of risk; and supported the development of necessary technical and human resources supporting NRC's risk-informed activities. PRA research aimed at improving the NRC's understanding of risk can positively affect the agency's regulatory activities, as evidenced by three case studies involving research on fire PRA, human reliability analysis (HRA), and pressurized thermal shock (PTS) PRA. These case studies also show that such research can take a considerable amount of time, and that the incorporation of research results into regulatory practice can take even longer. The need for sustained effort and appropriate lead time is an important consideration in the development of a PRA research program aimed at helping the agency address key sources of risk for current and potential future facilities.

• 대한전기학회논문지:시스템및제어부문D
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• 제53권5호
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• pp.374-379
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• 2004

This paper proposes an algorithm for human sensibility evaluation using 4-channel EEG signals of the prefrontal and the parietal lobes. The algorithm uses an artificial neural network and the multiple templates. The linear prediction coefficients are used as the feature parameters of human sensibility. Comfortableness for chairs and temperature/humidity are evaluated. Many conventional researches have emphasized that a wave of left prefrontal lobe is activated in case of positive sensibility and that of right prefrontal lobe is activated in case of negative sensibility. So the power ratio of a wave is obtained from FFT computation and the results are compared. The results of the comfortableness evaluation for temperature and humidity showed that the outputs of the proposed algorithm coincided with corresponding sensibilities depending on the task of the temperature and the humidity. The . conventional method using a wave is hardly related with comfortableness. And it is also observed that the uncomfortable state due to the high temperature and humidity can be easily changed to the comfortable state by small drop of the temperature and the humidity. It seems to be good results to get 66.7％ of evaluation performance in spite of using EEG and the subject independent approach.

• 한국의류학회지
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• 제45권1호
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• pp.73-93
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• 2021

This study typifies fashion mobile plays in a digital environment and explores the experiential value created by them through a case study of a fashion brand mobile app. For the case analysis, mobile plays were divided into four types: intrinsic motivation/active participation, intrinsic motivation/passive participation, external motivation/active participation, and external motivation/passive participation, depending on the mobile players motivation and level of participation. Among the global fashion brand mobile apps released from 2009 to 2019, 16 cases suitable for the analytical framework were used for final analyses. The main results are as follows. First, mobile play value include characteristics such as networkability, immersion, hyper-spatiality, and super-temporality in addition to the attributes of a traditional play such as spontaneity, uncertainty, regularity, and playfulness. Second, the four types of mobile play provide participants with an experiential value such as creative value, emotional value, social value, and exploitative value. This study has academic implications in terms of introducing a new framework that can typify mobile plays and suggest practical implications for what experiential value fashion companies can give consumers through mobile app marketing.

• Archives of Plastic Surgery
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• 제49권3호
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• pp.457-461
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• 2022

Kaposi's sarcoma (KS) is a cancer that causes patches of abnormal tissue to grow under the skin. It also occurs in the immunosuppressive population. KS is currently believed to be caused by infection with human herpes virus-8 (HHV-8) in non-human immunodeficiency virus patient. A 79-year-old female visited the outpatient clinic presenting with increasing number and size of palpable masses on both upper and lower extremities. She was first diagnosed as drug-erupted dermatitis and stopped her medications, but the symptoms got worse. We did partial biopsy, and KS with HHV-8 was diagnosed histopathologically. She planned to undergo further evaluations and proper treatments. This rare case suggests the need to consider a classic type of KS in the differential diagnosis of specific dermatologic symptoms such as macular, nodular, and darkish patches of upper or lower extremities in elderly patients. It is believed that this case helps to strengthen awareness of this rare disease.

• 한국안전학회지
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• 제35권4호
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• pp.64-73
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• 2020

As Korean government and safety-related organizations make continuous efforts to reduce the number of industrial accidents, accident rate has steadily declined since 2010, thereby recording 0.48% in 2017. However, the number of fatalities due to industrial accidents was 1,987 in 2017, which means that more efforts should be made to reduce the number of industrial accidents. As an essential activity for enhancing the system safety, accident analysis can be effectively used for reducing the number of industrial accidents. Accident analysis aims to understand the process of an accident scenario and to identify the plausible causes of the accident. Accident analysis offers useful information for developing measures for preventing the recurrence of an accident or its similar accidents. However, it seems that the current practice of accident analysis in Korean manufacturing companies takes a simplistic accident model, which is based on a linear and deterministic cause-effect relation. Considering the actual complexities underlying accidents, this would be problematic; it could be more significant in the case of human error-related accidents. Accordingly, it is necessary to use a more elaborated accident model for addressing the complexity and nature of human-error related accidents more systematically. Regarding this, HFACS(Human Factors Analysis and Classification System) can be a viable accident analysis method. It is based on the Swiss cheese model and offers a range of causal factors of a human error-related accident, some of which can be judged as the plausible causes of an accident. HFACS has been widely used in several work domains(e.g. aviation and rail industry) and can be effectively used in Korean industries. However, as HFACS was originally developed in aviation industry, the taxonomy of causal factors may not be easily applied to accidents in Korean industries, particularly manufacturing companies. In addition, the typical characteristics of Korean industries need to be reflected as well. With this issue in mind, we developed HFACS-K as a method for analyzing accidents happening in Korean industries. This paper reports the process of developing HFACS-K, the structure and contents of HFACS-K, and a case study for demonstrating its usefulness.

• 한국사회복지학
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• 제63권1호
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• pp.29-55
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• 2011

이 연구는 질적 사례연구방법을 활용하여 지적장애인거주시설에서의 인권관점에 기초한 사회복지실천을 종사자의 경험을 중심으로 분석한 것이다. 이를 위해, 장애인거주시설 중 대표적으로 인권관련활동을 하는 기관으로 추천받은 A기관을 선정하고 사례연구방법을 통해 조직 및 개인차원에서의 경험,성과 및 딜레마를 심층적으로 탐색하였다. 조직차원에서 인권관점에 기초한 사회복지실천은 이용자의 욕구를 어떻게 충족해 줄 것인가에 대한 관심으로부터 시작되었다. 그 과정에서 인권보장위원회 구성,인권규정 제정 등의 조직의 정비와 인권교육 및 인권관점을 강조하는 조직 문화 구축이 나타났다. 개인 차원에서 종사자들은 인권관점에 기초한 사회복지실천으로 장애인의 자기결정권과 선택권을 매우 중요하게 생각하고 있었다. 또한 인권관점에 기초한 사회복지실천은 이용자, 직원 및 기관 조직문화에 서 다양한 변화를 야기하는 것으로 나타났다. 그러나 실천과정 안에서 나타나는 새로운 딜레마로 인해 또 다른 고민과 대안을 끊임없이 모색하는 역동적 과정으로 분석되었다. 이 연구는 인권관련 선행연구들이 정책적, 이념적, 개념적 논쟁에 집중되어있는 것과 대조적으로 미시적 측면의 사회복지실천에서 인권관점이 어떻게 구현되고 있는지를 집중적으로 탐색한 국내 최초의 기초연구로서 그 함의가 크다.

• 한국조경학회지
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• 제32권1호
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• pp.157-169
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• 2004

This study aims to review the research trends concerning environmental psychology. The scope of review is limited to the papers that dealt with theoretical and case-directed investigation research about the relationship between socio-physical environments and human beings. The relationship has been investigated by diverse human reactions such as cognitive, emotional, analytical, behavioral, and comprehensive. 219 papers were reviewed in two steps. In the first step, the ratio of the papers in the field of environmental psychology to the total papers published in the Journal from 1973 to 2004 was analyzed. Second, all the 219 papers were classified by such three criteria as the type of the paper(theoretical, review, case investigation), the methodology taken, and the main theme of the paper. The main findings from the review are summarized as follows; 1. Out of the 219 papers, the number of the theoretical papers was 4 (1.8%), whereas the number of the case investigation papers was 185 (84.5%). 2. Out of the 30 review papers, the main methodology used was simple introduction (15 papers, 50%) and the main theme was research methodology (36%), whereas analytic comparison was used only in 10 papers (33%) and theory review was only found in 6 papers (20%). 3. Out of the 185 case investigation papers, experimental method was found in 34 papers (18%), whereas 99 papers used correlational method (54%). Based on the findings, it was suggested that both theoretical and case-directed research should be performed in order to enhance the state of art in environmental psychology. Theoretical research as a framework to understand the empirical findings are as important as the case-investigation research peformed by scientific experimental method.

• Parasites, Hosts and Diseases
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• 제22권1호
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• pp.37-42
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• 1984

이형흡충류의 하나인 Heterophyes heterophkes nocens에 의한 인체감염 2례가 치료후 충체를 얻세(제1예) 및 24세(제2예) 남자로 전남 고흥군 해안마을이 고향이거나 현재 거주지이며 제1예는 상복부 통증 및 소화불량 등의 증상을, 제2예는 EKG검사상 불정맥 및 ventricular premature be각 등 심장 기능이상과 설사, 복통 등 소화기 증상을 호소하였다. 1983연 4월 및 8월에 bithionol 30mg/kg 또는 prasiquantel 15mg/kg을 투여하고 설사편을 입체해부현미경하에서 검사한 바 각각 35및 67마리의 H. heterophyes noces가 수집되었다. 대편검사 또는 충체검사상 제 1예는 간흡충이, 제2예는 3종의 다른 이형흡충류와 광절렬두조충이 동시 감염되어 있었다. 환자들은 H. heterophyes nocens의 중간숙주인 숭어 (Mugil cephalus), 농어 (Lateolalabrax japonicus) 및 문절망둑(Acanthogobius navimanus) 등 반염수산 어류를 회로 먹은 정력이 있었다.

• Imaging Science in Dentistry
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• 제46권4호
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• pp.285-290
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• 2016

In this report, we describe the incidental finding of an oropharyngeal mass in a patient who presented with a chief complaint of temporomandibular pain. The patient was initially evaluated by an otorhinolaryngologist for complaints of headaches, earache, and sinus congestion. Due to worsening headaches and trismus, he was further referred for the management of temporomandibular disorder. The clinical evaluation was uneventful except for limited mouth opening (trismus). An advanced radiological evaluation using magnetic resonance imaging revealed a mass in the nasopharyngeal/oropharyngeal region. The mass occupied the masticatory space and extended superioinferiorly from the skull base to the mandible. A diagnostic biopsy of the lesion revealed a long­standing human papilloma virus (HPV­16)­positive squamous cell carcinoma of the oropharynx. This case illustrates the need for the timely radiological evaluation of seemingly innocuous orofacial pain.