• Title/Summary/Keyword: human body size

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A Study on Relationship to Risk Factors according to Menopausal Status in Breast Cancer (유방암 환자에 있어서 폐경상태에 따른 위험인자의 상관성 연구)

  • Yoon, Han-Sik
    • Journal of radiological science and technology
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    • v.23 no.1
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    • pp.49-54
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    • 2000
  • It is important to identify modifiable risk factors for breast cancer, because the breast cancer is one of the major causs of mortality among women. Some reported that obesity is a risk factor for breast cancer, but the results are not constant. Many risk factors are related to the duration of estrogenic stimulation of the breast. In general, early menarche and late menopause are positive risk factors. Human breast cancer has different characteristics according to the status of menopause(premenopause and postmenopause). In premenopausal women, about 60% of circulating estrogen is from the ovaries in the form of estradiol, and the remaining 40% is estrogen formed primarily in the adipose(fat) tissue via aromatization of androstenedion from the adrenal glands. After menopause this adipose cell production of estrone is the main source of estrogens and the level of estrone is maintained approximately at premenopausal levels. This study was undertaken to determine the role of body size and body mass index by status of menopause in development of breast cancer using retrospective case/control study. From March 1991 to February 1997 at the Wonkwang University Hospital, the breast cancer cases(n=72) and controls(n=86) were selected. By statistical analysis method, regression analysis, paired T-test and multiple logistic regression were done to estimate the influenced factors same as height, weight, BMI, age at menarche and age at menopause. The following results were obtained : 1. In premenopausal women, age at menarche was showed comparatively high correlation coefficients and BMI was described prominently highly in postmenopause. 2. At the results of multiple regression analysis, age at monarch, BMI and weight were showed as significant variables. In this method, critical factor ($R^2$) was 0.054. 3. Paired samples T-test was undertaken to test mean difference between two groups of cases and controls. The result of test performance showed a significant difference. 4. In comparison with women whose weight less than 50 kg, the ORs for the upper 5th group was 1.82(95% confidence interval). The heaviest women had a higher risk(OR=1.14, 95% confidence interval $1.12{\sim}1.31$, p=0.005). Higher body mass index was significantly associated with increased risk of premenopausal breast cancer (OR=1.01, 95% confidence interval $1.08{\sim}l.18$, p=0.05).

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A Morphologic Study of Sasang Constitution (사상인(四象人)의 형태학적(形態學的) 특징(特徵)에 관(關)한 연구(硏究))

  • Lee, Eui-ju;Kho, Byung-hee;Song, Il-Byung
    • Journal of Sasang Constitutional Medicine
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    • v.10 no.2
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    • pp.181-220
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    • 1998
  • 1. PURPOSE This is a quantitative analysis of Sasang Constitution by measuring human body except face. This study is carried out for the purpose of searching out the theory of Sa-cho and the morphologic theory of Sasang Constitution. 2. METHOD (1) SUBJECTS Subjects are 338 person came to Dept. of Sasang Constitutional Medicine (KyungHee Oriental Medical Center) and Oriental Medicine and Western Medicine Cooperative Health Examination Center (KyungHee Medical Center) from October 1997 to Jauary 1998. The mean age is $41.7{\pm}12.39$. (2) CLASSIFICATION OF SASANG CONSTITUTION QSCCII(Questionnaire for the Sasang Constitution Classification) is used for the Classification of Sasang Constitution. The distributions of Sasang Constitution Classification are Soeumin 83, Soyangin 98, and Taeumin 157. (3) MEASURING INSTRUMENT & ITEMS Length, Breadth, Circomferece, and Skinfold thickness of each body segment are measured by Martin's measuring instrument and Skinfold Caliper. Measured items of this study is based on Lohman's methods and is added new items. (4) DATA ANALYSIS The Volume, Weight, Rate, and Index of each group are calculated by using measuring items. The difference of each group is analyzed by SPSS 7.0 for Win. 3. RESULT (1) THE MORPHOLOGIC CHARACTERISTIC of TAEUMIN First of all, the Taeumin has a emormous morphology. His trunk is huge but head-neck and limbs is small. The volume and weight of head-neck is smaller than other body segments but the volume and weight of upper-abdomen is bigger than ones. (2) THE MORPHOLOGIC CHARACTERISTIC of SOEUMIN The Soeumin has a small morphology. His head-neck rate is bigger than Taeumin's but his trunk rate is smaller than Taeumin's. And his lower limbs rate is bigger than other constitution but it's not a significant difference. His neck is thinest and longgest than others. His chest is thin and narrow. His lower-abdomen rate is bigger than other constitution but it's difference is not significant. (3) THE MORPHOLOGIC CHARACTERISTIC of SOYANGIN Soyangin has a middle size at head-neck and chest part. But the rate of upper limb is higer than other constitution. And the rate of lower-abdomen part is lower than other constitution. but that's not significant.

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Studies on Anisakiasis Especially Morphological Studies on the Anisakinae Larva (Anisakiasis에 대한 조사연구(調査硏究) 특히 유충(幼蟲)의 형태학적(形態學的) 구조(構造)에 대하여)

  • Rim, Bong-Ho
    • Korean Journal of Veterinary Research
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    • v.21 no.2
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    • pp.105-112
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    • 1981
  • The morphological and structural studios of Anisakinae larva has been carried out since Sept. of 1980. The larva were collected from naturally infested eleven swine of 1,531 examined at Kwang-Ju abattoir and from marine fishes, Somber japonicus, bought at Kwang-Ju fish market. The results observed were as follow : 1. Anisakis larva found in the stomach wall and on the surface of the mucosa were more or less degenerated. According to the progress of degeneration, the cross sections showed varied structures (Fig. 6, 7). 2. Size of the larva both from swine and fishes were measured respectively in average(mm); 18.0 and 18.7 in body length, 0.30 and 0.41 in body width, 1.64 and 1.68 in esophagus(muscular-part), 0.56 and 0.67 in ventriculus (glandular part), and 0.13 and 0.12 in tail. It was notable that body length of the larva in this present data, 18.0mm and 1.87mm, were shorter than those in previous dada, 24.3mm from human cases and 28.4mm from, however, the present data were almost similar to the data, 1.75mm, from swine case. 3. The Boring tooth, Mucron, long ventriculus and short round tail were observed in the larva of this present study. These structures were differentiated from Anisakis type II larvae which was provided with short ventriculus, and conical and tapering tall without mucron. 4. The ventricular appendix and intestnal caecum were not present in the larva. These might be differentiated from other Anisakidae larva such as Terranova larvae, Contracaecum larvae, Raphidascaris larvae and Thynnascaris larvae. 5. The findings through the histological observation were a pair of Y-shaped or butterfly-shaped lateal chords, ventral and dorsal chords, excretory(Renette) cell, high columnar epithelial cells of digestive tract and muscle cells. These morphological characteristics revealed varied features in the structures in the degenerative degree of the larva in the stomach wall. 6. The above-mentioned characteristics of the larva observed could be indentified as Anisakis type I larvae. 7. The reports on natural infestation of domestic animal with Anisakis type I larvae were two swine cases in Korea and Japan respectively, On the other hand two human cases of the larva were reported in Korea and more than one thousand cases in Japan. In Twiwan no reports of human and domestic animal cases could be found.

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Development of a Korean Type Totally Implantable TAH (한국형 완전이식 인공심장의 개발)

  • Min, B.G.;Choi, W.W.;Ahn, J.M.;Park, S.K.;Park, C.Y.;Chang, J.K.;Kim, J.W.;Kim, H.C.;Kim, W.K.;Roh, R.J.
    • Proceedings of the KOSOMBE Conference
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    • v.1996 no.05
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    • pp.199-202
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    • 1996
  • Artificial hearts are intended for use in patients with severe forms of heart disease for which no surgical repair is possible. The moving-actuator pump was developed to decrease the overall volume size of the electromechanical total artificial heart (TAH) by eliminating the occupied space of the fixed-actuator in the conventional pusher-plate type pump. In our pump, the actuator moves back and forth for alternative ejections of left and right ventricles. The problem of fitting the TAH to atrial remnants and arterial vessels could also be improved by circular or penduluous mot ion of the actuator instead of linear mot ion of the pusher-plate in the conventional pumps. We have evaluated two types of moving- actuator pump; one is a rolling cylinder type, and the other a pendulum type pump. In the rolling cylinder pump, frictional energy loss exists between the pump housing's guide bars and the actuator's end caps, while the bottom rack under the cylindrical actuator increases the height of the pump, the pump is therefor not implantable inside the small chest of human-sized animals with a body weight of less than 70kg. The new human type pump has a penduluous mot ion actuator to correct the above problems while maintaining the advantage of the moving- actuator's small total volume. The totally implantable TAH is composed of a blood pump, a control system and pheriperal equipments. The blood pump, which is constructed by a moving actuator, a right and left blood sac, and four artificial valves, is implanted in the thoracic. In 1988, the first implantation of the rolling cylinder TAH was performed into a female calf weighing 100kg, and the cal f recovered to the degree of voluntary standing and eat ing and survived to 100 hrs. We then survived two female sheep weighing about 63kg with the new human type TAH for three days.

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Enhancement of Anticancer Activities of Ephedra sinica Stapf Extracts by Nano-encapsulation (마황 추출물의 나노 입자화를 통한 항암 활성 증진)

  • Jeong, Hyang-Suk;Kim, Seoung-Seop;Oh, Sung-Ho;Jeong, Myoung-Hoon;Choi, Woon-Yong;Seo, Yong-Chang;Na, Chun-Soo;Kwak, Hyeong-Geun;Lee, Hyeon-Yong
    • Korean Journal of Medicinal Crop Science
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    • v.18 no.3
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    • pp.143-150
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    • 2010
  • This study showed the increase of antitumor activities of water soluble E. sinica extract by nano-encapsulation process with lecithin. Five groups of lecithin only group (LO), lecithin nano-encapsulated E. sinica group (LE), E. sinica only group (EO), one negative control group (NCO) and positive control group (PCO) were set for several anticancer experiment and fed into Sarcoma-180 injected mice. The cytotoxicity of LE on the human normal kidney cell (HEK293) showed 14.8% lower than 19.2% of EO and 18.4% of LO. Growth of human liver carcinoma cell and human stomach carcinoma cell as representative of digestive system in vitro was inhibited up to about 85.1% and 87.3%, in adding 1.0 mg/$m{\ell}$ of LE, which values 15% higher than that from conventional EO. The survival rates of each mice group were 40%, 63%, 48%, 33% and 100%, respectively after 40 days of injecting Sarcoma-180. The increment of their body weights of the extract feeding groups was suppressed down to 10~15%, compared to the negative control. The nano-particles also reduced the hypertrophy of the internal organs such as spleen and liver down to 15~20%, compared to those as the other groups. Among them, LE effectively reduced the size of tumor form to 20%. From these results, in vitro and in vivo antitumor activities of E. sinica could be enhanced by using nano-encapsulation process with lecithin because of better permeation into the cancer cells by confocal observations.

Development of Bi-directional Grading Method for Uniform Easy-order System -Focused on Blouse for Adult Female- (유니폼의 이지오더 시스템을 위한 양방향 그레이딩 개발 -성인여성 블라우스를 중심으로-)

  • Choi, Young-Lim;Nam, Yun-Ja;Choi, Kueng-Mi
    • Journal of the Korean Society of Clothing and Textiles
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    • v.33 no.6
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    • pp.860-868
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    • 2009
  • To provide adequate fit for women over a range of sizes, the grading process should reflect their body dimensions. Current methods of creating sized garments are not addressing the need for a good or even an adequate fit for the easy-order system. This study suggests a grading rule allocating system that can improve the appropriateness of clothing for uniform easy-order system. Also, the study proposes a bi-directional grading method subdivided to horizontal and vertical direction. The grading rule allocating system suggested the size increments which improve the fitness of uniform. Using the 5th Size Korea data, the crosstabulation was conducted with 1305 females in the age group $20{\sim}49$ years, and the size increments including $155\sim165$ of height section and $79\sim94$ of bust section, was selected for easy-order system. Also, the bi-directional grading method subdivided in horizontal and vertical direction was followed by factor analysis based on the circumference and height. And the grading rules were calculated by regression analysis.

Consumer Characteristics Relating to Business Jacket Practices -Focus on Working Women in the U.S.- (미국 직장여성들의 비지니스 쟈켓 착용과 관련된 소비자 특성 분석)

  • Yoo, Seul-Hee
    • Journal of the Korean Society of Clothing and Textiles
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    • v.30 no.12 s.159
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    • pp.1649-1660
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    • 2006
  • IIn the United States, professional dress codes for working women have changed over time since the 1970s. Considering the changes, from conservative and traditional business uniforms in the 1970s, business casual in the late 1980s through 1990s, and the current revival of tailored business suits, this study investigated working women's business jacket practices and their association with personal, psycho-social, and physical characteristics. Working women's job satisfaction and corporate culture were also examined in relation to business jacket practices. Research data were collected by implementing mail surveys to 1,500 randomly selected working women in the United States. Of the 1,500 distributed questionnaires, a total of 312 were returned, of which 265 were deemed usable, yielding a 20.8% response rate. For data analysis, descriptive statistics, such as frequency, percentage distribution, mean scores, standard deviations, and Canonical Correlation were tabulated. The respondents ranged in age from 22 to 65. The mean age of the respondents was 44 years(SD=9.63). Most respondents were married(77.4%), working full-time(81.4%), career-oriented (77.2%), Caucasian(89.8%), had at least one child(78.9%), and had a professional job(75.9%). Working women's age, number of children, self-confidence in dressing, perceived importance of clothing, body frame size, and visibility to superiors and public were positively associated with business jacket practices, while age of first child, family size, dress size, and job satisfaction were negatively associated with business jacket practices.

Comparison of Nutritional Status of the Daejeon Metropolitan Citizens by Frequency of Eating Out (외식 빈도에 따른 대전시민의 영양상태 비교)

  • Suh, Yoon-Suk;Kang, Ji-Hyun;Kim, Han-Sook;Chung, Young-Jin
    • Journal of Nutrition and Health
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    • v.43 no.2
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    • pp.171-180
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    • 2010
  • This study aims at investigating the health and nutritional status of the adults according to frequency of eating out. One day food intake data were collected by 24 hr recall dietary survey and body size, blood pressure and some blood lipids and other constituents were measured on 137 Daejeon metropolitan citizens 20 yrs old and above who visited Chungnam National University Hospital for physical examination during the period of December 6, to December 15, 2008. The frequency of eating out were categorized into four levels: less than once a week, once a week, 2-3 times a week, 4 times a week and above. Body mass Index, waist circumference, blood pressure, blood lipid, blood glucose, GPT and GOT did not showed any significant difference according to the frequency of eating out of the subjects. Though, systolic blood pressures and serum levels of total cholesterol and LDL-cholesterol showed a little tendency to be high in the subjects eating out 2-3 times a week. In the contrary, serum triglyceride level tended to be low in the same group. The subjects eating out 4 times a week and over took more total protein, animal protein, animal fat, phosphorus and vitamin $B_2$ than any other group. Also protein energy ratio was the highest in the group eating out 4 times a week and above and they took more animal food group, other food group, beverages teas and alcohols than other groups eating out. These results showed that higher frequency of eating out leads to higher intake of protein, fat, phosphorus, animal food groups and other food groups (oils, beverages, seasonings) and to lower intake of vitamin C and plant food groups. It, thus, suggested that the strategy for restaurant business is required to provide the menu substituted animal food by more plant food.

Studies on Anisakis Type Larvae (Anisakis 형(型) 유충(幼蟲)에 관한 연구(硏究))

  • Lim, Jung Teck
    • Korean Journal of Veterinary Research
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    • v.15 no.2
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    • pp.293-307
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    • 1975
  • As it has been known recently that anisakis type larvae harbouring in marine fishes are a causal agent of zoonosis to human and probably to land living mammal animals, attention was focused on the study on the larvae in an aspect of epidemiology or epizootiology. The present work was conducted from 1966 to 1975 for i) survey on the harbouring status of anisakis type larvae in marine fishes of this country, ii) observation on the response to the experimental infestation of the larvae to the pigs, in the reason that they could well fetid raw fish viscera occasionally containing the larvae as a high protein source of swine food, and iii) observation on the larval resistance and response to vermicidal agents for the purpose of prevention of the larval infection to the mammal animals. The data obtained in the studies were summarized as follows: 1. In the survey on the status of larvae harbouring in main species of marine fishes of this country, 15 species, a total of 1,940 fishes, were observed and the result was summarized in table 2. Average number of larvae, in upper rank of 5 out of all 15 species of fishes, were as highest as 156 larvae ranging 74 to 450 in Pseudosciaena manchurica (chamjogi), 54.5 ranging 15 to 240 in Trichiurus haumela (kalchi), 35.6 ranging 8 to 112 in Trachurus japonica (junggengi), 30.6 ranging 4 to 65 in Parapristipama trilineatum (benjari) and 20.5 ranging 3 to 48 in Nibea argentata (boguchi) respectively. In morphological observation, size of the larvae in the fishes were varied, ranging from 2 to 32mm long, and a tendency to larger size and number of larvae in the fishes, which were wider sea migration, higher age and lager bodily size, was observed The favorite places harbouring the larvae in fishes were mainly around the intraperitoneal viscera such as mesentery, omentum, liver, pyloric suspensory, fat tissue and cloaca, and rarely in body muscles of fish. Fishes heartily infested with the larvae showed stunted growth decreased egg formation and severe damage of liver. 2. In the experimental infestation of the larvae to normal pigs, as illustrated in table 3, a group with large dose of larvae (a total of 1,800 larvae, 300 larvae Per dose, twice in a dart for 3 days) showed acute clinical syndrome terminatine death with a week course, whereas two groups with less dose of larvae (a total of 180~360 larvae, 10 larvae per dose, at 5 days interval for 70~180 days) showed subclinical syndrome with remarkably stunted growth as. much as approximately one half of body size in contest to the control pigs. In the pathological findings, a group with large dose of larvae showed macroscopically larvae penetrating to the gastric wall with severe gastroenteritis, and histopathologically various acute lesions caused by active larvae penetration into the wall of stomach and interstine, whereas two groups with less dose of larvae showed chronic lesions such as hypertrophy and verminous granulomatous swelling of gastric wall, suggesting strongly the possibility of natural infestation of larvae to swine. 3. In the resistance of the larvae to the chemical solutions, the larvae tolerated for 2 days in 15 percent solution of sodium chloride and acetic acid, and for 7 days in 70 percent solution of ethyl alcohol. In the resistance to the temperature, the larvae died within 1 second at $62^{\circ}C$ and tolerated for 24 hours at $-3^{\circ}C$, 12 hours $-5^{\circ}C$ respectively. 4. For the experiment on the vermicidal effect to larvae, general vermicidal drugs such as Neguvon, Combantrin, antimony Potassium, piperazine adipate and piperazine dihydrochloride, oxidizer such as potassium permanganate and potassium chlorate, and dyes such as gentian violet and crystal violet were used, and among them, as illustrated in table 6, potassium permanganate was proved as the best. In the successive test for the practical use of potassium permanganate, vermicidal effect in seawater solution of potassium permanganate and common-water solution of potassium permanganate were compared, and then retested by dipping the fish viscera including the larvae into the two different solutions of potassium permanganate. The result through these tests indicated that 0.01 percent common water and sea-water solution of potassium permanganate could be apparently recommended as a preventive vermicidal solution, having 90 to 100 percent vermicidal effect by dipping for 12 to 24 hours even though sea-water solution of potassium permanganate had a tendency to slightly less effect than the common-water solution of potassium permanganate (Table 8).

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Human Embryonic Stem Cell-derived Neuroectodermal Spheres Revealing Neural Precursor Cell Properties (인간 배아줄기세포 유래 신경전구세포의 특성 분석)

  • Han, Hyo-Won;Kim, Jang-Hwan;Kang, Man-Jong;Moon, Seong-Ju;Kang, Yong-Kook;Koo, Deog-Bon;Cho, Yee-Sook
    • Development and Reproduction
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    • v.12 no.1
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    • pp.87-95
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    • 2008
  • Neural stem/precursor derived from pluripotent human embryonic stem cells (hESCs) has considerable therapeutic potential due to their ability to generate various neural cells which can be used in cell-replacement therapies for neurodegenerative diseases. However, production of neural cells from hESCs remains technically very difficult. Understanding neural-tube like rosette characteristic neural precursor cells from hESCs may provide useful information to increase the efficiency of hESC neural differentiation. Generally, neural rosettes were derived from differentiating hEBs in attached culture system, however this is time-consuming and complicated. Here, we examined if neural rosettes could be formed in suspension culture system by bypassing attachment requirement. First, we tested whether the size of hESC clumps affected the formation of human embryonic bodies (hEBs) and neural differentiation. We confirmed that hEBs derived from $500{\times}500\;{\mu}m$ square sized hESC clumps were effectively differentiated into neural lineage than those of the other sizes. To induce the rosette formation, regular size hEBs were derived by incubation of hESC clumps($500{\times}500\;{\mu}m$) in EB medium for 1 wk in a suspended condition on low attachment culture dish and further incubated for additional $1{\sim}2$ wks in neuroectodermal sphere(NES)-culture medium. We observed the neural tube-like rosette structure from hEBs after $7{\sim}10$ days of differentiation. Their identity as a neural precursor cells was assessed by measuring their expressions of neural precursor markers(Vimentin, Nestin, MSI1, MSI2, Prominin-1, Pax6, Sox1, N-cadherin, Otx2, and Tuj1) by RT-PCR and immunofluorescence staining. We also confirmed that neural rosettes could be terminally differentiated into mature neural cell types by additional incubation for $2{\sim}6$ wks with NES medium without growth factors. Neuronal(Tuj1, MAP2, GABA) and glial($S100{\beta}$ and GFAP) markers were highly expressed after $2{\sim}3$ and 4 wks of incubation, respectively. Expression of oligodendrocyte markers O1 and CNPase was significantly increased after $5{\sim}6$ wks of incubation. Our results demonstrate that rosette forming neural precursor cells could be successfully derived from suspension culture system and that will not only help us understand the neural differentiation process of hESCs but also simplify the derivation process of neural precursors from hESCs.

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