• Journal of the Korea Society of Computer and Information
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• v.28 no.4
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• pp.121-131
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• 2023

The Chinese three northeastern three provinces - Heilongjiang, Liaoning, and Jilin - hold significant geographical, geopolitical, and commercial importance due to their location allowing for cross-border trade and transportation with North Korea. These provinces are crucial for establishing a complex Eurasian logistics network in line with South Korea's new northern policy. The Chinese three northeastern three provinces, as this region is known, boasts excellent maritime transportation links between South Korea, China, and North Korea, making it an logistics hub for transporting goods to Eurasia and Europe through multimodal transport. This study highlights the importance of securing a logistics hub area by fostering cooperation and friendly relations with China's three northeastern three provinces, which are crucial to the success of the New Northern Policy. In particular, the study aims to analyze current status of trade with these region and freight volume transported by ships and recommend political advice for securing logistics hub and revitalizing maritime transport. As the policy suggestion, this study is to establish a logistics hub by implementing joint port operations, constructing port infrastructure jointly, and operating shipping companies together. Additionally, we propose ways to revitalize the maritime passenger transport business between Korea and China, which involves expanding cultural exchanges and developing content.

• Journal of Satellite, Information and Communications
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• v.10 no.2
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• pp.102-108
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• 2015

In general, two way satellite communication systems based on TDMA(Time Division Multiple Access) require network clock synchronization between hub station and remote terminals. This paper describes basic concepts for network clock synchronization based on NCR(Network Clock Reference) clock recovery scheme as suggested in DVB-S2/ RCS2 international standards. in addition, a new NCR insertion method has been proposed and evaluated in terms of supporting CCM mode as well as ACM mode which optimizes throughput by changing code rates and modulation types ranging from QPSK to 32-APSK.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.8
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• pp.3681-3685
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• 2012

Background: In breast cancer, estrogen receptors have been demonstrated to interact with transcription factors to regulate target gene expression. However, high-throughput identification of the transcription regulation relationship between transcription factors and their target genes in response to estradiol is still in its infancy. Purpose: Thus, the objective of our study was to interpret the transcription regulation network of MCF7 breast cancer cells exposed to estradiol. Methods: In this work, GSE11352 microarray data were used to identify differentially expressed genes (DEGs). Results: Our results showed that the MYB (v-myb myeloblastosis viral oncogene homolog [avian]), PGR (progesterone receptor), and MYC (v-myc myelocytomatosis viral oncogene homolog [avian]) were hub nodes in our transcriptome network, which may interact with ER and, in turn, regulate target gene expression. MYB can up-regulate MCM3 (minichromosome maintenance 3) and MCM7 expression; PGR can suppress BCL2 (B-cell lymphoma 2) expression; MYC can inhibit TGFB2 (transforming growth factor, beta 2) expression. These genes are associated with breast cancer progression via cell cycling and the $TGF{\beta}$ signaling pathway. Conclusion: Analysis of transcriptional regulation may provide a better understanding of molecular mechanisms and clues to potential therapeutic targets in the treatment of breast cancer.

• Journal of the Korean Society of Safety
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• v.32 no.5
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• pp.88-95
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• 2017

As the safety fields are expanding to a variety of industrial fields, safety technology has been developed by convergence between industrial safety fields such as mechanics, ergonomics, electronics, chemistry, construction, and information science. As the technology convergence is facilitating recently advanced safety technology, it is important to explore the trends of safety technology for understanding which industrial technologies have been integrated thus far. For studying the trends of technology, the patent is considered one of the useful sources that has provided the ample information of new technology. The patent has been also used to identify the patterns of technology convergence through various quantitative methods. In this respect, this study aims to identify the convergence patterns and fields of safety technology using association rule mining(ARM)-based patent co-classification(co-class) analysis. The patent co-class data is especially useful for constructing convergence network between technological fields. Through linkages between technological fields, the core and hub classes of convergence network are explored to provide insight into the fields of safety technology. As the representative method for analyzing patent co-class network, the ARM is used to find the likelihood of co-occurrence of patent classes and the ARM network is presented to visualize the convergence network of safety technology. As a result, we find three major convergence fields of safety technology: working safety, medical safety, and vehicle safety.

• Journal of Institute of Control, Robotics and Systems
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• v.12 no.12
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• pp.1241-1248
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• 2006

In high reliability systems for industrial network such as railway signal system, fieldbus protocols have been known to satisfy the real-time and fault tolerant requirements. But, the application of fieldbus has been limited due to the high cost of hardware and software, and the difficulty in interfacing with multi-vendor products. Therefore, as an alternative to fieldbus, the computer network technology, especially Ethernet(IEEE 802.3), is being adapted to the industrial network. In this paper, we propose a switched Ethernet based railway signal system because of its very promising prospect for industrial application due to the elimination of uncertainties in the network operation. In addition, we propose the redundancy architecture for the reliability of network components. More specifically, this paper presents an analytical performance evaluation of switched Ethernet for railway signal system, and shows experimental evaluation of redundancy architecture.

• Parasites, Hosts and Diseases
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• v.58 no.5
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• pp.513-525
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• 2020

Clonorchis sinensis is a food-borne trematode that infects more than 15 million people. The liver fluke causes clonorchiasis and chronical cholangitis, and promotes cholangiocarcinoma. The underlying molecular pathogenesis occurring in the bile duct by the infection is little known. In this study, transcriptome profile in the bile ducts infected with C. sinensis were analyzed using microarray methods. Differentially expressed genes (DEGs) were 1,563 and 1,457 at 2 and 4 weeks after infection. Majority of the DEGs were temporally dysregulated at 2 weeks, but 519 DEGs showed monotonically changing expression patterns that formed seven distinct expression profiles. Protein-protein interaction (PPI) analysis of the DEG products revealed 5 sub-networks and 10 key hub proteins while weighted co-expression network analysis (WGCNA)-derived gene-gene interaction exhibited 16 co-expression modules and 13 key hub genes. The DEGs were significantly enriched in 16 Kyoto Encyclopedia of Genes and Genomes pathways, which were related to original systems, cellular process, environmental information processing, and human diseases. This study uncovered a global picture of gene expression profiles in the bile ducts infected with C. sinensis, and provided a set of potent predictive biomarkers for early diagnosis of clonorchiasis.

• Korean Management Science Review
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• v.34 no.2
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• pp.15-33
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• 2017

This paper considers a Bayesian Network analysis for understanding the heterogeneous cross-category effects of different promotion activities and developing an efficient overall promotion strategy for a large retail store. More specifically we differentiate price reduction promotion and floor promotion and study their heterogeneous effect on consumer purchase behavior under a market basket setting. We then utilize Bayesian networks in identifying complex association structure in market basket dataset by analyzing the effects of different promotional activities and also include the effects of time, family income and size. We find from our Bayesian network analysis that the dominant cross-category promotion effect of price promotion is the indirect effect whereas the dominant cross-category promotion effect of floor promotion is the direct effect. Also, among the demographic variables we find that family size of the household is linked with more product categories compared to income and see that there are differences in the extent of the effects by product category. Finally, we also show the existence of products acting as a network hub and how they can be utilized by retailers faced with a limited marketing budget and suggest a more efficient promotion strategy.

• Reproductive and Developmental Biology
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• v.37 no.4
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• pp.185-192
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• 2013

Many countries have implemented genetic evaluation for fertility traits in recent years. In particular, reproductive trait is a complex trait and need to require a system-level approach for identifying candidate genes related to the trait. To find the candidate gene associated with reproductive trait, we applied a weighted gene co-expression network analysis from expression value of bovine genes. We identified three co-expressed modules associated with reproductive trait from bovine microarray data. Hub genes (ZP4, FHL2 and EGR4) were determined in each module; they were topologically centered with statistically significant value in the gene co-expression network. We were able to find the highly co-expressed gene pairs with a correlation coefficient. Finally, the crucial functions of co-expressed modules were reported from functional enrichment analysis. We suggest that the network-based approach in livestock may an important method for analyzing the complex effects of candidate genes associated with economic traits like reproduction.

• Genomics & Informatics
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• v.19 no.1
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• pp.4.1-4.9
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• 2021

Lip and oral cavity cancer, which can occur in any part of the mouth, is the 11th most common type of cancer worldwide. The major obstacles to patients' survival are the poor prognosis, lack of specific biomarkers, and expensive therapeutic alternatives. This study aimed to identify the main genes and pathways associated with lip and oral cavity carcinoma using network analysis and to analyze its molecular mechanism and prognostic significance further. In this study, 472 genes causing lip and oral cavity carcinoma were retrieved from the DisGeNET database. A protein-protein interaction network was developed for network analysis using the STRING database. VEGFA, IL6, MAPK3, INS, TNF, MAPK8, MMP9, CXCL8, EGF, and PTGS2 were recognized as network hub genes using the maximum clique centrality algorithm available in cytoHubba, and nine potential drug candidates (ranibizumab, siltuximab, sulindac, pomalidomide, dexrazoxane, endostatin, pamidronic acid, cetuximab, and apricoxib) for lip and oral cavity cancer were identified from the DGIdb database. Gene enrichment analysis was also performed to identify the gene ontology categorization of cellular components, biological processes, molecular functions, and biological pathways. The genes identified in this study could furnish a new understanding of the underlying molecular mechanisms of carcinogenesis and provide more reliable biomarkers for early diagnosis, prognostication, and treatment of lip and oral cavity cancer.

• Journal of the Korean Professional Engineers Association
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• v.34 no.1
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• pp.14-22
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• 2001

Kimpo International Airport, located within the Seoul metropolitan district, experienced a sudden surge of passengers and cargo in recent years. In 1990, MOCT sponsored feasibility studios and Youngjong Island location was selected as the most suitable choice among four proposed sites to build a new airport. The construction work was then commenced in November 1992. Phase I project facilities are scheduled to start its operation in March 2001 with an annual capacity of 27 million passengers and 1.7 million tons of cargo for both enplaning and deplaning from International liners. Kimpo International Airport will remain in operation primarily for domestic passengers and cargo only. Phase II project construction work will add two more runways with its related facilities by 2005. Inchon International Airport will then conveniently serve 100 million passengers for enplaning and deplaning, and 7 million tons of inbound and outbound cargo annually in its full capacity. All the airport facilities In phase I and phase II periods are constructed to meet international standards. A fully integrated transportation network and logistics function systems should be accomplished prior to the full operation of the airport. With these sccomplishments, the state-of-the-art airport is poised to meet the needs of a rapidly growing worldwide air transport industry, and will more than adequately fulfill its role as a hub airport for the Northeast Asia region.