• 프린팅코리아
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• 제12권11호
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• pp.90-91
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• 2013

한국HP(대표 함기호, www.hp.co.kr)는 세계 최초 울트라북 워크스테이션인 HP ZBook 14와 업계 최초로 고속 데이터 전송 기술인 인텔 썬더볼트 및 최신 기능으로 무장한 워크스테이션 및 디스플레이를 포함한 Z시리즈 제품군을 공개했다. 이번에 선보인 Z시리즈는 매년 진행되는 HP 워크스테이션 솔루션 월드(HP Workstation Solution World)를 통해 공개됐으며, HP ZBook 모바일 워크스테이션 3종, 프로세서와 그래픽 성능이 향상된 HP Z데스크탑 워크스테이션 3종, 그리고 HP Z디스플레이(HP Z Displays) 신제품 2종이 포함됐다.

• 월간포장계
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• 통권199호
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• pp.62-65
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• 2009

• Clinical and Experimental Pediatrics
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• 제45권4호
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• pp.482-488
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• 2002

목 적 : 신속 요소분해효소 검사는 H. pylori 감염 진단에 있어서 위내시경 검사가 시행되는 병원에서 우선적으로 시행되는 검사이다. 또한 위내시경상 검사상 결절성 위염을 보이는 경우 H. pylori 감염 빈도 가 높은 것으로 알려져 있다. 본 연구에서는 위내시경 소견인 결절성 위염의 진단적 의의와 신속 요소분해 효소 검사인 CLO 및 HpKit 검사의 양성 반응 시간별 검출률을 전향적으로 비교 분석하였다. 방 법: 1999년 7월부터 2000년 5월까지 연세대학교 세브란스병원 소아과에서 상복부 동통을 주소로 위내시경 검사를 시행받은 환아 212례를 대상으로 위전정부, 위체부에서 각각 3회씩 조직 생검을 시행하였고 각각 1조각씩 CLO 검사, HpKit 검사 및 조직 검사에 이용하였다. CLO 및 HpKit 검사는 생검조직의 양성 반응 시간을 각각 15분, 30분, 1시간, 2시간, 3시간, 24시간에 따라 나누어 판독하였고, 24시간 이후는 CLO 검사의 경우 6일째까지, HpKit 검사의 경우 5일째까지 판독하였다. 생검 조직의 Hematoxylineeosin 염색 또는 Alcian-yellow 염색을 기준지표로 하여 결절성 위염, CLO 및 HpKit 검사의 예민도, 특이도, 양성기대치 및 음성기대치를 구하였다. 결 과: 일반적 판정 기준 시간인 3시간째 판정한 CLO 검사의 진단적 예민도는 68.4%, 특이도는 100%였고, HpKit 검사는 위전정부 및 위체부에서 시행한 경우 진단 예민도는 모두 65.8%, 특이도는 100%였으며, CLO 및 HpKit 검사의 예민도와 특이도 사이에 유의한 차이는 없었다(P>0.05). CLO 검사와 HpKit 검사에서 검체와의 반응 후 시간 경과에 따른 양성률은 CLO 검사의 경우 24시간 경과시에는 예민도와 특이도가 각각 73.7% 및 99.4%로 특이도에 큰 변화 없이 예민도가 점차 증가하였고, 144시간(6일)째에도 특이도는 94.8%로 다소 감소하였으나 예민도는 89.5%로 3시간이나 24시간째와 비교하여 현저히 높아짐을 알 수 있었다. HpKit 검사는 위전정부의 경우(HpKit-A) 24시간 경과시 예민도는 68.4%로 3시간 경과시에 비하여 3% 정도 증가하였으나 특이도는 91.4%로 9% 정도 감소하였고, 120시간(5일) 경과시는 예민도는 86.8%로 증가하였으나 특이도는 59.2%로 현저히 감소하였다. 위체부의 경우(HpKit-B) 24시간 경과시 예민도는 3시간 경과시에 비하여 65.8%로 변화가 없었으나 특이도는 97.1%로 3% 정도 감소하였고, 120시간(5일) 경과시는 예민도는 84.2%로 증가하였으나 특이도는 77.0%로 현저히 감소하였다. 또한 24시간 경과시 위전정부와 위체부의 예민도는 각각 68.4% 및 65.8%로 비슷하였으나 특이도는 각각 91.4% 및 97.1%로 위체부의 특이도가 전정부보다 높았다. 내시경 소견상 결절성 위염의 H. pylori 감염의 예민도와 특이도는 각각 78.9% 및 93.7%로 CLO 검사 및 HpKit 검사보다 예민도는 더 높고 특이도는 비슷하였다. 결 론: CLO 검사와 HpKit 검사는 3시간 이내에 신속히 판정을 요구하는 경우 매우 예민하고 특이도가 우수한 검사 방법이나 소아의 경우 3시간째의 예민도가 너무 낮기 때문에 CLO 검사는 6일 지나서 판정함으로서 높은 예민도를 이용할 수 있을 것으로 생각된다. 또한 결절성 위염의 위내시경 소견은 신속 요소분해효소 검사가 유용하지 않을 경우 H. pylori 감염을 진단할 수 있는 좋은 지표가 될 것으로 사료된다.

• Journal of Microbiology and Biotechnology
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• 제32권2호
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• pp.170-175
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• 2022

3-Hydroxypropionic acid (3HP) is a platform chemical and can be converted into other valuable C3-based chemicals. Because a large amount of glycerol is produced as a by-product in the biodiesel industry, glycerol is an attractive carbon source in the biological production of 3HP. Although eight 3HP-producing aldehyde dehydrogenases (ALDHs) have been reported so far, the low conversion rate from 3-hydroxypropionaldehyde (3HPA) to 3HP using these enzymes is still a bottleneck for the production of 3HP. In this study, we elucidated the substrate binding modes of the eight 3HP-producing ALDHs through bioinformatic and structural analysis of these enzymes and selected protein engineering targets for developing enzymes with enhanced enzymatic activity against 3HPA. Among ten AbKGSADH variants we tested, three variants with replacement at the Arg281 site of AbKGSADH showed enhanced enzymatic activities. In particular, the AbKGSADH^R281Y variant exhibited improved catalytic efficiency by 2.5-fold compared with the wild type.

• Molecules and Cells
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• 제26권3호
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• pp.217-227
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• 2008

Heterochromatin protein 1 (HP1) was first described in Drosophila melanogaster as a heterochromatin associated protein with dose-dependent effect on gene silencing. The HP1 family is evolutionarily highly conserved and there are multiple members within the same species. The multi-functionality of HP1 reflects its ability to interact with diverse nuclear proteins, ranging from histones and transcriptional co-repressors to cohesion and DNA replication factors. As its name suggests, HP1 is well-known as a silencing protein found at pericentromeres and telomeres. In contrast to previous views that heterochromatin is transcriptionally inactive; noncoding RNAs transcribed from heterochromatic DNA repeats regulates the assembly and function of heterochromatin ranging from fission yeast to animals. Moreover, more recent progress has shed light on the paradoxical properties of HP1 in the nucleus and has revealed, unexpectedly, its existence in the euchromatin. Therefore, HP1 proteins might participate in both transcription repression in heterochromatin and euchromatin.

• 한국초지조사료학회지
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• 제15권3호
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• pp.222-230
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• 1995

This study was canied out to ddermine optimum areas for various sizes of land coverage of the farm machinery utilization in 1993-1994. A kind of machinery size and work systems were classed as the power tiller of 10HP+man power, the tractor of 35~46HP (tractor of 64~86HP and attachment were leased to harvest work), 64-86HP+ attachment and 90- 105HP+ attachment, respectively. \ulcornerhe results are summarized as follows: 1. The optimum areas of tractors of 90~105HP, 64~86HP and the power tiller of lOHP were estimated as 21.9 (corn-rye cropping system)- 26.9ha (sorghum $\times$ sudangrass - rye cropping system), 14.7 - 22.8ha and 1.2 - 1.61ha, respectively. The break-even-point areas of the tractors of 90-105HP. 64-86HP and the power tiller of lOHP were 16.6 (corn-rye cropping system)- 19.9ha (sorghum $\times$ sudangrass - rye cropping system), 12.5 - 16.lha and 0.12-0.13ha, respectively. 2. The optimum areas (land sizes, annual field capacity) for 50 cows by feeding rate(%) of roughage to concentrate were 6.8ha, 13.6ha in the 4060, 8.5ha, 17.0ha in the 5050 and 10.2ha, 20.4ha in the 60:40, and in case of 30 cows, it were 4.lha, 8.2ha in the 40:60, respectively. In the former case for the form of work system was the trador of 90-105HP+attachment and 64~86HP+ attachment, and the latter was the tractor of 35~46HP (tractor of 64~86HP and attachment were leased to harvest work) and 64-86HP+ attachment. 3. Productiori cost for corn-rye cropping system reducted to 51.8% in 102.9 wonkg dry matter the tractor of 90~ 105HP+ attachment with 213.4 wonkg dry matter the power tiller of 10HP+ man power.

• Journal of Acupuncture Research
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• 제32권1호
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• pp.23-36
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• 2015

Objectives : This study was designed to investigate the neuroprotective effects of Hominis-Placenta (HP)on dopaminergic neurons. Methods : We examined the effect of invitro administration of HP against 1-methyl-4-phenylpyridinium( MPP+)-induced dopaminergic cell loss in primary mesencephalic culture and also used behavioral tests and performed analysis in the striatum and the substantia nigra of mouse brain, to confirm the effect of HP on dopaminergic neurons in an invivo 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)-induced PD mouse model. Animals were assigned to four groups: (1) Group 1(vehicle-treatedgroup), (2) Group 2(MPTPonlytreated group), (3) Group 3(MPTP+ saline-treated/$ST_{36}$ group), and (4) Group 4(MPTP+HP-treated/$ST_{36}$ group). HP at $20{\mu}L$ of 48 mg/kg dose was injected at $ST_{36}$ for 4 weeks at 2-day intervals. MPTP in saline was injected intraperitoneally each day for 5 days from the $8_{th}$ treatment of HP. We performed the pole test and rota-rod test on the first and seventh day after the last MPTP injection. To investigate the effect of HP on dopaminergic neurons, we performed analysis in the striatum and the substantia nigra of mouse brain after treatment with HP and/or MPTP. Results : Treatment with HP had no influence on cell proliferation and caused no cell toxicity in $PC_{12}$ and $HT_{22}$ cells. Our study showed that HP significantly prevented cell loss and protected neurites against MPP+ toxicity. Although the invivo treatment of HP herbal acupuncture at $ST_{36}$ showed a tendency to improve movement ability and protected dopaminergic cells and fibers in the substantia nigra and the striatum, it did not show significant changes compared with the MPTP treated group. Conclusions : These data suggest that HP could be a potential treatment strategy in neurodegenerative diseases such as Parkinson's disease.

• International Journal of Industrial Entomology and Biomaterials
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• 제8권1호
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• pp.117-121
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• 2004

Soluble proteins of silkworm hemolymph were investigated by means of isoelectric focusing (IEF). The protein spectra during ontogenesis of races and inter-races hybrids kept in Bulgaria was studied. A total of 51 protein bands in the hemolymph from fourth larval instar to imago were ascertained. Stage specific expression was established. The specific expression of some protein bands in the individual spectra manifest phenotype of gene determinate polymorphism (HP F, HP J, HP K, HP L, HP Q - in the zone with pH gradient 3.5-6.2 and HP K, HP L, HP N, HP P, HP T - in the zone with pH gradient 9.5 - 6.2). Breed specific expression was observed. On the basis of the obtained results, it was established that the investigated breeds are heterogeneous and the isoelectric focusing method is successful when specifying the inner-race and inter-race polymorphism in silkworm.

• Journal of Pharmaceutical Investigation
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• 제23권3호
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• pp.165-177
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• 1993

The relationship between the plasma haloperidol (HP) concentration and clinical response, and the effects of its active metabolite, reduced haloperidol (RH) on clinical response of HP were investigated in schizophrenic patients. In clinical study I, with 17 schizophrenic patients (male 8, fermale 9) who were administered with three different fixed doses of HP (15, 30 and 50 mg/day) for 3 weeks, the concentrations of HP and RH in plasma and blood and clinical response had been checked before and every week during the study. The clinical response was evaluated by the method of brief psychiatric rating scale (BPRS), and relative improvement of clinical response based on baseline BPRS (before drug treatment) was calculated. The concentrations of HP and RH in plasma and blood were assayed by HPLC. In clinical study II, the plasma RH/HP concentration ratios were checked in 11 patients who were administered with high doses of HP, over 60 mg a day, because of the poor clinical response at usual doses of HP. Plasma HP concentration and relative improvement of BPRS at 3 week in schizophrenic patients showed a 'curvilinear' relationship, and the clinical response was improved relatively over 50% based on the baseline BPRS in the range of $5{\sim}57\;ng/ml $ of HP in plasma. Also, the plasma RH concentrations were increased nonlinearly as the plasma HP concentration increased, and in high plasma HP concentration, over 30 ng/mI, clinical response gradually decreased, while the plasma RH/HP concentration ratio increased nonlinearly. Blood partition coefficients of HP and RH were not changed according to daily HP dose and duration of drug therapy. From these results, it is noted that the higher plasma RH/HP concentration ratio, resulted from the accumulation of RH as HP concentration increased, might explain the 'curvilinear' decrease of HP clinical response.

• Journal of Animal Science and Technology
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• 제50권1호
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• pp.133-144
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• 2008

미트패티 제품에 열풍건조 단감분말(HP)과 동결건조 단감분말(FP)을 각각 3%(HP-3%, FP- 3%)와 6%(HP-6%, FP-6%)를 첨가하여 제조한 후 폴리비닐랩으로 포장한 후 4℃에 저장하였다. 수분함량은 대조구와 HP-3%가 다른 처리구에 비하여 유의적으로 높았으며(p<0.05), 조단백질 함량은 FP-6%, 조지방 함량은 FP-3% 처리구가 다른 처리구에 비하여 높았으며, 조회분 함량은 유의적인 차이가 없었다(p>0.05). 저장기간이 경과함에 따라 pH, L* 및 a*값은 모든 처리구에서, 보수력은 CTL와 HP-6%, 가열감량은 HP-3%에서 유의적으로 감소하였다(p< 0.05). 미트패티의 직경과 두께는 저장기간이 경과함에 따라 감소하였다. VBN은 저장기간이 경과함에 따라 모든 제품에서 증가하였다(p<0.05). 처리구들의 TBARS는 저장 전 기간 동안 CTL보다 유의적으로 높았다(p<0.05). 저장 8일까지 총균수는 4.61 log10 CFU/g 수준을 유지하였다. 관능검사결과, 향과 풍미, 육색 및 전체적인 기호도는 처리구가 더 좋은 점수를 얻었다(p<0.05).