• Asian Pacific Journal of Cancer Prevention
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• v.13 no.2
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• pp.463-467
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• 2012

Purpose: To assess the safety and efficacy of a gemcitabine plus docetaxel regimen as a second line therapy for patients with advanced soft tissue sarcoma (STS) resistant to doxorubicin and ifosfamide-based therapy. Patients and Methods: Medical records of 64 patients with advanced STS who received gemcitabine plus docetaxel regimen as a second line treatment between May 2006 and June 2011 were examined. All patients had been previously treated with doxorubicin plus ifosfamide-based regimen at first line setting. Patients received gemcitabine 900 $mg/m^2$ on days one and eight intravenously over 90 minutes, followed by docetaxel 75 $mg/m^2$ on day eight intravenously over one hour. Cycles were repeated every 3 weeks. Results: The male-to-female ratio was 37/27 and the median age was 44 years (range; 19-67 years). Objective responses were observed in 13 (20.3 %) patients (2 CR, 11 PR) and stable disease in 21 (32.8 %). Total clinical benefit (CR+PR+SD) was observed in 34 (53.1 %). Median overall survival (OS) was 18 months (95% confidence interval (CI):12.1-23.9) and Median time to progression (TTP) was 4.8 months (95% CI: 3.6-6). A total of 243 cycles of chemotherapy were administered. The median number of cycle was 3 (range;1-11). The most common grade 3-4 hematologic toxicity was neutropenia (35.9 %). The most common nonhematologic toxicities consisted of nausea/vomiting (37.5 %), mucositis (32.8 %), peripheral neuropathy (29.7%), and fatigue (26 %). There was no toxicity-related death. Conclusion: The combination of gemcitabine plus docetaxel is an active and tolerable regimen as a second line therapy for patients with advanced soft tissue sarcoma who have failed doxorubicin and ifosfamide-based therapy.

• Journal of Digital Convergence
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• v.18 no.12
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• pp.267-278
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• 2020

ESS is an essential requirement for resolving power shortages and power demand management and promoting renewable energy at a time when the energy paradigm changes. In this paper, we propose a cost-effective ESS Peak-Shaving operation plan through load and solar power generation forecast. For the ESS operation plan, electric load and solar power generation were predicted through RMS, which is a statistical measure, and a target load reduction guideline for one hour was set through the predicted electric load and solar power generation amount. The load and solar power generation amount from May 6th to 10th, 2019 was predicted by simulation of load and photovoltaic power generation using real data of the target customer for one year, and an hourly guideline was set. The average error rate for predicting load was 7.12%, and the average error rate for predicting solar power generation amount was 10.57%. Through the ESS operation plan, it was confirmed that the hourly guide-line suggested in this paper contributed to the peak-shaving maximization of customers.Through the results of this paper, it is expected that future energy problems can be reduced by minimizing environmental problems caused by fossil energy in connection with solar power and utilizing new and renewable energy to the maximum.

• Journal of Acupuncture Research
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• v.28 no.3
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• pp.55-71
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• 2011

Objectives : The purposes of this preliminary study was to examine the feasibility of recruiting women into a clinical trial designed to examine the effects of acupuncture in treating urinary incontinence (UI) in premenopausal women with delivery history and the feasibility of performing the study procedures. We also tried to determine if there was preliminary evidence to suggest that acupuncture may be effective in reducing UI and improving disease-specific quality of life. Methods : This study was a pragmatic randomized clinical trial. Subjects between the ages of 20 and 49 years were randomly assigned to a treatment(n=11) or control group(n=11) and analyzed. Both groups were supposed to do Kegel exercise at home during 4 weeks and acupuncture was applied to the treatment group twice a week(8 sessions) additionally. Subjects performed 1 hour pad test and completed a 3-day urination diary, international consultation on incontinence modular questionnaire(ICIQ), and incontinence - quality of life(I-QOL) at base line and 5 weeks. Results : Both group showed improvement in 1 hour pad test and the reducing amount of UI was significantly larger in treatment group(p=0.0182). The significant improvements in ICIQ and I-QOL were also observed in treatment group and sustained until the follow-up measurement at 16 weeks. Any adverse reaction related to acupuncture did not happen. Conclusions : It was feasible to recruit subjects and perform the study procedures. The positive results of this study support the requirement for additional research investigating the efficacy of acupuncture in the treatment of UI in women.

• Proceedings of the Materials Research Society of Korea Conference
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• 2011.05a
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• pp.41.2-41.2
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• 2011

Recently, scaling down of ULSI (Ultra Large Scale Integration) circuit of CMOS (Complementary Metal Oxide Semiconductor) based electronic devices become much faster speed and smaller size than ever before. However, very narrow interconnect line width causes some drawbacks. For example, deposition of conformal and thin barrier is not easy moreover metallization process needs deposition of diffusion barrier and glue layer. Therefore, there is not enough space for copper filling process. In order to overcome these negative effects, simple process of copper metallization is required. In this research, Cu-V thin alloy film was formed by using RF magnetron sputter deposition system. Cu-V alloy film was deposited on the plane $SiO_2$/Si bi-layer substrate with smooth and uniform surface. Cu-V film thickness was about 50 nm. Cu-V layer was deposited at RT, 100, 150, 200, and $250^{\circ}C$. XRD, AFM, Hall measurement system, and XPS were used to analyze Cu-V thin film. For the barrier formation, Cu-V film was annealed at 200, 300, 400, 500, and $600^{\circ}C$ (1 hour). As a result, V-based thin interlayer between Cu-V film and $SiO_2$ dielectric layer was formed by itself with annealing. Thin interlayer was confirmed by TEM (Transmission Electron Microscope) analysis. Barrier thermal stability was tested with I-V (for measuring leakage current) and XRD analysis after 300, 400, 500, 600, and $700^{\circ}C$ (12 hour) annealing. With this research, over $500^{\circ}C$ annealed barrier has large leakage current. However V-based diffusion barrier annealed at $400^{\circ}C$ has good thermal stability. Thus, thermal stability of vanadium-based thin interlayer as diffusion barrier is good for copper interconnection.

• The Journal of Engineering Geology
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• v.23 no.3
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• pp.271-281
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• 2013

Freeze-thaw experiments were conducted to evaluate changes in surface roughness and physical properties in samples of granite from Ilgwang and Imki mines, Korea. The temperature range in the experiments was $-20^{\circ}C$ to $40^{\circ}C$, based on typical summer and winter temperatures in Korea, and the surface was observed every 20 cycles. One cycle comprised 1 hour of heating or cooling of the samples and 1 hour during which the target temperature was maintained. With increasing repetitions of the freeze-thaw experiment, porosity increased by 0.05%-0.15% in the two samples and the dry weight increased, whereas the volume of the soil and saturation weight decreased. Observations by confocal laser scanning microscope (CLSM) revealed that line and surface roughness parameters showed a tendency to increase and decrease, respectively, with elapsed time. Changes in surface roughness were apparent on the CLSM images.

• Journal of the Korean Society for Railway
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• v.12 no.5
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• pp.700-706
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• 2009

Unlike high-speed KTX trains and dual track railways, most single-track railways are not popular among passengers because of long travel hours. As a solution to the problem, tilting trains will be deployed along the conventional line. Tilting train has a mechanism that enables increased speed on regular and curved railway tracks. As a train rounds a curve at speed, objects inside the train experience centrifugal force. This can cause packages to slide about or seated passengers to feel squashed by the outboard armrest due to its centripetal force, and standing passengers to lose their balance. Tilting trains possess a top speed of up to 180 km per hour as opposed to the previous 140 km per hour, so allow the train to pass curve at higher speed without affecting passenger comfort. This paper describes the methodology study to estimate the benefits, especially on the extra benefits in case of tilting actuation.

• KSBB Journal
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• v.23 no.4
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• pp.317-322
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• 2008

The Biochemical Oxygen Demand(BOD) is one of important parameters for the most widely used method of organic pollution in wastewater and wastewater treatment effluent. As the conventional BOD test needs 5-day long incubation period, it is thus incompatible with real time control of wastewater treatment plant. To resolve this problem, in the present study an on-line Dissolved Oxygen(DO) monitoring system was used to observe the transient change of dissolved oxygen concentration in livestock wastewater. The system was composed of BOD sensor, amplifier and computer. It was observed that the concentration of the microorganism in the livestock wastewater was relatively constant during the growth period of initial one hour, which allowed the assumption of the constant Oxygen Uptake Rate(OUR) within one hour of measurement. It was thus concluded that the present scheme provided a protocol for automatic measurement of BOD in livestock wastewater, which can be applicable to optimal control of livestock wastewater treatment plant.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.26 no.2
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• pp.143-150
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• 1990

A cooperative Korea-Japan investigation for the demersal fisheries resources of the East China Sea was carried out by using the training ship Oshoro Maru belong to Hokkaido University Japan, during 5-12 November, 1989. The research vessel sampled 24 stations with demersal trawls on the East China Sea continental shelf, and 96 nautical miles of track line were surveyed hydroacoustically. The echo sounder used during the survey was of a scientific type having echo integration capabilities and the computer system was programmed to obtain echo integration data for each depth stratum between the transducer and the bottom. The target strength of fish school(TS per 1kg) was estimated from the relationship between mean volume backscattering strength and catches caught by the demersal trawls. The results obtained can be summarized as follows: 1. Approximately 96 species were identified from survey catches. 2. The mean volume backscattering strength for the layer occupied by bottom trawls at 25 and 100 KHz were-63.9 dB and -67.3 dB, respectively. Then the average catch per unit time of each trawl haul was 58.8 kg/hour. 3. The mean volume backscattering strength for the entire layer between the transducer and the bottom at 25 and 100KHz were -61.9 dB and -67.0 dB, respectively. 4. The mean fish school target strength per unit weight(TS/kg) at 25 and 100 KHz were -23.6 dB/kg and -26.6 dB/kg, respectively.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.40 no.1
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• pp.1-8
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• 2004

The single line hook fishery for giant pacific octopus, Parotopus dofleini is one of the important in coastal Kangwon-do of Korea, where was caught an average of 4,000 ton during the period of 1996~2000. The fishing gear is consisted of a single buoy line, a buoy and a hook. In this study, the responses of giant pacific octopus to single line hook gear were examined in an experimental tank using a video camera in order to know hooking mechanism and improve hook. Giant pacific octopus tend to envelop the bait with their arms by rush or slowly swimming towards it. When they rush to the bait, they show much feeding behaviour as withdrawing after enveloping the bait using two arms. But when they approach with slowly swimming to bait, they show feeding behaviour as stopping after enveloping the bait using one arm. and then, the highly hooking rate appeared more often in the case of latter then former. The average feeding time on a sardine, giant pacific octopus and pork fat showed the range of 1 to 30 min, 10 to 50 min, and 50 min to over 1 hour, respectively. This indicates that it takes longer time for giant pacific octopus to eat the tough meat than the soft meat. The performance concerned with hooking showed that the 'B' type hook with a short shank was more favorable than the 'A' type hook with a long shank. However, the 'A' type hook has the advantage of easy dropping out caught octopus, compared to the 'B' type.

• The Journal of the Korea Contents Association
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• v.15 no.12
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• pp.153-164
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• 2015

This research focuses on analyzing how leisure satisfaction of line dance participating middle-aged and old women impacts on self esteem and quality of life. By identifying the relationship between these factors, benefit of line dancing by middle-aged and old women will be confirmed. The result of this study are as follows. First, group participating in 2 hour class of line dancing had highest leisure satisfaction. Secondly, in analyzing the effect of leisure satisfaction on self-esteem, health factor was the only sub-factor of leisure satisfaction to impact self-esteem. Thirdly, in analyzing the effect of leisure satisfaction on quality of life, health factor was the only sub-factor of leisure satisfaction to have effect on quality of life sub-factors, such as daily life satisfaction, emotional satisfaction, and environmental satisfaction. Fourthly, self-esteem also directly affects quality of life. Since health factor of leisure satisfaction directly affected self-esteem and quality of life, a causal relationship can be seen between the three variables: leisure satisfaction, self-esteem, and life quality.