• STI Policy Review
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• 제5권2호
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• pp.1-19
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• 2014

The concept of a holistic innovation policy is defined in this article, with discussions of what it is, why it is relevant, and how it can be implemented to enhance product innovation. It is shown that the innovation systems approach has diffused rapidly during the latest decades and has completely replaced the linear view in the field of innovation research. The majority of European countries are striving in the direction of developing a more holistic innovation policy. However, it is concluded that the innovation policies in European countries are still dominantly linear despite the fact that holistic policy seems to be the driving vision. Innovation policy is behindhand. Why innovation policy is still linear is also preliminarily discussed. Policymakers attending conferences on innovation are practically always in favor of holistic (systemic, broad-based, comprehensive, etc) innovation policies, have abandoned the linear view by learning from innovation research. The division between "linear" and "holistic" seems to be located within the community where innovation policies are designed and implemented, a community composed of policymakers (administrators/bureaucrats) and elected politicians. Perhaps the dividing line is between these two groups in that politicians, who actually make the decisions, may still reflexively believe in the linear view. Nevertheless, there seems to be a failure in communication between researchers and politicians in the field of innovation and there is therefore a strong need to involve innovation researchers in policy design and implementation to a much higher degree. Another way to increase the degree of holism could be to separate innovation policy from research policy, since their integration tends to cement the linear character of innovation policy. The empirical results are based on a questionnaire sent to twenty-three EU Member States, out of which nineteen (83%) responded. Part of the work for this article was carried out for the European Research and Innovation Area Committee (ERAC) of the European Commission (DG RTD).

• International Journal of Advanced Culture Technology
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• 제7권1호
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• pp.155-161
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• 2019

This study was to identify the effects of home visit intervention program for Holistic Healthcare of multi-culture Couples. It used a non-equivalent control group pretest-posttest design quasi-experimental research. The subjects of this study consist of 20 couples for experimental and control groups. Multi-cultural couples comprised of foreign women married to Korean men in farm and fishery areas. The research tools were used stress index by SA-3000P (Medicare co. Ltd. KOREA), Center for Epidemiologic Studies-Depression Scale (CES-D), and World Health Organization Quality of Life (WHOQOL-Bref). The experimental group of the wives had lower stress index than the control group, the experimental group of the husband showed lower stress index than the control group, (t=-3.14, p=.002). The wife (t=-3.75, p=.001) and husband (t=-4.20, p=.001) of the experimental group showed lower depression scores than the control group. Both the wife (t=3.86, p=.001) and husband (t=5.28, p=.001) showed higher scores for quality of life compared to the control group. It was found that this holistic healthcare home visit program is an effective program to make improvements on stress, depression and quality of life for multi-cultural couples. Therefore, as the intervention program developed in this study is home visits for the holistic health of multi-cultural couples, and it is judged that it can be implemented at the local social health centers or healthcare centers.

• 한국공간구조학회:학술대회논문집
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• 한국공간구조학회 2005년도 춘계학술발표회 및 정기총회 2권1호(통권2호)
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• pp.52-66
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• 2005

Tension and Membrane have the potential to enable the realization of lightweight structures that have the attractive features of structures efficiency and aesthetical expression. Compared with pure (thorough-bred) tension structures such as cable net, air dome and tensegrity, so called hybrid tension structures such as beam string, tensegric system and other mixed structures have Potential still to be realized. After synnaruzubg the simple definition of tensegric structure, some holistic designs for hybrid tension structures completed recently in the author's practice are given.

• Advances in Traditional Medicine
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• 제4권3호
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• pp.137-156
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• 2004

Altruistic virtuous caring, possibly originated from religion and/or spirituality, is indispensable for holistic health through channeling vital energy with diet, exercise and meditation. This is a participant-observed medical anthropological research of a first generation Korean elderly immigrant health professional woman living in a four generational family. She had hypertension and was concerned about possible attack of stroke. Multi-religious, spiritual, and cosmological vital energy based on holistic Nature-oriented health beliefs and practices influenced by psychosocial, cultural and economic background, education, self- discipline and self-cultivation of individual, and group or family may create health. Self-care beliefs based on confidence in self-control of one's life style for oneself and others influence individual and group health practice. The holistic alternative health beliefs and practices were proved to be efficacious and beneficial by her self-evaluation, evaluation of significant others, biomedical professionals, and laboratory tests. That may have potential application for global health.

• 성인간호학회지
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• 제28권5호
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• pp.501-513
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• 2016

Purpose: The purpose of this study was to identify attitudes of male baby boomer toward holistic health using Q-methodology. Methods: Q-methodology is analysed through the subjectivity of each type of attitudes. Thirty-five q-statements were selected from a total of 145 statements. These statements were categorized into six areas (Physical, psychological, spiritual, work and leisure, love and friendship, culture). The recruited P-sample consisted of thirty-four male baby boomers from one town and two cities. The 35 selected Q-statements from each of 35 participants were classified into the shape of a normal distribution using a 9-point scale. The collected data were analysed using the PQMethod Program 2.11. Results: Four types of male baby boomer attitudes towards holistic health were identified. The first is a relationship oriented-marital relationship oriented type, the second type is an economic oriented- job seeking type, the third type is a nature friendly oriented-independent living type, and the fourth type is health oriented-physical health seeking type. Conclusion: The results of this study indicated that different approaches to holistic health promotion program could be developed based on the four types of holistic health attitudes among baby boom generation males in Korea.

• 한국정보전자통신기술학회논문지
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• 제9권1호
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• pp.58-66
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• 2016

본 연구에서는 자연치유와 전인적 의학으로서의 단식요법에 대하여 고찰하고자 한다. 연구방법으로는 종교사상에서 나타난 단식의 역사와 의의를 찾아 문헌적으로 고찰하였으며, 단식이 심신치유에 적용된 사례를 연구, 분석하였다. 연구결과 첫째, 단식은 종교사상에서 정신적인 중대한 역할을 함으로 단식행위가 인간의 삶에서 정신적으로 미치는 영향력이 큰 것으로 나타났다. 둘째, 단식은 인간의 심신을 치유하는 수단으로서 오랜 과거로부터 오늘날에까지 이어져 내려오는 자연치유적 의료행위로 중대한 역할을 하고 있는 것으로 나타났다. 결과적으로 단식요법은 자연치유적 방법에 의한 전인적 의학으로서 중요한 가치를 가진다는 점을 알 수 있었다. 본 연구의 시사점은 단식요법을 통해 현대사회에 각종 질병의 요인으로 작용하는 스트레스성 질병과 생활습관성 만성질환에 대하여 전인적 의학 차원에서의 효율적 치유의 방향과 근거를 제시하는데 기초 자료가 될 것으로 사료된다.

• Journal of Ginseng Research
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• 제45권4호
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• pp.465-472
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• 2021

Background: Ginseng can help regulate brain excitability, promote learning and memory, and resist cerebral ischemia in the central nervous system. Ginsenosides are the major effective compounds of Ginseng, but their protein targets in the brain have not been determined. Methods: We screened proteins that interact with the main components of ginseng (ginsenosides) by affinity chromatography and identified the 14-3-3 ζ protein as a potential target of ginsenosides in brain tissues. Results: Biolayer interferometry (BLI) analysis showed that 20(S)-protopanaxadiol (PPD), a ginseng saponin metabolite, exhibited the highest direct interaction to the 14-3-3 ζ protein. Subsequently, BLI kinetics analysis and isothermal titration calorimetry (ITC) assay showed that PPD specifically bound to the 14-3-3 ζ protein. The cocrystal structure of the 14-3-3 ζ protein-PPD complex showed that the main interactions occurred between the residues R56, R127, and Y128 of the 14-3-3 ζ protein and a portion of PPD. Moreover, mutating any of the above residues resulted in a significant decrease of affinity between PPD and the 14-3-3 ζ protein. Conclusion: Our results indicate the 14-3-3 ζ protein is the target of PPD, a ginsenoside metabolite. Crystallographic and mutagenesis studies suggest a direct interaction between PPD and the 14-3-3 ζ protein. This finding can help in the development of small-molecular compounds that bind to the 14-3-3 ζ protein on the basis of the structure of dammarane-type triterpenoid.

• 한국심리학회지 : 문화 및 사회문제
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• 제29권2호
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• pp.253-273
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• 2023

본 연구는 문화적 특성 중 하나인 분석적-종합적 사고 양식이 고의성 판단에 어떠한 영향을 미치는지, 그 과정에서 범죄 사건의 전형성이 어떠한 역할을 하는지 확인하기 위해 수행되었다. 이를 위해, 사건 가해자 및 피해자의 도덕적 특성을 바탕으로 범죄의 전형성을 다르게 조작한 사건에서 고의성 판단의 심리적 기제를 확인하였다. 연구 결과, 사람들은 범죄 사건의 전형성이 높을수록 고의성을 높게 판단하였다. 또한, 상대적으로 종합적 사고 양식을 보이는(그리고 인과성과 변화 인식이 높은) 사람들은 사건 가해자의 고의성을 낮게 판단하는 것으로 나타났다. 특히, 분석적-종합적 사고 양식은 범죄의 전형성과 상호작용하여 고의성 판단에 영향을 미친다는 것을 확인하였다. 구체적으로 종합적 사고를 하는(그리고 인과성이 높은) 사람들은 전형적인 사건에서는 가해자의 고의성을 높게 판단한 반면, 비전형적인 사건에서는 고의성을 낮게 판단하였다. 이 결과는 분석적 사고에 비해 종합적 사고를 하는 사람들이 가해자뿐만 아니라 피해자의 도덕적 특성을 고려한 범죄 전형성에 근거한 고의성 판단을 더 강하게 한다는 것을 의미한다. 본 연구의 의의와 함께 분석적-종합적 사고 양식과 범죄 전형성 및 고의성 판단과의 관계에 대해 논의하였다.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2013년도 춘계학술대회 논문집
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• pp.459-460
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• 2013

• Journal of Ginseng Research
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• 제46권5호
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• pp.666-674
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• 2022

Background: Ginsenosides and their metabolites have antidepressant-like effects, but the underlying mechanisms remain unclear. We previously identified 14-3-3 ζ as one of the target proteins of 20 (S)-protopanaxadiol (PPD), a fully deglycosylated ginsenoside metabolite. Methods: Corticosterone (CORT) was administered repeatedly to induce the depression model, and PPD was given concurrently. The tail suspension test (TST) and the forced swimming test (FST) were used for behavioral evaluation. All mice were sacrificed. Golgi-cox staining, GSK 3β activity assay, and Western blot analysis were performed. In vitro, the kinetic binding analysis with the Biolayer Interferometry (BLI) was used to determine the molecular interactions. Results: TST and FST both revealed that PPD reversed CORT-induced behavioral deficits. PPD also ameliorated the CORT-induced expression alterations of hippocampal Ser9 phosphorylated glycogen synthase kinase 3β (p-Ser9 GSK 3β), Ser133 phosphorylated cAMP response element-binding protein (p-Ser133 CREB), and brain-derived neurotrophic factor (BDNF). Moreover, PPD attenuated the CORT-induced increase in GSK 3β activity and decrease in dendritic spine density in the hippocampus. In vitro, 14-3-3 ζ protein specifically bound to p-Ser9 GSK 3β polypeptide. PPD promoted the binding and subsequently decreased GSK 3β activity. Conclusion: These findings demonstrated the antidepressant-like effects of PPD on the CORT-induced mouse depression model and indicated a possible target-based mechanism. The combination of PPD with the 14-3-3 ζ protein may promote the binding of 14-3-3 ζ to p-GSK 3β (Ser9) and enhance the inhibition of Ser9 phosphorylation on GSK 3β kinase activity, thereby activating the plasticity-related CREBeBDNF signaling pathway.