• Journal of Nutrition and Health
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• 제30권4호
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• pp.415-424
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• 1997

Serum lipid levels and fatty acid composition of serum phospholipids(PL) were investigated in 24 healthy male subjects who consumed either corn oil(CO) rich In linoleic acid(LA), perilla oil(PO) rich in $\alpha$-linolenic acid($\alpha$-LNA), or canola oil acid(OA) as a major fat source fir 5 weeks. The PO and the CNO groups showed significant(P <0.05) increases in serum high density lipoprotein-cholesterol(HDL-C) levels and in ratios of HDL- C/total cholesterol(TC) compared with initial values measured at the beginning of the study. Significantly(p <0.05) increased concentrations of serum triglycerides(TG) ware observed after 5 weeks of the CO based diet compared with both its intial value and the concentration observed after 5 weeks with the PO-based diet. fatty acid composition of serum PL reflected changes in dietary fatty acid composition and metabolism. Compared with the initial levels, significandy increased contents of eicosapentaenoic acid(EPA) and docosahexaenoic acid(DHA) were observed in serum PL of the PO group and significantly increased contents of $\alpha$-LNA and EPA were observed in the CNO group. Arachidonic acid(AA) content of serum PL did not change in the CO group during the study period, although, the increase in LA was significant(P <0.05). Compared with the CO-based diet, both the PO and the CNO-based diets seem to have beneficial effects on atherosclerosis by influencing the serum lipid profile and fatty acid composition of serum PL.

• 생명과학회지
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• 제19권3호
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• pp.334-342
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• 2009

본 연구는 streptozotocin (STZ)으로 당뇨를 유발한 실험쥐에 대한 Psidium guajava L. 잎(Pg), Lagerstroemia speciosa L. 잎(Ls) 추출물 그리고 혼합물 A (Pg, Ls, Morus indica L. 잎 추출물, Pinus densiflora needles 추출물, Acanthopanax senticosus M. roots 추출물)의 효과를 조사하였다. 4주간 streptozotocin (STZ)으로 당뇨를 유발한 실험쥐에 이들 추출물을 섭취시킨 결과 Pg, Ls 그리고 혼합물 A의 섭취는 당뇨 대조군에 비해 혈당을 각각 20%, 14% 그리고 24% 감소시켰다. 또한 이들 추출물의 섭취는 총 콜레스트롤, 중성지방, 유리지방산을 감소시켰고 인슐린과 HDL-콜레스트롤을 효과적으로 증가시켰다. 결론적으로 혼합물 A는 Pg와 Ls 추출물에 비해 혈당 및 지질 감소, 인슐린 증가 효과 그리고 기능적으로 손상된 베타세포의 회복이 더 높은 것으로 나타났다. 따라서 혼합물 A는 개별적으로 사용한 Pg와 Ls 추출물에 비해 더욱 유익한 상승효과를 발휘하는 것으로 증명되었다.

• 보건교육건강증진학회지
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• 제24권3호
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• pp.1-19
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• 2007

Objectives: The purpose of the this study was to evaluate lifestyle intervention program for the treatment of the metabolic syndrome. Methods: Subjects of this study were 700 adults with metabolic syndrome who took health examinations in health promotion centers of Korea Association of Health Promotion between May 1 and June 30, 2006. Subjects were randomly assigned to an experimental group and a comparison group. Participants in the experimental group received intensive 3-month lifestyle modification intervention and participants in the comparison group received minimal information on lifestyle modification. Pre test and Post test were carried out to evaluate the effectiveness of the intervention program. Results: After the intensive intervention on lifestyle modification(healthy diet, physical activity, moderate drinking, stress management, and smoking cessation), the levels of blood pressure, waist circumference, fasting blood glucose and triglycerides were significantly reduced for those in experimental group(P<0.001). For those in comparison group, the levels of blood pressure(P<0.001), waist circumference(P<0.001), and triglycerides(P<0.01) were significantly reduced after the intervention. No change in the levels of high-density lipoprotein cholesterol were observed in both groups. After 3-month intervention, the prevalence of metabolic syndrome was reduced to 35.7% in experimental group and 48.5% in comparison group. Conclusion: This study has demonstrated the efficacy of therapeutic lifestyle intervention for the management of metabolic syndrome.

• Preventive Nutrition and Food Science
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• 제7권4호
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• pp.454-460
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• 2002

While atherosclerosis is a major killer, there is now concern that mortality from the disease will increase due to the rising incidence of type II diabetes. Because diet can potentially influence both diseases, it is important to elucidate the role of diet in the progression of atherosclerosis. In addition, the mechanisms involved in dietary-related alterations of the disease need to be defined to guide public health recommendations to reduce athero-sclerosis incidence and limiting unwanted side effects. Since diet is thought to play a role in atherosclerosis even without added complications due to type II diabetes, reducing the incidence of that metabolic disease will not be enough. While evidence is increasing that high intake of carbohydrate can lead to type II diabetes and atherosclerosis, the preponderance of existing evidence indicates that intake of specific fats as a major dietary causal factor. It has recently been hypothesized that a dietary fat link to atherosclerosis may depend partly on the activity of a transcriptional regulator, the peroxisome proliferator activated receptors (PPAR). Thusfar, PPAR $\alpha$, $\beta$/$\delta$ and ${\gamma}$, have been shown to play a major role in metabolism, inflammation, and cancer. Furthermore, PPAR may regulate specific processes associated with atherosclerosis such as triglyceride and low density lipoprotein (LDL) metabolism; the reverse cholesterol transport pathway; lipid accumulation within plaques; the local inflammatory response and plaque stability. Synthetic ligands for PPAR have been developed; however, natural ligands include specific fatty acids and their metabolites. Though the role of PPAR in atherosclerosis has been reported with respect to synthetic ligands, additional studies need to be done with established and possible natural ligands. In this review, we will focus on the relation of dietary fat to PPAR alteration of atherosclerosis.

• 한국보건간호학회지
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• 제24권1호
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• pp.39-48
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• 2010

Purpose: To examine the effects of a 36-week resistance training program on body composition, fitness and blood lipid profiles in the obese elderly. Method: fourteen subjects were assigned into the resistance training group. The 12-16 exercise sessions were performed for 60min with 15-25 repetitions twice per week for 36 weeks. Data were analyzed by paired t-test with SPSS version 12.0 for Windows. Results: Significant changes were evident in weight (t=5.983, p<.001), body mass index (t=5.922, p<.001), % body fat (t=3.480, p=.004), and fat free mass (t=-2.592, p=.022). Concerning exercises, no significance was noted for back scratch (t=-1.814, p=.093), but were for 2-min step (t=-3.075, p=.009), arm curl (t=-2.223, p=.045), chair stand (t=-3.671, p=.003), chair sit and reach (t=-2.508, p=.026), and 8-ft up and go (t=5.545, p<.001). No significant changes were evident in total cholesterol (t=1.189, p=.279), and total glucose (t=0.689, p=.517), while the change in high-density lipoprotein was significant (t=3.535, p=.012). Conclusion: The 36-week resistance training program enhanced body composition and physical fitness, but not blood lipid profiles in obese elderly subjects.

• 생물정신의학
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• 제13권2호
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• pp.103-109
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• 2006

Objective : Associations of vascular risk/disease or apolipoprotein E ${\varepsilon}4$(APOE4) with geriatric depression has been unclear at a population level. This study aimed to evaluate whether there would be interactions of vascular risk/disease and APOE4 on depression in a Korean elderly population. Methods : 732 community residents aged 65 or over were assessed for depression(GMS), information on vascular risk/disease(reported stroke, transient ishemic attack, heart disease, hypertension, diabetes, smoking), examinations for vascular risk/disease(blood pressure, blood tests for glucose and lipid profiles, body size), APOE genotypes, demographic characteristics(age, gender, education), physical health, and cognitive function(MMSE). Results : Previous stroke and lower level of high density lipoprotein(HDL) cholesterol were significantly associated with geriatric depression independent of demographic characteristics, physical illnesses, and cognitive function. These associations were statistically significant only in those with APOE4, although the interaction terms didn't reach to statistical significance. Conclusion : Associations between vascular risk/disease and geriatric depression might be more prominent in those with APOE4. However further research would be needed to clarify this issue.

• 한국콘텐츠학회논문지
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• 제12권12호
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• pp.363-371
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• 2012

본 연구는 당뇨환자와 일반인을 대상으로 $VO_2peak$가 복부둘레, 혈중지질 및 혈압에 어떠한 영향을 미치는지 알아본 결과 당뇨환자인 경우 $VO_2peak$와 복부둘레에서 부적상관을 나타냈으며 유의한 차이가 나타났다. 고밀도 지단백 콜레스테롤은 정적상관을 보였으며 유의한 차이가 나타났다. 일반인의 $VO_2peak$와 이완기혈압에서는 정적상관을 보였으며 유의한 차이가 나타났다. 당뇨환자의 복부둘레에서 $VO_2peak$에 통계적으로 유의한 영향을 미치는 것으로 나타났으며, 일반인의 이완기 혈압에서 $VO_2peak$에 통계적으로 유의한 영향을 미치는 것으로 나타났다. 또한 집단 간 복부둘레, $VO_2peak$, 고밀도 지단백 콜레스테롤, 중성지방, 혈압에서 집단 간 유의한 차이가 나타났다. 따라서 유산소능력($VO_2peak$) 지표들을 모니터링 함으로써 당뇨 환자들은 심혈관 질환의 위험요인을 관리할 수 있을 것으로 보인다. 또한 유산소능력을 향상시키는 운동을 실시하는 것 역시 심혈관 질환의 위험도를 낮추기 위한 좋은 방안이라고 사료된다.

• 대한한의학회지
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• 제27권1호
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• pp.118-129
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• 2006

Objectives : A human being is classified into 4 constitutions(Taeyangin, Soyangin, Taeumin, and Souemin) and each constitution has the different incidence, treatment and prevention of disease in Sasang Constutional Medicine[SCM], The purpose of this study is to find relative risk(RR)s of each risk factors including Sasang Constitution[SC] for incidence of ischemic stroke. Methods : In 344-case patients with ischemic stroke and 1446 healthy control subjects without ischemic stroke, we evaluated sex, age. height, weight, BMI, ECG abnormality, hypertension, diabetes mellitus, blood lipid level and SC. These data were statistically analysed to investigate the relations between risk factors and the incidence of ischemic stroke by chi-square test. And then significant factors were analysed to get each adjusted odds ratio[OR] by binary logistic regression analysis. Results : ECG abnormality, hypertension, diabetes mellitus, HDL(high density lipoprotein) cholesterol, and SC were significantly related to the incidence of ischemic stroke, while age, sex and BMI were adjusted in a binary logistic regression analysis. Especially in SC, the incidence of ischemic stoke in Tae-eumin and Soyangin were higher than that in Soeumin (Tae-eumin OR=11.68[95% CI: 6.26-21.80], Soyangin OR=4.64[95% CI: 2.66-8.10]). Conclusions : These results suggested that SC may be one of important risk factors for ischemic stroke and it should be a useful data for prediction of incidence of ischemic stroke.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제23권1호
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• pp.89-97
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• 2020

Purpose: Obese children may often present with advanced bone age. We aimed to evaluate the correlation between factors associated with childhood obesity and advanced bone age. Methods: We enrolled 232 overweight or obese children. Anthropometric and laboratory data, and the degree of nonalcoholic fatty liver disease (NAFLD) were measured. We analyzed factors associated with advanced bone age by measuring the differences between bone and chronological ages. Results: The normal and advanced bone age groups were comprised of 183 (78.9%) and 49 (21.1%) children, respectively. The prevalence of advanced bone age significantly increased as the percentiles of height, weight, waist circumference, and body mass index (BMI) increased. BMI z-score was higher in the advanced bone age group than in the normal bone age group (2.43±0.52 vs. 2.10±0.46; p<0.001). The levels of insulin (27.80±26.13 μU/mL vs. 18.65±12.33 μU/mL; p=0.034) and homeostatic model assessment-insulin resistance (6.56±6.18 vs. 4.43±2.93; p=0.037) were significantly higher, while high density lipoprotein-cholesterol levels were lower (43.88±9.98 mg/dL vs. 48.95±10.50 mg/dL; p=0.005) in the advanced bone age group compared to those in the normal bone age group, respectively. The prevalence of advanced bone age was higher in obese children with metabolic syndrome than in those without (28.2% vs. 14.7%; p=0.016). The prevalence of advanced bone age was higher in obese children with a more severe degree of NAFLD. Conclusion: Advanced bone age is associated with a severe degree of obesity and its complications.

• 생명과학회지
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• 제20권8호
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• pp.1230-1234
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• 2010

천연 허브에서 추출된 정유의 스트레스 완화능이 알려지면서 화장품, 식품 산업뿐 아니라 다양한 기능성 제품에 활용되고 있다. 본 연구에서는 정유 향 흡입의 스트레스 완화 효과에 대한 과학적인 근거를 마련하기 위하여 마우스의 구속 스트레스에 대한 3가지 정유의 흡입 효과를 비교 하였다. 마우스를 1시간 구속한 경우 혈청 코티졸 농도의 유의적인 상승, 체온의 저하 및 혈중 중성지질의 상승을 확인하였으며, 10% 라벤더 오일을 30분간 흡입 한 경우, 혈청 코티졸 농도 상승 및 체온 저하가 유의적으로 억제되어 스트레스 완화 효과가 가장 좋았다. 한편 혈중 중성지질의 증가 억제효과는 실버퍼 오일 흡입에서 유의적으로 감소하였다. 본 연구에서는 폭넓게 사용되는 정유를 이용하여 정유 향 흡입의 스트레스 완화 효과를 측정 함으로서 앞으로의 연구와 활용에 대한 기본적인 과학적 근거를 마련하였다.