• Biomolecules & Therapeutics
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• v.13 no.2
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• pp.90-94
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• 2005

Prazosin hydrochloride is an antihypertensive drug with selective ${\alpha}_1$-adrenoreceptor blocking effects. A simple high performance liquid chromatographic method has been developed and validated for the quantitative determination of prazosin in human plasma. A reversed-phase C18 column was used for the separation of prazosin and terazosin (internal standard) with a mobile phase composed of water, acetonitrile and triethylamine(75:25:0.1, V/V;pH5.0) at a flow rate of 1.5 ml/min. the fluorescence detector was set at excitation and emissionwavelengths of 250 and 370 nm, respectively. Intra-and inter-day precision and accuracy were acceptable for all quality control samples including the lower limit of quantification of 0.5 ng/ml. Good recovery (>80%) was seen in plasma. Prazosin was stable in human plasma under various storage conditions. This method was used successfully for a pharmacokinetic study in plasma after oral administration of a single 2-mg dose as prazosin base to 16 healthy volunteers. The maximum plasma concentration of prazosin was 23.1 ${\pm}$ 16.5 ng/ml at 2.1 h, and the mean area under the curve and elimination half-life were calculated to be 108.4 ${\pm}$ 74.2 ng ${\cdot}$hr/ml and 2.5 ${\pm}$ 0.6 h, respectively.

• Journal of Astronomy and Space Sciences
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• v.11 no.1
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• pp.131-145
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• 1994

The Cosmic Ray Experiment (CRE) is one of the modules flown on board the KITSAT-1 satellite and consistes of two sub-systems: the Total Dose Experiment (TDE) and the Cosmic Particl Experiment(CPE). The purpose of CRE is to characterize the space radiation environment as encountered by an Earth-orbiting spacecraft. KITSAT-1 orbit is dominated by the inner Van Allen radiation belt. This region has a large population of high energy protons which contributes significantly to both long-term and transient radiation effects. The data shows that the inner Van Allen radiation belt is very stable and the solar activity influences the CPE, TDE data and SEU(Single Event Upset) rates. The result also shows that much larger high energy particle flux is recorded than the predictions of the CREME code.

• Biomolecules & Therapeutics
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• v.14 no.1
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• pp.40-44
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• 2006

Mirtazapine is an antidepressant agent with dual action on both the noradrenergic and serotonergic neurotransmitter systems. A simple high performance liquid chromatographic method has been developed and validated for the quantitative determination of mirtazapine in human plasma. A reversed-phase Cl8 column was used for the determination of mirtazapine with a mobile phase composed of 0.01M ammonium acetate solution (pH 4.2) and acetonitrile (75:25, v/v%) at a flow rate of 1.2 mL/min. Terazosin hydrochloride was used as an internal standard. The fluorescence detector was set at excitation and emission wavelengths of 290 and 350 nm, respectively. Intra- and inter-day precision and accuracy were acceptable for all quality control samples including the lower limit of quantification of 3 ng/mL. Mirtazapine was stable in human plasma under various storage conditions. This method was used successfully for a pharmacokinetic study using plasma samples after oral administration of a single 30 mg dose as mirtazapine base to 8 healthy volunteers. The maximum plasma concentration of mirtazapine was $64.1{\pm}28.0ng/mL$ at 1.8 h, and the area under the curve and elimination half-life were calculated to be $674.1{\pm}218.5ng\;h/mL\;and\;23.4{\pm}3.8h$, respectively.

• Journal of Astronomy and Space Sciences
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• v.14 no.1
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• pp.80-86
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• 1997

High energy particles in the earth's radiation belts cause transient and long term effects on electronic materials, devices, and integrated circuits on board the satellites. Hence, it is very important to have the information on the space radiation environment and the damage on the electronics caused by the se high energy particles. One of the radiation monitor devices frequently used in space is RADFET, a specially designed MOSFET with a thick gate oxide region. The present study focuses on the calibration of RADFET TOT500 using the $Co^{60}{\gamma}-ray$ source. The result shows that the response of RADFET is very sensitive to the change of temperature. The peculiar behavior observed in the TDE (Total Dose Experiment) on board the KITSAT-1 is identified as the thermal effect due to the change in the eclipse rate of the satellite.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2016.05a
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• pp.785-787
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• 2016

In this study, we studied the gamma-radiation effect of fiber Bragg gratings on the high temperature annealing condition. The fiber Bragg gratings were exposed to gamma-radiation up to a dose of 30.8 kGy at the dose rate of 115 Gy/min. According to the experimental data and analysis results, the gratings that were stabilized at different temperatures have clearly shown that exposure to higher temperatures increases their radiation sensitivity.

• Journal of Yeungnam Medical Science
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• v.7 no.2
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• pp.109-114
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• 1990

The basic strategy of irradiation is to deliver a dose to the cancer that is high enough to make cancer cells incapable of reproduction, while keeping the doses to the various healthy tissues below tolerable levels. In order to improve local control and survival, as a boost therapy after external radiotherapy, high dose rate transcatheteric irradiation using remote control afterloading system(RALSTRON-20B) was used for twelve patients with head and neck cancers. Present results showed complete remission of cancer in 9 out of 12 patients without treatment related complications. Although this procedure is easy to operate, well trained skillful hand is essential for good results. Furthermore our experience suggested that meticulous treatment planning should be developed for better results.

• Journal of radiological science and technology
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• v.26 no.1
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• pp.39-44
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• 2003

The aim of this study is to evaluate a efficient w/v% barium suspension and w/v% sodium carboxy methyl cellulose (SCMC) for small bowel examination. Between november 2001 and june 2002, 370 patients were examined small bowel examination with oral administration of barium suspension mixed with SCMC. we classified into six groups including A(fine type 40% $BaSO_4$ mixed 0.5% SCMC and 600 ml 0.5% SCMC administration), B(fine type 30% $BaSO_4$ mixed 0.5% SCMC), C(fine type 20% $BaSO_4$ mixed 0.5% SCMC), D(fine type 25% $BaSO_4$ mixed 0.5% SCMC), E(D mixed coarse type 25% $BaSO_4$ mixed 0.5% SCMC), F(D mixed coarse type 25% $BaSO_4$ mixed 0.75% SCMC). We measured transparency rate of contrast media transit time, administration dose, viscosity and particle size. The transparency rate was higher then 80 kV and 90 kV in 100 kV in the same 20 mAs condition. Transit time was the fastest in A group(mean trans time 56 minutes) and the slowest in E group(mean 100 minutes), Administration dose was the smallest in A group(mean dose 541 ml and the most in E group(mean 1,100 ml), viscosity was the lowest in E(125.1 mpa/s) and the highest in A(375.5 mpa/s), and particle size was $1.0\;{\mu}m$ in A, B, C, and D group, $0.6\;{\mu}m,\;1.0\;{\mu}m,\;10.0\;{\mu}m$ in E, F group. In conclusion, we propose that the efficient condition for small examination is high voltage technique, high density $BaSO_4$, and 0.625% w/v SCMC.

• Journal of Information Technology Services
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• v.8 no.2
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• pp.147-156
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• 2009

As the result of the rapid development of IT technology, an on-line diagnostic system using the field bus communication network coupled with a smart sensor module will be widely used at the nuclear power plant in the near future. The smart sensor system is very useful for the prompt understanding of abnormal state of the key equipments installed in the nuclear power plant. In this paper, it is assumed that a smart sensor system based on the fieldbus communication network for the surveillance and diagnostics of safety-critical equipments will be installed in the harsh-environment of the nuclear power plant. It means that the key components of fieldbus communication system including microprocessor, FPGA, and ASIC devices, are to be installed in the RPV (reactor pressure vessel) and the RCS (reactor coolant system) area, which is the area of a high dose-rate gamma irradiation fields. Gamma radiation constraints for the DBA (design basis accident) qualification of the RTD sensor installed in the harsh environment of nuclear power plant, are typically on the order of 4 kGy/h. In order to use a field bus communication network as an ad-hoc diagnostics sensor network in the vicinity of the RCS pump area of the nuclear power plant, the robust survivability of IT-based micro-electronic components in such intense gamma-radiation fields therefore should be verified. An intelligent CCD camera system, which are composed of advanced micro-electronics devices based on IT technology, have been gamma irradiated at the dose rate of about 4.2kGy/h during an hour UP to a total dose of 4kGy. The degradation performance of the gamma irradiated CCD camera system is explained.

• Korean Journal of Plant Tissue Culture
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• v.27 no.2
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• pp.143-148
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• 2000

This study was carried out to know the optimum dose of gamma-ray for the induction of mutation in vitro and the characteristics of the mutants induced by gamma-ray in persimmon (Diospyros kaki Thunb.). The LD50 (50% lethal dose) for in vitro shoots of the cultivar, Nishimurawase was between 1 krad and 2 krad and about 1 krad for the cultivar, Ichikikeijiro. As the dose of gamma-ray increased, the length of shoots decreased and necrosis of buds increased. For the cultivar, Nishmurawase, 37.5∼58.3% shoots rooted and the rooting rate and the number of roots per shoot was low in high gamma-ray. The irradiated young plants which were grown in the growth cabinet for 6 weeks were shorter in shoot length and had more branches than non-irradiated plants. The survival rate of irradiated plants grown in the green house for 3 months was 33%, while 77% for control plants.

• The Journal of Korean Society for Radiation Therapy
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• v.4 no.1
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• pp.71-77
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• 1990

The present study was undertaken to investigate effects of ionizing radiation on DNA synthesis and chromosomal abnormality in cultured submandibular gland(SG) cells. SG cells from C57BL/6N Crj mice were cultured in Dulbecco's modified Eagle's medium (DME) supplemented with $10\%$ fetal bovine serum, antibiotics and fungizone. The cultured SG cells were irradiated with graded doses of gamma ray ($^{60}Co$) at a dose rate of 58.4rad/min. The effect of irradiation of $^{60}Co$ on DNA synthesis in cultured cells was evaluated by measuring the incorporation of 3H-TdR. Using conventional chromosome techniques and Giemsa staining methods, chromosomal abnormalities in cultured SG cells, induced by irradiation of $^{60}Co$ werw examined. Cytological observations were carried out by a light microscope with high resolving power. The results obtained were as follows : 1. DNA synthesis of SG cells was quantitatively dependent on a radiation dose compare to control. 2. A polyploids and few chromosome-type break, such as single and double breaks, deltions and triradial figures were more predominantly in irradiated SG cells than in control. This increase of chromosomal abnormality was in the proposition to the irradiation doses.