• Clinical and Experimental Pediatrics
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• v.64 no.7
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• pp.355-363
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• 2021

Background: Nephrotic syndrome (NS) is a common renal disorder in children attributed to podocyte injury. However, children with the same diagnosis have markedly variable treatment responses, clinical courses, and outcomes, suggesting molecular heterogeneity. Purpose: This study aimed to explore the molecular responses of podocytes to nephrotic plasma to identify specific genes and signaling pathways differentiating various clinical NS groups as well as biological processes that drive injury in normal podocytes. Methods: Transcriptome profiles from immortalized human podocyte cell line exposed to the plasma of 8 subjects (steroid-sensitive nephrotic syndrome [SSNS], n=4; steroid-resistant nephrotic syndrome [SRNS], n=2; and healthy adult individuals [control], n=2) were generated using microarray analysis. Results: Unsupervised hierarchical clustering of global gene expression data was broadly correlated with the clinical classification of NS. Differential gene expression (DGE) analysis of diseased groups (SSNS or SRNS) versus healthy controls identified 105 genes (58 up-regulated, 47 down-regulated) in SSNS and 139 genes (78 up-regulated, 61 down-regulated) in SRNS with 55 common to SSNS and SRNS, while the rest were unique (50 in SSNS, 84 genes in SRNS). Pathway analysis of the significant (P≤0.05, -1≤ log2 FC ≥1) differentially expressed genes identified the transforming growth factor-β and Janus kinase-signal transducer and activator of transcription pathways to be involved in both SSNS and SRNS. DGE analysis of SSNS versus SRNS identified 2,350 genes with values of P≤0.05, and a heatmap of corresponding expression values of these genes in each subject showed clear differences in SSNS and SRNS. Conclusion: Our study observations indicate that, although podocyte injury follows similar pathways in different clinical subgroups, the pathways are modulated differently as evidenced by the heatmap. Such transcriptome profiling with a larger cohort can stratify patients into intrinsic subtypes and provide insight into the molecular mechanisms of podocyte injury.

• The Korean Journal of Physiology and Pharmacology
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• v.25 no.2
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• pp.119-129
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• 2021

Bladder cancer is one of the most common types of cancer. Most gene mutations related to bladder cancer are dominantly acquired gene mutations and are not inherited. Previous comparative transcriptome analysis of urinary bladder cancer and control samples has revealed a set of genes that may play a role in tumor progression. Here we set out to investigate further the expression of two candidate genes, centromere protein U (CENPU) and mitochondrial ribosomal protein s28 (MRPS28) to better understand their role in bladder cancer pathogenesis. Our results confirmed that CENPU is up-regulated in human bladder cancer tissues at mRNA and protein levels. Gain-of-function and loss-of-function studies in T24 human urinary bladder cancer cell line revealed a hierarchical relationship between CENPU and MRPS28 in the regulation of cell viability, migration and invasion activity. CENPU expression was also up-regulated in in vivo nude mice xenograft model of bladder cancer and mice overexpressing CENPU had significantly higher tumor volume. In summary, our findings identify CENPU and MRPS28 in the molecular pathogenesis of bladder cancer and suggest that CENPU enhances the progression of bladder cancer by promoting MRPS28 expression.

• The Journal of the Korea Contents Association
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• v.21 no.2
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• pp.520-527
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• 2021

In this study, we focused on the low practicality of traditional outdoor advertisements due to uniformity of materials, shapes, and designs, so in order to improve it, we will analyze impact on the practicality of outdoor advertisements depends on the attached type of advertising signboards. The research method is to set up a research model and hypotheses through a literature review and conduct a survey and then perform factor analysis and hierarchical regression analysis. Hypothesis1. The evaluation factors (readability, formability or symbolism) of outdoor advertising signboard in traditional markets will affect their practicality. Hypothesis 2. The type of attached advertising signboards (protruding type or wall-type) in traditional markets will control the impact of each evaluation factors' on practicality. In a result, readability and formability will affect practicality. To increase practicality, the size, color, font, layout and etc. of outdoor advertising signboards should be well recognized to get the better understanding. Also, practicality will be increased by the harmonization and the sense of balance.

• The Journal of the Korea Contents Association
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• v.21 no.1
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• pp.674-683
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• 2021

In this study, we investigated the effect of HPV related Health Belief and Self-Efficacy on HPV Infection Preventive Behavioral Intention considered to be the main impact in determining disease prevention behavior. Subjects of this study were female college students attending a four-year college. It was collected 405 data analyzed with SPSS 25.0 Statistics Program. In order to understand the effect of the subject's HPV related Health Belief and Self-Efficacy on HPV Infection Preventive Behavioral Intention, the general characteristics influenced HPV Infection Preventive Behavioral Intention were introduced as a control variable, and analyzed with Hierarchical Multiple Regression Analysis. Personal health belief and self-efficacy need to be improved to develop interventions that can increase HPV Infection Preventive Behavioral Intention in female college students. Based on the research results, it is necessary to develop and operate various programs to improve HPV prevention behavior.

• Journal of the Korean Society of School Health
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• v.34 no.2
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• pp.115-122
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• 2021

Purpose: The purpose of this descriptive research is to identify how stress from Covid-19, health beliefs, and social support of college students affect health prevention. Methods: The subjects of the study were 128 university students, excluding health major students, at one university in D City. The survey was conducted from August 1 to 31, 2020. The survey questionnaire consists of 8 items on stress from COVID-19, 12 items adapted from a health belief measurement tool, 12 items from a social support measurement tool, and 11 items adapted from a tool that measures health preventive behaviors. The collected data were analyzed using the hierarchical multiple regression analysis method with SPSS 26.0. Results: In model 1, stress from COVID-19 was statistically significant (β=-.403, p=.003). Model 2 added four health belief factors into Model 1. Stress (β=-.419, p<.001), perceived severity (β=-.193, p=.030), and perceived barriers (β=-.182, p=.009) were statistically significant. In model 3, stress (β=-.413, p<.001), perceived barriers (β=-.147, p=.034), and social support (β=.194, p=.011) were statistically significant. The regression equation was significant (F=15.395, p=<.001) and the model's explanatory power was 53.1%. Conclusion: The results show that when college students had a high degree of health beliefs about COVID-19, the degree of health preventive behaviors was proportionally high. To make them practice preventive health behaviors, it is necessary to develop infection control education programs to improve health beliefs.

• Journal of Preventive Medicine and Public Health
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• v.55 no.6
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• pp.568-577
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• 2022

Objectives: Many studies have shown that social distancing, as a non-pharmaceutical intervention (NPI) that is one of the various measures against coronavirus disease 2019 (COVID-19), is an effective preventive measure to suppress the spread of infectious diseases. This study explored the relationships between traditional health-related behaviors in Korea and social distancing practices during the COVID-19 pandemic. Methods: Data were obtained from the 2020 Community Health Survey conducted by the Korea Disease Control and Prevention Agency (n=98 149). The dependent variable was the degree of social distancing practice to cope with the COVID-19 epidemic. Independent variables included health-risk behaviors and health-promoting behaviors. The moderators were vaccination and unmet medical needs. Predictors affecting the practice of social distancing were identified through hierarchical multiple logistic regression analysis. Results: Smokers (adjusted odds ratio [aOR], 0.924) and frequent drinkers (aOR, 0.933) were more likely not to practice social distancing. A greater degree of physical activity was associated with a higher likelihood of practicing social distancing (aOR, 1.029). People who were vaccinated against influenza were more likely to practice social distancing than those who were not (aOR, 1.150). However, people with unmet medical needs were less likely to practice social distancing than those who did not experience unmet medical needs (aOR, 0.757). Conclusions: Social distancing practices were related to traditional health behaviors such as smoking, drinking, and physical activity. Their patterns showed a clustering effect of health inequality. Therefore, when establishing a strategy to strengthen social distancing, a strategy to protect the vulnerable should be considered concomitantly.

• Korean Journal of Culture and Social Issue
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• v.28 no.3
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• pp.307-329
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• 2022

This study aimed to explore factors which can predict interpersonal tolerance and intolerance. Specifically, the study examined whether tolerance and intolerance would be explained by demographic variables, social desirability, empathy (cognitive empathy and affective empathy), fear of compassion for others, social trust, and zero-sum belief. Participants in the study were 445 adults (218 males and 227 females) who completed an online survey. Data were analyzed by using hierarchical regression analyses to control the effects of demographic variables and social desirability. The results indicated that tolerance was explained by gender, subjective socioeconomic status, social desirability, cognitive empathy, and social trust. In addition, intolerance was predicted by social desirability, fears of compassion for others, and zero-sum belief. It means that the constructs of tolerance and intolerance are distinct, and different factors predict tolerance and intolerance, respectively. Therefore, it would be necessary to develop realistic ways to promote tolerance and to prevent intolerance at the same time in order to achieve co-existence in a multicultural and diverse society.

• Journal of Digital Convergence
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• v.19 no.11
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• pp.415-424
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• 2021

The purpose of the current study is to to examine the psychometric properties of the Subjective Agingwell Scale (SAS). Three hundred and forty two elders completed the SAS and the scales assessing subjective well-being, optimism, perceived control and adhering to healthy behavior. The 11-item SAS that displays good internal reliability and good fit to the three-factor model consisting of cognitive satisfaction, positive affect, and spiritual fullness. Correlational analyses with measures of subjective agingwell, subjective well-being, and optimism provide evidence for construct validity. Moreover, the results from hierarchical regression analyses show criterion-related validity of the SAS. This scale could be used in the field to measure and promote subjective agingwell.

• Journal of the Society of Disaster Information
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• v.19 no.1
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• pp.146-160
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• 2023

Purpose: The construction industry is a complex mechanism in which multiple processes are carried out at the same time, and the frequency and severity of accidents account for a higher proportion than other industries, and the accident fatality rate also accounts for more than 50% of all industries. In order to reduce such accidents, the government's disaster investigation method analyzes the limitations from the system safety point of view and proposes improvement plans. Method: The main contents of the government's serious accident investigation were identified, and the effectiveness/adequacy was analyzed from the system safety point of view. Result: Disaster investigation and analysis techniques tailored to violations and compliance were limited in providing fundamental solutions, and alternatives for accident prevention were possible for each component of the system when safety constraints, controls, and hierarchical interactions were combined. Conclusion: When combining the disaster investigation and analysis method from the current accident analysis method from the perspective of system safety, it is possible to identify the problems of interaction by class and communication process, so it is possible to suggest alternatives to prevent accidents from an integrated perspective.

• Journal of the Korean Society of School Health
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• v.36 no.1
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• pp.9-19
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• 2023

Purpose: The purpose of the study was to identify the factors affecting the practice of COVID-19 infection preventive behaviors in university students focusing on the extended health beliefs model (HBM) and the theory of planned behavior (TPB). Methods: Data was collected from November 1, 2021 to November 30, 2021. The participants were 180 university students at 3 universities. The data was analyzed through the independent t-test, one-way ANOVA, Scheffé test, Pearson's correlation coefficient, and multiple regression by using SPSS/WIN 24.0. Results: In the first stage of hierarchical regression analysis, it was shown that perceived barrier and self-efficacy, among the HBM variables, were significant factors, explaining 18.4% of the infection preventive behaviors (F=7.73, p<.001). In the 2nd stage, it was shown that self-efficacy, among the TPB variables, was a significant factor, explaining 15.3% of the infection preventive behaviors (F=11.80, p<.001). In the 3rd stage, it was shown that perceived barrier and self-efficacy, among the HBM and TPB variables, were significant factors, explaining 18.5% of the infection preventive behaviors (F=6.08, p<.001). Conclusion: When an effective infection preventive behavior program is developed and provided for students to improve their self-efficacy and reduce perceived barrier based on the results, it will contribute to the improvement of infection prevention behaviors among university students.