• Molecules and Cells
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• v.40 no.7
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• pp.450-456
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• 2017

Mammalian physiology and behavior are regulated by an internal time-keeping system, referred to as circadian rhythm. The circadian timing system has a hierarchical organization composed of the master clock in the suprachiasmatic nucleus (SCN) and local clocks in extra-SCN brain regions and peripheral organs. The circadian clock molecular mechanism involves a network of transcription-translation feedback loops. In addition to the clinical association between circadian rhythm disruption and mood disorders, recent studies have suggested a molecular link between mood regulation and circadian rhythm. Specifically, genetic deletion of the circadian nuclear receptor Rev-$erb{\alpha}$ induces mania-like behavior caused by increased midbrain dopaminergic (DAergic) tone at dusk. The association between circadian rhythm and emotion-related behaviors can be applied to pathological conditions, including neurodegenerative diseases. In Parkinson's disease (PD), DAergic neurons in the substantia nigra pars compacta progressively degenerate leading to motor dysfunction. Patients with PD also exhibit non-motor symptoms, including sleep disorder and neuropsychiatric disorders. Thus, it is important to understand the mechanisms that link the molecular circadian clock and brain machinery in the regulation of emotional behaviors and related midbrain DAergic neuronal circuits in healthy and pathological states. This review summarizes the current literature regarding the association between circadian rhythm and mood regulation from a chronobiological perspective, and may provide insight into therapeutic approaches to target psychiatric symptoms in neurodegenerative diseases involving circadian rhythm dysfunction.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.25 no.10A
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• pp.1461-1472
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• 2000

Recently, the mobile users seem to be rapidly increasing and then the capacity limit will be reached at close hand. In these situations, to provide them with good quality of service in the coming future, newly planned cell design is needed. In the next generation mobile communication systems, namely IMT-2000, good quality services will be possible only by designing the cell structure hierarchically with the help of appropriate cell planning. In the research process, the standardization reports on the future mobile cellular IMT-2000 system (3GPP) are investigated and the parameters, that are essential to cell planning, are also researched. Modeling of IMT-2000 radio link and the numerical analysis on that make it possible to calculate the forward/reverse link budget, system capacity call blocking probability Erlang capacity and cell coverage. In planning the cell of IMT-2000 system, various parameters are considered, such as hierarchical cell structure, number of users, data service forms and propagation area environments. From the results, efficient cell planning methods are proposed. Through this thesis efficient cell planning and maximum capacity will be achieved in the beginning of commercial IMT-2000 service.

• Science of Emotion and Sensibility
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• v.11 no.3
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• pp.301-312
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• 2008

Satisfaction of consumer preferences is a key factor for the success of the products. Therefore, design mangers try to develop the profitable products through the intensive survey on the consumer preferences. Although the studies on the preferable product design and the design factors have long been carried out, most of these studies dealt only with the design factors preferable for individual product category ignoring the relationship of the product categories which are related to each other. For designers and design managers, in this study, we propose the guidelines of successful product development by finding preferred common and distinct design factors through analysis of the relations between the consumer preferences and design factors in various portable electric devices. To this end, we analyzed the preferred common and distinct design factors from portable electric devices including the electronic dictionaries, notebook computers, cellular phones, and MP3 players. We used hierarchical regression analysis for the effects of the design factors on the preferences among the product categories and regression analysis for the effects among each product category. The analysis on the preferred common design factors among the four product categories revealed that consumers did not care about the whole body type but preferred white color, metallic and glassy texture in the body. Also, the preferred design factors in the each product category are as follows; oval body shape and black color in electronic dictionaries, white color, metallic and glassy texture in notebook computers, plastic texture in cellular phones, rectangular body shape and plastic texture in MP3 players. In the case of notebook computers, the preferred common and distinct design factors were the same. We expect these results will be helpful for designers and design managers to identify the preferred design factors to consider when developing the various portable electric devices.

• Journal of the Korean association of regional geographers
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• v.22 no.3
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• pp.681-702
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• 2016

Two different modelling approaches to dune dynamics have been established thus far; continuous models that emphasize the precise representation of wind field, and feedback-based models that focus on the interactions between dunes, rather than aerodynamics. Though feedback-based models have proven their capability to capture the essence of dune dynamics, the compatibility issues on these models have less been addressed. This research investigated, mostly from the theoretical point of view, the algorithmic compatibility of three feedback-based dune models: sand slab models, Nishimori model, and de Castro model. Major findings are as follows. First, sand slab models and de Castro model are both compatible in terms of flux perspectives, whereas Nishimori model needs a tuning factor. Second, the algorithm of avalanching can be easily implemented via repetitive spatial smoothing, showing high compatibility between models. Finally, the wind shadow rule might not be a necessary component to reproduce dune patterns unlike the interpretation or assumption of previous studies. The wind shadow rule, rather, might be more important in understanding bedform-level interactions. Overall, three models show high compatibility between them, or seem to require relatively small modification, though more thorough investigation is needed.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.12
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• pp.6155-6157
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• 2012

Background: Mutations in the MAPK (Mitogen Activated Protein Kinase) signaling pathway - EGFR/Ras/RAF/MEK have been associated with the development of several carcinomas. ERK2, a downstream target of the MAPK pathway and a founding member of the MAPK family is activated by cellular signals emanating at the cell membrane. Activated ERK2 translocates into the nucleus to transactivate genes that promote cell proliferation. MKP - a dual specific phosphatase - interacts with activated ERK2 via the common docking (CD) domain of the later to inactivate (dephosphorylate) and effectively terminate further cell proliferation. A constitutively active form of ERK2 carrying a single point mutation - E322K in its CD domain, was earlier reported by our laboratory. In the present study, we investigated the prevalence of this CD domain E322K mutation in 88 well differentiated OSCC tissue samples. Materials and Method: Genomic DNA specimens isolated from 88 oral squamous cell carcinoma tissue samples were amplified with primers flanking the CD domain of the ERK2 gene. Subsequently, PCR amplicons were gel purified and subjected to direct sequencing to screen for mutations. Results: Direct sequencing of eighty eight OSCC samples identified an E322K CD domain mutation in only one (1.1%) OSCC sample. Conclusions: Our result indicates that mutation in the CD domain of ERK2 is rare in OSCC patients, which suggests the role of genetic alterations in other mitogenic genes in the development of carcinoma in the rest of the patients. Nevertheless, the finding is clinically significant, as the relatively rare prevalence of the E322K mutation in OSCC suggests that ERK2, being a common end point signal in the multi-hierarchical mitogen activated signaling pathway may be explored as a viable drug target in the treatment of OSCC.

• Molecular & Cellular Toxicology
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• v.3 no.3
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• pp.190-194
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• 2007

Gastric adenocarcinoma (GA) is a major tumor type of gastric cancers and subdivides into several different tumors such as papillary, tubular mucinous, signet-ring cell and adenosquamous carcinoma according to histopatholigical determination. In other hand, GA is also subdivided into intestinal and diffuse type of adenocarcinoma by the Lauren?fs classification. In this study, we have examined differential gene expression pattern analysis of three histologically different GAs of 24 samples by using DNA microarray containing approximately 19000 genetic elements. The hierarchical clustering analysis of 24 gastric adenocarcinomas (12 of intestinal type, 7 of diffuse type and 5 of mixed type) resulted in two major subgroup on dendrogram, and two subgroups included most of intestinal and diffused type of GAs respectively. Supervised analysis of 19 intestinal and diffuse type GAs by using Wilcoxon rank T-test (P<0.01) resulted in 100 outlier genes which exactly separated intestinal and diffuse type of GA by differential gene expression. In conclusion, genome-wide analysis of gene expression of GAs suggested that GAs may subclassify as intestinal and diffused type of GA by their characteristic molecular expression. Our results also provide large-scale genetic elements which reflect molecular differences of intestinal and diffuse type of GAs, and this may facilitate to understand different molecular carcinogenesis of gastric cancer.