• 동의생리병리학회지
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• 제22권2호
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• pp.277-281
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• 2008

The objectives of this study lie in theoretical establishment of Bobee-tang for curing the asthenic syndrome of spleen through analyzing the component medicines and combination principles of Hyeongok's Bobee-tang, and furthermore, maximizing the clinical use of Bobee-tang. This study analyzed the component medicines and combination principles of Hyeongok's Bobee-tang based on the theory for properties and tastes of herbal medicines from the ${\ulcorner}$Yellow Emperor's Canon of Internal Medicine${\lrcorner}$, the theory for principal herbal medicine, assistant herbal medicine, adjuvant herbal medicine, dispatcher herbal medicine, and the five elements doctrine. Hyeongok's Bobee-tang is an odd prescription, composed of 7 kinds of ingredients : No.1 Radix Ginseng (2don;7.5 g), No.2 Rhizoma Atractylodis Macrocephalae (1don;3.75 g), No.3 Carapax Et Plastrumtestudinis (1don), No.4 Concha Ostreae (1don), No.5 Cortex Cinnamomi (1don), No.6 Rhizoma Zingiberis Praeparatae (1don), and No.7 Radix Glycyrrhizae (1don). First, to cure the asthenic syndrome of the spleen, the methods of invigorating the spleen and the heart, and purging the liver should be used according to the five elements doctrine. Secondly, herbal medicines appropriate for those treatment methods should be chosen according to the theory for properties and tastes of herbal medicine and thirdly, the combination of those herbal medicines should be carried out according to the theory for principal herbal medicine, assistant herbal medicine, adjuvant herbal medicine, dispatcher herbal medicine. As a good example, Hyeongok's Bobee-tang is combined according to the above theories. In conclusion, this formula was created by applying to the theory for properties and tastes of herbal medicines.

• 대한한방소아과학회지
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• 제19권2호
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• pp.243-253
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• 2005

Objective : In this study we aimed to· investigate the parental recognition on Herbal Medication. The result showed that parents concerned about the effect of Herbal Medication on liver function and gaining weight. Therefore, we had a retrospective study on the effect of Herbal Medicaion on liver function and gaining weight. Method : In parent's recognition study, we surveyed 354 parents of children who make a first visit to Department of Oriental Pediatrics in ${\bigcirc}{\bigcirc}$ Medical Center from 3 October to 2 November 2005. In retrospective study, we examined medical record of 22 children who visited to Department of Oriental Pediatrics in Kyunghee Medical Center from 30 September 2005 to 1 January 2005. Height, weight, BMI, body fat mass, body fat ratio, AST and ALT were estimated at two points; before and after Herbal Medicaion treatment. Result: The mean of expectation of parents on the efficacy of Herbal Medication was 75.14 on the VAS scale, which was interpreted as significantly high. The result showed the effect of Herbal Medicaion on liver function(48%) and gaining weight(53%) took the largest portion. When we observe the effect of Herbal Medication on Liver function, after Herbal Medication treatment we have slightly increased AST and slightly decreased ALT, but they were not statistically significant. Also we observe the effect of Herbal Medication on getting obesity after Herbal Medication treatment. The result showed that we have slightly decreased BMI, body fat mass, body fat ratio, but they were not statistical1y significant. Conclusion : Our report shows parents of children have high expectation and stand favorable on the efficacy of the Herbal Medication. We found that parents concerned the most about the effect of Herbal Medicaion on liver function and gaining weight. Our retrospective study showed that Herbal Medicaion treatment on children has relationship with neither liver function nor the degree of obesity.

• 한국자원식물학회지
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• 제28권6호
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• pp.718-726
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• 2015

In this study, the inhibitory activities of fifty plant extracts on IgE-mediated degranulation in the rat basophilic leukemia cell line (RBL-2H3 cells) were measured; the release of interleukin (IL)-4 and β-hexosaminidase from IgE-sensitized cells treated with the plant extracts was measured; and the effects of the plant extracts on cell viability were tested. The results of the analysis of plant extracts at 20 μg/ml, including the aerial part of Magnolia sieboldii K. Koch, exhibited suppressive activities upon the release of IL-4. Furthermore, several plant extracts including methanol extracted from Lindera erythrocarpa Makino (aerial part) at the same concentration significantly inhibited the release of β-hexosaminidase. Twenty-six of the plant extracts, including methanol extract of Weigela subsessilis (Nakai) L. H. Bailey (branch), showed a cell proliferation effect of over 80% at 100 μg/ml. In conclusion, the results suggest that the leaf/stem of Geum japonicum Thunb. and the stamen/ovary of Nelumbo nucifera Gaertn., which exhibited effective inhibition on β-hexosaminidase release and IL-4 release from mast cells and showed high cell viability, could be useful candidates as anti-allergy materials.

• 대한한의학방제학회지
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• 제29권4호
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• pp.297-310
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• 2021

Objectives : In traditional herbal medicine, as clinical experience increased, the number of herbal formulas also increased. For example, there are 61,739 herbal formulas in Pujifang, and 96,592 in Dictionary of Traditional Chinese Medicine Prescriptions. In chapter of Clear Heat (CH; 淸熱劑) of textbook, the 38 formulas were presented. For enhancing understanding of herbal formula, a large majority of books explained each individual formula with description or figure about interactions between constituent herbs. But there is no study on the interrelationship of each CH herbal formulas. This study investigated the interrelationship of CH herbal formulas. Methods : The CH herbal formula were analyzed with the ingredients, actions and clinical applications by literature study. Results : To improve cognition the interrelationship of CH herbal formulas, we analyzed the formulas and established the 16 interrelations of herbal formulas. Conclusions : Finally, this study established the interrelation of herbal formula as one figure. This result could contribute to improve cognition on the interrelationship of CH herbal formulas.

• Journal of Applied Biological Chemistry
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• 제63권4호
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• pp.393-399
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• 2020

방풍(Saposhnikoviae Radix, SR) 과 식방풍(Peucedani Japonici Radix, PR)은 각각 다른 기원식물을 가지며 속과 종이 다르지만 한국, 중국, 및 일본에서 대표적인 전통 한약재로 오랫동안 혼용되어 사용되었다. 본 연구에서는 방풍과 식방풍의 판별 마커를 확인하기 위하여 UPLC-QTOF/MS를 이용한 대사체 프로파일링 및 다변량 통계분석을 진행하였다. 그 결과, 5-O-methylvisammioside와 peucedanol을 각각 방풍과 식방풍의 지표성분으로 선정하였으며, UPLC를 이용하여 분석법을 검증하였다. 제안된 방풍 및 식방풍의 지표성분에 대한 분석법 검증은 방풍과 식방풍의 분류와 품질 평가 및 성분 검증을 위한 효과적인 방법이 될 것으로 기대된다.

• 한국약용작물학회:학술대회논문집
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• 한국약용작물학회 2010년도 심포지엄 및 추계학술발표회
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• pp.213-214
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• 2010

• 한국약용작물학회:학술대회논문집
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• 한국약용작물학회 2010년도 심포지엄 및 추계학술발표회
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• pp.211-212
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• 2010

• 한국약용작물학회:학술대회논문집
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• 한국약용작물학회 2010년도 심포지엄 및 추계학술발표회
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• pp.215-216
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• 2010

• 한국약용작물학회:학술대회논문집
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• 한국약용작물학회 2012년도 심포지엄 및 춘계학술발표회
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• pp.219-220
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• 2012

• 생약학회지
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• 제43권4호
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• pp.328-337
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• 2012

In order to investigate anti-inflammatory, anti-allergic and anti-obesity activities of Samchulkunbi-tang (SCT; Shen zhu jian pi-tang) water and 70% ethanol (EtOH) extracts, in vitro inhibitory activities against nitric oxide (NO), prostaglandin $E_2$ $PGE_2$), interleukin (IL)-6 and tumor necrosis factor (TNF)-${\alpha}$ production in lipopolysaccharide-stimulated RAW 264.7 cells, and macrophage-derived chemokine (MDC/CCL22) and regulated on activation of normal T-cell-expressed and -secreted (RANTES/CCL5) production in TNF-${\alpha}$/interferon-${\gamma}$-stimulated HaCaT and BEAS-2B cells as well as glycerol-3-phosphate dehydrogenase (GPDH) activity and leptin production in 3T3-L1 cells were determined. A HPLC was used for quantification of the seven marker components (albiflorin, paeoniflorin, liquiritin, naringin, hesperidin, poncirin and glycyrrhizin) of SCT water and 70% EtOH extracts. SCT showed inhibitory effects against MDC and RANTES production in HaCaT cells, as well as RANTES production in BEAS-2B cells. In addition, SCT reduced not only NO, $PGE_2$, IL-6 and TNF-${\alpha}$ production in RAW 264.7 cells, but also GPDH activity and leptin production in 3T3-L1 cells. Furthermore, the biological activities and the contents of six compounds (except paeoniflorin) were higher in 70% EtOH extract than water extract. These results suggest that SCT has anti-inflammatory, anti-allergic and anti-obesity activities. These efficacies of 70% EtOH extract are relatively higher than that of water extract.