• 제목/요약/키워드: herb drug

검색결과 317건 처리시간 0.024초

Prevention of Murine Acquired Immunodeficiency Syndrome (MAIDS) Development by Oriental Herb Extracts

  • Yang, Yun-Hee;Yang, Joo-Sung
    • Journal of Applied Biological Chemistry
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    • 제48권4호
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    • pp.170-177
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    • 2005
  • Oriental medicinal herb extracts (OHE) showing anticancer activities were investigated for effectiveness as antiviral drugs. Infection of MuLV to cell line resulted in formation of giant syncytia. Number of giant syncytia in culture treated with OHE decreased by 40% compared to that of non-OHE-treated cell culture. To determine OHE effects on progeny release, RT-PCR was performed. In vivo animal studies demonstrated effectiveness of OHE as antiviral drug when administered orally. After OHE administration, viral cytopathic effects decreased. Infected mice showed splenomegaly and over-proliferation of lymphocytes with decreased CD4+ cell counts. These symptoms decreased in OHE-treated mice, indicating OHE maybe useful therapeutics against MuLV/MAIDS as Human Immunodeficiency Virus (HIV)/AIDS animal model. Results show XC plaque assay and in vivo MAIDS model using MuLV are suitable tools for screening anti-retroviral drug candidates.

Herbal pathies (Unani, Ayurveda) need to review their way of research

  • Parray, Shabir ahmad;Parray, Zahoor ahmad;Zohaib, Sharique;Iqbal, Syed mohd faisal;Ahmad, Suhail
    • 셀메드
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    • 제7권1호
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    • pp.2.1-2.3
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    • 2017
  • World health organization has recently published a strategic plan for the development and promotion of traditional system of medicine. Herbal pathies especially Unani and Ayurvedic systems of medicines have great scope in this aspect. But, there are several problems with these pathies in the current era, as the way of research and identification is still on classical system. The correct identification of medicinal plant is one of the major problems in both the system. This should be corrected with the modern tools and techniques. The various types of data including recent discoveries, economical growth, ethnobotanical literature and extremely rapid increase in herbal journals and books have emerged great scope for these pathies. At the same time several challenges and threats are present including herb-drug interaction, false reports, toxicity studies etc. In this review paper, opportunities, threats, and researches to be focused will be discussed.

지실(枳實)에 함유된 Flavonoid 성분의 분석 (Analytical study on the flavonoid of Poncirus trifoliata)

  • 황귀서
    • 대한예방한의학회지
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    • 제1권1호
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    • pp.55-58
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    • 1997
  • It is well known that Poncirus trifoliata harmonizes the Stomach dissipates the Nodules of Liver and manages Vitality. This herb has been used for stomachache, vomitting, nausea, abdominal distension and swelling of testis in the Oriental Medicine. A major components of Poncirus trifoliata consist of a various flavonoids such as poncirin, naringin, hesperidin, neohesperidin, rhoifolin, poncimarin, poncitrin. Generally pharmacological activities of an oriental medicinal drug may be different due to diverse origin, harvest season and storage Period. In this study, we aimed to measure the contents of poncirin and naringin, major flavonoid of this herb, to determine the quality of Poncirus trifoliata.

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Effects of Korean traditional herbal formula for common cold on the activities of human CYP450 isozymes

  • Jin, Seong Eun;Ha, Hyekyung;Jeong, Soo-Jin;Shin, Hyeun-Kyoo
    • 대한한의학회지
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    • 제35권2호
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    • pp.47-59
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    • 2014
  • Objectives: Most drug interactions are attributed to the inhibition or induction of the activity of cytochrome P450s (CYP450). Although the regulation of CYP450s by drugs has been widely reported, there have been few studies on influence of traditional herbal formulas on the drug-metabolizing enzymes. Because herbal formulas have been used traditionally to treat various diseases and because herb-drug interactions are crucial factors determining therapeutic efficacies, a systematic evaluation of the effects of herbal formulas is important. Methods: The effects of Galgeun-tang (GGT, gegen tang), Gumiganghwal-tang (GMGHT, jiuweiqianghuo tang), Insampaedok-san (ISPDS, renshenbaidu powder), Samsoeum (SSE, shensu drink), Socheongryong-tang (SCRT, xiaoqinglong-tang) and Sosiho-tang (SSHT, xiaochaihu tang) that are traditional herbal formulas used to treat common cold, on drug-metabolizing enzymes were evaluated through an in vitro CYP3A4, CYP2D6, CYP2C19 and CYP2E1 inhibition assay to assess its interaction potential with synthetic drugs. The inhibitory effects of herbal formulas were characterized with $IC_{50}$ values. Results: These six herbal formulas inhibited the activities of CYP3A4, 2C19, 2D6 and 2E1, in a concentration-dependent manner. Among the six herbal formulas, GGT critically inhibited CYP2C19, CYP2D6 and CYP2E1. GMGHT also inhibited CYP2D6 and CYP2E1 to a greater extent than the other CYP450 isozymes. Additionally, SSE and SSHT may change the effects of medicines that depend primarily on the CYP2C19 and CYP2E1 pathways. On the other hand, ISPDS and SCRT were not inhibited CYP3A4, CYP2C19, CYP2D6 and CYP2E1-mediated metabolism. Conclusions: These findings provide useful information regarding the safety and effectiveness of herbal formulas.

약진 환자 치험 1례 (A Case of Drug Eruption)

  • 지선영;이상곤;임진호
    • 한방안이비인후피부과학회지
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    • 제18권2호
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    • pp.104-108
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    • 2005
  • Drug eruption refers to an adverse effect which is unintentionally given rise to by dosage, injection, inhalation, suppository and ointment, etc. Maculopapular, urticarial, morbilliform, papulosquamous, pustular, and bullous morphologies may be encountered. Adverse drug reactions also can cause pruritus or dysesthesia unaccompanied by rash. We treated a patient suffered from maculopapular rash and pruritus with acupuncture, herb medication and wet dressing. After treatment we observed the improvement. Based on this study, it is considered that oriental medical treatment can be applied to the management of drug eruption.

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L-Phenylalanine이 시호 캘러스의 Saikosaponin 함량에 미치는 영향 (Effects of L-Phenylalanine on the Saikosaponin Content of Bupleurum falcatum Callus)

  • 성락선
    • 생약학회지
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    • 제27권4호
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    • pp.354-358
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    • 1996
  • This experiment was conducted to find out the effects of L-phenylalanine on the saikosaponin content of callus induced from Bupleurum falcatum leaf segments. In the fresh and dry weight of callus, the addition of 2,4-D than L-phenylalanine was significantly effective. However, the L-phenylalanine treatment rather than 2,4-D was effective for high saikosaponin accumulation in the callus of Bupleurum falcatum.

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Molecular Mechanism of Inflammatory Signaling and Predominant Role of Saposhnikovia divaricata as Anti-inflammatory Potential

  • Khan, Salman;Kim, Yeong Shik
    • Natural Product Sciences
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    • 제19권2호
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    • pp.120-126
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    • 2013
  • Natural products have always been a pivotal source of new drug development. Dry roots of Saposhnikovia divaricata (Turcz.) Schischk. (Umbelliferae) is a perennial herb and is also known as Bang Pung in traditional medicine. Numerous in vitro and in vivo studies have revealed the diverse pharmacological effects of S. divaricata and its role in the treatment of various diseases. This herb has exhibited significant inhibitory effects against inflammation and associated disorders. The present study explored the ethnopharmacological applications and molecular mechanisms behind the anti-inflammatory effects of S. divaricata herb and a single compound blockade of multi-signaling inflammatory cascades. Taken together, this review provides insight into the potential role of S. divaricata against various inflammatory diseases.

일부(一部) 농어촌주민(農漁村住民)의 상병(傷病) 및 의료이용도(醫療利用度)에 관(關)한 조사연구(調査硏究) (A Study on Sickness and Utilization of Medical Care in a Rural Area of Kyunggido)

  • 장용태
    • Journal of Preventive Medicine and Public Health
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    • 제9권1호
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    • pp.139-146
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    • 1976
  • This survey attempted to determine the overall health situation in Kyunggido in terms of sickness prevalence, sickness distribution, demand for medical care by type, and utilization of medical care. The survey was conducted on 766 households, or 4,065 people, from July 1-31, 1975. The findings from the survey are as follows: 1) In terms of age distribution, 28.7% of the sample was from 10-19, the 40-49 age group was the next largest group, and those over 60 made up 7% of the sample. 2. The education distribution is as follows, 30.4% completed primary school, 22.4% had no formal education, 20.6% attended but did not onplete primary school, and 1.8% attended unversities or higher. 3) In terms of occupation, 55.9% were unemployed or family employees, which represents a large dependent population, 30.4% of the workers were employed in farming or fisheries. 4. The marital status is as follows, 58.8% of the women were married, 32.3% unmarried, and 7.5% divorced. 5) The prevalence rate of mouthy illness was 19.7% of 100 infant, 42.8% became fatally ill within the first year of life. This is a very high percentage compared with more developed nations. 6) Of those reportion on illness, 54.6% sought treatment. The rate of treatment was highest in infants at 77.7%. Us age increased, demand for treatment decreased to 43.1% for those in the aldest age group. The oldest age group also had the highest rate of non treatment at 56.8%. 7) The demand for medical care showed that 65.6% utilized drug stores, 20.2% utilized hospitals and clinics, 5.4% used herbdrug-stores and herb clinices, and 3.9% relied upon folk medicine and withch craft. 8) The utilization of medical facilties by sex is as follows, 65.1% of the men and 66.0% of the women used drug stores, and 19.2% of the men and 20.2% of the women used hospitals and clinics. However, more men (3.5%) were hospitalized than women (1.8%) 9) In terms of out-patient care, the largest age group of males was 10-19 (28.2%), and the largest age group of females was 0-9 (30.8%). There was no sex difference in the use of western pharmacies. Menaged 30-39 and women aged 50-59 were the most frequent users of herb clinics. 10) The rate of receiving treatment at drugstore hospitals went towards declining level in the second case of what While increaing much more at herb clinics and folk medicines in the second case than the first one. 11) After primary utilization of hospitals, 32.7%. of the adults aged 20-59 used drug-stores as a secondary source of care, and 12.8% of children and youth under age 20 continued receiving care at hospitals. 12) After primary utilization of drug-stores, 32.5 % of the adults continued to seek care at drug stores and 1.8% used hospitals. 4.2% of those over age 60 utilized folk medcine and witch craft.

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최근의 약초재배 현황과 유통구조의 개선 (The latest Situation of Medicinal Hers Culture and Improvement of Distribution Structure)

  • 안상득
    • 한국자원식물학회지
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    • 제4권2호
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    • pp.67-74
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    • 1991
  • 동양에서는 생약을 주로 한약조제에 많이 이용되고 있으나 서양에서는 신의약품 개발과 제조에 이용되고 있다. 그러나 최근에 와서는 국내외를 막론하고 제약업계에서 양약의 제조와 신의약품 개발에 치중하여 생약의 수요가 증가하고 있다. 따라서 당국에서는 계획생산에 대한 지도와 자금지원, 품종관리, 재배 및 신의약품개발에 대한 연구지원, 수입통제에 의한 농민보호등 제도적 지원을 강화하여 우리나라 주종 재배약초의 자포자기적인 생산기피현상을 막아야 할 것이다.

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식물상반(食物相反)에 관한 연구 (A Study on the Inhibitory Function Among Foods and Herb Drugs)

  • 유준상;김선형;양상묵;김달래;김동준
    • 사상체질의학회지
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    • 제13권2호
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    • pp.124-137
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    • 2001
  • The purpose of this research was to investigate the inhibitory function among foods and herb drugs. I have gone over literatures of mainly ${\ll}$Eum-Sun-Jung-Yo(飮膳正要)${\gg}$ on the basis of ${\ll}$Dong-Eui-Bo-Gam (東醫寶鑑)${\gg}$ about the properties and flavors of foods and herb drugs. And then I came to get some conclusion as follows. 1. The foods mentioned above are meats, birds, fishes, spices and vegetables. 2. If the foods mentioned above were eaten for a long time, and then it can cause stirring Wind or Qi or Fire inside the body. 3. What it means in the context of the chapter ${\ulcorner}$Sik-Mul-Sang-Ban : Inhibitory Function Among Foods and Herb Drugs(食物相反)${\lrcorner}$ that 'Do not eat the paired foods or herb drugs at a same time' and 'Do not eat the paired foods or herb drugs together for a long time.' 4. The Cold natured foods were not eaten at a same time. 5. The Hot or Warm natured foods were not eaten at a same time. 6. The contrary natured foods were not eaten at a same time. Because they were eaten at a same time, it raise a Occurrence of Cold and Heat syndromes and a Qi disorder.

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