• Title/Summary/Keyword: heme

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Heme proton resonances assignments based on nuclear Overhauser effect

  • Li, Chun-Ri;Kim, So-Sun;Lu, Ming;Park, Jang-Su
    • Journal of the Korean Magnetic Resonance Society
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    • v.11 no.1
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    • pp.48-55
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    • 2007

  • NMR signals of two hemes were assigned to particular hemes in the crystal structures by nuclear Overhauser effect experiments. The results showed that the hemes with the highest and lowest redox potentials in the one-electron reduction process correspond to the hemes I and IV in the crystal structure.

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The Correlation Between Conformations and Activities of ${\omega}$-Pyridylalkenoic Acids (${\omega}$-피리딜 알켄산의 형태와 활성간의 상관관계)

  • Rhee, Jong-Dal;Doh, Seong-Tak
    • YAKHAK HOEJI
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    • v.41 no.3
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    • pp.298-304
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    • 1997

  • Molecular mechanics and conformation search methods were carried oyt to investigate the relationship between conformations and thromboxane synthetase ingibitory activities of om ega-pyridylalkenoic acids. The initial geometries of ${\omega}$-pyridylalkenoic acids and heme part of cytochrome P-450 were obtained from MM+ geometry optimization. The bond lenths and angles were not varied by step during the conformation searching. Stable conformers of some ${\omega}$-pyridylalkenoic acids were obtained by comformational search method. The distances were 8.5~10.8 ${\AA}$- between N atom at 3-position of pyridine ring and C atom at carboxylic group of stable ${\omega}$-pyridylalkenoic acids. The conformations of ${\omega}$-pyridylalkenoic acids and heme part complex were determined by same method. In theses structures, benzene ring and ethylene group in ${\omega}$-pyridylalkenoic acids are making the structure more rigid and increase inhbitory activity. The electron donating groups in C atom shich is connected to pyridine ring also increase activity.

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Comparative Study on Cytochrome Oxidase of Rat Muscle Tissues (쥐 근조직의 Cytochrome Oxidase에 대한 비교 연구)

  • Song, Eun-Sook
    • The Korean Journal of Zoology
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    • v.29 no.1
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    • pp.70-74
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    • 1986

  • Cytochrome oxidase activities have been compared from crude sumibitochondrial preparations of rat skeletal muscle tissues. Fast red (type $II_A$) preparation has highest cytochrome oxidase activity, slow red (type I) next, and fast white (type $II_B$) the lowest. Differences of electrophoretic mobilities have been detected by heme staining. Migration of heme band is in the order of slow red>fast red>fast white from fastest to slowest. Results of immunoelectrophoresis have substantiated the above finding.

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Cytotoxicity of Copper Nanoparticles in Cultured Human Bronchial Epithelial Cells (BEAS-2B) (구리로 만든 나노입자의 기관지상피세포에 미치는 독성)

  • Park Eun-Jung;Park Kwangsik
    • Toxicological Research
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    • v.21 no.4
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    • pp.303-307
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    • 2005

  • Nanomaterials, which ranges in size from 1 to 100 nm, have been used to create uqnique devices at the nanoscale level possessing novel physical and chemical functional properties. However, the toxicities of nanomaterials have not been fully tested and the risk of nanomaterials is emerging issues in these days. In this study, the cytotoxicity of copper nanoparticles was tested in cultured human bronchial epithelial cells. As a results, copper nanoparticles showed cytotoxicity similar with cupric ion and the apoptotic mechanisms of DNA fragmentation and caspase-3 activation were involved. Induction of heme oxygenase-1 and thioredoxin reductase by copper nanoparticles indicated that cytotoxicity of copper nanoparticles is likely to be mediated through oxidative stress.

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