• Journal of Food Hygiene and Safety
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• v.32 no.3
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• pp.171-178
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• 2017

This study evaluated the protective effect of Chungkookjang (CKJ) extract, a Korean traditional fermented soybean product made from Bacillus species in rice straw and boiled soybean, and one of its main flavonoids, genistein, against Trp-P-1 induced cytotoxicity and DNA damage in HepG2 cells. CKJ and genistein exhibited protective effect against Trp-P-1 induced cytotoxicity and Trp-P-1 induced DNA single strand breaks. CKJ and genistein inhibited Trp-P-1 induced CYP1A1 and CYP1A2 transcription in HepG2 cells. Our results indicated that CKJ and genistein have the protective effect against Trp-P-1 induced cytotoxicity and DNA damage. Via inhibiting expression of CYP1A1 and CYP1A2. CKJ can be used as a promising functional food material that prevents the genotoxicity induced by carcinogens produced by the heat treatment of foods such as heterocyclic amines (HCAs) that cause genomic instability.

• Proceedings of the Korea Concrete Institute Conference
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• 2008.11a
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• pp.697-700
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• 2008

Recently, high strength, flowability, and durability of concrete were required according to increase of large scale and high rise structure. However, cracks occurred easily on the high performance concrete. In this reason, using expansion agent for reducing shrinkage cracks were increased, but it did not consider on durability of high performance concrete. Accordingly, this study1 investigated the resistance of shrinkage and damage form salt by mixing CSA expansion agent on the blast-furnace slag cement and mixed cement for the low heat of hydration by three components. The cases that 8% of expansion agent was mixed and the proportion was OPC were expanded till 43.7 times compared with control concrete. For the resistance to the damage of salt, it was improved when mixing ratio was incresed and the maximum size of coarse aggregate growed bigger. In this study, the resistance to the damage of salt of the cases that 8% of expansion agent was mixed was improved about 16% compared with control concrete.

• Proceedings of the Korea Concrete Institute Conference
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• 2008.11a
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• pp.661-664
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• 2008

The structure which is located in special surroundings like ocean-environment is physically and chemically eroded by seawater or salt damage, and then concrete-structure becomes deteriorated by iron corrosion and swelling pressure which leads to remarkably decline durability due to cracks and exploitation. As a measure against salt damage, it is actively being examined to use the blended cement that controls salt damage and fix chloride in the process of hydration. In this study, therefore, to examine the property of marine concrete added admixture, marine concrete is manufactured by adding high-strength admixture(omega2000) by 0, 5, 10, and 15% to low heat-blended cement. Then it shows that the compressive strength of manufactured marine cement tends to increase and chloride penetration resistance improves.

• Proceedings of the Korea Concrete Institute Conference
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• 2008.11a
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• pp.477-480
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• 2008

In tunnel, though the frequency of fire occurrence is relatively lower than other structures, the characteristics of sealed space tends to cause the temperature to rapidly rise to more than $1000^{\circ}C$ within 5 minutes after fire, which might eventually lead to a large fire that usually results in a loss of lives and the damage to the properties, not to mention a huge cost necessary for repair and maintenance after fire. Referring to foreign tunnel fire scenarios, it clarified the heat transfer characteristics of concrete PC panel lining depending on fire intensity (ISO, MHC, RWS), and to identify the range of thermal damage, the evaluation was carried out using ITA standard. As a result, 39mm under ISO fire condition, 50mm under MHC and 100mm under RWS were measured. And when it comes to spalling, 30mm was measured under RWS. When PC panel was designed to serve the support, a fire resistance to the minimum depth of 100mm of the concrete that might be damaged under the fire shall be maintained, and in case of a non-support structure, PC lining shall have at least 100mm thickness.

• Molecular & Cellular Toxicology
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• v.1 no.2
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• pp.73-77
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• 2005

Nickel is the one of potent environmental, the occupational pollutants and the classified human carcinogens. It is a serious hazard to human health, when the metal exposure. To prevent human diseases from the heavy metals, it is seemingly important that understanding of how nickel exerts their toxicity and carcinogenic effect at a molecular and a genomic level. The process of nickel absorption has been demonstrated as phagocytosis, iron channel and diffusion. Uptaked nickel has been suggested to induce carcinogenesis via two pathways, a direct DNA damaging pathway and an indirect DNA damaging pathway. The former was originated from the ability of metal to generate Reactive Oxygen Species (ROS) and the reactive intermediates to interact with DNA directly. Ni-generated ROS or Nickel itself, interacts with DNAs and histones to cause DNA damage and chromosomal abnormality. The latter was originated from an indirect DNA damage via inhibition of DNA repair, or condensation and methylation of DNA. Cells have ability to protect from the genotoxic stresses by changing gene expression. Microarray analysis of the cells treated with nickel or nickel compounds, show the specific altered gene expression profile. For example, HIF-I (Hypoxia-Inducible Factor I) and p53 were well known as transcription factors, which are upregulated in response to stress and activated by both soluble and insoluble nickel compounds. The induction of these important transcription factors exert potent selective pressure and leading to cell transformation. Genes of metallothionein and family of heat shock proteins which have been known to play role in protection and damage control, were also induced by nickel treatment. These gene expressions may give us a clue to understand of the carcinogenesis mechanism of nickel. Further discussions on molecular and genomic, are need in order to understand the specific mechanism of nickel toxicity and carcinogenicity.

• Journal of Welding and Joining
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• v.28 no.5
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• pp.69-74
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• 2010

Irradiation behavior of the reactor pressure vessel SA508 class 3 steel weld metals was examined by Charpy V Notch impact specimens. The specimens were exposed to a fluence of $2.8{\times}1019$ neutrons(n)/$cm^2$(E>1 MeV) at $288^{\circ}C$. The irradiation damage of weld metal was evaluated by comparison between unirradiated and irradiated specimens in terms of absorbed energy and lateral expansion. The specimens for neutron irradiation were welded by submerged arc welding process at a heat input of 3.2 kJ/mm which showed good toughness in terms of weld microstructure, absorbed energy and lateral expansion. The post-irradiation Charpy V notch 41J and 68J transition temperature elevation were $65^{\circ}C$ and $70^{\circ}C$, respectively. This elevation was accompanied by a 20% reduction in Charpy V notch upper shelf energy level. The lateral expansion at 0.9mm irradiated Charpy specimens showed temperature elevation of $65^{\circ}C$ and was greatly decreased due to radiation damage.

• Fire Science and Engineering
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• v.24 no.4
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• pp.86-91
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• 2010

In event of a tunnel fire, all kinds of equipment can be destroyed in high temperature that can exceed $1300^{\circ}C$, fatal structural demage can be caused by spalling of concrete structural elements. To make matters worse, there is a high possibility of the secondary damage which can lead to the collapse of the shear resisting structure. Accordingly, it is time that we developed the technology to counter fires in connection with the fire-resistant design of a tunnel structure. To secure the reliability of the fire-resistance performance of a tunnel structure, it is necessary to assess the fire's behavior on every structural element exposed to the fire as well as to calculate the tunnel fire intensity and the quantity of heat released. In this study, we drew out the fire damage range of each structural element of a tunnel and the minimum thickness of concrete cover for each fire-resistant material through some actual experiments of fire behavior on the structural elements of a tunnel.

• The Journal of the Convergence on Culture Technology
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• v.9 no.4
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• pp.577-585
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• 2023

This study applied ALOHA Program to predict the damage caused by fire and explosion predicted to occur from gas leakage at LPG stations and presented plans to prevent damages by diagramming the impact range and distance. The propane gas leakage from LPG stations causes human damage like breathing issues and property damage, including building destruction to residents in the surrounding areas. As a way to reduce this, first, the hazardous substance safety manager of the LPG station needs to check frequently whether the meters and safety valves are working properly to prevent leakage in advance. Second, the LPG stations' storage tanks should be worked by the person who received "hazardous substance safety manager training" under the provisions of the Act on the Safety Control of Hazardous Substances and has been appointed as a "hazardous substance safety manager" by the fire department. Third, LPG station's various safety device functions, such as overfill prevention devices, must be checked on a regular basis. Finally, wearing work clothes and shoes that prevent static electricity at LPG stations is highly recommended, as static can cause a fire when gas leaks.

• Journal of the Korean Applied Science and Technology
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• v.35 no.3
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• pp.787-796
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• 2018

This study was conducted to investigate the effects of probiotic mixture on fecal ammonia, caecal microorganism, immune response, egg quality and production in layer under heat stress (HS).A total of four hundred 50 week olds Hy-Line Brown layers were randomly divided into four groups of 100 heads each: C (control, room temperature $25^{\circ}C$), HS (heat stress $33^{\circ}C$), PM (HS plus probiotic mixture 500, 750 mg/kg of diets). Egg production, egg quality, spleen weight, blood IgG and lymphocyte concentrations were increased in the PM group compared to the HS group, while mortality, the heterophil:lymphocyte (H:L) ratio, and corticosterone levelswere significantly decreased. Lactobacillus was increased in the PM group compared to the HS group, but E. coli, coliform bacteria and aerobic bacteria were significantly reduced. Fecal ammonia production was significantly increased in the HS group compared to the PM group. In conclusion, the results of this study that these mixed probiotics can reduce the heat damage of the summer laying hens and can be an effective nutritional strategy to reduce odor generation from feces, and to improve egg quality and laying production through immune response and caecal microbial balance.

• The Journal of the Korea Contents Association
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• v.20 no.5
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• pp.525-535
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• 2020

This study aims to evaluate the economic value of the heat wave watch/warning (HW/W) forecast provided by the KMA (Korea Meteorological Administration) for the public sector. Local govermenments of Korea currently use the HW/W forecasts as a major input variable to determine the preparative requisite level for reducing potential damage by extreme heat events. To assess the value of the HW/W, which is not a marketable commodity, a decision-making model taking into account the cost and loss was established. The 'cost' variable was defined as the heat wave countermeasures budget for Seoul and Busan in 2016, and the 'loss' variable was set as the amount of health insurance claims for those 65 and older obtained from the Health Insurance Review and Assessment Service. Using this model, the value of the HW/W in 2016 was calculated as KRW 4,133M and KRW1,090M for Seoul and Busan, respectively. In addition, if the KMA reduces the False Alarm of the HW/W by a single instance, the value will be increased by KRW 76.6M and KRW 16.8M for the two cities. The results of this study are useful in quantitatively estimation of the value of the HW/W forthe public sector.