• Nutrition Research and Practice
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• v.6 no.2
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• pp.97-105
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• 2012

$Schizandra$ $chinensis$ Baillon is a traditional folk medicine plant that is used to treat and prevent several inflammatory diseases and cancer in Korea, but the underlying mechanisms involved in its anti-allergic activity are not fully understood. This study was designed to investigate mechanisms of anti-allergic activity of a $Schizandra$ $chinensis$ Baillon water extract (SCWE) in immunoglobulin E (IgE)-antigen complex-stimulated RBL2H3 cells and to assess whether gastric and intestinal digestion affects the anti-allergic properties of SCWE. Oxidative stress is an important consequence of the allergic inflammatory response. The antioxidant activities of SCWE increased in a concentration-dependent manner. RBL-2H3 cells were sensitized with monoclonal anti-dinitrophenol (DNP) specific IgE, treated with SCWE, and challenged with the antigen DNP-human serum albumin. SCWE inhibited ${\beta}$-hexosaminidase release and expression of interleukin (IL)-4, IL-13, and tumor necrosis factor-alpha (TNF-${\alpha}$) mRNA and protein in IgE-antigen complex-stimulated RBL2H3 cells. We found that digested SCWE fully maintained its antioxidant activity and anti-allergic activity against the IgE-antigen complex-induced activation of RBL-2H3 cells. SCWE may be useful for preventing allergic diseases, such as asthma. Thus, SCWE could be used as a natural functional ingredient for allergic diseases in the food and/or pharmaceutical industries.

• The Journal of the Korea Contents Association
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• v.10 no.3
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• pp.222-231
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• 2010

This study surveyed on the actual condition for food habits of high-school students in some of Gangwon region, and on the oral-health knowledge level according to the food habits. Its findings are as follows. 1. As a result of students' eating a light meal, the students, who eat a light meal once a day, were the largest with 46.5%. In consequence of examining about the time of eating 46.5% in students, the students, who eat a light meal irregularly, were the largest with 39.0%. 2. As a result of examining about food that students eat as a light meal, the students, who eat pizzas much as a light meal, were the largest with 40.1%. There was significant difference by gender(p<001), by division(p<.05), by parents' monthly income(p<.05) and by monthly pocket money(p<.001) 3. As a result of examining about students' food habit, the total average out of 10-point perfection was 5.03. Thus, students were indicated to be not so good in food habits. As a result of examining students' recognition on a light meal, which has influence upon dental caries, the students, who recognize that candy and chocolate have influence upon dental caries, were the largest with 49.2%. As a result of examining about oral health knowledge according to the actual condition for students' food habits, by frequency of eating a light meal, the students, who eat a light meal once per 3~4 days, had the highest oral-health knowledge. The students, who eat a light meal under once per week, had the low oral-health knowledge, and showed significant difference according to frequency of eating a light meal.

• Journal of Korean Academy of Nursing Administration
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• v.22 no.3
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• pp.303-312
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• 2016

Purpose: The purpose of this study was to identify relationships among self-esteem, social support, nursing organizational culture, experience of workplace bullying, and the consequences of workplace bullying in hospital nurses, and then to provide basic information for developing workplace bullying prevention programs. Methods: Participants were 122 hospital nurses from three general hospitals. Data collection was done during April and May 2015. Data were collected using self-report questionnaires which were used to identify participants' characteristics, self-esteem, social support, nursing organizational culture, and workplace bullying. Results: Approximately one quarter of the nurses had experienced workplace bullying in the past six months. Hierarchical regression analysis showed that experience of workplace bullying (${\beta}=.45$) and self-esteem (${\beta}=-.31$) explained 53.3% of the variance in consequences of workplace bullying. Conclusion: Based on the findings that experiencing workplace bullying and having a low self-esteem were likely to increase workplace bullying in hospital nurses, there is a need to develop prevention and intervention programs on avoiding or dealing with workplace bullying.

• Journal of Korea Multimedia Society
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• v.10 no.12
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• pp.1741-1751
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• 2007

The imprecise computation technique ensures that all time-critical tasks produce their results before their deadlines by trading off the quality of the results for the computation time requirements of the tasks. In the imprecise computation, most scheduling problems of satisfying both 0/1 constraints and timing constraints, while the total error is minimized, are NP-complete when the optional tasks have arbitrary processing times. In the previous studies, the reasonable strategies of scheduling tasks with the 0/1 constraints on uniprocessors and multiprocessors for minimizing the total error are proposed. But, these algorithms are all off-line algorithms. Then, in the on-line scheduling, NORA(No Off-line tasks and on-line tasks Ready upon Arrival) algorithm can find a schedule with the minimum total error. In NORA algorithm, EDF(Earliest Deadline First) strategy is adopted in the scheduling of optional tasks. On the other hand, for the task system with 0/1 constraints, NORA algorithm may not suitable any more for minimizing total error of the imprecise tasks. Therefore, in this paper, an on-line algorithm is proposed to minimize total error for the imprecise real-time task system with 0/1 constraints. This algorithm is suitable for the imprecise on-line system with 0/1 constraints. Next, to evaluate performance of this algorithm, a series of experiments are done. As a consequence of the performance comparison, it has been concluded that IOSMTE(Imprecise On-line Scheduling to Minimize Total Error) algorithm proposed in this paper outperforms LOF(Longest Optional First) strategy and SOF(Shortest Optional First) strategy for the most cases.

• Journal of the Korean Society of Safety
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• v.29 no.6
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• pp.68-75
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• 2014

It is very important to classify explosion hazardous area (EHA) suitably and to use proper explosion-proof electric installations for facilities using flammable gases and liquids. In the past, various examples in the Notification of Ministry of Employment and Labor were referred to in classifying EHA. But, at present, many companies use the hypothetical volume in Korean Standards (KS). This study reviews the validity of EHA classification based on the hypothetical volume by comparing the calculated radii of EHA with those obtained by a consequence analysis program called PHAST and a mathematical approach in British Standards (BS). The radii of EHA by the hypothetical volume were found to be slightly larger than those by the other two methods. This was attributed to rather conservative uses of a safety factor(k) and a correction factor(f) for availability of ventilation in calculating the hypothetical volume. Since the differences are not so conspicuous, however, it is concluded that the hypothetical volume in KS is a valid means for the classification of EHA. This study also presents a table of the radii of EHA for easy reference by small-scale companies using city gas, C3-LPG and flammable liquid(toluene), respectively. The table consists of 25 leakage scenarios corresponding to combinations of 5 pipe(nozzle) sizes and 5 operating conditions for each flammable gas and liquid.

• Journal of Korean Society for Atmospheric Environment
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• v.21 no.E1
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• pp.1-11
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• 2005

The concentration levels of gaseous elemental mercury (GEM) in ambient air have been investigated from a monitoring station located in Yang Jae district of Seoul, Korea for a long-term period covering 1997 through 2002. The mean concentration of Hg, if computed based on its hourly measurement data for this six-year period, was $5.32\pm3.53 ng m^{-3} (N = 27,170)$. The inspection of the diurnal distribution patterns indicated the presence of notably high concentration levels during nighttime relative to daytime (e.g., the mean hourly value as high as $9 ng m^{-3}$ in winter nighttime). When divided seasonally, the highest mean of $6.12 ng m^{-3}$ was also observed during winter followed by spring, fall, and summer. The results of our analysis confirmed the relative dominance of winter (seasonally) or nighttime (diurnally), while exhibiting a complicated trend on a long-term basis. Examination of our data over a different temporal scale consistently indicated that dynamic changes in Hg concentrations occurred through time in line with changes in the strength and diversity of the source processes. It is thus acknowledged that the presence of unusually high Hg levels is the consequence of intense man-made activities, while such signatures can vary in a competitive manner.

• The Korean Journal of Physiology and Pharmacology
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• v.16 no.1
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• pp.71-77
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• 2012

Mitochondrial dynamics and distribution is critical for their role in bioenergetics and cell survival. We investigated the consequence of altered fission/fusion on mitochondrial function and motility in INS-1E rat clonal ${\beta}$-cells. Adenoviruses were used to induce doxycycline-dependent expression of wild type (WT-Mfn1) or a dominant negative mitofusin 1 mutant (DN-Mfn1). Mitochondrial morphology and motility were analyzed by monitoring mitochondrially-targeted red fluorescent protein. Adenovirus-driven overexpression of WT-Mfn1 elicited severe aggregation of mitochondria, preventing them from reaching peripheral near plasma membrane areas of the cell. Overexpression of DN-Mfn1 resulted in fragmented mitochondria with widespread cytosolic distribution. WT-Mfn1 overexpression impaired mitochondrial function as glucose- and oligomycin-induced mitochondrial hyperpolarization were markedly reduced. Viability of the INS-1E cells, however, was not affected. Mitochondrial motility was significantly reduced in WT-Mfn1 overexpressing cells. Conversely, fragmented mitochondria in DN-Mfn1 overexpressing cells showed more vigorous movement than mitochondria in control cells. Movement of these mitochondria was also less microtubule-dependent. These results suggest that Mfn1-induced hyperfusion leads to mitochondrial dysfunction and hypomotility, which may explain impaired metabolism-secretion coupling in insulin-releasing cells overexpressing Mfn1.

• Environmental Analysis Health and Toxicology
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• v.7 no.1_2
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• pp.1-16
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• 1992

Biologically, MGK-264 (N-octyl bicycloheptene dicarboximide) acts as a synergists for insecticides mainly pyrethrins and pyrethroids. It's used extensively in combination with pyrethrin and piperonyl butoxide and also with personal insect repellent and cockroach repellents. But the toxic effect of MGK-264 in mamalians was a relatively little known therefore in this studies it was initiated to examine the toxic effect of MGK -264 in rats. For 5 weeks it administrated daily in each 250 mg and 500 mg of MGK-264 per kg of body weight in rats. 1) The body weight gain and the LYMPH (%) value in blood were observed a slight tendency to reduce in accordance with amount of dose and number treatment time. 2) The content of cytochrome P-450 and activity of NADPH-cytochrome c reductase were decreased in liver and those were observed some tendency in the kidney as liver but not significant. 3) The liver cholinesterase activity in the both 250 mg/kg and 500 mg/kg per kg of body weight with treated groups and the liver aniline hydroxylase in 500 mg/kg treated group were gradually decreased from 4 weeks after treated groups. In consequence it would sugested that the toxic effect of MGK-264 was low but in could offer hazard effect in liver and nervers system of rats if it was administrated move dose of MGK-264 and agumented in number of treated time.

• Journal of Environmental Science International
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• v.20 no.8
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• pp.1049-1059
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• 2011

This paper examines the effects of the partial solar eclipse of 22 July 2009 across the Korean peninsular on surface temperature and ozone concentrations in over the Busan metropolitan region (BMR). The observed data in the BMR demonstrated that the solar eclipse phenomenon clearly affects the surface ozone concentration as well as the air temperature. The decrease in temperature ranging from 1.2 to $5.4^{\circ}C$ was observed at 11 meteorological sites during the eclipse as a consequence of the solar radiation decrease. A large temperature drop exceeding $4^{\circ}C$ was observed at most area (8 sites) of the BMR. Significant ozone drop (18~29 ppb) was also observed during the eclipse mainly due to the decreased efficiency of the photochemical ozone formation. The ozone concentration started to decrease at approximately 1 to 2 hours after the event and reached its minimum value for a half hour to 2 hours after maximum eclipse. The rate of ozone fall ranged between 0.18 and 0.49 ppb/min. The comparison between ozone measurements and the expected values derived from the fitted curve analysis showed that the maximum drop in ozone concentrations occurred at noon or 1 PM and was pronounced at industrial areas.

• Journal of Physiology & Pathology in Korean Medicine
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• v.17 no.3
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• pp.842-844
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• 2003

Miller Fisher syndrome is characterized by ophthalmoplegia, ataxia and areflexia and develops after respiratory tract viral infection. Other events are GI tract infection, vaccination, digitalis intoxication, insect bite and delivery. Diagnosis of Miller Fisher syndrome can be made with clinical history taking, cardinal symptoms and normal findings of CT or MRI. We have experienced a case of Miller Fisher syndrome and treated with herbal medicine, eletro-acupuncture at paralytic external ophthalmic muscles. We enforced electro-acupuncture for 10 minutes daily. We used the PG-306 electro-acupuncture products(Suzuki Iryoki Co. Japan) and applied the low consequence wave of 1-8Hz. In 3 months, all the main symptoms disappered and the patient improved in health. Based on this experience, herbal medicine and eletro-acupuncture can be applied to the Miller Fisher syndrome.