• 생물정신의학
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• 제21권3호
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• pp.107-113
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• 2014

Objectives Restless legs syndrome (RLS) is a sleep disorder characterized by uncomfortable and unpleasant sensations in the legs and an urge to move the legs, usually at night. The aim of this study is to investigate the incidence of RLS in patients with late life depression and its influence on various clinical outcomes such as severity of depression, sleep quality, cognitive function, and quality of life and accordingly, to elucidate the clinical significance of RLS in patients with late life depression (LLD). Methods This study enlisted 170 depressive patients aged 65 years or older from an outpatient clinic. Structured diagnostic interviews were performed using the Korean version of the Mini-International Neuropsychiatric Interview. All patients completed the questionnaires, including the International RLS Severity Scale, the Korean version of Short-Form 36-Item Health Survey (SF-36), and the Pittsburgh Sleep Quality Index (PSQI). The severity of depression was evaluated by the Korean form of the Geriatric Depression Scale (KGDS) and the level of global cognition was assessed by the Mini-Mental State Examination in the Korean version of The Consortium to Establish a Registry for Alzheimer's Disease Assessment Packet (MMSE-KC). Results The incidence of RLS was 17.6% in LLD patients. RLS was more prevalent among the subjects with major depressive disorder (MDD) than those with minor depressive disorder or subsyndromal depressive disorder. The RLS group showed higher score in the KGDS than the Non-RLS group but the difference did not reach the statistical significance (p = 0.095, Student t-test). The mean PSQI score was significantly higher in the RLS group than in the Non-RLS group (p = 0.001, Student t-test). The MMSE-KC score was also lower in the RLS group than in Non-RLS group (p = 0.009, analysis of covariance). But, there was no difference in the score of SF-36 between the RLS group and the Non-RLS group. Conclusions RLS is common in LLD patients, especially in the patients with MDD and is associated with poor sleep quality and cognitive dysfunction, indicating that RLS is clinically significant in patients with LLD. Therefore, RLS should be considered as an important clinical issue in the management of LLD.

• Journal of Acupuncture Research
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• 제32권3호
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• pp.163-173
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• 2015

Objectives : The aim of this study is to determine whether Chinemys reevesii Gray pharmacopuncture is a clinically effective treatment for women with knee osteoarthritis. Methods : Female patients with knee osteoarthritis were recruited from May $1^{st}$, 2014 to April $15^{th}$, 2015 at the Department of Acupuncture & Moxibustion Medicine of Dong-Eui University Korean Medical Hospital. Patients were randomly assigned to two groups. 4.0 ml of Chinemys reevesii Gray pharmacopuncture was injected at acupuncture points of the experimental group(n = 24) twice a week for three weeks. The control group(n = 24) received 5 % dextrose injections in order to identically stimulate the same acupuncture points of $ST_{35}$, $ST_{34}$, $SP_9$, $SP_{10}$, $GB_{34}$, $LR_8$, $EX-LE_4$, and $EX-LE_2$. The Short-Form McGill Pain Questionnaire(SF-MPQ), the Korean Western Ontario and McMaster Universities Osteoarthritis Index(KWOMAC), and the European Quality of Life-5 Dimensions(EQ-5D) were recorded to evaluate treatment efficacy at first visit, after two weeks and four weeks from the initial visit. Results : 40 patients completed the trial. The experimental group showed more significant improvement than the control group in the scores of SF-MPQ, KWOMAC, and EQ-5D. However, there was no significant difference between groups in a few of the assessment scales. Conclusions : Chinemys reevesii Gray pharmacopuncture can be an effective treatment in control of pain, improvement in function and health-related quality of life for women with knee osteoarthritis.

• 한국산학기술학회논문지
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• 제18권12호
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• pp.557-563
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• 2017

본 연구는 지역사회와 시설에 거주중인 치매환자들의 단계에 따라 기본적 일상생활수행, 수단적 일상생활수행을 파악하여 임상현장에 근거를 제시하고 치매환자 관리를 위한 기초자료를 제공하고자 하였다. 자료 수집은 전국에 소재한 요양원, 주간보호센터, 지역사회, 보건소, 요양병원, 요양원, 광역치매지원센터 등 15개의 기관에서 실시하였으며, 2015년 10월 1일 ~ 2015년 11월 20일까지 지역사회거주 치매환자 100명, 시설거주 치매환자 100명을 평가하였다. 모든 자료는 연구자와 평가방법에 대해 충분한 교육을 받은 평가자들이 ADCS-ADL, S-IADL, S-ADL, MMSE-K를 직접 평가하였다. 치매환자의 단계별 일상생활수행수준의 차이를 비교하기 위해 일원배치 분산분석 후 사후검정과 시각적 그래프를 통해 분석하였으며 거주형태와 치매단계에 따른 분석은 독립표본 t 검정을 실시하였다. 지역사회거주 치매환자와 시설거주 치매환자의 일상생활수행수준의 차이를 비교한 결과 수단적 일상생활수행과 기본적 일상생활수행의 모든 항목이 중등도 치매단계에서 차이를 보였으며(p<.01), 사후검정결과 최경도, 경도와 중등도 간에 차이가 있는 것으로 보였다. 치매거주 형태별로 일상생활수행의 차이를 확인한 결과 모든 단계에서 유의한 차이를 보이지 않았다(p>.05). 본 연구의 결과로 미루어 볼 때 향후 진행되는 치매연구에서는 효과의 지표로써 일상생활수행평가의 적용 시 기본적 일상생활수행보다는 수단적 일상생활의 변화를 확인하는 것이 매우 중요할 것으로 사료된다.

• 한국식품영양과학회지
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• 제29권4호
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• pp.701-711
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• 2000

본 연구는 우리나라의 식생활에 적절한 영양 평 가 방법을 제시하는데 기여하고자 하는 목적으로, 경북지역에 거주하는 성인 남녀 196명을 대상으로 24시간 회상법을 통해 개인별 영양소 섭취상태를 조사한 후 영양상태를 질적, 양 적으로 평가하였다. 본 연구의 결과는 다음과 같다. 경북지역 성인 남녀의 일일 평균 영양소 섭취량은 비교적 양호한 편이나, 칼슘과 비타민 A에서 영양 권장량보다 적은 83%, 77%를 섭취했으며, 칼슘을 제외한 모든 영양소에서 남자의 평균 섭취량이 여자의 평균 섭취량보다 많았다. INQ로 살펴본 영양소 섭취의 질적 평가는 비타민 C가 2.39로 가장 높게 나왔으며, 비타민 A가 0.84, 칼슘이 0.89의 점수를 보여 Ca과 비타민 A는 양과 질 측면에서 우려되는 것으로 조사되었다. 평균 영양소 적정도는 남자가 0.88, 여자가 0.86으로 남녀 간에 차이가 없었다. 영양소 섭취량과 각 용니과의 상관관계에서 남자의 경우에는 영양소 섭취량과 유의 한 관계를 나타내는 요인으로서 지방과 연령 사이에만 유의한 양의 관계가 나타난 반면 여 자의 경우에는 나이, 식사 섭취 횟수는 대부분의 영양소에서 유의적인 양의 상관관계를 보 였다. 남자는 가계 총수입이 높을수록 식사 중의 비타민 B2 영양밀도가 높았으며 여자의 경 우에는 INQ 중에서 인(p<0.050)과 철분(p<0.05)이 연령과 유의한 양의 상관관계를 보였다. MAR은 여자의 경우에 한하여 연령(p<0.05)과 양의 상관관계를, 학력(p<0.01)과 유의적인 음의 상관관계를 보였으며 하루식사횟수(p<0.001)와도 유의한 양의 관계를 나타내었다. 이 상을 종합해 볼 때 경북지역에 거주하는 성인의 경우 남자가 여자에 비해 영양섭취상태가 전반적으로 양호하다고 할 수 있으며 여자 20대의 경우에 영양섭취가 가장 저조하였고 특히 칼슘과 비타민 A의 섭취가 부족하였다. 이연령층은 임신, 출산과 연결되는 영양취약집단이 므로 이들을 대상으로 규칙적인 식사의 중요성과 다양한 식품의 섭취를 홍보하는 영양교육 이 보건소를 통해 강화되어야 하리라고 보여진다.

• 한국동물위생학회지
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• 제29권1호
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• pp.55-63
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• 2006

Alcoholism and alcohol abuse are major public health concerns. This is linked to the injury of many organs, especially liver. Experiments were peformed to know the acute effects of LeeKwaDoo (LKD) induced by two-third partial hepatectomy (PH) in rats. In liver samples, regeneration parameters and histological assessment were performed. For the blood biochemical study, the blood were assayed with AST, ALT. The portal branch of liver lobes was ligated in the male Sprague-Dowley rats, two-thirds partial hepatectomies were also performed. It was estimated bodyweight and relative liver weight for the index of liver mass. For the marker of blood chemistry, we investigate the serum sample of rats and demonstrated the level of AST, ALT. Remaining tissues of liver developed as microscopic structures. Resection of the lobes in PH+LKD group resulted in a marked change of liver weight, blood chemistry and histological changes. The initiation of the proliferative response in PH group stimulated as well as reduction of the liver mass. On the other hands, the Initiation of the proliferative response in PH+LKD group delayed. Eventually, both PH group and PH+LKD group was restored relative liver weigh after 7 day. In conclusion, the acute adminstration of LKD seems to inhibit the initial response of liver regeneration through alcohol effects.

• Journal of Nutrition and Health
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• 제41권8호
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• pp.786-796
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• 2008

본 연구는 초등학생의 영양소 섭취상태, 식습관, 학업스트레스 및 이들 요인과 학업성취도와의 관계를 분석해보고자 경기도 부천 소재 초등학교 5학년 학생 224명을 대상으로 2007년 7월에 실시하였다. 본 연구대상 학생은 정상범위의 신장과 체중 및 신체충실지수를 나타내고 있었으나 남학생에 비해 여학생에서 마른 학생의 비율이, 여학생에 비해 남학생의 비만율이 더높았다. 영양소 섭취상태는 대부분 권장량 수준으로 섭취하고 있었으며, 단백질, 비타민 A, 비타민 B1는 120% 이상 섭취하고 있었다. 그러나 칼슘 (61%)과 엽산 (66%)은 부족하게 섭취하고 있었으며, 식이섬유소와 칼륨, 엽산의 섭취량은 여학생이 남학생보다 많았다 (p < 0.05). 탄수화물：단백질：지방의 섭취비율과 n-3계열과 n-6계열 지방산 모두 적정량을 섭취하고 있었다. 식습관은 전반적으로 양호하였으으나 남학생이 여학생에 비해 불량한 편이었으며 학업스트레스는 남녀 모두 총 점수의 40% 정도로 스트레스를 적게 받고 있는 것으로 나타났다. 학업성취도는 영양소 섭취상태 (에너지, 단백질, 인, 칼륨, 아연, n-6계열 지방산, 다중불포화지방산)가 좋을수록 (p < 0.05), 식습관점수가 높을수록 좋았다 (p < 0.05). 반면, 외식 빈도수가 적을수록 학업성취도가 높은 경향을 보였다. 학업스트레스는 학업성취도가 높을수록 적게 받고 있었다 (p < 0.01). 본 연구 결과, 학업성취도가 높은 사람일수록 영양소 섭취상태와 식습관이 좋았으며 학업스트레스를 적게 받고 있었다. 따라서 영양교사와 학부모 및 담임교사들은 아동에게 체계적인 영양교육을 실시함으로서 아동의 영양 상태증진 및 올바른 식습관 정립을 통하여 학업성취도 향상에도 일부 기여할 수 있을 것으로 기대된다.

• 대한간호학회지
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• 제47권6호
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• pp.794-805
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• 2017

Purpose: Interface pressure is a factor that contributes to the occurrence of pressure injuries. This study aimed to investigate interface pressure at common sites of pressure injury (occipital, gluteal and peritrochanteric areas), to explore the relationships among risk factors, skin condition and interface pressure, and to identify risk factors influencing interface pressure. Methods: A total of 100 patients admitted to the intensive care unit were enrolled at a tertiary teaching hospital in Korea. Interface pressure was recorded by a scanning aid device (PalmQ). Patient data regarding age, pulmonary disease, Braden Scale score, body mass index, serum albumin, hemoglobin, mean blood pressure, body temperature, and oxygen saturation were included as risk factors. Data collected from July to September 2016 were analyzed using binary logistic regression. Results: The mean interface pressure of the occipital, gluteal, and right and left peritrochanteric areas were 37.96 (${\pm}14.90$), 41.15 (${\pm}16.04$), 53.44(${\pm}24.67$), and 54.33 (${\pm}22.80$) mmHg, respectively. Predictive factors for pressure injuries in the occipital area were age ${\geq}70$ years (OR 3.45, 95% confidence interval [CI]: 1.19~9.98), serum albumin deficit (OR 2.88, 95% CI: 1.00~8.26) and body temperature ${\geq}36.5^{\circ}C$ (OR 3.12, 95% CI: 1.17~8.17); age ${\geq}70$ years (OR 2.81, 95% CI: 1.10~7.15) in the right peritrochanteric area; and body temperature ${\geq}36.5^{\circ}C$ (OR 2.86, 95% CI: 1.17~6.98) in the left peritrochanteric area. Conclusion: Our findings suggest that old age, hypoalbuminemia, and high body temperature may be contributory factors to increasing interface pressure; therefore, careful assessment and nursing care of these patients are needed to prevent pressure injury. Further studies are needed to establish cutoff values of interface pressure for patients with pressure ulcers.

• Parasites, Hosts and Diseases
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• 제53권5호
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• pp.553-559
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• 2015

Research on micro-level assessment of the changes of socio-economic status following health interventions is very scarce. The use of household asset data to determine wealth indices is a common procedure for estimating socio-economic position in resource poor settings. In such settings information about income is usually lacking, and the collection of individual consumption or expenditure data would require in-depth interviews, posing a considerable risk of bias. In this study, we determined the socio-economic status of 213 households in a community population in an island in the north-western Tanzania before and 3 year after implementation of a participatory hygiene and sanitation transformation (PHAST) intervention to control schistosomiasis and intestinal worm infections. We constructed a household 'wealth index' based housing construction features (e.g., type of roof, walls, and floor) and durable assets ownership (e.g., bicycle, radio, etc.). We employed principal components analysis and classified households into wealth quintiles. The study revealed that asset variables with positive factor scores were associated with higher socio-economic status, whereas asset variables with negative factor scores were associated with lower socio-economic status. Overall, households which were rated as the poorest and very poor were on the decrease, whereas those rated as poor, less poor, and the least poor were on the increase after PHAST intervention. This decrease/increase was significant. The median shifted from -0.4376677 to 0.5001073, and the mean from -0.2605787 (SD; 2.005688) to 0.2605787 (SD; 1.831199). The difference in socio-economic status of the people between the 2 phases was highly statistically significant (P<0.001). We argue that finding of this study should be treated with caution as there were other interventions to control schistosomiasis and intestinal worm infections which were running concurrently on Kome Island apart from PHAST intervention.

• 한방비만학회지
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• 제13권1호
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• pp.33-45
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• 2013

Objectives: This study was aimed to find out the characteristics of ordinary symptoms between the control and patient groups, diagnosed as overweight or obesity, in Soyang, Taeeum, and Soeum Constitutions and among those 3 groups. Methods: As a prospective cross-sectional study based on medical records, 9213 patients, who visited Kyung Hee University Medical Center from May in 2007 to June in 2010, were included. To diagnose the constitution, Revised Questionnaire for the Sasang Constitution Classification II and examinations by oriental medical doctors who majored in Sasang Constitution Medicine were performed. Based on the World Health Organization criteria for Asian obesity assessment, body mass index (BMI) was classified into 3 groups; more than 25 as obesity, 23 to 25 as overweight, and less than 23 as normal. Ordinary symptoms questionnaire, which consists of 46 questions in 8 categories, were given to the subjects. One-way ANOVA test in continuous variables and chi-square test in categorical variables were carried out to analyze statistical significance. Results and Conclusions: 1) In general characteristics, we could find out the significant differences in age, sex, height, weight, BMI, waist circumference, blood pressure, total cholesterol, triglyceride, low density lipoprotein cholesterol, high density lipoprotein cholesterol, fasting blood sugar, and hemoglobin A1c among the 3 Constitutional groups. 2) Soyang Constitution of overweight and obesity has tendency to have higher appetite, like cool or cold water, defecate more, swear more, dislike heat, and have warmer or hotter extremities in the ordinary symptoms, compared with the control group. 3) Taeeum Constitution of overweight and obesity has tendency to have higher appetite, like cool or cold water, defecate more, swear more, dislike heat, and have warmer or hotter extremities in the ordinary symptoms, compared with the control group. 4) Soeum Constitution of overweight and obesity has tendency to have higher appetite and less fatigue in the ordinary symptoms, compared with the control group. 5) Soeum Constitution showed the slightest increase in appetite, preference about room temperature water, less number of feces, and feeling of chill and warmer extremities in ordinary symptoms, compared with Soyang and Taeeum Constitutions. Taeeum Constitution showed the distinct increase in appetite and sweating in ordinary symptoms, compared with Soyang and Soeum Constitutions.

• The Korean journal of internal medicine
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• 제33권6호
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• pp.1224-1233
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• 2018

Background/Aims: The objective of this study was to determine the efficacy and safety of add-on therapy with certolizumab pegol (CZP) in active rheumatoid arthritis (RA) patients of a single ethnicity. Methods: In this 24-week, phase 3, randomized, double-blind, placebo-controlled trial, eligible patients (n = 127) were randomized 2:1 to subcutaneous CZP + methotrexate (MTX; 400 mg at week 0, 2, and 4 followed by 200 mg every 2 weeks) or placebo + MTX. Results: At week 24, the American College of Rheumatology criteria for 20% (ACR20) response rate was significantly greater with CZP + MTX than with placebo (66.7% vs. 27.5%, p < 0.001). Differences in ACR20 response rates for CZP vs. placebo were significant from week 1 (p < 0.05) and remained significant through week 24. The CZP group reported significant improvement in physical function and disability compared to the placebo group (p < 0.001) at week 24, as assessed by Korean Health Assessment Questionnaire-Disability Index (KHAQ-DI). Post hoc analysis indicated that the proportion of patients who had ACR70 responses, Disease Activity Score 28 (DAS28) low disease activity, and DAS28 remission at week 24 was greater in CZP + MTX-treated patients who achieved a decrease in DAS28 ${\geq}1.2$ (43.8%) at week 4 than in nonresponders. Among 18 (22.2%) and 14 patients (35.0%) in CZP and placebo groups who had latent tuberculosis (TB), none developed active TB. Most adverse events were mild or moderate. Conclusions: CZP treatment combined with MTX in active RA patients with moderate to severe disease activity and an inadequate response to MTX resulted in rapid onset of efficacy, which is associated with better clinical outcome at week 24 and has an acceptable safety profile, especially in an intermediate TB-burden population.