• Archives of Plastic Surgery
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• 제34권1호
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• pp.119-122
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• 2007

Purpose: Although liposarcoma is the second most common soft tissue sarcoma in adults, the incidence of liposarcoma of the head and neck is rare. There is only one reported case in Korea and moreover, only in adolescence. We report a case of liposarcoma on the neck in a 32-year-old male in adult. Methods: The patient had a slow growing, none tender mass on the posterior neck without lymphadenopathy, which has been present for 3 years and recurred twice during that time. MRI showed a 1.5 cm sized ovoid, well demarcated mass that was located in the subcutaneous layer of the posterior neck. Results: The mass was surgically removed. The resection margin was free of tumor on frozen biopsy and histopathologic examination indicated myxoid and round cell liposarcoma. The whole body F-18 FDG PET-CT applied on the fourteenth day postoperatively, revealed a moderate FDG-uptaking soft tissue lesion showing postoperative wound healing process on the posterior neck region and there was no distant metastasis. Conclusion: Liposarcoma is the second most common soft tissue sarcoma in adults. But, it rarely involves the head and neck region. Prognosis is principally dependent on histologic subtype and grade. Low grade liposarcoma such as well differentiated and myxoid liposarcoma tend to recur locally, rarely metastasize. On the other hand, high grade liposarcoma such as round cell and pleomorphic liposarcoma have higher rates of local recurrence and distant metastasis. Complete surgical excision provides the most effective means of treatment. Radiotherapy or chemotherapy can be used as an asjunctive treatment modality.

• Archives of Plastic Surgery
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• 제38권4호
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• pp.458-464
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• 2011

Purpose: Metacarpal fractures are common hand injury that may require operative intervention to ensure adequate reduction and stabilization. Traditionally, titanium miniplate was used for rigid fixation of bone fractures. However, the use of permanent plate lends itself to multiple complications such as infection, exposure of the hardware, tendon adhesions, tendon rupture, prolonged pain, bony atrophy and osteoporosis (stress shielding), metal sensitization, and palpation under the skin. This study evaluated the usefulness and stability of biodegradable plates and screws for treatment of metacarpal bone fractures. Methods: There was 17 patients who had surgery for metacarpal bone fracture from April 2007 to June 2010. All patients had open reduction and internal fixation. We used absorbable plates and screws (Inion CPS$^{(R)}$) for internal fixation. Postoperative results were assessed with x-ray. Stability of plates and screws, healing process and its complications were observed by clinical and radiographic assessment. Results: All patients were successfully reduced of bone fracture, and fixations with absorbable plates and screws were stable. The mean follow up period was 7.1 months. 2 patients complained postoperative pain, but they were relieved with analgesics. All patients experienced transient stiffness, but they were relieved with active assistive range of motion after removal of splint. No patients suffered complications which could be occurred by using metallic plate. Conclusion: There was no critical complications such as re-fracture or nonunion among patients. No patients suffered side effects related with metallic implants. Biodegradable implants can offer clinically stable and attractive alternative to metallic implants to stabilize metacarpal bone fractures in the hand.

• Archives of Plastic Surgery
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• 제37권4호
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• pp.317-322
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• 2010

Purpose: There is no clear evidence of the original cause of hypertrophic scar, and the effective method of treatment is not yet established. Recently the steps of searching in gene and molecular level are proceeding. we are trying to recognize the difference between keratinocytes of hypertrophic scar and normal skin. Then we do support the comprehension of the scar formation mechanism and scar management. Methods: Total RNAs were extracted from cultured keratinocytes from 4 hypertrophic scars and normal skins. The cDNA chips were prepared. A total of 3063 cDNAs from human cDNA library were arrayed. And the scanning data were analyzed. Results: On microarray, heat shock protein, pyruvate kinase, tumor rejection antigen were more than 2 fold intensity genes. Among them, heat shock 70 kd protein showed the strongest intensity difference. Conclusion: In this study, it can be concluded that heat shock proteins play an important role in the process of wound healing and scar formation. This study provides basic biologic information for scar research. The new way of the prevention and treatment of scar formation would be introduced with further investigations.

• Restorative Dentistry and Endodontics
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• 제23권1호
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• pp.20-42
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• 1998

The present study was designed to understand the basic principles of the laser system and to assess the optimal coditions of the Nd:YAG laser irradiation system in order to expand the use of the laser system in the dental field. The laser system used in this study was a pulsed-wave output type and the power level is 9 watts. The incisors of developing rats were irradiated with the laser system explained above for 0.5, 1, and 2 seconds giving energy density 71, 167, and 215 J/$cm^2$ respectively. The rats were sacrificed just after irradiation or 10 minutes and 10 days after irradiation. The specimens were examined with the stereoscope, light microscope and transmission electron microscope. The results are as follows: 1. The tissue removal efficiency (depth of the cavity formed) is increased with the energy density after Nd:YAG laser irradiation. 2. The carbonized area is increased with the energy density. Cracks and melted appearance are seen in all kinds of the energy densities. 3. The lacunae in the damaged alveolar bone by the laser irradiation were empty, while those in the newly formed bone were occupied with the osteocytes. The damaged alveolar bone was repaired by the osteoblasts and macrophages on the periphery of the bone matrix. 4. The damaged enamel was replaced by the loose connective tissues showing many kinds of cells. The ameloblasts were differntiated on the replaced loose connective tissue. 5. The damaged dentin was repaired by the irregular dentin formed by the odontoblasts differentiated from the mesenchymal cells migrated from the pulp core.

• Journal of Oral Medicine and Pain
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• 제25권2호
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• pp.159-165
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• 2000

Subsequent to an allogenic stem cell transplantation(ASCT) on patients with hematologic malignancy(AML, ALL, CML, multiple myeloma, lymphoma etc.), chronic GVHD(graft versus host disease), which is an immunological reaction, occurs. With treatment results from patients who were diagnosed with ALL(acute lymphocytic leukemia), undergone BMT(bone marrow transplantation) and showed oral and skin lesions due to GVHD, treatment of oral manifestations of leukemia and its general management were studied. 90% of patients with chronic GVHD show change in the oral mucosa causing oral manifestations such as leukoplakia, lichenoid change of the oral mucosa, mucosal atrophy, erythema, ulceration and xerostomia. In treating GVHD, extensive systemic immunosuppression cause bacterial, viral, fungal infection that are fatal, and even if the treatment is successful, the patient is already in a severe immunosuppressed state. Therefore, localized target therapy is preferred. In another words, topical application(rinse, cream, ointment etc.) of cyclosporin and steroid in treating oral chronic GVHD is highly recommended, and the use of PUVA(Psoralen Ultraviolet A) and thalidomide is reported to be effective. In treating such diseases, dental treatment to control pain and prevent secondary infection of oral manifestations is very important. To those patients with systemic diseases who show limited effect by general dental treatment, non-invasive treatment such as the dental laser, in addition to the use of drugs, may be necessary to actively treat pain and help the healing process. For greater results, new effective methods are to be developed for treatment.

• 사상체질의학회지
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• 제20권3호
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• pp.218-224
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• 2008

1. Objectives Constipation is a common symptom affecting 16.5% of general population in Korean countries. However, many people are looking for constipation due to the hospital. The clinical studies in herbal medicine to cure rectal tenesmus and constipation caused by the stress of the case. 2. Methods We have tried researching effect of herbal medicines(Chungpyesagan - tang and kalkunseunggi-tang) treatments to Stress caused by Taeumin rectal tenesmus and constipation patient. 3. Results A Taeumin patient diagnosed to rectal tenesmus and constipation was treated with Taeumin herbal medicines (Kalkunseunggi - tang treatments) and change of patient's the feces number of times and abdomen discomfort were improved. 4. Conclusions The cause of constipation variety as was treatments is various. The constitutional treatment with Kalkunseunggi - tang may have an effect on management of constipation. So we report the healing process and results of this patient in this study.

• Archives of Plastic Surgery
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• 제48권5호
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• pp.553-558
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• 2021

The diagnosis of the main complications resulting from lipoabdominoplasty has not yet been standardized. Infrared thermal imaging has been used to assess possible complications, such as necrosis and changes in micro- and macro-circulation, based on perforator mapping techniques, among others. The objective of this study was to present two clinical cases involving thermal imaging monitoring of the healing process of lipoabdominoplasty in the immediate postoperative evaluation and its preliminary results. Infrared thermography was performed 24 hours after the operation and on postoperative days 5, 25, and 27. In clinical case 1, it was found that the delta-R (∆T_R)-defined as the difference in minimum temperature between the highest and lowest points in the SA3 region (caution suction area) following the classification established by Matarasso-was 0.4℃ at 24 hours after surgery and decreased to 0.1℃ on a postoperative day 5. There were no complications in this case. In contrast, in clinical case 2, the ∆T_R was 1.7℃ at 24 hours after surgery (upon hospital discharge) and remained high, at 2.2℃, on postoperative day 5. A higher ∆T_R was found in the second patient, who developed necrosis of the surgical wound. The ∆T_R thermal index may be a new tool for predicting possible complications, complementing the clinical evaluation and therapeutic decision-making.

• 구강회복응용과학지
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• 제35권2호
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• pp.64-71
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• 2019

무치악 환자의 교합평면 수준을 결정할 때 후구치삼각융기는 흔하게 이용하는 해부학적 지표 중 하나로 연조직 덩어리이며 의치의 의해 피개 되어야 한다. 후구치삼각융기의 형태는 다양성을 보이며 이는 최후방 치아 발거에 따른 치유과정을 통해 형성되는 변화는 필연적이기 때문이다. 본 문헌고찰은 후구치삼각융기의 형태에 있어서 해부학적 관계와 임상적인 가치를 고려하고 형태적인 분류에 관해 고찰하고자 하였다.

• 한국해안·해양공학회논문집
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• 제31권4호
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• pp.209-220
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• 2019

해빈 안정화를 위해 거치되는 강성 구조물의 규모는 해빈의 자기 치유 능력이 구현되는 해빈 대순환 과정이 훼손되지 않는 범위에서 결정되어야 하나 최근 지나치게 대형화 되어 광폭 잠제도 빈번하게 차용되고 있는 실정이다. 이러한 시각에 기초하면 Irie et al.(1994)가 제안한 왜도 된 연흔모양 매트는 규모가 크지 않다는 점에서 현재 선호되는 광폭잠제의 대안이 될 수 있을 것으로 판단된다. 전술한 왜도 된 연흔모양 매트의 해빈 안정화 효과는 매트의 유수 단면 축소부에서 강제되는 와류가 run-down 시 외해방향으로 이송되는 표사를 얼마나 효과적으로 포획할 수 있느냐에 따라 결정되는 것으로 추정된다. 본 논문에서는 이러한 가설을 확인하기 위해 수치모의를 수행하였다. 수치모형은 Navier-Stokes 식과 물리기반 지형모형으로 구성하였으며, 모의 결과 왜도 된 연흔모양 매트 정점부에서 강제된 와류에 의해 포획된 표사가 해안 방향으로 이송되는 등 왜도 된 연흔모양 매트의 해빈 안정화 효과를 구성하는 주요 기작과 해빈 안정화 효과를 확인할 수 있었다.

• Journal of Ginseng Research
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• 제43권1호
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• pp.68-76
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• 2019

Background: In colorectal cancer (CRC), 40-60% of patients develop metastasis. The epithelial-mesenchymal transition (EMT) is a pivotal and intricate process that increases the metastatic potential of CRC. The aim of this study was to investigate the effect of Korean Red Ginseng extract (RGE) on colorectal metastasis through inhibition of EMT and the metastatic abilities of CRC cells. Methods: To investigate the effect of RGE on the metastatic phenotypes of CRC cells, CT26 and HT29 cells were evaluated by using an adhesion assay, a wound-healing assay, an invasion assay, zymography, and real-time reverse transcription-polymerase chain reaction. Western-blot analysis was conducted to elucidate the molecular mechanisms of RGE, which showed an inhibitory effect on the transforming growth factor-${\beta}1$ ($TGF-{\beta}1$)-induced EMT in HT29 cells. Additionally, the antimetastatic effect of RGE was evaluated in a mouse model of lung metastasis injected with CT26 cells. Results: RGE decreased the adhesion and migration ability of the CT26 cells and TGF-${\beta}1$-treated HT29 cells. The invasion ability was also reduced by RGE treatment through the inhibition of matrix metalloproteinase-9 expression and activity. Moreover, RGE suppressed the TGF-${\beta}1$-induced EMT via TGF-${\beta}1$/Smad-signaling-mediated Snail/E-cadherin expression in HT29 cells and lung tissue in CT26 tumor-bearing mice. Conclusion: Our results demonstrated that RGE inhibited colorectal lung metastasis through a reduction in metastatic phenotypes, such as migration, invasion, and the EMT of CRC cells.