• 인간식물환경학회지
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• 제24권6호
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• pp.663-672
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• 2021

Background and objective: As the 'Healing Agriculture Research and Development and Promotion Act' came into effect on March 25, 2021, social interest in agro-healing has been increasing exponentially. This study was conducted to analyze the priorities of agro-healing classification system and to provide basic data to inform policy directions and related research for the development and activation of agro-healing. Methods: The survey data collected from 18 experts were analyzed using the analytic hierarchy process (AHP) method in determine the relative weights of the main and sub-criteria for the classification system. There were three main criteria identified: agro-healing input industry, agro-healing service industry, and agro-healing-related/derived industry. There were also 11 sub-criteria. Results: The top three sub-criteria with the highest complex weights include "community service," "social rehabilitation" and "treatment and rehabilitation," all of which correspond to the main criterion "agro-healing service industry". In addition, the complex weights of the sub-criteria corresponding to the main criterion "agro-healing related/derived industry" are as follows: "other agro-healing support service," which ranked 4th, and "training and education institutions for agro-healing experts," which ranked 5th when prioritizing the criteria. Conclusion: The results of this study suggest that the main criterion to be considered first in establishing a classification system is "agro-healing service industry". Therefore, it is necessary to continue research on detailed service classifications and systems with verified validity to ensure expertise in human resources, and organization related to social purpose services in agro-healing.

• 셀메드
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• 제2권3호
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• pp.23.1-23.7
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• 2012

The healing properties of medicinal maggots (larval stage of Lucilia sericata) are widely used in the chirurgical debridement of non-healing wounds including diabetic foot ulcers, venous and pressure ulcers, where classical approaches have failed. Several kinds of wounds are prone to complications coming out of a specific wound bed environment. There are multi-resistant bacterial species present, their pathogenic impact is multiplied by their ability to form a biofilm. Moreover, immunological events in chronic wounds differ from those in acute wounds. Non-healing wounds are cycled in the early inflammation phase with increased levels of inflammation attributes like inflammation cytokines and matrix metalloproteinases produced by inflammation phase cells. Application of larval therapy promotes progress in the healing process to the next stages involving tissue granulation and re-epithelisation. Larval debridement is an effective method of cleaning the wound of cell debris, necrotic tissue and bacterial load. This happens in a mechanical and biological manner, but the whole complex mechanism of the maggot healing activity is still not fully elucidated. Centuries of clinical practice brings noticeable proof of the maggots' beneficial effect in wound healing management. This long history led to the investigation of the bioactive components of the larval body and its extracts in vitro. We introduce a review which describes the immunomodulation impact of maggot body components on the cellular and molecular levels of the wound healing process.

• 대한수의학회지
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• 제39권5호
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• pp.974-985
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• 1999

Osteoporosis is defined as a decrease in bone mass that leads to an increased risk of fracture. The therapeutic effect of $1{\alpha}$,25 dihydroxycholecalciferol, the hormonal form of vitamin $D_3$ that mediates calcium translation in intestine and bone, on the healing process of fracture has still been controversial. These studies were designed to understand the healing process of normal fibular fracture, the osteoporotic changes after ovariectomy, and the therapeutic effects of $1{\alpha}$,25 dihydroxycholecalciferol on the osteoporotic fracture in rats. The simple transverse fractures of rat fibulae were produced with a rotating diamond saw. The changes of the biochemical and mechanical indices of rats were investigated. The mechanical study based on bending test revealed the healing of the fibular fracture in the 5th week after simple transverse fracture. The osteoporosis impaired more the healing of osteoporotic fibular fracture than normal non-osteoporotic fibular fracture. The healing process of osteoporotic fracture was facilitated by the treatment with $1{\alpha}$,25 dihydroxycholecalciferol, however, was delayed more than the healing process of normal fracture. The bone strength based on the bending test also confirmed this tendency. The bone strengths in the 5th week after fracture of normal bone, osteoporotic bone, and $1{\alpha}$,25 dihydroxycholecalciferol-treated osteoporotic bone were 75%, 41%, and 67%, respectively, in comparison with those of intact bone. In conclusion, $1{\alpha}$,25 dihydroxycholecalciferol was effective in promoting the osteoporotic fracture healing.

• 대한치과의사협회지
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• 제16권1호통권104호
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• pp.43-50
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• 1978

The purpose of this study is to determine the effects of Cyclophosphamide on the healing process of fractures of the mice. Tweny-one young adult male mice were used. All of them were experimentally fractured in the left mandibular body areas, and Cyclophosphamide 0.1mg. per 30gr. body wt. was administrated intramuscularly to the experimental group. the mice of both control and experimental groups were sacrificed 1,3,5,7,10,14, and 21st day after operations and microscopic slides were made. The author has observed the histopathological findings. The results were as follows; 1. There were no specific difference between the experimental and control group in the early stage (1~5th day after operation) of the healing process of the mandibular fracture. 2. In the healing process of fractures 7-10th day after operation, the fibrous tissure formation and osteoblastic activity were poor in the experimental groop compared with the control group. 3. In the healing process of fractures 14-21th day after operation, the connective tissue and new bone formation were very poor in the experimental group compared with the control group. 4. On the whole, cyclophosphamide affected the experimentally fractured wound to delay healing in the jaw bone of the mice.

• 한국건설순환자원학회논문집
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• 제9권3호
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• pp.367-374
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• 2021

본 연구는 기계·화학적 에너지를 활용하는 메카노케미칼 공정기술을 자기치유 혼화재에 적용하기 위한 목적으로 진행되었다. 기계·화학적 공정기술을 자기치유 혼화재 제조 공정에 적용하여 치유 소재의 활성화 에너지를 증가시켜 치유성능에 미치는 영향을 확인하고자 하였다. 자기치유 모르타르에 사용한 자기치유 소재는 팽창/팽윤제를 주요 구성물로 선정하고 탄산염 촉진제와 무기염 첨가제를 기타 첨가제로 혼입하였으며, 기계·화학 처리공정 적용에 의한 치유 소재의 활성화도 및 개질화 반응이 가능한 재료로 선택하였다. 기계·화학 처리공정에 대한 자기치유 혼화재의 기초평가는 XRD, FT-IR 분석으로 확인하였으며, 자기치유 모르타르의 치유 성능평가는 정수위 투수시험을 이용하여 치유율을 확인하였다. 치유성능 확인결과 기계·화학 처리 공정을 적용한 WM3 시료(MC360min)가 공정처리 하지 않은 WM1 시료에 대비 치유성능이 4.1% 증가하였으며, 자기치유율은 평균 94.3%로 확인되었다.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2004년도 춘계학술대회 논문집
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• pp.309-314
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• 2004

This study focused on the introduction of damage repair for polymeric composite carbody. called selfing tech-healinique. using microcapsules loaded with the healing agent The manufacturing process for microcapsules with the healing agent was introduced and tile characteristics of microcapsules manufactured by varying with various manufacturing process variables were evaluated. The DCPD was used for the healing agent and microcapsules were made of urea-formaldehyde resin. The magnitude and the size distribution of microcapsules were measured by a particle size analyzer using laser diffraction technique. Thermal stability was investigated by using a TGA under continuous and isothermal heating conditions for the healing agent. microcapsules without the healing agent. microcapsules with the healing agent.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제12권2호
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• pp.21-33
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• 1990

This study was performed to evaluate the effects of preoperative and postoperative radiation on the healing of surgical wound and the relationship between surgery-radiation interaval histopathologically. Experimental animals were 64 rats of Sprague-Dawely strain weighing about 180grams. In postoperative radiation group, a single dose of 1000 rads irradiation was delivered on 1,2,3, weeks after incision and 24 animals were sacrificed on the 1st, 3rd, 7th, and 14th day after radiation. In preoperative radiation group incision was performed on 1,2,3,4 weeks after a single dose of 1000 rads and 32 animals were sacrificed on the 1st, 3rd, 7th, and 14th after incision. Tissue specimens were prepared as usual methods and stained with hematoxyline-eosin for ordinary light microscopy. Histopathologic study revealed the following favorable results : 1. In 2 and 3 weeks radiation group after incision, the healing process was unaffected by radiation. 2. In 1 week radiation group after incision, the healing process was slightly retarded, as compared with 2,3 weeks radiation group after incision. 3. In 1,2 and 3 weeks incision group after radiation, the healing process appeared about 7 days later than that of control group. 4. In 4 weeks incision after radiation, the healing process was unaffected by radiation.

• 대한임상전기생리학회지
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• 제5권2호
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• pp.23-33
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• 2007

Summary of background data: At the wound from life of the human being very regarding at and a healing process the wound in the portion which is important meantime the many research is accomplished and healing process at the wound the research is small very from the physical therapy territory. Purpose: This study was performed to examine the effects of cold therapy and pulsed ultrasound treatment in the process of acute wound healing. To this end, we measured changes in the length of the wounds, and observed tissues through an optical microscope in order to evaluate the healing process of the acute wounds. Methods: We divided twenty Sprague-Dawley rats into four experimental groups of five rats each and treated them for three days after wound creation. Then we extracted tissues from the wounds on day 6th after wound creation and then took them out for hematoxylin-eosin(HE) staining. We measured changes in the length of the wounds every other day. Result: We were able to detect significant statistical differences in the cold therapy and pulsed ultrasound-treated wounds compared with control wounds. We observed tissues through an optical microscope and found the tissues in cold therapy and pulsed ultrasound-treated wounds healed well. Conclusions: Overall results indicated that the use of cold therapy and pulsed ultrasound treatment were effective in the process of acute wound healing.

• 대한지리학회지
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• 제51권1호
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• pp.109-125
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• 2016

인간의 삶에서 치유는 떼어낼 수 없는 관계에 있다. 최근 치유의 요구가 증가하면서 이를 위한 공간, 장소, 나아가 이동에 대한 지리적 연구가 필요한 시점이다. 본 연구는 서울 한양도성길 낙산구간 걷기를 사례로 걷기의 과정에서 어떠한 치유요소가 작용하며 그 지리적 함의가 무엇인지를 밝히는 데 목적을 두었다. '치유적 모빌리티' 개념과 틀을 바탕으로 181건의 블로그 텍스트를 연구 자료로 활용하였고 치유요소들을 분류한 결과, '기상 기후', '걷기 산책', 그리고 '야경'이 주요 요소로 분석되었다. 또한, 치유의 걷기 과정을 주요 요소들을 다룬 블로그 내러티브 분석으로 살펴본 결과, 치유의 장소만들기, 제한요인으로서 시간, 야경 속 사회적 신체라는 지리학적 함의를 찾을 수 있었다.

• Journal of Microbiology and Biotechnology
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• 제17권10호
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• pp.1661-1669
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• 2007

Gamma-aminobutyric acid (GABA) is a non-protein amino acid. It is well known for its role as an inhibitory neurotransmitter of developing and operating nervous systems in brains. In this study, a novel function of GABA in the healing process of cutaneous wounds was presented regarding anti-inflammation and fibroblast cell proliferation. The cell proliferation activity of GABA was verified through an MTT assay using murine fibroblast NIH3T3 cells. It was observed that GABA significantly inhibited the mRNA expression of iNOS, IL-$1{\beta}$, and TNF-${\alpha}$ in LPS-stimulated RAW 264.7 cells. To evaluate in vivo activity of GABA in wound healing, excisional open wounds were made on the dorsal sides of Sprague-Dawley rats under anesthesia, and the healing of the wounds was apparently assessed. The molecular aspects of the healing process were also investigated by hematoxylineosin staining of the healed skin, displaying the degrees of re-epithelialization and linear alignment of the granulation tissue, and immunostaining and RT-PCR analyses of fibroblast growth factor and platelet-derived growth factor, implying extracellular matrix synthesis and remodeling of the skin. The GABA treatment was effective to accelerate the healing process by suppressing inflammation and stimulating re-epithelialization, compared with the epidermal growth factor treatment. The healing effect of GABA was remarkable at the early stage of wound healing, which resulted in significant reduction of the whole healing period.