• Imaging Science in Dentistry
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• v.31 no.3
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• pp.135-143
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• 2001

Purpose : To evaluate the effect of all-trans-retinoic acid on radiosensitivity and radiation-induced apoptosis in NHOK, HEp-2 and FaDu cell lines. Material and Methods: We measured the changes in survival fraction at 2 Gy (SF2), α and β after treatment of retinoic acid (1μM) prior to irradiation with doses of 2, 4, 6 and 10 Gy and correlated the radiosensitizing effect of retinoic acid with them. Also, apoptosis induction was assayed with the flow cytometry on days 1,2, 3, 4 and 5 after irradiation (2, 10 and 20 Gy) combined with retinoic acid. Results and Conclusion: SF2 values for NHOK, HEp-2 and FaDu cell lines were 0.54, 0.64 and 0.41, respectively and the cell line of FaDu was the most radiosensitive. For cell lines of NHOK and HEp-2, pretreatment of cells with retinoic acid resulted in a significant decrease of the SF2 values. The α/β ratios of x-ray survival curve were 8.714 (NHOK), 4.098 (HEp-2) and 11.79 (FaDu). The α/β ratio for NHOK decreased on pretreatment with retinoic acid, whereas those for HEp-2 and FaDu increased. Radiation induced apoptosis in all cell lines but, retinoic acid did not affect the apoptosis.

• The Journal of Korean Academy of Prosthodontics
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• v.40 no.4
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• pp.396-405
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• 2002

The purpose of this study was to evaluate the effects of four metal surface treatments on the shear bond strength of reline resin to Ni-Cr alloy. The denture base metal used in this study was Ni-Cr alloy(Ticonium Premium 100. Ticonium Co., U.S.A.). 120 specimens were divided into five metal surface treatments: sandblasting only, MR. BOND(Tokuyama Corp.. Japan), Cesead Opaque Primer(Kuraray Co., Japan), METALPRIMER II(GC Corp., Japan) and Super-Bond C&B(Sun Medical Co., Japan) after sandblasting. They were bonded with one of three reline resins Mild Rebaron(GC Corp., Japan), Mild Rebaron LC(GC Corp., Japan) and Meta Base M(Sun Medical Co., Japan). Then they were thermocycled 1,000 times at temperature of $4^{\circ}C$ and $60^{\circ}C$. The shear bond strengths were measured using the universal testing machine(Instron, Model 4301, England) with a cross-head speed of 2 mm/min. The results were as follows : 1. All metal primers and adhesive cement significantly improved the bond strength of reline resin to Ni-Cr alloy compared with sandblasted specimens. 2. In Mild Rebaron and Mild Rebaron LC. Cesead Opaque Primer showed the highest bond strength, but the differences among Cesead Opaque Primer, MR. BOND and METALPRIMER II were not significant. The bond strength of Cesead Opaque Primer was significantly different with that of Super-Bond C&B. 3. In Meta Base M, Super-Bond C&B showed the highest bond strength, but there was no difference between Super-Bond C&B and three metal primers. 4. There was no difference in the bond strength between Mild Rebaron and Mild Rebaron LC when metal surface was treated with the same method. 5. The bond strengths of Mild Rebaron and Mild Rebaron LC treated with Cesead Opaque Primer were higher than that of Meta Base M. The bond strengths of Mild Rebaron treated with MR. BOND and METALPRIMER II was higher than that of Meta Base M, However, there was no difference among three reline resins treated with Super-Bond C&B.

• BMB Reports
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• v.51 no.11
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• pp.584-589
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• 2018

Secondary prevention via earlier detection would afford the greatest chance for a cure in premalignant lesions. We investigated the exomic profiles of non-malignant and malignant changes in head and neck squamous cell carcinoma (HNSCC) and the genomic blueprint of human papillomavirus (HPV)-driven carcinogenesis in oropharyngeal squamous cell carcinoma (OPSCC). Whole-exome (WES) and whole-genome (WGS) sequencing were performed on peripheral blood and adjacent non-tumor and tumor specimens obtained from eight Korean HNSCC patients from 2013 to 2015. Next-generation sequencing yielded an average coverage of $94.3{\times}$ for WES and $35.3{\times}$ for WGS. In comparative genomic analysis of non-tumor and tumor tissue pairs, we were unable to identify common cancer-associated early mutations and copy number alterations (CNA) except in one pair. Interestingly, in this case, we observed that non-tumor tonsillar crypts adjacent to HPV-positive OPSCC appeared normal under a microscope; however, this tissue also showed weak p16 expression. WGS revealed the infection and integration of high-risk type HPV16 in this tissue as well as in the matched tumor. Furthermore, WES identified shared and tumor-specific genomic alterations for this pair. Clonal analysis enabled us to infer the process by which this transitional crypt epithelium (TrCE) evolved into a tumor; this evolution was accompanied by the subsequent accumulation of genomic alterations, including an ERBB3 mutation and large-scale CNAs, such as 3q27-qter amplification and 9p deletion. We suggest that HPV16-driven OPSCC carcinogenesis is a stepwise evolutionary process that is consistent with a multistep carcinogenesis model. Our results highlight the carcinogenic changes driven by HPV16 infection and provide a basis for the secondary prevention of OPSCC.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.37 no.2
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• pp.311-324
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• 2017

Energy loss at manholes under surcharged flow is considered as one of the major causes of inundation in urban area. Therefore, it is necessary to analyze the flow characteristics to reduce the energy loss in the surcharged four-way combining manhole. In this study, hydraulic experimental apparatus was constructed considering the results of the present survey. Square manholes and pipe diameters were reduced to 1/5 by applying sewer facility standards. Numerical simulations were carried out with the Fluent 6.3 model to derive the invert condition which can reduce the energy loss in the surcharged four-way combining square manhole. The hydraulic experiments were carried out according to the various conditions of the lateral flow rate($Q_{lat}/Q_{out}$), discharge of outflow pipe (2.0, 3.0, 4.0, 4.8 l/sec), and invert shape (rectangle and square open conduit type). The crossed invert was not found to improve the drainage capacity of the surcharged four-way rectangular combining manhole. However, the improved rectangle open conduit type invert and square open conduit type invert were analyzed to improve the drainage capacity by reducing the head loss coefficients by about 8% and 28%, respectively. Therefore, in order to increase the drainage capacity of urban facilities, it is possible to install and use the improved invert proposed in this study.

• Korean Journal of Biological Psychiatry
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• v.6 no.1
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• pp.21-29
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• 1999

Traumatic Brain Injury(TBI) of any severity can result in broad and persisting biopsychosocial sequelae. Depression after TBI occur at a greater frequency than in the general population, with estimates approaching 25% to 50% for major depression, and 155 to 30% for dysthmia. Acute onset depressions are related to lesion location and may have their etiology in biological response of the injured brain, whereas delayed onset depressions may be mediated by psychosocial factors, suggesting psychological reactions as a possible mechanism. Anxious depressions are associated with right hemisphere lesions, whereas major depressions alone are associated with left dorsolateral frontal and left basal ganglia lesions. However, there is insufficient information to postulate a specific neuroanatomic model for TBI-related depression.

• Korean Journal of Biological Psychiatry
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• v.10 no.2
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• pp.168-176
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• 2003

Objectives:We investigated the characteristics of P300 generators in obsessive-compulsive disorder(OCD) patients by using voxel-based statistical parametric mapping of current density images. Methods:P300 generators, produced by a rare target tone of 1500Hz under a frequent non-target tone of 1,000Hz, were measured in 15 right-handed OCD patients and 15 controls. Low Resolution Electromagnetic Tomography(LORETA), using a realistic head model of the boundary element method based on individual MRI, was applied to the 128-channel EEG. Statistical parametric mapping(SPM) was applied for the statistical analysis. Results:We found that both groups had the mean current density of P300 in the parietal, temporal and prefrontal lobe. There was a trend for decreased current density in the prefrontal area in OCD patients. The statistical comparison showed current density increase in the supraparietal area, a statistically significant longer P300 latency and a trend for reduced P300 amplitude in OCD patients. Conclusion:It suggests that P300 source of both groups exists in multiple brain regions at the same time. And both groups had no statistically significant differences in the current density of P300 except for increased current density in the supraparietal area in OCD patients. But, considering the statistically significant longer P300 latency, a trend for reduced P300 amplitude and relative mean current density reduction in the prefrontal area in OCD patients, this study suggests that the frontal lobe may have a reduced normal inhibitory process in OCD patients.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.7
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• pp.12-19
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• 2020

The clustered heterogeneous wireless sensor network is comprised of sensor nodes and cluster heads, which are hierarchically organized for different objectives. In the network, we should especially take care of managing node resources to enhance network performance based on memory and battery capacity constraints. For instances, if some interesting events occur frequently in the vicinity of particular sensor nodes, those nodes might receive massive amounts of data. Data congestion can happen due to a memory bottleneck or link disconnection at cluster heads because the remaining memory space is filled with those data. In this paper, we utilize drones as mobile sinks to resolve data congestion and model the network, sensor nodes, and cluster heads. We also design a cost function and a congestion indicator to calculate the degree of congestion. Then we propose a data congestion map index and a data congestion mapping scheme to deploy drones at optimal points. Using control variable, we explore the relationship between the degree of congestion and the number of drones to be deployed, as well as the number of drones that must be below a certain degree of congestion and within communication range. Furthermore, we show that our algorithm outperforms previous work by a minimum of 20% in terms of memory overflow.

• Journal of Korean Tunnelling and Underground Space Association
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• v.18 no.3
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• pp.257-272
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• 2016

It is usually not an easy task to counter-measure on time and appropriately when confronting with troubles in mechanized tunnelling job-sites because of the limitation of available spaces to perform those actions with the existence of disk cutter, cutter head, chamber and other various apparatus in Tunnel Boring Machine (TBM). So, it is important to predict the ground condition ahead of a tunnel face during tunnel excavation. Efforts have been made to utilize geophysical methods such as elastic wave survey, electromagnetic wave survey, electrical resistivity survey, etc for predicting the ground condition ahead of the TBM tunnel face. Each prediction method among these geophysical methods has its own advantage and disadvantage. Therefore, it might be needed to apply several geophysical methods rather than just one to predict the ground condition ahead of the tunnel face in the complex and/or mixed grounds since those methods will compensate among others. The problem is that each prediction method will give us different answer on the predicted ground condition; how to combine different solutions into a most reasonable and representative predicted value might be important. Therefore, in this study, we proposed a methodology how to systematically combine each prediction method utilizing probabilistic analysis as well as analytic hierarchy process. The proposed methods is applied to a virtual job site to confirm the applicability of the model to predict the ground condition ahead of the tunnel face in the mechanized tunnelling.

• Journal of the Korean Society of Marine Environment & Safety
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• v.23 no.4
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• pp.400-406
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• 2017

The model used in this study was reversed to analyze the cause of excessive damage that occurred inside the rotating system and pipe system of a centrifugal-type seawater pump on a ship. For this purpose, internal flow analysis on a cooling seawater pump was performed using CFD. As a result, the shape and boundary conditions of the target pump were set by reverse engineering, and pump efficiency at a design operating point of $125m^3/h$ was calculated as 85.3 % with a head of 32.0 m. The maximum efficiency point of the target pump was estimated to be 86.2 % at $150m^3/h$, but this differed from the actual operating point. At $112.5m^3/h$, which was the lowest flow point, flow was unstable due to the characteristics of the low flow point and analysis convergence was not good. The purpose of this study was to clarify the cause of ongoing cavitation in seawater pumps and piping systems in operation. Future research will be needed to clarify causes for pipe systems in the future by performing calculations for the total piping system of an inlet and outlet, in addition to measuring the flow rate of each branch pipe.

• Journal of Korean Tunnelling and Underground Space Association
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• v.16 no.2
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• pp.249-260
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• 2014

When a train enters the tunnel at high speed, the pressure wave occurs. When this pressure wave reaches at the exit of tunnel, some are either emitted to the outside or reflected in tunnel by the form of expansion wave. The wave emitted to the outside forms the impulsive pressure wave. This wave is called 'Micro Pressure Wave'. The micro pressure wave generates noise and vibration around a exit portal of tunnel. When it becomes worse, it causes anxiety for residents and damage to windows. Thus, it requires a counterplan and prediction about the micro pressure wave for high speed railway construction. In this paper, the effects of train head nose and tunnel portal shape were investigated by model test, measurement for the micro pressure wave at the operating tunnel as well as numerical analysis for the gradient of pressure wave in the tunnel. As results, a method for predicting the intensity of the micro pressure wave is suggested and then the intensity of the micro pressure wave is analyzed by the tunnel length and the cross-sectional area.