• Journal of the Institute of Electronics and Information Engineers
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• v.51 no.1
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• pp.97-103
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• 2014

In this paper, a clock-data recovery using a 1/8-rate phase detector is proposed. The use of a conventional full or half-rate phase detector requires relatively higher frequency of a recovered clock, which is a burden on the design of a sampling circuit and a VCO. In this paper, a 1/8-rate phase detector is used to lower the frequency of the recovered clock and a linear equalizer is used as a input circuit of a phase detector to reduce the jitter of the recovered clock. A test chip fabricated in a 0.13-${\mu}m$ CMOS process is measured at 1.5-GHz for a 3-Gb/s PRBS input and 1.2-V power supply.

• JSTS:Journal of Semiconductor Technology and Science
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• v.13 no.3
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• pp.185-192
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• 2013

In this paper, a clock and data recovery (CDR) circuit that supports triple data rates of 1.62, 2.7, and 5.4 Gbps for DisplayPort 1.2 standard is described. The proposed CDR circuit covers three different operating frequencies with a single VCO switching the operating frequency by the 3-bit digital code. The prototype chip has been designed and verified using a 65 nm CMOS technology. The recovered-clock jitter with the data rates of 1.62/2.7/5.4 Gbps at $2^{31}$-1 PRBS is measured to 7/5.6/4.7 $ps_{rms}$, respectively, while consuming 11 mW from a 1.2 V supply.

• Archives of Pharmacal Research
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• v.29 no.4
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• pp.339-342
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• 2006

A simple high performance liquid chromatographic (HPLC) method was developed for the determination of tolperisone in human plasma. Tolperisone and internal standard (chlorphenesin) were isolated from 1 mL of plasma using 8 mL of dichlormethane. The organic phase was collected and evaporated under nitrogen gas. The residue was then reconstituted with 300 mL aliquot of mobile phase and a 100 mL aliquot was injected onto the $C_{18}$ reverse-phased column. The mobile phase, $45\%$ methanol containing $1\%$ glacial acetic acid and $0.05\%$ 1-hexanesulfonic acid was run at a flow rate of 1 mL/min. The column effluent was monitored using UV detector at 260 nm. The retention times for tolperisone and the internal standard were approximately 7.1 and 8.4 min, respectively. The standard curve was linear with minimal intra-day and inter-day variability. The quantification limit of tolperisone in human plasma was 10 ng/ mL. The proposed method has been applied to the determination of pharmacokinetic profile of tolperisone in Koreans. The T max of tolperisone in Koreans $(0.94{\pm}0.42\;h)$ was not significantly differ from that reported in Europeans (0.5-1 h), but the mean half-life in Koreans $(1.14{\pm}0.27\;h)$ was shorter than that in Europeans $(2.56{\pm}0.2\;h)$. The proposed HPLC method is simple, accurate, reproducible and suitable for pharmacokinetic study of tolperisone.