• Genomics & Informatics
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• v.20 no.1
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• pp.9.1-9.6
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• 2022

Mendelian randomization (MR) uses genetic variation as a natural experiment to investigate the causal effects of modifiable risk factors (exposures) on outcomes. Two-sample Mendelian randomization (2SMR) is widely used to measure causal effects between exposures and outcomes via genome-wide association studies. 2SMR can increase statistical power by utilizing summary statistics from large consortia such as the UK Biobank. However, the first-order term approximation of standard error is commonly used when applying 2SMR. This approximation can underestimate the variance of causal effects in MR, which can lead to an increased false-positive rate. An alternative is to use the second-order approximation of the standard error, which can considerably correct for the deviation of the first-order approximation. In this study, we simulated MR to show the degree to which the first-order approximation underestimates the variance. We show that depending on the specific situation, the first-order approximation can underestimate the variance almost by half when compared to the true variance, whereas the second-order approximation is robust and accurate.

• Current Optics and Photonics
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• v.7 no.3
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• pp.263-272
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• 2023

A collimator refers to an optical system that images a collimated beam at a desired point. A resolution target located at a near distance can be converted into a virtual image located at a long distance. To test the resolution for mobile cameras, a large target is placed at a long distance. If a collimator system is used, the target can be placed at a near distance. The space required for a resolution inspection can thus be drastically reduced. However, to inspect a mobile camera, the exit pupil of the collimator system and the entrance pupil of the mobile camera must match, and the stop of the collimator system must be located on the last surface. Because a collimator system cannot be symmetrical with respect to the stop, the distortion becomes extremely large, which can be corrected by combining the collimator symmetrically with respect to the object plane. A novel system was designed to inspect an optical lens on a mobile phone. After arranging the refractive power, lenses were added using the equivalent lens design method. The distortion was reduced to less than 1%. This optical system satisfies a half-field angle of 45° and an optical performance sufficient for inspection.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.16 no.5 s.96
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• pp.465-471
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• 2005

A method of calculation fur propagating and focusing of focused beams generated in antenna arrays, using BPM(Beam Propagation Method), is presented in this paper. Based on the diffraction theory, the beam focusing and Propagation is studied specially for the case of the antenna way fed by the Rotman lens that is able to focus microwave power on its focal arc or generate multiple beams. There are difficulties in performing a full-wave simulation using a commercial EM simulation tool for propagating and focusing of beams because of the structural complexity and the feeding assignment of the antenna array. Therefore, as an alternative solution, the BPM is presented to calculate the beam propagation from the aperture-type antennas. From the point of view of optics, the propagations of the lens have been simplified from the Fresnel diffraction integral to the Fourier transform. Using Fourier Transform, a beam propagation method is developed to show improvement of the resolution by controlling the wavefront of wave Propagating from an aperture-type antenna array. The beam width(or spot size) and the intensity are calculated for a focused beam propagating from an array having $10\lambda$ of its size. For the beams with $20\lambda,\;30\lambda$, and $50\lambda$ of geometrical focal length, the half-power beam widths(or spot size) are about 1.1\lambda,\;1.3\lambda,\;and\;1.9\lambda$ respectively.

• Journal of Biomedical Engineering Research
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• v.24 no.3
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• pp.217-231
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• 2003

Coded excitation with complementary Golay sequences is an effective means to increase the SNR and penetration of ultrasound imaging. in which the two complementary binary codes are transmitted successively along each scan-line, reducing the imaging frame rate by half. This method suffers from low frame rate particularly when multiple transmit focusing is employed, since the frame rate will be further reduced in proportion to the number of focal zones. In this paper. a new ultrasound imaging technique based on simultaneous multiple transmit focusing using modified orthogonal Golay codes is proposed to improve lateral resolution with no accompanying decrease in the imaging frame rate, in which a pair of orthogonal Golay codes focused at two different focal depths are transmitted simultaneously. On receive, these modified orthogonal Golay codes are separately compressed into two short pulses and individually focused. These two focused beams are combined to form a frame of image with improved lateral resolution. The Golay codes were modified to improve the transmit power efficiency (TPE) for practical imaging. Computer simulations and experimental results show that the proposed method improves significantly the lateral resolution and penetration of ultrasound imaging compared with the conventional method.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.35 no.2C
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• pp.148-154
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• 2010

In this paper, we first review LDPC codes in general and a belief propagation algorithm that works in logarithm domain. LDPC codes, which is chosen 802.11n for wireless local access network(WLAN) standard are required a large number of computation due to large size of coded block and iteration. Therefore, we presented three kinds of low computational algorithm for LDPC codes. First, sequential decoding with partial group is proposed. It has same H/W complexity, and fewer number of iteration's are required at same performance in comparison with conventional decoder algorithm. Secondly, we have apply early stop algorithm. This method is reduced number of unnecessary iteration. Third, early detection method for reducing the computational complexity is proposed. Using a confidence criterion, some bit nodes and check node edges are detected early on during decoding. Through the simulation, we knew that the iteration number are reduced by half using subset algorithm and early stop algorithm is reduced more than one iteration and computational complexity of early detected method is about 30% offs in case of check node update, 94% offs in case of check node update compared to conventional scheme.

• Archives of design research
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• v.9
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• pp.1101-1114
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• 1994

As of today-half a century has passed after 1945, the liberation from Japanese imperialism-it's significant to introspect our culture. On the one hand our culture has succeeded due to the peculiar history, but on the other hand it hasn't. So to speak, it has gained in Quantity but lost in Quality. There are keen, international competition and exchange in the modern culture. So the Qualitive success of modern design depends on if it had an original character or not. According to Korean rapid industrialization, technological extence, and economic growth, the export has increased greatly, but package design hasn't been match for them. Korean expoters have been meeting with cutthroat competition in world market. Under these circumstances it's very important that we have a real understand and interest in our culture, we strengthen the competitive power of home products with good package design. This is our age of not home market but world market. We live in an age when design wins, so that we have to develop the good design native to Korea. Many designers have proposed their opinions with the characteristic designs, but it has been only a fragmentary and passive method. We must seek for the new method more positively. The effective and proper method resolves itself into the following four points. First, to understand Korean history and culture. Second, to have the exact grip of this economic situation. Third, to promote the national emotion. Fourth, in conclusion, to accord the package design with them. We cannot put off this task to overcome the cultural subordination, to place Korea on a firm cultural basis in the world, and to contribute to the cultural exchange of package design. First, to understand Korean history and culture. Second, to have the exact grip of this economic situation. Third, to promote the national emotion. Fourth, in conclusion, to accord the package design with them. We cannot put off this task to overcome the cultural subordination, to place Korea on a firm cultural basis in the world, and to contribute to the cultural exchange of package design.

• Transactions on Electrical and Electronic Materials
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• v.12 no.2
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• pp.51-55
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• 2011

We investigated the etching characteristics of zinc oxide (ZnO) thin films deposited by the atomic layer deposition method. The gases of the inductively coupled plasma chemistry consisted of $Cl_2$, Ar, and $O_2$. The maximum etch rate was 40.3 nm/min at a gas flow ratio of $Cl_2$/Ar=15:5 sccm, radio-frequency power of 600 W, bias power of 200 W, and process pressure of 2 Pa. We also investigated the plasma induced damage in the etched ZnO thin films using X-ray diffraction (XRD), atomic force microscopy and photoluminescence (PL). A highly oriented (100) peak was present in the XRD spectroscopy of the ZnO samples. The full width at half maximum value of the ZnO sample etched using the $O_2/Cl_2$/Ar chemistry was higher than that of the as-deposited sample. The roughness of the ZnO thin films increased from 1.91 nm to 2.45 nm after etching in the $O_2/Cl_2$/Ar plasma chemistry. Also, we obtained a strong band edge emission at 380 nm. The intensities of the peaks in the PL spectra from the samples etched in all of the chemistries were increased. However, there was no deep level emission.

• Journal of the Korean Society for Nondestructive Testing
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• v.27 no.5
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• pp.383-392
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• 2007

In this paper, we study the prediction of depth and width of a defect in steam generator tube in nuclear power plant using neural network. To this end, we first generate eddy current testing (ECT) signals for 4 defect patterns of SG tube: I-In type, I-Out type, V-In type, and V-Out type. In particular, we generate 400 ECT signals for various widths and depths for each defect type by the numerical analysis program based on finite element modeling. From those generated ECT signals, we extract new feature vectors for the prediction of defect size, which include the angle between the two points where the maximum impedance and half the maximum impedance are achieved. Using the extracted feature vector, multi-layer perceptron with one hidden layer is used to predict the size of defects. Through the computer simulation study, it is shown that the proposed method achieves decent prediction performance in terms of maximum error and mean absolute percentage error (MAPE).

• Journal of the Semiconductor & Display Technology
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• v.4 no.1 s.10
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• pp.9-16
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• 2005

In this paper, with loosely coupled transformer Relies-parallel resonant type DC/DC converter is analyzed and adopted to the power source of a TFLM(Transverse Flux Linear Motor). To get more efficient operating mode of the series-parallel resonant type DC/DC converter, theoretical analysis using normalized parameters are accepted. The analysis includes a specially made ferrite transformer with two separately wound half cores in order to evaluate analytically and experimentally the changes in magnetizing the leakage fluxes and inductances caused by the distance between the halves. The proposed converter must be operated in switching Pattern III among the three switching patterns for the Zero Voltage Switching operation. According to Pulse Frequency Modulation(PFM) control method, the output voltage of the proposed circuit can be controlled. The results of the theoretical development are compared with practical measurements from a prototype system.

• Journal of the Korean Institute of Telematics and Electronics C
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• v.35C no.9
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• pp.11-20
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• 1998

High-speed complex-number arithmetic units are essential to baseband signal processing of modern digital communication systems such as channel equalization, timing recovery, modulation and demodulation. In this paper, a new complex-number multiplication algorithm is proposed, which is based on redundant binary (RB) arithmetic combined with radix-4 Booth recoding scheme. The proposed algorithm reduces the number of partial product by one-half as compared with the conventional direct method using real-number multipliers and adders. It also leads to a highly parallel architecture and simplified circuit, resulting in high-speed operation and low power dissipation. To demonstrate the proposed algorithm, a prototype complex-number multiplier-accumulator (CMAC) core with 10-bit operands has been designed using 0.8-$\mu\textrm{m}$ N-Well CMOS technology. The designed CMAC core contains about 18,000 transistors on the area of about 1.60 ${\times}$ 1.93 $\textrm{mm}^2$. The functional and speed test results show that it can operate with 120-MHz clock at V$\sub$DD/=3.3-V, and its power consumption is given to about 63-mW.