• Journal of Acupuncture Research
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• 제37권4호
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• pp.203-208
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• 2020

This literature review was designed to investigate the effects of the microneedle therapy system (MTS) on alopecia in experimental, and clinical studies. The MTS is acupuncture needling therapy delivered by a roller. A literature review of studies published before May 2020 was conducted using 9 online databases, and a total of 13 studies (4 in vivo studies and 9 clinical trials) were included. Most studies showed that the MTS was effective when used in combination with other treatments. In vivo studies reported an increased level of hair growth factors following treatment. Typically, 1.5 mm needles were used in the MTS treatment and photographic evaluation (by either camera or microscope) was reported in most studies. Oriental medicine research included 2 in vivo studies, which reported positive effects when combined with the MTS. There were no reported severe side effects. the MTS might be safe and has a drug delivery effect. Further studies need to be conducted regarding the frequency and needle length depending on the type of alopecia using Oriental and Western medicine.

• 복식
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• 제50권
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• pp.97-118
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• 2000

The purposes of the present research were (1) to investigate the sociological factors influencing the increase of ambivalence and the relationship between, the ambivalence and fashion change(2) to categorize sets of the ambivalence expressed for contemporary fashion and (3) to examine the frequency and the patterns of ambivalence presented for contemporary fashion. This research was conducted through in depth literature review and content analysis. Data was collected from 806 colored pictures presented on 'Collections' from 1972 to 1988. Eight types of clothing cues were incluede: look color texture decorative motifs of clothing collar sleeve and wearer's headdress/hair style and make-up. The results of this study were as follows: 1 The popularization of culture has been accelerated by mass production mass consumption and mass media. Since the 1980s postmodernism and poststructuralism have resulted in the breakdown of dualistic distinction. As the ambiguity of meaning in appearance increases the meaning is negotiated constantly for identity. 2. The most frequenctly expressed ambivalence in clothing was feminity/masculinity and tradition/modernity and wealth/poverty was the least. The number of ambivalent expression were the highest during 1990s. The rapid growth in ambivalence of tradition/modernity was found in 1970s feminity/masculinity in 1980s and modesty/immodesty in 1990s. Within a clothing style ambivalence was manifested through feminine look in white for beauty/ugliness feminine look mainly in yellow/red for wealty/poverty sexy look dominantly in black for modesty/immodesty androgynous look in black for feminity/masculinity and through ecology look most frequently in black for tradition/modernity.

• BMB Reports
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• 제46권1호
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• pp.31-36
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• 2013

Heat shock proteins play an important role in plant stress tolerance and are mainly regulated by heat shock transcription factors (Hsfs). In this study, we generated transgenic rice over-expressing OsHsfA7 and carried out morphological observation and stress tolerance assays. Transgenic plants exhibited less, shorter lateral roots and root hair. Under salt treatment, over-expressing OsHsfA7 rice showed alleviative appearance of damage symptoms and higher survival rate, leaf electrical conductivity and malondialdehyde content of transgenic plants were lower than those of wild type plants. Meanwhile, transgenic rice seedlings restored normal growth but wild type plants could not be rescued after drought and re-watering treatment. These findings indicate that over-expression of OsHsfA7 gene can increase tolerance to salt and drought stresses in rice seedlings.

• BMB Reports
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• 제45권4호
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• pp.253-258
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• 2012

The dermal papilla cells (DPCs) of hair follicles are known to secrete paracrine factors for follicular cells. Shotgun proteomic analysis was performed to compare the expression profiles of the secretomes of human DPCs and dermal fibroblasts (DFs). In this study, the proteins secreted by DPCs and matched DFs were analyzed by 1DE/LTQ FTICR MS/MS, semi-quantitatively determined using emPAI mole percent values and then characterized using protein interaction network analysis. Among the 1,271 and 1,188 proteins identified in DFs and DPCs, respectively, 1,529 were further analyzed using the Ingenuity Pathway Analysis tool. We identified 28 DPC-specific extracellular matrix proteins including transporters (ECM1, A2M), enzymes (LOX, PON2), and peptidases (C3, C1R). The biochemically-validated DPC-specific proteins included thrombospondin 1 (THBS1), an insulin-like growth factor binding protein3 (IGFBP3), and, of particular interest, an integrin beta1 subunit (ITGB1) as a key network core protein. Using the shotgun proteomic technique and network analysis, we selected ITGB1, IGFBP3, and THBS1 as being possible hair-growth modulating protein biomarkers.

• 한국식품위생안전성학회지
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• 제15권4호
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• pp.304-314
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• 2000

최근 고등학교 급식 전면 실시 방침에 따른 학교급식의 확대와 더불어 급식의 위탁화가 가속되고 있는 실정으로 급식의 규모는 점차 확대되고 있다. 그러나 단기간에 성장한 국내급식 산업은 위탁급식업체간 수준차이가 많으며, 그 위생관리 수준은 선진 외국의 수준과 비교하였을 때 아직은 초보적인 단계에 지나지 않는다. 이에 본 연구의 목적은 서을 시내에 위치한 위탁급식을 실시하는 C고등학교에서 제공되는 음식 중 카레갈치튀김, 미역오이냉채,돈가스의 생산 공정별 각 단계에서 HACCP를 적용하여 시간, 온도, pH, Aw, 미생물 분석을 통하여 위해요소를 분석하고 통제방법을 설정하는 것이다. 또한 국내 급식과정에서 볼 수 있는 각 계절별 상온방치를 예상하여 모의실험을 한 후의 미생물적 안전성을 조사하였다. 각 음식의 생산 단계에서 음식의 위해요인 발생은 온도, 소요시간, pH, Aw, 기구 및 용기의 위생 등의 복합적 요인에 기인하는 것으로 나타났다. 카레갈치튀김의 경우 조리, 급식 전 보관단계, 미역 오이냉체는 전처리, 조리 급식 전 보관단계, 돈가스·소스는 조리, 급식전 보관단계가 중점관리점(Critical Control Point)로 나타났다. 또한 음식이 급식때까지 실온에 지연되는 시간을 최소화함으로써 미생물 증식이 상당히 억제될 수 있으리라 기대된다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권20호
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• pp.8793-8796
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• 2014

Objective: To explore the influence of serum vascular endothelial growth factor (VEGF) level on therapeutic outcome and diagnosis/prognostic value in patients with cervical cancer. Materials and Methods: A total of 37 patients diagnosed with cervical cancer by biopsy were selected and treated with concurrent chemoradiotherapy. Double-antibody sandwich enzyme-linked immunosorbent assay (ELISA) was adopted before treatment to assess VEGF levels, and its relationships with clinicopathological features and short-term therapeutic effects were analyzed. Results: The median VEGF level in 37 patients before treatment was 647.15 (393.35~1125.16) pg/mL. Serum VEGF levels in patients aged <50 years, in International Federation of Gynecology and Obstetrics (FIGO) stage IIIa~IVa, with lymph node metastasis and tumor size >4 cm were significantly increased (P<0.05). The complete remission (CR) rate was 48.7% (18/37), partial remission (PR) rate was 35.1% (13/37), stable disease (SD) rate was 13.5% (5/37) and progressive disease (PD) rate was 2.70% (1/37), so the objective remission rate (ORR) after treatment was 83.8% (31/37). Logistic regression analysis showed that tumor size and serum VEGF level before treatment were independent risk factors affecting the therapeutic outcome, and the higher the level of serum VEGF, the worse the prognosis when tumor size>4 cm. Some 56.8% of patients manifested with myelosuppression, 37.8% with leucopenia, 24.3% with thrombocytopenia, 5.41% with diarrhea, 46.0% with nausea and vomiting, 21.6% with hair loss and 8.11% with hepatic and renal injury during the treatment. Conclusions: Serum VEGF level may reflect the degree of malignancy of cervical cancer and predict therapeutic effect, which is of great importance to cancer diagnosis and prognosis.

• Journal of Ginseng Research
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• 제48권1호
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• pp.1-11
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• 2024

Fresh ginseng is prone to spoilage due to its high moisture content. For long-term storage, most fresh ginsengs are dried to white ginseng (WG) or steamed for hours at high temperature/pressure and dried to form Korean Red ginseng (KRG). They are further processed for ginseng products when subjected to hot water extraction/concentration under pressure. These WG or KRG preparation processes affect ginsenoside compositions and also other ginseng components, probably during treatments like steaming and drying, to form diverse bioactive phospholipids. It is known that ginseng contains high amounts of gintonin lysophosphatidic acids (LPAs). LPAs are simple lipid-derived growth factors in animals and humans and act as exogenous ligands of six GTP-binding-protein coupled LPA receptor subtypes. LPAs play diverse roles ranging from brain development to hair growth in animals and humans. LPA-mediated signaling pathways involve various GTP-binding proteins to regulate downstream pathways like [Ca²⁺]_i transient induction. Recent studies have shown that gintonin exhibits anti-Alzheimer's disease and antiarthritis effects in vitro and in vivo mediated by gintonin LPAs, the active ingredients of gintonin, a ginseng-derived neurotrophin. However, little is known about how gintonin LPAs are formed in high amounts in ginseng compared to other herbs. This review introduces atypical or non-enzymatic pathways under the conversion of ginseng phospholipids into gintonin LPAs during steaming and extraction/concentration processes, which exert beneficial effects against degenerative diseases, including Alzheimer's disease and arthritis in animals and humans via LPA receptors.

• 부모자녀건강학회지
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• 제1권
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• pp.75-87
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• 1998

These days social and economical changes have influence on the structure of family and the role of family members. Working mothers and widowers with children are increasing because of economical difficulties. Support from relatives are decreasing because of the conspicuous trend toward nuclear families. According to these reasons androgynous fathers are required. Today's fathers in Korea socially and culturally have learned about traditional parenting, but they are changing their fathering styles to meet the demands of the times. However they don't have their own fathering models. Therefore nurses who hold an advantageous position to teach and support from clinic have to encourage them to care their infants. The purposes of this study were to define father's care giving in infancy, understand influencing factors on fathering, and the differences between fathering and mothering, then contribute to nursing implementation for supporting fathers. This study was designed to review references about father's care giving. The results were follows: Six aspects of parent participation were direct care. indirect care, play, decision-making concerning the child, amount of time of sole responsibility for the child and overall availability to the child. Direct care involved feeding, bathing, going to child if child awakens. dressing, putting child to bed, taking child to doctor, nurse, or dentist, transporting child to and from sitter, day care, or school, washing child's hair. Indirect care involved cleaning up after child, preparing child's food, fixing child's broken playthings, washing child's clothes, arranging baby-sitting, shopping for child's toys and clothes, transporting baby-sitter to and from your home. Young fathers were gradually participating in direct care like feeding, taking child to doctor. Father's care giving stimulated mothering and promoted parent-infant relationship. Influencing factors of fathering would be divided into father characteristics, surrounding factors, infant attributes. Father characteristics were age, role perception, relationship with parent. Surrounding factors were the opportunity of early contact, support system, spouse's expectation, marital adjustment, feeding type, past experience of care giving. Infant attributes were temperament, behavior, age, sex. The differences between fathering and mothering were reviewed. Fathers were poor at care giving. but their caring was similar to mother's. This subtle difference positively worked upon infant's growth and development. On the basis of these theoretical data, nurses can empower fathers to cooperate with mothers in caring infants.

• Journal of Preventive Medicine and Public Health
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• 제26권4호
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• pp.628-649
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• 1993

국민학생들의 학습부진에 관련된 요인을 조사하여 의학적 예방 및 치료 대책을 고안해 보기 위해, 대구 시내에서 고소득층 밀집지역과 저소득층 밀집지역의 국민학교 1개씩을 선정하고, 각 학교의 2, 4, 6학년 학생 중 학업 성적이 하위 10%에 속하는 학생(학습부진군) 175명과 이에 대한 대조군으로 성적이 상위 5%에 속하는 학생(우수군) 97명을 대상으로 하여 이들에게 시력검사, 청력검사, 신체검사(체중, 신장, 두위)를 한 후, 고대 Stanford-Binet test를 이용한 지능검사와 TAI-K로 시험불안반응검사를 하고 발달소아학 전문의사가 신경학적 검진을 하였다. 아동의 어머니에게는 가정 환경, 어머니의 출산력, 아동의 출생 전후 및 과거력에서 의학적 특이사항, 그리고 행동양상에 관해 설문조사하고, 담임 선생에게 설문지를 통해 학교에서의 행동양상을 조사하였다. 아동의 두발을 적당량 채취하여 두발중 납, 카드뮴, 아연의 함량을 원자흡광분광광도계로 분석하였다. 학습부진과 각 요인과의 단순상관 관계분석에서 통계적으로 유의한 요인들을 이용한 다중지수형 회귀분석 (multiple logistic regression analysis)을 하여 학습부진의 관련요인을 찾았다. 단순분석에서 학습부진과 유의한 관련성이 있는 것은 남아인 경우, 출산순위가 높은 경우, 결손가정인 경우, 부모의 학력이 낮거나 직업이 노동직인 경우, 아동의 체중, 신장 및 두위가 작은 경우, 시력장애가 있는 경우, 지능지수가 낮은 경우, 시험불안반응점수가 높은 경우, 과잉활동성 아동인 경우로 나타났다. 다중지수형 회귀분석결과 학습부진과 관련되는 요인은 아동의 높은 출산순위 (odds ratio=2.06), 남아인 경우(odds ratio=5.91), 결손가정(odds ratio=9.29), 신장이 표준치-1 표준편차보다 작은 경우(odds ratio=11.12), 높은 시험불안점수(odds ratio=1.07), 과잉활동성 장애아동(odds ratio=9.67), 그리고 지능지수(odds ratio=0.85)였다. 두발중 중금속 함량의 분석결과 모두 학습부진과 뚜렷한 관련성이 없었으며, 납과 카드뮴의 함량은 학습부진군과 우수군 모두 남아가 여아에 비해 높았으며, 남은 학년과 역상관 관계(p<0.05)를, 아연은 정상관 관계(p<0.05)를 나타내었다. 학습부진과 유의한 관련성이 있는 요인들 중 조정가능한 것은 출산순위, 신장, 과잉활동성 장애 등으로, 가족계획을 통해 알맞은 수의 자녀를 갖도록 하고, 영유아기에서부터 사춘기에 이르기까지 적절한 영양공급을 하며, 과잉활동성 아동을 조기에 발견하여 의사의 진단을 받아 치료를 받도록 하는 것이 학습부진을 예방 및 해결하는데 도움이 될 것이다. 또한 부모와 담임 선생이 학습부진아에게 본인의 지적능력 이상의 기대나 학습의 강요로 불안을 조장하지 않도록 해야 할 것이다.

• 미생물학회지
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• 제55권3호
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• pp.206-212
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• 2019

Propionibacterium acnes (P. acnes)는 모낭과 모공 속에 존재하며 세포 찌꺼기, 피지 및 주변 피부 조직의 대사 부산물을 에너지와 영양소로 사용한다. 과도한 피지생성과 모낭의 막힘으로 피지 생성이 증가하면 P. acnes의 증식 및 성장을 유발할 수 있다. 모낭에 있는 P. acnes의 급속한 성장은 염증을 일으킬 수 있는 세포 손상, 신진 대사 부산물을 생성한다. 본 연구는 S. iscoensis Hieron. (S. iscoensis) 추출물이 P. acnes에 의한 염증반응을 조절할 가능성이 있는지 확인하고, 그 신호 전달 기전을 밝히고자 하였다. S. iscoensis 추출물은 마우스 대식세포주인 Raw 264.7에서 P. acne에 의해 유도되는 IL-$1{\beta}$, TNF-${\alpha}$, iNOS와 같은 염증성 사이토카인의 발현을 매우 효과적으로 억제하였다. 이러한, 염증성 사이토카인의 발현 억제는 NF-${\kappa}B$와 NF-AT와 같은 전사 조절 인자의 활성화 저해를 통해 일어남을 확인하였다. 그러나, MAPK 신호 전달 기전과는 상관이 없음을 확인하였다. 이 연구는 S. iscoensis 추출물이 여드름의 치료제로 사용될 가능성이 있음을 최초로 제안한다.