• Proceedings of the KSME Conference
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• 2000.04a
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• pp.363-368
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• 2000

Densification, grain growth, and phase transformation of nanocrystalline ceramic powder were investigated under pressureless sintering, sinter forging, and hot pressing. A constitutive model for densification of nanocrystalline ceramic powder was proposed and implemented into a finite element program (ABAQUS). A grain growth model was also proposed by including the effect of applied stress on grain growth when phase transformation occurs. Finite element results by using the proposed models well predicted densification behavior, deformation, and grain growth of nanocrystalline titania powder during pressureless sintering, sinter forging, and hot pressing.

• International Journal of Oral Biology
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• v.34 no.4
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• pp.185-190
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• 2009

This study examined the effects of red light generated from a light emitting diode (LED) upon proliferation and mitochondrial stress in human gingival fibroblasts (hGFs). Cells were exposed to LED-generated red light at a clinically relevant intensity and distance with a 610-630 nm wavelength for various times (0-48 min). At different exposure times, cells were processed for the analysis of succinate dehydrogenase (SDH) activity, proliferation, mitochondrial membrane potential (MMP) and cytotoxicity. Cell cycle progression was also investigated by flow cytometry after staining with propidium iodide. Red light exposure was found to inhibit SDH activity and DNA synthesis in hGFs in a time-dependent manner. Light exposure also reduced the MMP levels in these cells and this was closely associated with a $G_0/G_1$ arrest. In contrast, exposure of hGFs to red light for 48 min led to a dramatic loss of MMP with an attendant increase in cytotoxicity. These findings demonstrate that LED-generated red light may cause mitochondrial stress and growth inhibition in hGFs during tooth whitening therapy, depending on the length of the exposure.

• BMB Reports
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• v.47 no.10
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• pp.575-580
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• 2014

In this study, we investigate whether arsenite-induced DNA damage leads to p53-dependent premature senescence using human glioblastoma cells with p53-wild type (U87MG-neo) and p53 deficient (U87MG-E6). A dose dependent relationship between arsenite and reduced cell growth is demonstrated, as well as induced ${\gamma}H2AX$ foci formation in both U87MG-neo and U87MG-E6 cells at low concentrations of arsenite. Senescence was induced by arsenite with senescence-associated ${\beta}$-galactosidase staining. Dimethyl- and trimethyl-lysine 9 of histone H3 (H3DMK9 and H3TMK9) foci formation was accompanied by p21 accumulation only in U87MG-neo but not in U87MG-E6 cells. This suggests that arsenite induces premature senescence as a result of DNA damage with heterochromatin forming through a p53/p21 dependent pathway. p21 and p53 siRNA consistently decreased H3TMK9 foci formation in U87M G-neo but not in U87MG-E6 cells after arsenite treatment. Taken together, arsenite reduces cell growth independently of p53 and induces premature senescence via p53/p21-dependent pathway following DNA damage.

• The Korean Journal of Physiology and Pharmacology
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• v.25 no.6
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• pp.565-574
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• 2021

Astrocytes are activated in response to brain damage. Here, we found that expression of Kir4.1, a major potassium channel in astrocytes, is increased in activated astrocytes in the injured brain together with upregulation of the neural stem cell markers, Sox2 and Nestin. Expression of Kir4.1 was also increased together with that of Nestin and Sox2 in neurospheres formed from dissociated P7 mouse brains. Using the Kir4.1 blocker BaCl₂ to determine whether Kir4.1 is involved in acquisition of stemness, we found that inhibition of Kir4.1 activity caused a concentration-dependent increase in sphere size and Sox2 levels, but had little effect on Nestin levels. Moreover, induction of differentiation of cultured neural stem cells by withdrawing epidermal growth factor and fibroblast growth factor from the culture medium caused a sharp initial increase in Kir4.1 expression followed by a decrease, whereas Sox2 and Nestin levels continuously decreased. Inhibition of Kir4.1 had no effect on expression levels of Sox2 or Nestin, or the astrocyte and neuron markers glial fibrillary acidic protein and β-tubulin III, respectively. Taken together, these results indicate that Kir4.1 may control gain of stemness but not differentiation of stem cells.

• (The) Korean Journal of Educational Psychology
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• v.31 no.2
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• pp.265-282
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• 2017

The purpose of this study was to applicate systematic RTI educational service by providing reading fluency program to identify high-risk students with dyslexia of a shadow zone based on their growth rate. Twenty-two students of 1st to 5th graders were selected as study subjects through "2016 Kyungi-Do Project of the Dyslexia Excellence Program". An individualized reading fluency program was provided through 8-10 sessions over a period of 3 months. The program was developed based on evidence-based reading strategies with the consideration of each student's educational needs. As results, three groups were identified with their learning growth rates: concerned, improving, and discrepancy groups. The study identified three students in a discrepancy group as students with dyslexia. Based on these results, implications and suggestions for further educational identification process along with effect programs were discussed.

• Journal of Fashion Business
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• v.28 no.1
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• pp.98-112
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• 2024

The purpose of this study was to provide basic information on the development of local governments and upcycling industries that want to establish centers in the future. The study investigated the current situation and programs of domestic upcycling centers for regional sustainable growth. As a result of comparing and analyzing the programs operated by the upcycling centers by region, they could be classified into culture and arts experience programs, resource circulation experience programs, and environmental culture education programs according to the nature of the operation programs that are more focused on in addition to the experience and education programs reflected by each center. Among the upcycling materials and items used in the operation program, fashion-related education was being operated in a more diverse manner in the area of culture and arts experience programs. As a result of the analysis, it was found that it was necessary to establish a smooth material supply network, develop an in-depth step-by-step upcycling fashion education program, and strengthen the upcycling center program using regional characteristics. The results of this study are significant in that they provide the local governments with basic information for the establishment of upcycling centers in areas where the upcycling centers have not been established. In addition, this study presents the types and directions of programs necessary for establishing upcycling centers in the future.

• International conference on construction engineering and project management
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• 2024.07a
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• pp.1316-1316
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• 2024

Greenhouses require various control systems to create an optimal environment, and from an architectural engineering perspective, the uniformity of the internal environment is crucial for crop growth. However, greenhouses are structurally exposed to external weather conditions, leading to a high probability of variations in temperature, humidity, CO2 levels, lighting, etc., across different zones within the greenhouse. Such non-uniformity can impact the growth rate, quality, and yield of crops, highlighting the necessity of maintaining a consistent environment within the greenhouse. To address this, experiments utilizing Computational Fluid Dynamics (CFD) simulations were conducted targeting greenhouses in Pocheon, South Korea, focusing on the central heating and cooling systems to propose an optimal design considering the uniformity of internal temperatures. Subsequently, validation was performed using measurements from temperature and humidity sensors within the greenhouses. The heating and cooling systems operate based on indoor temperatures, activating cooling when indoor temperatures exceed the set cooling temperature in summer and heating when temperatures fall below the set heating temperature in winter. A standard greenhouse model was set as case 1, and experiments were conducted by adjusting the position and spacing of the fabric ducts of the heating and cooling systems, resulting in six categorized cases. Variations in temperature and humidity distribution were observed among the cases, and quantitative analysis provided optimal positions and spacing for the fabric ducts. The results of this study can serve as foundational data for developing environmental control solutions for agricultural facilities.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.56 no.4
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• pp.541-548
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• 2023

Behavior serves as an important indicator of the effects of environmental stressors on organisms. In this study, one-year-old abalone Haliotis discus hannai (15.1±0.8 mm) were used and each 0.34 m2 tank was stocked with 100, 150, 200, 250, and 300 juvenile abalone. After 328 days, we found that the low stocking density treatment showed significantly higher growth, whereas the high stocking density treatment showed significantly lower growth. In addition, abalone showed a lower rate of movement, distance moved, and velocity at higher stocking densities, but only velocity differed significantly. In contrast, In the Supplied the feed tanks significant difference between the moving distance and velocity. When the two groups of different sizes were mixed in tank, the rate of movement, distance moned, and velocity showed significant differences between differently-sized indivisuals. Our study indicates that breeding abalone at high densities has a negative effect on their growth and survival, which is thought to primarily be caused by spatial competition, and secondarily by differences in body size, ultimately affecting growth and productivity.

• Asian-Australasian Journal of Animal Sciences
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• v.13 no.8
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• pp.1154-1161
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• 2000

Two experiments were conducted to evaluate the efficacy of cupric citrate (Cu-citrate) relative to cupric sulfate $(CuSO_4)$ as a Cu source for weanling and grow-finish pigs. In addition, the use of liver and bile Cu concentrations as indices of the bioavailability of Cu sources was investigated. Experiment one consisted of a nursery phase (35 d; initial BW=6.4 kg, final BW=21.4 kg) followed by a grow-finish phase (103 d; initial BW=21.5 kg, final BW=111.7 kg). Experiment two only consisted of a nursery phase (35 d; initial BW=6.3 kg, final BW=18.6 kg). Dietary treatments were identical for both experiments and consisted of: control (10 ppm $CuSO_4$); control+66 or 225 ppm $CuSO_4$; control+33, 66, or 100 ppm Cu-citrate. An antibiotic was included in diets for Exp. 1 but not Exp. 2. In both experiments, growth performance variables were similar for pigs receiving Cu-citrate and $CuSO_4$; however, growth performance was not improved by high concentrations of $CuSO_4$. Liver and bile Cu were increased (p<0.05) by 225 ppm $CuSO_4$; however, lower dietary concentrations of Cu from either $CuSO_4$ or Cu-citrate did not affect the Cu concentration of liver or bile relative to that observed in the control pigs. Irrespective of Cu source, there was no linear (p>0.10) increase in plasma Cu with increasing Cu concentrations in the diet for both experiments. However, the plasma Cu concentrations were highest (p<0.10) in pigs receiving diets supplemented with 225 ppm $CuSO_4$. Sixteen randomly chosen pigs per treatment in Exp. 1 were continued through the grow-finish phase. Body weight gain and feed intake were improved (p<0.10) by 66 ppm $CuSO_4$, but other dietary Cu treatments did not alter pig performance compared to the control diet. Plasma Cu concentrations were increased (p<0.10) by 225 ppm $CuSO_4$ in the growing phase and by 225 ppm $CuSO_4$ and 100 ppm Cu-citrate in the finishing phase. These data reveal no consistent effect of $CuSO_4$ on performance; therefore, it is difficult to assess the efficacy of these two Cu sources. In addition, these studies demonstrate that liver and bile Cu are not good indicators of Cu bioavailability in pigs fed adequate to pharmacological concentrations of Cu.

• The Korean Journal of Elementary Counseling
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• v.10 no.1
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• pp.77-94
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• 2011

The purpose of this study was to think about 'the nature of the mind' through the extraction of contents related to the 'mind' which is contained in "Non-eo(the Analects of Confucius)" and to devise a 'Non-Eo' counseling program intended for elementary school students by finding out counseling elements related to the growth of the mind. The 'Non-Eo' counseling program developed in this study was 10 lessons of forty minutes each and divided the group counseling procedure into three phases as introduction, progress, and wrap-up. The subjects of this study were 40 elementary school students in upper grades in a specific county: 20 students in the control and experimental group respectively. The 'Non-Eo' counseling program was applied to the experimental group twice a week for five weeks and it was not applied to the control group. Two measurement tools were used in order to verify the effects: the self-esteem measurement test adopted by Gong, Tae-Su(1998) which was originated from the selfesteem measurement test for children developed by Coopersmith(1967) and the friendship measure test adopted by Jo, Seong-rye(2001) which originated from the friendship measure test developed by Furman and Bierman(1983). The results were as follows; Firstly, there was a significant difference between the growth of self-esteem of the students in the experimental group and that in the control group; in general, the p-value of the experimental group was .032. Secondly, there was a significant difference between the growth of friendship of the students in the experimental group and that in the control group; in general, the p-value of the experimental group was .046. The fact that this study carried out a new counselling approach called 'Non-Eo' counseling based on the contents related to 'the growth of the mind' in "Non-eo" is of great significance.