• Journal of Microbiology and Biotechnology
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• 제18권1호
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• pp.138-144
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• 2008

The production of the entomopathogenic and phytotoxic cyclic depsipeptide beauvericin (BEA) was studied in submerged cultures of Fusarium oxysporum KFCC 11363P isolated in Korea. The influences of various factors on mycelia growth and BEA production were examined in both complete and chemically defined culture media. The mycelia growth and BEA production were highest in Fusarium defined medium. The optimal carbon and nitrogen sources for maximizing BEA production were glucose and $NaNO_3$, respectively. The carbon/nitrogen ratio for maximal production of BEA was investigated using response surface methodology (RSM). Equations derived by differentiation of the RSM model revealed that the production of BEA was maximal when using 108 mM glucose and 25 mM $NaNO_3$.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2004년도 하계학술대회 논문집 Vol.5 No.1
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• pp.33-36
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• 2004

The process modeling for the growth rate in pulsed laser deposition(PLD)-grown ZnO thin films is investigated using neural networks(NNets) and the process recipes is optimized via genetic algorithms(GAs). D-optimal design is carried out and the growth rate is characterized by NNets based on the back-propagation(BP) algorithm. GAs is then used to search the desired recipes for the desired growth rate. The statistical analysis is used to verify the fitness of the nonlinear process model. This process modeling and optimization algorithms can explain the characteristics of the desired responses varying with process conditions.

• 한국미생물·생명공학회지
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• 제48권3호
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• pp.337-343
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• 2020

Haematococcus sp.를 대상으로 mixotroph 형태에서 배양을 위한 배지 최적화 연구를 수행하였다. 기본 배지로는 modified MS 배지가 적절했으며, 탄소원으로는 glucose가, 그리고 농도는 10 g/l가 적합하였다. 질소원으로는 KNO₃를 선정하였으며, 농도는 1.9 g/l이 최적이었다. 최적의 배지조건에서 Haematococcus sp.를 초기 접종량(0.18 g/l)로 접종하여 14일 후에 5.58 ± 0.25 g/l로 성장하였으며, 이는 건조 세포중량 기준으로 약 31배의 성장한 것이다. 이때 생성된 클로로필은 172.16 ± 7.79 mg/l였으며, 카로티노이드는 42.33 ± 1.91 mg/l이었다. 본 연구의 결과는 추후 미세조류 대량 배양과 대사산물의 생산에 이용가능한 기초자료가 될 수 있을 것이라 판단된다.

• Journal of Electrical Engineering and Technology
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• 제12권2호
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• pp.541-548
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• 2017

An increasing concern is paid to short-term voltage stability with the growth of penetration of induction motor loads. Reactive power reserve(RPR) of power system is critical to improve voltage stability. A definition of short-term voltage stability-related RPR(SVRPR) is proposed. Generators vary their contributions to voltage stability with their location and system condition, etc. Voltage support coefficient based on the second-order trace sensitivity method is proposed to evaluate SVRPR's contribution to short-term voltage stability. The evaluation method can account for the generator's reactive support in transient process and the contingency severity. Then an optimization model to improve short-term voltage stability is built. To deal with multiple contingencies, contingency weight taking into account both its probability and severity is proposed. The optimization problem is solved by primal dual interior point method. Testing on IEEE_39 bus system, it is indicated that the method proposed is effective. Short-term voltage stability is improved significantly by the way of SVRPR optimization. Hence, the approach can be used to prevent the happening of voltage collapse during system's contingency.

• 한국금형공학회:학술대회논문집
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• 한국금형공학회 2008년도 하계 학술대회
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• pp.203-208
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• 2008

Recently, the modern society in development and industrial growth is investing a lot of time and much effort to improvement and environment of life quality. Thus, the casting tape which uses environmentally friendly and human body friendly water hardening process Polymer is rapidly substituted for the gypsum cast product which has been plentifully used in medical treatment. Until currently, prior researches have a tendency to focusing the analysis about chemical creation expense and reaction quality rather than the issue about optimization of the process for this polymerization. In the polymerization process which has been accomplished with actual same chemical creation expense, there has been a problem which is the possibility of getting a different result. This is because the optimization of respectively control factors is not accomplished which affect at polymerization process. Therefore, this research sees the chemical qualities of casting tape Polymer, consequently selects the polymerization process which is suitable. And, by using a experimental design, this research will evaluate the affects which the respective factors have on remaining NCO and viscosity. futhermore, this research will carry out the process optimization which can get the above results.

• 한국결정성장학회지
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• 제31권6호
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• pp.258-263
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• 2021

ZnO 바리스터는 다결정구조를 가지는 반도체 소자로 결정립과 입계의 미세구조 제어를 통해 비선형적인 전류/전압 특성을 가지기 때문에 서지(surge)전압으로부터 회로를 보호하는 역할을 한다. 이러한 ZnO 바리스터에서 원하는 전기적 물성을 얻기 위해서는 소결 공정에서 미세구조의 제어가 중요하다. 따라서 소결 공정에서 중요한 변수들과 소결체의 전기적 물성인 유전율로 구성된 데이터셋을 정의한 후 실험계획법 기반으로 데이터를 수집했다. 수집된 실험데이터셋을 기계학습 알고리즘에 학습하여 메타모델을 개발했고, 개발된 메타모델에 수치기반 최적화 알고리즘인 HMA(Hybrid Metaheuristic Algorithm)를 적용하여 최대 유전율을 가질 수 있는 공정조건을 도출했다. 이러한 메타모델 기반의 최적화를 다변수 시스템인 세라믹공정에 적용한다면 최소한의 실험만으로 최적 공정조건 탐색이 가능할 것으로 판단된다.

• 한국전기전자재료학회논문지
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• 제16권2호
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• pp.102-107
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• 2003

This study puts focus on the optimization of growth temperature of CIGS absorber layer which affects severely the performance of solar cells. The CIGS absorber layers were prepared by three-stage co-evaporation of metal elements in the order of In-Ga-Se. The effect of the growth temperature of 1st stage was found not to be so important, and 350$^{\circ}C$ to be the lowest optimum temperature. In the case of growth temperature at 2nd/3rd stage, the optimum temperature was revealed to be 550$^{\circ}C$. The XRD results of CIGS films showed a strong (112) preferred orientation and the Raman spectra of CIGS films showed only the Al mode peak at 173cm$\^$-1/. Scanning electron microscopy results revealed very small grains at 2nd/3rd stage growth temperature of 480$^{\circ}C$. At higher temperatures, the grain size increased together with a reduction in the number of the voids. The optimization of experimental parameters above mentioned, through the repeated fabrication and characterization of unit layers and devices, led to the highest conversion efficiency of 15.4% from CIGS-based thin film solar cell with a structure of Al/ZnO/CdS/CIGS/Mo/glass.

• 한국해양바이오학회지
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• 제16권1호
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• pp.36-44
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• 2024

This study attempted to improve the growth of the freshwater microalgae, Parachlorella kessleri, through the sequential optimization of culture conditions. This attempt aimed to enhance the microalgae's ability to fixate atmospheric CO₂. Culture temperature and light intensity appropriate for microalgal growth were scanned using a high-throughput photobioreactor system. The supplied air flow rate varied from 0.05 to 0.3 vvm, and its effect on the growth rate of P. kessleri was determined. Next, sodium phosphate buffer was added to the culture medium (BG11) to enhance CO₂ fixation by increasing the availability of CO₂(HCO₃^-) in the culture medium. The results indicated that optimal culture temperature and light intensity were 20℃-25℃ and 300 μE/m²/s, respectively. Growth rates of P. kessleri under various air flow rates highly depended on the increase of the culture's flow rate and pH which determines CO₂ availability. Adding sodium phosphate buffer to BG11 to maintain a constant neutral pH (7.0) improved microalgal growth compared to control conditions (BG11 without sodium phosphate). These results indicate that the CO₂ fixation rate in the air could be enhanced via the sequential optimization of microalgal culture conditions.

• 한국생물공학회:학술대회논문집
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• 한국생물공학회 2003년도 생물공학의 동향(XII)
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• pp.153-156
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• 2003

The MRS medium is widely used as an optimized medium for the growth of Lactobacillus spp. and also used for the growth of Leuconostoc spp. Leuconostoc mesenteroides shows quite different physicochemical properties compared to Lactobacilli spp. and it is one of the major strain of kimchi fermenting microorganisms with its usefulness in our traditional foods and availability in biotechnology in the future, specifically tailor-made medium is necessary for the growth of Leuconostoc mesenteroides. Sequential experimental designs (Plackett-Burman, fractional factorial, steepest ascent, central composite design and response surface methodology) were introduced to optimize and improve the Leuconostoc medium. Fifteen medium ingredients were investigated and fructose, sodium acetate and ammonium citrate were determined to give a critical and positive effect for cell-growth. The yield of biomass using the optimal medium was improved more than that of the MRS medium and the result of fed-batch culture showed the capability of the improvement in cell mass similar to the E.coli system.

• 한국생물공학회:학술대회논문집
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• 한국생물공학회 2000년도 추계학술발표대회 및 bio-venture fair
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• pp.317-320
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• 2000

The optimal temperature and pH for both mycelial growth and exe-biopolymer production by Cordyceps millitaris in shake flask culture were found to be $20^{\circ}C$ and 6.0, respectively. Sucrose (4%) and corn steep powder (1%) were the most suitable carbon and nitrogen source for mycelial growth and exo-biopolymer production. The maximum specific growth rate $(0.142h^{-1})$ was achieved when sucrose was used as the sole carbon source. Exo-biopolymer production was increased with the increase in C/N molar ratio concentration, probably due to the facilitated carbon uptake. Under the optimal culture conditions, the maximum mycelial growth exe-biopolymer concentration were reached to around 13.3 g dry cell weigh/l and 3.33 g/l, respectively.