• Herbal Formula Science
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• v.11 no.2
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• pp.83-94
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• 2003

This study aimed to investigate the effects of each constituent-herb of Sagoonja- Tang on the plasma corticosterone level in mice exposed to cold stress. Sagoonja-Tang is composed of Ginseng Radix, Atractylodis Radix, Poria, and Glycyrrhizae Radix. Each constisuent-herb(0.5g/kg, 1.0g/kg) was administered intragastrically to mice 1hr prior to expose to forced cold water swimming($4{\circ}C$, 3min) before measuring the change of plasma corticosterone level of mice. The results were as follows: 1. At 30 minutes after the cold stress for 3 minutes the most significant increase of corticosterone level was shown. 2. Ginseng group(PGR group) didn't show any significant changes. 3. Atractylodis group(AR group) showed significant decrease at 0.5g/kg dose (P<0.01). But it didn't show significant changes at 1.0g／kg dose. 4. Poria group(P group) didn't show significant changes. But it showed slightly increase at 1.0g/kg dose. 5. Glycyrrhizae group(GR group) didn't show significant changes. These data revealed that Atractylodis macrocephalae Rhizoma might have the anti-stress effect through the control of plasma corticosterone level and the dose of herbs had a different effect on the plasma corticosterone level in mice exposed to cold stress.

• Journal of Korean Academy of Fundamentals of Nursing
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• v.8 no.3
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• pp.293-301
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• 2001

Purpose: The purpose of this study was to investigate the effect of exercise therapy and relaxation therapy on the level of ACTH and cortisol in workers and to determine, from this information, the effectiveness of applied exercise therapy and relaxation therapy as a nursing intervention method for workers experiencing stress. Method: The subjects were divided into an exercise therapy group. a relaxation therapy group, and a control group. The research design was a nonequivalent control group pretest-posttest design (exercise therapy : n=12. relaxation therapy: n=12, control group, the group without exercise or relaxation therapy: n= 12). The subjects in the exercise therapy group were given a particular intensity for each kp over 30 min, bicycle ergometer which uses the LX PE training system before and after four weeks of training. The subjects did 60-70% exercise intensity exercise therapy for eight weeks The relaxation therapy subjects were trained using a modified Jacobson's relaxation technique for eight weeks. The exercise and relaxation therapy groups were trained at the following intensity for eight weeks (3 times/week, 30 min/day). Changes in the levels of ACTH and cortisol were identified. Two-way ANOVA and multiple range test (SNK: Student Newman Keul) were used to examine the effects of exercise therapy and relaxation therapy at four and eight weeks. Result: 1. Changes in the level of ACTH in the relaxation therapy group were statistically significant at .05 level, and were better than that of the exercise therapy group after eight weeks. But there was no significant difference between the exercise therapy group and the control group. 2. Change in the level of cortisol in the relaxation therapy group were statistically significant at .05 level as compared to the exercise therapy group and the control group after four weeks, but not after eight weeks. Also, the relaxation therapy was statistically significant at .05 level after four weeks compared to before treatment, but there was a tendency toward increased cortisol after eight weeks. Conclusion: Relaxation therapy was found to be more effective in stress treatment than exercise therapy and as such is a desirable nursing intervention method for stress hormone reduction in workers.

• The Korean Journal of Community Living Science
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• v.19 no.1
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• pp.11-19
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• 2008

This study was made to provide basic materials required to develop the program for desirable change of eating behavior which might be regarded as the aim of nutrition education. In this study, the relationship between the factors known to be affecting eating behavior like nutrition knowledge and dietary self efficacy was examined with high grade elementary students in Gangwon Province. The results are as follows; First, positive relationship was observed with significant difference(p<0.001) in the relationships between eating behavior and dietary self efficacy(r=0.465), between nutrition knowledge level and eating behavior(r=0.216) and between nutrition knowledge level and dietary self efficacy(r=0.312). Second, the ratio explaining the effect of dietary self efficacy and nutrition knowledge on eating behavior was 22.3%, and it affected in the order of significance level such that dietary self efficacy(p<0.001) and nutrition knowledge level(p<0.05). Third, the level of desirable eating behavior was consistent with the level of nutrition knowledge. And the scores of nutrition knowledge were $28.97{\pm}4.66$ for 'poor' group, $30.01{\pm}3.85$ for 'normal' group, $31.13{\pm}3.94$ for 'good' group and $31.75{\pm}4.10$ for 'excellent' group. When the scores of eating behavior was considered in accordance with the level of nutrition knowledge, there was difference between the groups with poor and normal scores and the groups with good and excellent scores(p<0.001), however, there was no difference between poor and normal group, and between good and excellent group. Fourth, it was found that dietary self efficacy affected the eating behavior level by level. The eating behavior score was $23.82{\pm}5.25$ for the poor dietary self efficacy group, $26.88{\pm}4.00$ for the normal group, $30.27{\pm}3.66$ for the good group and $32.81{\pm}3.79$ for the excellent group. It showed that as the degree of dietary self efficacy increased the degree of eating behavior increased in all four groups (p<0.001).

• Journal of the East Asian Society of Dietary Life
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• v.11 no.4
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• pp.268-273
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• 2001

This study was performed to investigate the effects of HBM(Healthy Body Maker) on the weight loss and serum cholesterol level of rats. Twenty male Sprague-Dawley rats weighing 200$\pm$5g were grouped into 2. Rats were raised for 6 weeks with diet containing 0% and 5% of HBM. 1. There were no clinical signs for all the experimental period(6 weeks) in 0% and 5% groups. 2. At 3 and 6 weeks. body weight of 5% HBM group was significantly lower than that of control group. respectively(p<0.05, p<0.01). 3. At 4 weeks. the level of MCHC of 5% HBM group was significantly higher than that of control group(p<0.01) And at 6 weeks the level of RBC and Hct of 5% HBM group were significantly higher than those of control group(p<0.05) 4. At 6 weeks. the level of serum cholesterol of 5% HBM group was significantly lower than that of control group. 5. Absolute liver weight of 5% HBM group was significantly lower than that of control group(p<0.05). 6. Minor subaceous sickness of liver cell in the control group appeared but no symptom of liver cell in 5% HBM group. It is concluded that HBM was a safe and effective diet food which aided in inducing weight loss in rat without any observed harmful clinical side effects.

• Physical Therapy Rehabilitation Science
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• v.6 no.4
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• pp.170-175
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• 2017

Objective: The anti-inflammatory effects of low-level laser in burn wound model in rats were investigated. Design: Randomized controlled trial. Methods: The rats were assigned to three experimental groups. Group I received second-degree burn wounds; Group II received dressing film and low-level laser ($1.2J/cm^2$) treatment after a burn wound; Group III received dressing film and low-level laser ($2.3J/cm^2$) treatment after a burn wound. After inducing a deep second-degree burn wound, the wound was observed every day and the burn area diameter and retraction quantification at 1, 7, and 14 days were evaluated. Low-level laser was investigated on hematological parameters after 14 days. Effects of low-level laser on the inflammatory cytokines (tumor necrosis $factor-{\alpha}$ [$TNF-{\alpha}$] and interleukin-6 [IL-6]) concentrations in the serum were evaluated using immunosorbent assay kits. Results: Group III showed a significant difference in wound size on days 7 and 14 compared to Group I (p<0.05). Group II showed a significant difference in wound size on day 14 compared to Group I (p<0.05). For wound contraction percentage, both laser therapy treatment groups showed a significant difference compared with Group I (p<0.05). There was also a significant difference in wound contraction percentage in Group III compared to Group II (p<0.05). Compared with the model control group, decreased $TNF-{\alpha}$ and IL-6 levels in the serum was observed at 14 days after burn wound induction. Conclusions: The results of this study suggest that low-level laser therapy can assist in burn wound healing, which might be associated with decreased concentrations of $TNF-{\alpha}$ and IL-6 related proinflammatory cytokines.

• Restorative Dentistry and Endodontics
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• v.23 no.2
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• pp.607-617
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• 1998

The purpose of this study was to evaluate the apical sealing ability of lateral condensation method, vertical condensation method, and MicroSeal obturation system. Sixty-four extracted anterior teeth were instrumented to #40 using Profile. Three groups of 20 teeth were obturated by lateral condensation technique, vertical condensation technique, and and MicroSeal obturation system. Control group were not obturated. Teeth were immersed in resorcinol-formaldehyde resin for 5 days at $4^{\circ}C$, and the resin was allowed to polymerize completely for 4 days at room temperature. Teeth were ground horizontally at 1,5mm(level 1), 2.5mm(level 2), and 3.5mm(level 3) from the anatomic apex and examined with a stereomicroscope at X40 magnification. The photographs were taken a at X40 magnification of the filling in each level and scanned. The leakage area, which was filled with the resin, was measured at each of the three levels. Each ratio of leakage was evaluated by calculating the ratio of thearea of the resin to the total area of the canal and was analyzed statistically. The results were as followed: 1. Vertical condensation group had significantly higher percentage of the area which was obturated by gutta percha than other two technique at each level. 2. At the level 1, there was the greatest leakage in the lateral condensation group, but there was no statistically significant(P>0.05) 3. At the level 2, there was the least leakage in the MicroSeal group, and the most leakage in the lateral condensation group. There was statistically significant difference between the MicroSeal group and the lateral condensation group(P<0.05). 4. At the level 3, there was least leakage in the vertical condensation group, and the most leakage in the lateral condensation group. There was statistically significant difference between the vertical condensation group and the lateral condensation group(P<0.05).

• Korean Journal of Veterinary Research
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• v.15 no.2
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• pp.153-159
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• 1975

In order to investigate the effect of cobalt-60 gamma irradiation on the blood picture, the mice were subjected to single whole-body gamma irradiation externally. In this experiment 42 of 12 weeks old white mice were used and animals were allotted to group of three. On of chose groups served as control and the others as test groups that were exposed to single dose of 370 Rads (group I) and 500 Rads (group II). The exposure dose rate were averaged 33 Rads per Minute. The results obtained in this experiment were as follows: 1. Erythrocyte counts in both test groups dropped to the lowest level at 4 weeks postirradiation, returning towards the control level, but in recovery, group I showed rather prumpt compared with group II. Erythrocyte count in group II was significantly lower than that of group I. 2. Total leukocyte counts dropped to the lowest loved at 2 weeks postirradiation and group I recovered to normal level at 4 weeks postirradiation. Recovery group II was very slow and it reached to the control level on 12 weeks postirradiation. Leukocyte count was significantly different between group I and II. 3. Neutrophil count was increased to the highest level at 2 weeks postirradiation, with recovery to normal value after 8 weeks in group I and 12 weeks in group II, respectively. Neutrophil count was significantly different between group I and II. 4. Lymphocyte count dropped to the lowest level at 2 weeks postirradiation, with recovery to normal average after 8 weeks in group I and 12 weeks in group II, respectively. Lymphocyte count was significantly different between group I and II. 5. The other leukocyte count was increased after the irradiation and recovered at 12 weeks postirradiation in both test groups. The other leukocyte count was significantly different between group I and II.

• Journal of Nutrition and Health
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• v.36 no.7
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• pp.675-683
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• 2003

This study investigated the effect of dietary $\beta$-carotene supplementation on lipid peroxidation and anti oxidative enzyme activity as indices of oxidative stress in diabetic rats. Fifty Sprague-Dawley male rats aging 7 weeks were used as experimental animals, which were divided into the non-diabetic control group and the diabetic group. The diabetic group received an intraperitoneal injection with streptozotocin to induce diabetes. Then the diabetic rats were divided into four dietary groups which contained different amounts of $\beta$-carotene; 0%, 0.002%, 0.02%, or 0.2% of the diet. The diabetic rats were fed the experimental diets and the non-diabetic rats were fed the basal diet without $\beta$-carotene supplementation for 2 weeks and then sacrificed. The diabetic group had a significantly higher blood glucose level than the non-diabetic group. However, blood glucose level were not significantly changed by the level of dietary $\beta$-carotene supplementation. Compared to the non-diabetic control group, the diabetic control group indicated a significant increase of plasma thiobarbituric acid reactive substance (TBARS). Liver TBARS level also tended to be higher in diabetic control group, although it was not significant. The $\beta$-carotene supplementation did not reduce plasma TBARS level. However, Liver TBARS level was significantly decreased when 0.02% or more $\beta$-carotene was supplemented in the diet. The liver lipofuscin level in the diabetic control group was higher than in the non-diabetic control group, but the effect of $\beta$-carotene supplementation did not show any differences. Superoxide dismutase activity was significantly lower in the diabetic group, but it was increased in groups receiving 0.02% or more $\beta$-carotene. Compared to the non-diabetic control group, lower activities of catalase and glutathione peroxidase were observed in the diabetic control group, although it was not significant. Catalase and glutathione peroxidase activities tended to increase as the levels of $\beta$-carotene supplementation increased, although it was not statistically significant. Therefore, it seems that dietary $\beta$-carotene supplementation might reduce diabetic complications by partly decreasing the lipid peroxidation and increasing the activity of antioxidative enzyme in diabetes.

• Journal of the Korean Applied Science and Technology
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• v.4 no.1
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• pp.91-97
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• 1987

Because of its more complete hydrolysis and rapid absorption, MCT is expected its usefulness in the diets of patients with malabsorption syndrom. Also, several authors reported that serum cholesterol level was lower after MCT feedings. In this study, rate of each experimental group were fed for 4weeks with 20％ MCT, 20％ corn oil, mixed diet of 10％ MCT and 10％ corn oil, mixed diet of 17％ corn oil and 3％ shortening. After experimental diet, it was measured to growth rate and serum cholesterol, triglyceride and phospholipid level. The results were as follows; 1. The body weight gain was the lowest in MCT group and others were lower than control group. 2. Serum total cholesterol level was the lowest in corn oil group and others were significantly lower than control group. Free cholesterol level was lower in all experimental groups than control group too. 3. Serum HDL-cholesterol level was significantly higher in all experimental groups than control group. 4. The ratio of VLDL, LDL-Cholesterol to HDL-Cholesterol was significantly lower in all experimental groups than control group. 5. Serum triglyceride level was higher in all experimental groups than control group. Serum phospholipid level was significantly in only mixed diet group of corn oil and shortening than control group. 6. The ratio of total cholesterol to phospholipid was significantly lower in corn oil diet group than control group.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.25 no.4
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• pp.573-583
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• 2015

Objectives: This study was carried out to evaluate the effect of noise exposure and aging on changes in hearing threshold level and the relationship between age and noise. Materials: The author selected 274 male shipyard and assembly line workers as the noise exposed group and 582 males not exposed to noise as the general population group. Data were collected from five years of consecutive annual audiometric tests performed from 2008 to 2012. Results: In the general population and noise exposed groups, there was a reverse phenomenon that hearing threshold level for 2009 was lower than that of 2008, which seemed to be due to the learning effect, but from 2010 hearing threshold level increased. In the noise exposed group, the mean hearing threshold level in the left ear was significantly higher than that for right ear. In the general population group, the older was the age, the higher was the hearing threshold level, especially at 4000 Hz. In the general population and noise exposed groups, frequency, age group and noise exposure independently affected hearing threshold level, and there was no relationship between age and noise exposure. Over all frequencies, the change of hearing threshold level was larger in the noise exposed group than in the general population group. In the noise exposed group below thirty years old, the change at 4000 Hz was remarkable. Conclusions: Age and noise exposure seem to affect hearing threshold level independently and contribute to an additive effect on hearing threshold level.