• 대한한방종양학회지
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• 제3권1호
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• pp.169-191
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• 1997

Hyangpaeyangyeongtang, which was first prescribed in the book of Euijonggumgam (醫宗金鑑), has been widely applied to the treatment of scrofula and carbuncle in the neck and tumor as well in the oriental medicine. The Fritillariae roylei bulbus was also used as an anti-tumor medicine. In order to investigate the effect of Hyangpaeyangyeongtang and Fritillariae roylei bulbus extracts on the immune responses to the epithelioma induced by 3-methylcholanthrene and prostaglandin-$F_2{\alpha}$ in mice, the change of epithelioma size was observed and delayed type hypersensitivity, hemagglutinin titer, hemolysin titer, rosette forming cells, natural killer cell activity, lymphocyte transformation, productivity of interleukin-2 and phagocytic activity were also measured. The results were as follows; 1. The epithelioma size was decreased with statistical significance in the Hyangpaeyangyeongtang group at the 14th day, as compared with the control group. 2. Delayed type hypersensitivity was not shown any decrease in the Hyangpaeyangyeongtang group and the Fritillariae roylei bulbus group, as compared with the control group. 3. Hemagglutinin titer was increased with statistical significance in the Hyangpaeyangyeongtang group, but not in the Fritillariae roylei bulbus group as compared with the control group. 4. Hemolysin titer was increased with statistical significance in the Hyangpaeyangyeongtang group, but not in the Fritillariae roylei bulbus group as compared with the control group. 5. Rosette forming cells were not increased in the Hyangpaeyangyeong tang group, but increased with statistical significance in the Fritillariae roylei bulbus group as compared with the control group. 6. Natural killer cell activity at the ratio 100:1 of effector cells to target cells was increased with statistical significance in the Hyangpaeyayeongngtang group and the Fritillariae roylei bulbus group respectively, and the natural killer cell activity at the ratio of 50:1 and 10:1 of effector cells to target cells Hyangpaeyangyeongtang group was increased with statistical significance as compared with the control group. 7. Lymphocyte transformation was increased in the Hyangpaeyangyeong tang group and the Fritillariae roylei bulbus group respectively, as compared with the control group. 8. Productivity of interleukin-2 was increased in the Hyangpaeyangyecing tang group and the Fritillariae roylei bulbus group respectively, as compared with the control group. 9. Phagocytic activity was not shown any decrease in the Hyangpaeyangyeongtang group and the Fritillariae roylei bulbus group, as compared with the control group.

• 대한수학교육학회지:학교수학
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• 제16권3호
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• pp.613-631
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• 2014

본 연구는 초등학교 5학년 수학영재 학생들의 소수와 합성수에 대한 개념형성의 과정을 활동이론의 틀로 분석한 것으로 계산기 환경의 소집단 활동체계가 개인이 개념 형성하는데 어떤 영향을 주는지 살펴보았다. 자료 분석은 학생 활동지, 관찰 기록, 동영상과 인터뷰의 녹취록을 활용하였다. Vygotsky, Tall & Vinner의 개념 형성 과정을 적용하여 학생들의 수학적 개념 형성의 수준을 파악하였고, 활동이론에 기초한 교실 전체 집단 활동체계와 소집단 활동체계를 분석하여 학생의 개념 형성 단계를 도식화하였다. 본 연구 결과에 따르면 서로 다른 소집단에 속하는 구성원은 소집단 활동을 하고 난 후 한 학생은 의사개념 단계로 발전하였지만 다른 한 학생은 복합적 사고 단계를 벗어나지 못하여 소집단의 활동체계의 활동요소간의 상호작용이 활동 주체인 각 학생의 수학적 개념 형성 과정에 영향을 주었다.

• 가정과삶의질연구
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• 제30권6호
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• pp.115-127
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• 2012

This study's aim was to analyze the effect of a project activity based on role play on 5-year-olds' mathematical ability. The participants of this study were 56 5-year-olds from two educational institutions for young children located in two metropolitan cities in Korea. The experimental group (n=28) participated in a project activity based on role play, while the comparative group (n=28) did not. The "Mart Play" project activity based on role play was developed emergently by the children and teachers of the experimental group. The children's mathematical ability was measured before and after the experiment. The data were analyzed using t-test and ANCOVA. As a result, the project activity based on role play had an effect on the improvement of 5-year-olds' mathematical ability generally, but not on their measurement ability.

• Journal of Nutrition and Health
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• 제34권7호
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• pp.734-740
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• 2001

The purpose of this study was to investigate the effect of green tea catechins on the antioxidative defense enzyme activity of kidney in diabetic rats. Sprague-Dawley male rats weighting 100$\pm$10g were randomly assigned to one normal and three STZ-induced diabetic groups; catechin free diet(DM-0C group), 0.25% catechin diet(DM-0.25C group) and 0.5% catechin diet(DM-0.5C group). Diabetes was induced by intravenous of 55mg/Kg body weight of STZ in sodium citrate buffer(pH 4.3) after 4 weeks feeding of experimental diets. Rats were sacrified at the 6th day of diabetic states. Superoxide dismutase(SOD) activity in kidney was decreased by 25% and 20% in DM-0C and DM-0.25C groups compared with normal group, DM-0.5C group was not significantly different when compared with normal group. Glutathione peroxidase(GSHpx) activity in kidney was were no significant differences the diabetic groups compared to normal group. Xanthin oxidase(XOD) activity was increased by 110% and 63% in DM-0C and DM-0.25C groups compared with normal group, DM-0.5C group was not significantly different when compared with normal group. The contents of superoxide radical(O$_2$)in kindney were 116% and 33%, respectively, higher in DM-0C and DM-0.25C groups than normal group. DM-0.5C group and normal groups were similar levels in their superoxide radical contents of kidneys. Levels of TBARS(thiobarbituric acid reactive substance) in kidney were increased by 62% in DM-0C group, when compared with normal group, but those of DM-0.5C group were similar to that of normal groups. These results indicate that free radical generation system was weakened and free radical scavenger system was enhance in kidney of STZ-induced diabetics rats by dietary catechin. Thereby it may reduce renal disorders such as oxidative damage and aging of tissue.

• 사상체질의학회지
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• 제23권3호
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• pp.374-390
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• 2011

1. Objectives: The purpose of this study is to investigate the effect of Suhwagije-tang(SGT) distillate on the immune activity of spleen cells of aged SD rats. 2. Methods: We used 10, 50, 72 weeks old SD rats in this study. Spleen cells from SD rats were stimulated with ConA and treated with 1% Vitamin C(Vit.C) or Suhwagijetang distillate(SGT). After 24 hours, the concentrations of IL-2, IL-4, IL-10, IFN-${\gamma}$ in the cell culture supernatant were measured by ELISA. 3. Results and Conclusions 1) At all concentration of SGT distillate, survival rates of liver cells were higher than the control group. In addition, 50% SGT distillate group's cell survival rates were significantly higher than other groups. 2) In 10 weeks SD rats(SGT group), the concentration of IL-2 significantly decreased in comparison with ConA group, Vit.C group. In 52 weeks SD rats(SGT group), the concentration of IL-2 significantly decreased in comparison with ConA group. 3) In 10, 52 weeks SD rats(SGT group), the concentration of IL-4 significantly decreased in comparison with ConA group. 4) In 10 weeks SD rats(SGT group), the concentration of IL-10 significantly decreased in comparison with ConA group. And in 72 weeks SD rats(SGT group), the concentration of IL-10 significantly increased in comparison with Vit.C group. 5) In 52, 72 weeks SD rats(SGT group), the concentration of IFN-${\gamma}$ significantly decreased in comparison with 10 weeks SD rats(SGT group). These results suggest that Suhwagije-tang(SGT) distillate has the effect of increasing the immune activity of spleen cells of aged SD rats.

• 대한통합의학회지
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• 제1권1호
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• pp.11-22
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• 2013

Purpose : The purpose of this study was to investigate the effects of music intervention upon lighting on stress. Method : The participants 60 college students, were divided three groups. Two groups were apply each music and bright lighting(bright lighting groups) and music and dark lighting(dark lighting groups) during 13minutes at Snozelen and the other group was control group. Each groups were assessed stress resistance, activity of parasympathetic nerve, activity of sympathetic nerve, balance of ANS, physical arousal by EKG of CANS 3000, at before and after other each intervention. The analyses were performed using version of SPSS 17. Result : The change rate of bright lighting group was showed statistically significant decrease in stress resistance compared to control group. And the change rate of dark lighting group was showed statistically significant decrease in resistance stress, activity of parasympathetic nerve, and balance of ANS compared to control group and statistically significant increase in stress resistance and activity of parasympathetic nerve compared to bright lighting group. Conclusion : The results of this study indicate that music intervention on dark lighting is more effective on decrease of stress than application of bright lighting and general lighting.

• 대한간호학회지
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• 제40권4호
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• pp.580-588
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• 2010

Purpose: The purpose of this study was to examine effects of decreased locomotor activity on mass, Type I and II fiber cross-sectional areas of ipsilateral and contralateral hindlimb muscles 21 days after establishing the Parkinson's disease rat model. Methods: The rat model was established by direct injection of 6-hydroxydopamine (6-OHDA, 50 ${mu}g$) into the left substantia nigra after stereotaxic surgery. Adult male Sprague-Dawley rats were assigned to one of two groups; the Parkinson's disease group (PD; n=17) and a sham group (S; n=8). Locomotor activity was assessed before and 21 days after the experiment. At 22 days after establishing the rat model, all rats were anesthetized and soleus and plantaris muscles were dissected from both ipsilateral and contralateral sides. The brain was dissected to identify dopaminergic neuronal death of substantia nigra in the PD group. Results: The PD group at 21 days after establishing the Parkinson's disease rat model showed significant decrease in locomotor activity compared with the S group. Weights and Type I and II fiber cross-sectional areas of the contralateral soleus muscle of the PD group were significantly lower than those of the S group. Conclusion: Contralateral soleus muscle atrophy occurs 21 days after establishing the Parkinson's disease rat model.

• International Journal of Oral Biology
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• 제46권2호
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• pp.94-97
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• 2021

The purpose of this study was to introduce a new in vitro method for evaluating the antimicrobial activity of toothpaste, reflecting the actual toothbrushing time and the dilution of toothpaste by salivation. We designed three experimental groups and one negative control group. The experimental groups were (1) 90 μL of toothpaste + 10 μL 1X phosphate-buffered saline (PBS, 9/10 dilution group), (2) 50 μL of toothpaste + 40 μL 1X PBS (1/2 dilution group), and (3) 25 μL of toothpaste + 65 μL 1X PBS (1/4 dilution group). During toothbrushing, saliva is continuously secreted into the oral cavity and the toothpaste concentration is diluted over time during toothbrushing. Therefore, the 1/2 and 1/4 dilution experimental groups were added. The negative control group was toothpaste diluted 20,000-fold with 1X PBS. Miracle Fresh Doctor toothpaste and Streptococcus mitis KCOM 1350, Prevotella intermedia KCOM 1107, Fusobacterium nucleatum subsp. polymorphum KCOM 1322, and Aggregatibacter actinomycetemcomitans KCOM 1306 were used as the toothpaste and target bacterial strains, respectively. The number of bacterial cells plated on agar plates in the negative control group was 1,000 CFU. If the number of colonies on the experimental group plate was less than one, the treatment was considered to have > 99.9% bactericidal activity. These results suggest that this new in vitro method for antimicrobial evaluation could be used as the standard method for testing the antimicrobial activity of toothpaste.

• 대한치위생과학회지
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• 제4권1호
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• pp.79-87
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• 2021

Background: The purpose of the present study was to confirm the degree of physical activity and oral health behaviors of adolescents, and to investigate the relationship between them. Methods: The present study utilized data from the 15th (2019) Korea Youth Risk Behavior Web-Based Survey data, which included a total of 57,303 adolescents for analysis. Statistical analysis was performed using PASW Statistics 21.0. The significance level for significance was set at 0.05. Results: The rate of toothbrushing before sleeping was 1.152 times higher in the group that performed muscle strengthening exercises more than 3 times a week than in the group that did not (p < 0.001). The rate of use of oral hygiene products was 1.246 times higher in the group that performed physical activity for 60 min or more every day than in the group that did not, and 1.207 times higher in the group that performed muscle strength exercise at least 3 times a week than in the group that did not (p < 0.001). Conclusions: Adolescents who engaged in physical activities had a high rate of practice for some oral health behaviors. These results suggested that the group with positive health behaviors has a higher rate of oral health behavior practice, showing that health behaviors are highly interrelated.

• The Journal of Korean Physical Therapy
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• 제26권1호
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• pp.33-40
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• 2014

Purpose: The aim of this study was to identify the effects of the lower trunk stabilization exercise using neurodevelopmental technique (NDT) on muscle activity in lumbar region and balance in the patients with hemiplegia. Methods: Fifteen participants were allocated in two groups: NDT group (n=8) or control group (n=7). NDT group performed NDT exercise program, while control group conducted walking exercise. Both interventions were given for 30 minutes a day, 3 times a week, for 5 weeks. To measure the muscle activity in rectus abdominis (RA), external oblique (EO) and internal oblique (IO), electromyography (EMG) was used. And, Timed-Up and Go (TUG) test and Berg-Balance Scale (BBS) were performed to assess balance before and after intervention. Results: NDT group showed a significant improvement of muscle activity in RA and EO, while control group did not show significant changes in three muscles. Also, there was a significant difference in muscle activity of RA and EO between two groups. In BBS and TUG test, participants in two groups showed significant improvements after intervention. Especially, significant difference was observed in TUG test between two groups (p<.05). Conclusion: This study demonstrated that NDT exercise is an effective intervention to improve the muscle activity in trunk region and to increase balance in patients with stroke. Thus, we suggested that NDT exercise program would be a treatment intervention in stroke rehabilitation.